The multifaceted role of PIP2 in leukocyte biology.
Roma, Italy. In Cell Mol Life Sci, Dec 2015
The coordination of these different aspects relies on the spatio-temporal organisation of distinct PIP2 pools, generated by the main PIP2 generating enzyme, phosphatidylinositol 4-phosphate 5-kinase (PIP5K).
Amplifying Btk's signal.
Bethesda, United States. In Immunity, 2003
Data from Carpenter and colleagues (Saito et al., this issue of Immunity) now suggest that Btk also activates phosphatidylinositol-4-phosphate 5-kinase (PIP5K), thereby stimulating a positive feedback loop that generates PI(4,5)P2, the substrate for both phosphoinositide 3-kinase (PI3K) and PLC-gamma.