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Bromodomain PHD finger transcription factor

FAC1, NURF301, BPTF, Falz
This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Histone, CAN, SWI, V1a, HAD
Papers on FAC1
BPTF is required for c-MYC transcriptional activity and in vivo tumorigenesis.
Real et al., Madrid, Spain. In Nat Commun, Dec 2015
Here we report that c-MYC interacts with BPTF, a core subunit of the NURF chromatin-remodelling complex.
BPTF promotes tumor growth and predicts poor prognosis in lung adenocarcinomas.
Wu et al., Dalian, China. In Oncotarget, Nov 2015
BPTF, a subunit of NURF, is well known to be involved in the development of eukaryotic cell, but little is known about its roles in cancers, especially in non-small-cell lung cancer (NSCLC).
Dual Screening of BPTF and Brd4 Using Protein-Observed Fluorine NMR Uncovers New Bromodomain Probe Molecules.
Pomerantz et al., Minneapolis, United States. In Acs Chem Biol, Nov 2015
A library of 229 small molecules was screened against the first bromodomain of Brd4 and the BPTF bromodomain.
Chromatin-Remodelling Complex NURF Is Essential for Differentiation of Adult Melanocyte Stem Cells.
Davidson et al., Illkirch-Graffenstaden, France. In Plos Genet, Oct 2015
ShRNA-mediated silencing of the NURF subunit BPTF revealed its essential role in several melanoma cell lines and in untransformed melanocytes in vitro.
The prognostic significance of bromodomain PHD-finger transcription factor in colorectal carcinoma and association with vimentin and E-cadherin.
Fang et al., Hengyang, China. In J Cancer Res Clin Oncol, Aug 2015
PURPOSE: Bromodomain PHD-finger transcription factor (BPTF) is a chromatin-mediated regulation of transcription factor, playing an important role in embryogenesis and differentiation.
The Chromatin Remodeling Protein Bptf Promotes Posterior Neuroectodermal Fate by Enhancing Smad2-Activated wnt8a Expression.
Wang et al., Beijing, China. In J Neurosci, Jul 2015
Bptf and Smad2 directly bind to and activate the wnt8a promoter through recruiting NURF remodeling complex.
Functional proteomics of the epigenetic regulators ASXL1, ASXL2 and ASXL3: a convergence of proteomics and epigenetics for translational medicine.
Katoh, Tokyo, Japan. In Expert Rev Proteomics, Jun 2015
Phylogenetic analyses of 139 human PHD fingers revealed that ASXL PHD fingers cluster with those of BPTF, DIDO, ING1, KDM5A (JARID1A), KMT2E (MLL5), PHF2, PHF8 and PHF23.
The role of BPTF in melanoma progression and in response to BRAF-targeted therapy.
Kashani-Sabet et al., San Francisco, United States. In J Natl Cancer Inst, May 2015
BACKGROUND: Bromodomain PHD finger transcription factor (BPTF) plays an important role in chromatin remodeling, but its functional role in tumor progression is incompletely understood.
BPTF Associated with EMT Indicates Negative Prognosis in Patients with Hepatocellular Carcinoma.
Lu et al., Hengyang, China. In Dig Dis Sci, Apr 2015
Bromodomain PHD-finger transcription factor (BPTF) could regulate embrogenesis and stem cell differentiation, and it may be involved in tumor progression and EMT.
Upregulated MiR-1269 in hepatocellular carcinoma and its clinical significance.
Chen et al., Nanning, China. In Int J Clin Exp Med, 2014
There were 9 targeted genes which had been shown concurrently by at least 4 databases: AGAP1, AGK, BPTF, C16orf74, DACT1, LIX1L, RBMS3, ZNF706 and BMPER.
Enhancer interaction networks as a means for singular olfactory receptor expression.
Lomvardas et al., San Francisco, United States. In Cell, 2014
In particular, we establish the role of the transcription factor Bptf as a facilitator of both enhancer interactions and OR transcription.
Recurrent inactivation of STAG2 in bladder cancer is not associated with aneuploidy.
Real et al., Madrid, Spain. In Nat Genet, 2013
A discovery exome sequencing screen (n = 17), followed by a prevalence screen (n = 60), identified new genes mutated in this tumor coding for proteins involved in chromatin modification (MLL2, ASXL2 and BPTF), cell division (STAG2, SMC1A and SMC1B) and DNA repair (ATM, ERCC2 and FANCA).
Diverse epigenetic strategies interact to control epidermal differentiation.
Watt et al., Cambridge, United Kingdom. In Nat Cell Biol, 2012
We discovered a network of genetic interactions involving EZH2, UHRF1 (both known to regulate epidermal self-renewal), ING5 (a MORF complex component), BPTF and SMARCA5 (NURF complex components).
Recognition of a mononucleosomal histone modification pattern by BPTF via multivalent interactions.
Allis et al., New York City, United States. In Cell, 2011
The PHD-adjacent bromodomain in BPTF binds with marked selectivity H4K16ac, in combination with H3K4me3 at the mononucleosome level.
Epigenetic regulation of stem cell maintenance in the Drosophila testis via the nucleosome-remodeling factor NURF.
Matunis et al., Baltimore, United States. In Cell Stem Cell, 2010
required for stem cell maintenance in the Drosophila testis
A novel translocation breakpoint within the BPTF gene is associated with a pre-malignant phenotype.
Rotter et al., Israel. In Plos One, 2009
the novel translocation breakpoint within the BPTF gene is associated with a pre-malignant phenotype
Alternative splicing of NURF301 generates distinct NURF chromatin remodeling complexes with altered modified histone binding specificities.
Badenhorst et al., Birmingham, United Kingdom. In Plos Genet, 2009
Study demonstrates that three NURF301 isoforms are expressed and that these encode functionally distinct NURF chromatin remodeling complexes.
The expression of three genes in primary non-small cell lung cancer is associated with metastatic spread to the brain.
Izraeli et al., Ramat Gan, Israel. In Clin Cancer Res, 2009
High FALZ expression is associated with metastatic spread to the brain in primary non-small cell lung cancer.
Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression.
Shi et al., Boston, United States. In Nature, 2007
Here we report that, in contrast to the PHD fingers of the bromodomain PHD finger transcription factor (BPTF) and inhibitor of growth family 2 (ING2), which bind methylated H3K4 (H3K4me3), the PHD finger of BHC80 binds unmethylated H3K4 (H3K4me0), and this interaction is specifically abrogated by methylation of H3K4.
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