gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Structure specific recognition protein 1

The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known. [provided by RefSeq, Jul 2008] (from NCBI)
Sponsored links
Top mentioned proteins: Histone, POLYMERASE, Spt16, CAN, H2A
Papers on FACT
SSRP1 contributes to the malignancy of hepatocellular carcinoma and is negatively regulated by miR-497.
Guoan et al., Guangzhou, China. In Mol Ther, Feb 2016
UNASSIGNED: The aim of this study is to clarify the clinical implication and functional role of structure specific recognition protein 1 (SSRP1) in hepatocellular carcinoma (HCC) and explore the underlying mechanism of aberrant high expression of SSRP1 in cancers.
Tandem affinity purification of histones, coupled to mass spectrometry, identifies associated proteins and new sites of post-translational modification in Saccharomyces cerevisiae.
Pamblanco et al., Burjassot, Spain. In J Proteomics, Feb 2016
The histone chaperone Rtt106p, two members of chromatin assembly FACT complex and Psh1p, an ubiquitin ligase, were the most abundant proteins obtained with both H3-TAP and H4-TAP, regardless of the cell extraction medium stringency.
Cognitive effects of donepezil therapy in patients with brain tumors: a pilot study.
DeAngelis et al., New York City, United States. In J Neurooncol, Feb 2016
There was also an improvement in self-reported quality of life (FACT-Br, social well-being subscale; p = 0.01).
[Structure and function of histone chaperone FACT].
Studitsky et al., Philadelphia, United States. In Mol Biol (mosk), Nov 2015
FACT is heterodimer protein complex and histone chaperone that plays an important role in maintaining and modifying the chromatin structure during various DNA-dependent processes.
Comparison of dabrafenib and trametinib combination therapy with vemurafenib monotherapy on health-related quality of life in patients with unresectable or metastatic cutaneous BRAF Val600-mutation-positive melanoma (COMBI-v): results of a phase 3, open-label, randomised trial.
Robert et al., Marseille, France. In Lancet Oncol, Oct 2015
In this pre-specified exploratory analysis, we prospectively assessed HRQoL in the intention-to-treat population with the European Organisation for Research and Treatment of Cancer quality of life (EORTC QLQ-C30), EuroQoL-5D (EQ-5D), and Melanoma Subscale of the Functional Assessment of Cancer Therapy-Melanoma (FACT-M), completed at baseline, during study treatment, at disease progression, and after progression.
Reconstitution of mitotic chromatids with a minimum set of purified factors.
Hirano et al., Wako, Japan. In Nat Cell Biol, Aug 2015
Here we report an in vitro system in which mitotic chromatids can be reconstituted by mixing a simple substrate with only six purified factors: core histones, three histone chaperones (nucleoplasmin, Nap1 and FACT), topoisomerase II (topo II) and condensin I.
A systematic review of patient-reported outcome instruments of dermatologic adverse events associated with targeted cancer therapies.
Lacouture et al., Singapore, Singapore. In Support Care Cancer, Aug 2015
Four instruments were general dermatology (Skindex-16©, Skindex-29©, Dermatology Life Quality Index (DLQI), and DIELH-24) and two were symptom-specific (functional assessment of cancer therapy-epidermal growth factor receptor inhibitor-18 (FACT-EGFRI-18) and hand-foot syndrome 14 (HFS-14)).
Histone H2A/H2B chaperones: from molecules to chromatin-based functions in plant growth and development.
Shen et al., Shanghai, China. In Plant J, Jul 2015
Here we focus on plant histone H2A/H2B chaperones, particularly members of the NUCLEOSOME ASSEMBLY PROTEIN-1 (NAP1) and FACILITATES CHROMATIN TRANSCRIPTION (FACT) families, discussing their molecular features, properties, regulation and function.
Identifying Predictors of Taxane-Induced Peripheral Neuropathy Using Mass Spectrometry-Based Proteomics Technology.
Hershman et al., New York City, United States. In Plos One, 2014
Women with early stage breast cancer receiving adjuvant taxane chemotherapy were assessed with the FACT-Ntx score and serum was collected before and after the taxane treatment.
Crystal Structure of Human SSRP1 Middle Domain Reveals a Role in DNA Binding.
Li et al., Hefei, China. In Sci Rep, 2014
SSRP1 is a subunit of the FACT complex, an important histone chaperone required for transcriptional regulation, DNA replication and damage repair.
Comparison of the EORTC QLQ-BN20 and the FACT-Br quality of life questionnaires for patients with primary brain cancers: a literature review.
Bottomley et al., In Support Care Cancer, 2014
PURPOSE: This review compares and contrasts the development, validity, and characteristics of two quality of life (QOL) assessment tools used in patients with primary brain cancers: the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Brain Cancer Module (EORTC QLQ-BN20) and the Functional Assessment of Cancer Therapy-Brain (FACT-Br).
Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification.
Kouzarides et al., Cambridge, United Kingdom. In Nature, 2014
We show that the Q105 residue is part of the binding site for the histone chaperone FACT (facilitator of chromatin transcription) complex.
The impact of symptom burden on patient quality of life in chronic myeloid leukemia.
Frankfurt et al., Chicago, United States. In Oncology, 2013
The FACT-Leu is a validated tool that measures leukemia-specific and more general QoL concerns.
Structural basis of histone H2A-H2B recognition by the essential chaperone FACT.
Ladurner et al., München, Germany. In Nature, 2013
Facilitates chromatin transcription (FACT) is a conserved histone chaperone that reorganizes nucleosomes and ensures chromatin integrity during DNA transcription, replication and repair.
Control of transcriptional elongation.
Lis et al., Ithaca, United States. In Annu Rev Genet, 2012
We then discuss Pol II elongation through the bodies of genes and the roles of FACT and SPT6, factors that allow Pol II to move through nucleosomes.
Histone chaperone FACT coordinates nucleosome interaction through multiple synergistic binding events.
Luger et al., Fort Collins, United States. In J Biol Chem, 2012
specific FACT subunits synchronize interactions with various target sites on individual nucleosomes to generate a high affinity binding event and promote reorganization.
Biphasic chromatin binding of histone chaperone FACT during eukaryotic chromatin DNA replication.
Tada et al., Sendai, Japan. In Biochim Biophys Acta, 2011
Studies suggest that that even though FACT has rapid chromatin-binding activity, the binding pattern of FACT on chromatin changes after origin licensing, which may contribute to the establishment of its functional link to the DNA replication machinery.
The histone chaperone FACT: structural insights and mechanisms for nucleosome reorganization.
Luger et al., Fort Collins, United States. In J Biol Chem, 2011
The histone chaperone FACT: structural insights and mechanisms for nucleosome reorganization.
Genome-wide analysis of self-renewal in Drosophila neural stem cells by transgenic RNAi.
Knoblich et al., Vienna, Austria. In Cell Stem Cell, 2011
alternatively spliced isoforms control self-renewal in neuroblast lineages
Concordant and opposite roles of DNA-PK and the "facilitator of chromatin transcription" (FACT) in DNA repair, apoptosis and necrosis after cisplatin.
Lazaro et al., Boston, United States. In Mol Cancer, 2010
DNA-PK and FACT both play roles in DNA repair. Therefore both are putative targets for therapeutic inhibition.
share on facebooktweetadd +1mail to friends