factor V Leiden
Endothelial Dysfunction and Altered Coagulation As Mediators of Thromboembolism in Behçet Disease.
Madrid, Spain. In Semin Thromb Hemost, Sep 2015
These factors, together with the increased levels of homocysteine observed in BD patients, induce the endothelial cell expression of adhesion molecules (VCAM-1 and ICAM-1) and tissue factor; the release of cytokines, soluble CD40L (sCD40L), matrix metalloproteinase-9, and blood coagulation factor V; the inhibition of fibrinolysis; the disruption of nitric oxide metabolism; and the increase in platelet reactivity and lipid peroxidation.
Differential risks in men and women for first and recurrent venous thrombosis: the role of genes and environment.
Leiden, Netherlands. In J Thromb Haemost, 2014
No difference in prevalence or strength for other venous thrombosis risk factors was observed, such as plaster cast immobilization, hospitalization, surgery, trauma, malignancy, hyperhomocysteinemia, factor V Leiden, prothrombin G20210A, or blood group non-O.
Activated protein C resistance assay and factor V Leiden.
Graz, Austria. In N Engl J Med, 2014
The authors suggest that functional testing for activated protein C resistance is cheaper and more clinically relevant than genetic testing to detect a factor V Leiden mutation in identifying persons who are at risk for thromboembolism.