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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Phosphoinositide kinase, FYVE finger containing

Fab1, PIKfyve, Fab1p, FabI, P235, PIP5K, PIP5K3
Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. This gene encodes an enzyme (PIKfyve; also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns(3,5)biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. In contrast, PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKfyve also has protein kinase activity. PIKfyve regulates endomembrane homeostasis and plays a role in the biogenesis of endosome carrier vesicles from early endosomes. Mutations in this gene cause corneal fleck dystrophy (CFD); an autosomal dominant disorder characterized by numerous small white flecks present in all layers of the corneal stroma. Histologically, these flecks appear to be keratocytes distended with lipid and mucopolysaccharide filled intracytoplasmic vacuoles. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010] (from NCBI)
Top mentioned proteins: ACID, CAN, V1a, HAD, STEP
Papers using Fab1 antibodies
Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice
Supplier
Dolmetsch Ricardo E. et al., In The Journal of Cell Biology, 2006
... 1.2 (1:500; AB5156; Millipore), PIKfyve (1:500; 6C7; Abnova), Myc (1:500; 4A6; Millipore), ...
Receptor activation alters inner surface potential during phagocytosis
Supplier
Grinstein Sergio et al., In The Journal of Cell Biology, 2005
... Goat polyclonal antibodies to PIP5K-α (N-20) were purchased from Santa Cruz Biotechnology, Inc ...
Papers on Fab1
Phosphatidylinositol 4-Phosphate 5-Kinase β Controls Recruitment of Lipid Rafts into the Immunological Synapse.
New
Viola et al., Milano, Italy. In J Immunol, Feb 2016
Spatiotemporal analysis of PIP2 synthesis in T lymphocytes suggested that distinct isoforms of the main PIP2-generating enzyme, phosphatidylinositol 4-phosphate 5-kinase (PIP5K), play a differential role on the basis of their distinct localization.
Phosphatidylinositol 3-Kinase Promotes V-ATPase Activation and Vacuolar Acidification and Delays Methyl Jasmonate-induced Leaf Senescence.
New
Xing et al., Guangzhou, China. In Plant Physiol, Feb 2016
Vacuolar acidification was suppressed by the PIKfyve inhibitor in 35S:AtVPS34-YFP Arabidopsis during MeJA-induced leaf senescence, but the decrease was lower than that in YFP-labeled Arabidopsis.
Efficacy and safety of AFN-1252, the first staphylococcus-specific antibacterial agent, in the treatment of ABSSSI, including patients with significant co-morbidities.
New
Murphy et al., Toronto, Canada. In Antimicrob Agents Chemother, Jan 2016
UNASSIGNED: This open-label non-controlled phase II multi-center trial was designed to evaluate safety, tolerability and efficacy of oral AFN-1252, a selective inhibitor of S. aureus enoyl-ACP reductase (FabI), given 200 mg PO twice-daily in the treatment of acute bacterial skin and skin structure infections (ABSSSI) due to staphylococci.
ucFabV Requires Functional Reductase Activity to Confer Reduced Triclosan Susceptibility in Escherichia coli.
New
Donato et al., Saint Paul, United States. In J Mol Microbiol Biotechnol, Jan 2016
The mutant and wild-type enzymes were introduced into E. coli, and their ability to confer triclosan tolerance as well as suppress a temperature-sensitive mutant of FabI were measured.
Evaluating thermodynamic integration performance of the new amber molecular dynamics package and assess potential halogen bonds of enoyl-ACP reductase (FabI) benzimidazole inhibitors.
New
Johnson et al., Chicago, United States. In J Comput Chem, Jan 2016
In the effort of developing an efficient and accurate TI protocol for FabI inhibitors lead optimization program, we carefully compared TI with different Amber molecular dynamics (MD) engines (sander and pmemd), MD simulation lengths, the number of intermediate states and transformation steps, and the Lennard-Jones and Coulomb Softcore potentials parameters in the one-step TI, using eleven benzimidazole inhibitors in complex with Francisella tularensis enoyl acyl reductase (FtFabI).
The multifaceted role of PIP2 in leukocyte biology.
Review
New
Galandrini et al., Roma, Italy. In Cell Mol Life Sci, Dec 2015
The coordination of these different aspects relies on the spatio-temporal organisation of distinct PIP2 pools, generated by the main PIP2 generating enzyme, phosphatidylinositol 4-phosphate 5-kinase (PIP5K).
[New antibacterial agents on the market and in the pipeline].
Review
New
Kern, Freiburg, Germany. In Internist (berl), Nov 2015
New agents in a very early developmental phase are FabI inhibitors, endolysines, peptidomimetics, lipid A inhibitors, methionyl-tRNA synthetase inhibitors and teixobactin.
Phosphatidylinositol 5-phosphate: a nuclear stress lipid and a tuner of membranes and cytoskeleton dynamics.
Review
Payrastre et al., Toulouse, France. In Bioessays, 2014
Recently, the contribution of several enzymes such as PIKfyve, myotubularins, and type II PtdInsP-kinases to PtdIns5P metabolism has gained a strong experimental support.
Phosphatidylinositol 3,5-bisphosphate: low abundance, high significance.
Review
Weisman et al., Ann Arbor, United States. In Bioessays, 2014
A complex of proteins that includes Fab1/PIKfyve, Vac14, and Fig4/Sac3 mediates the biosynthesis of PI(3,5)P2 , and mutations that disrupt complex function and/or formation cause profound consequences in cells.
Regulation of ion channels and transporters by AMP-activated kinase (AMPK).
Review
Föller et al., Tübingen, Germany. In Channels (austin), 2013
It stimulates phosphatidylinositol 3-phosphate 5-kinase PIKfyve and inhibits phosphatase and tensin homolog (PTEN) via glycogen synthase kinase 3β (GSK3β).
Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636.
GeneRIF
Shisheva et al., Detroit, United States. In Am J Physiol Cell Physiol, 2012
The results provide the first experimental evidence that the principal pathway for PtdIns5P intracellular production is through PIKfyve.
The nucleophosmin-anaplastic lymphoma kinase oncogene interacts, activates, and uses the kinase PIKfyve to increase invasiveness.
GeneRIF
Tronchère et al., Toulouse, France. In J Biol Chem, 2011
a role for PIKfyve in NPM-ALK-mediated invasion.
The phosphoinositide kinase PIKfyve is vital in early embryonic development: preimplantation lethality of PIKfyve-/- embryos but normality of PIKfyve+/- mice.
GeneRIF
Shisheva et al., Detroit, United States. In J Biol Chem, 2011
The phosphoinositide kinase PIKfyve is vital in early embryonic development: preimplantation lethality of PIKfyve-/- embryos but normality of PIKfyve+/- mice.
Regulation of PIP5K activity by Arf6 and its physiological significance.
Review
GeneRIF
Kanaho et al., Tsukuba, Japan. In J Cell Physiol, 2011
The recent advances in Arf6/PIP5K signaling and its linkage to cellular functions, are reviewed.
A novel PIKFYVE mutation in fleck corneal dystrophy.
GeneRIF
Petersen et al., Greece. In Mol Vis, 2010
A novel c.3060-3063 delCCTT (p.P968Vfs23) mutation in the PIKFYVE gene has been described in a five generation Greek family, which segregated with the fleck corneal dystrophy.
Inhibitors of FabI, an enzyme drug target in the bacterial fatty acid biosynthesis pathway.
Review
Impact
Tonge et al., Stony Brook, United States. In Acc Chem Res, 2008
In this Account, we summarize current progress in developing inhibitors of FabI, the NADH-dependent enoyl reductase from the type II bacterial fatty acid biosynthesis pathway (FAS-II), a validated but currently underexploited target for drug discovery.
Amplifying Btk's signal.
Impact
Schwartzberg, Bethesda, United States. In Immunity, 2003
Data from Carpenter and colleagues (Saito et al., this issue of Immunity) now suggest that Btk also activates phosphatidylinositol-4-phosphate 5-kinase (PIP5K), thereby stimulating a positive feedback loop that generates PI(4,5)P2, the substrate for both phosphoinositide 3-kinase (PI3K) and PLC-gamma.
BTK regulates PtdIns-4,5-P2 synthesis: importance for calcium signaling and PI3K activity.
Impact
Carpenter et al., Boston, United States. In Immunity, 2003
Upon B cell receptor activation, BTK brings PIP5K to the plasma membrane as a means of generating local PtdIns-4,5-P2 synthesis.
Triclosan offers protection against blood stages of malaria by inhibiting enoyl-ACP reductase of Plasmodium falciparum.
Impact
Surolia et al., Bengaluru, India. In Nat Med, 2001
Inhibition of [14C]acetate and [14C]malonyl-CoA incorporation into fatty acids in vivo and in vitro, respectively, by triclosan implicate FabI as its target.
A rhoptry-protein-associated mechanism of clonal phenotypic variation in rodent malaria.
Impact
Snounou et al., London, United Kingdom. In Nature, 1999
In the rodent malaria agent P. yoelii yoelii, a multigene family codes for merozoite rhoptry proteins of relative molecular mass 235,000 (p235 proteins); these proteins are thought to determine the subset of erythrocytes that the parasites invade.
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