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Fatty acid amide hydrolase 2

FAAH-2, AMDD, fatty acid amide hydrolase 2
This gene encodes a fatty acid amide hydrolase that shares a conserved protein motif with the amidase signature family of enzymes. The encoded enzyme is able to catalyze the hydrolysis of a broad range of bioactive lipids, including those from the three main classes of fatty acid amides; N-acylethanolamines, fatty acid primary amides and N-acyl amino acids. This enzyme has a preference for monounsaturated acyl chains as a substrate.[provided by RefSeq, Sep 2009] (from NCBI)
Top mentioned proteins: ACID, fatty acid amide hydrolase, AGE, CB1, GPR55
Papers on FAAH-2
A randomized, placebo-controlled pilot trial of the delta opioid receptor agonist AZD2327 in anxious depression.
Zarate et al., Bethesda, United States. In Psychopharmacology (berl), Feb 2016
RATIONALE: Patients with anxious major depressive disorder (AMDD) have more severe symptoms and poorer treatment response than patients with non-AMDD.
Simultaneous remediation of nutrients from liquid anaerobic digestate and municipal wastewater by the microalga Scenedesmus sp. AMDD grown in continuous chemostats.
McGinn et al., Halifax, Canada. In J Appl Microbiol, 2015
AMDD, to remediate nutrients from municipal wastewater, either as the sole nutrient source or after blending with wastewater obtained from the anaerobic digestion of swine manure.
Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypes.
Seshagiri et al., San Francisco, United States. In Nat Genet, 2015
In chRCC, we found TP53, PTEN, FAAH2, PDHB, PDXDC1 and ZNF765 to be significantly mutated.
Rare coding variants and X-linked loci associated with age at menarche.
Perry et al., Boston, United States. In Nat Commun, 2014
In addition, we identify common X-chromosome loci at IGSF1 (rs762080, P=9.4 × 10(-13)) and FAAH2 (rs5914101, P=4.9 × 10(-10)).
Defects in fatty acid amide hydrolase 2 in a male with neurologic and psychiatric symptoms.
Kaczocha et al., Vancouver, Canada. In Orphanet J Rare Dis, 2014
BACKGROUND: Fatty acid amide hydrolase 2 (FAAH2) is a hydrolase that mediates the degradation of endocannabinoids in man.
AMDD: antimicrobial drug database.
Khan et al., Alīgarh, India. In Genomics Proteomics Bioinformatics, 2012
Thus, we developed a comprehensive database, anti microbial drug database (AMDD), of known synthetic antibacterial and antifungal compounds that were extracted from the available literature and other chemical databases, e.g., PubChem, PubChem BioAssay and ZINC, etc.
Aryl Piperazinyl Ureas as Inhibitors of Fatty Acid Amide Hydrolase (FAAH) in Rat, Dog, and Primate.
Breitenbucher et al., San Diego, United States. In Acs Med Chem Lett, 2012
A potent and selective (does not inhibit FAAH-2) member of this class, JNJ-40355003, was found to elevate the plasma levels of three fatty acid amides: anandamide, oleoyl ethanolamide, and palmitoyl ethanolamide, in the rat, dog, and cynomolgous monkey.
Investigations of the human endocannabinoid system in two subcutaneous adipose tissue depots in lean subjects and in obese subjects before and after weight loss.
Pedersen et al., Århus, Denmark. In Int J Obes (lond), 2011
The expression of the degrading enzymes FAAH, FAAH2, MGL and MGL2 was differently affected by obesity, AT depot and weight loss.
Fine-scale survey of X chromosome copy number variants and indels underlying intellectual disability.
Raymond et al., Cambridge, United Kingdom. In Am J Hum Genet, 2010
Fine-scale analysis of rare variants in XLID families leads us to propose four additional genes, PTCHD1, WDR13, FAAH2, and GSPT2, as candidates for XLID causation and the identification of further deletions and duplications affecting X chromosome genes but without apparent disease consequences.
Biochanin A, a naturally occurring inhibitor of fatty acid amide hydrolase.
Fowler et al., Umeå, Sweden. In Br J Pharmacol, 2010
The compound did not interact to any major extent with CB(1) or CB(2) receptors, nor with FAAH-2.
Lipid droplets are novel sites of N-acylethanolamine inactivation by fatty acid amide hydrolase-2.
Deutsch et al., Stony Brook, United States. In J Biol Chem, 2010
results establish FAAH-2 as a bone fide N-acylethanolamine-catabolizing enzyme and suggest that inactivation is spatially separated in cells of higher mammals
Biochemical and biological properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase.
Webb et al., San Diego, United States. In Anesth Analg, 2009
Biochemical and biological properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase.
Tempo and mode in the endocannaboinoid system.
Kilpatrick et al., United States. In J Mol Evol, 2007
Next we used FUGE (tree-based maximum-likelihood model) to compute human lineage-specific Ka/Ks calculations for 18 genes, which ranged from 1.11 to 0.00, in rank order from highest to lowest: PTPN22, NAAA, TRPV1, TRPA1, NAPE-PLD, MAGL, PPARgamma, FAAH1, COX2, FAAH2, ABDH4, CB2, GPR55, DAGLbeta, PPARalpha, TRPV4, CB1, DAGLalpha; differences were significant (p < 0.0001).
Coevolution between cannabinoid receptors and endocannabinoid ligands.
Kilpatrick et al., United States. In Gene, 2007
We addressed this debate with a coevolutionary analysis, by examining genes for CB1, CB2, and ten genes that encode ligand metabolic enzymes: abhydrolase domain containing 4 protein, cyclooxygenase 2, diacylglycerol lipase paralogs (DAGLalpha, DAGLbeta), fatty acid amide hydrolase paralogs (FAAH1, FAAH2), monoglyceride lipase, N-acylethanolamine acid amidase, NAPE-selective phospholipase D, and protein tyrosine phosphatase non-receptor type 22. Gene trees (cladograms) of CB1, CB2, and ligand enzymes were obtained by searching for orthologs (tBLASTn) in the genomes of nine phylogenetically diverse species, aligning ortholog sequences with ClustalX, and applying Bayesian analysis (MrBayes).
A shifted repertoire of endocannabinoid genes in the zebrafish (Danio rerio).
Kilpatrick et al., United States. In Mol Genet Genomics, 2007
Zebrafish expressed orthologs of cannabinoid receptor 1, transient receptor potential channel vanilloid receptor 4, GPR55 receptor, fatty acid amide hydrolase 1, monoacylglycerol lipase, NAPE-selective phospholipase D, abhydrolase domain-containing protein 4, and diacylglycerol lipase alpha and beta; and paired paralogs of cannabinoid receptor 2, fatty acid amide hydrolase 2, peroxisome proliferator-activated receptor alpha, prostaglandin-endoperoxide synthase 2, and transient receptor potential cation channel subtype A1.
A second fatty acid amide hydrolase with variable distribution among placental mammals.
Cravatt et al., Los Angeles, United States. In J Biol Chem, 2007
FAAH2 is the second membrane-associated AS enzyme in humans that displays FAAH activity
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