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Structure specific recognition protein 1

FACT, SSRP1
The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known. [provided by RefSeq, Jul 2008] (from NCBI)
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Papers on FACT
Histone chaperone FACT coordinates nucleosome interaction through multiple synergistic binding events.
GeneRIF
Luger et al., Fort Collins, United States. In J Biol Chem, 2012
specific FACT subunits synchronize interactions with various target sites on individual nucleosomes to generate a high affinity binding event and promote reorganization.
Biphasic chromatin binding of histone chaperone FACT during eukaryotic chromatin DNA replication.
GeneRIF
Tada et al., Sendai, Japan. In Biochim Biophys Acta, 2011
Studies suggest that that even though FACT has rapid chromatin-binding activity, the binding pattern of FACT on chromatin changes after origin licensing, which may contribute to the establishment of its functional link to the DNA replication machinery.
The histone chaperone FACT: structural insights and mechanisms for nucleosome reorganization.
GeneRIF
Luger et al., Fort Collins, United States. In J Biol Chem, 2011
The histone chaperone FACT: structural insights and mechanisms for nucleosome reorganization.
Genome-wide analysis of self-renewal in Drosophila neural stem cells by transgenic RNAi.
Impact
GeneRIF
Knoblich et al., Vienna, Austria. In Cell Stem Cell, 2011
alternatively spliced isoforms control self-renewal in neuroblast lineages
Concordant and opposite roles of DNA-PK and the "facilitator of chromatin transcription" (FACT) in DNA repair, apoptosis and necrosis after cisplatin.
GeneRIF
Lazaro et al., Boston, United States. In Mol Cancer, 2010
DNA-PK and FACT both play roles in DNA repair. Therefore both are putative targets for therapeutic inhibition.
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