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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 29 Oct 2014.

Fanconi anemia, complementation group A

FAA, FAH, FANCA, fumarylacetoacetate hydrolase, fumarylacetoacetase
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group A. Alternative splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are the most common cause of Fanconi anemia. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, FANCC, FANCG
Papers using FAA antibodies
Cleavage and cytoplasmic relocalization of histone deacetylase 3 are important for apoptosis progression.
Supplier
Akhtar Asifa, In PLoS Genetics, 2006
... Darmstadt, Germany), the anti-phospho ATM from Cell Signalling technology, Inc (Boston, MA), the anti-H2A.Z and anti-FANCA from Abcam Inc (Cambridge, MA), the ...
Current concepts: Prosthetic-joint infections.
Supplier
Bergh Kåre et al., In Acta Orthopaedica, 2003
... , FAA agar (Merck) was incubated in an ...
Papers on FAA
Identification of amino acids associated with skeletal muscle growth in late gestation and at weaning in lambs of well-nourished sheep.
New
McCoard et al., Punta Arenas, Chile. In J Anim Sci, 30 Nov 2014
The objective of this study was to determine the association between intracellular free AA (FAA) profiles in skeletal muscle with muscle growth in twin and singleton fetuses in late pregnancy and at weaning, under an ad libitum feeding regime of the dam.
U2AF1 mutations alter splice site recognition in hematological malignancies.
New
Bradley et al., Hutchinson, United States. In Genome Res, 29 Oct 2014
U2AF1 mutations cause differential splicing of hundreds of genes, affecting biological pathways such as DNA methylation (DNMT3B), X chromosome inactivation (H2AFY), the DNA damage response (ATR, FANCA), and apoptosis (CASP8).
Extensive double humanization of both liver and hematopoiesis in FRGN mice.
New
Grompe et al., Tigard, United States. In Stem Cell Res, 06 Oct 2014
Immune-deficient, fumarylacetoacetate hydrolase (Fah(-/-)), Rag2(-/-) and Il2rg(-/-) deficient animals on the NOD-strain background (FRGN) were simultaneously co-transplanted with adult human hepatocytes and hematopoietic stem cells after busulfan and Ad:uPA pre-conditioning.
In vitro inhibition of matrix metalloproteinases, invasion and growth of Fanconi anemia human FANCA and FANCC lymphoblasts by nutrient mixture.
New
Rath et al., Santa Clara, United States. In Exp Oncol, 30 Sep 2014
In this study, we investigated effects of a nutrient mixture (NM) containing, ascorbic acid, lysine, proline and green tea extract, on human FANCA and FANCC lymphoblasts for viability, MMP secretion and invasion.
Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype.
New
Impact
Anderson et al., Cambridge, United States. In Nat Biotechnol, Jun 2014
We demonstrate CRISPR-Cas9-mediated correction of a Fah mutation in hepatocytes in a mouse model of the human disease hereditary tyrosinemia.
Direct reprogramming of human fibroblasts to functional and expandable hepatocytes.
New
Impact
Hui et al., Shanghai, China. In Cell Stem Cell, Apr 2014
Upon transplantation into mice with concanavalin-A-induced acute liver failure and fatal metabolic liver disease due to fumarylacetoacetate dehydrolase (Fah) deficiency, hiHeps restore the liver function and prolong survival.
Recurrent inactivation of STAG2 in bladder cancer is not associated with aneuploidy.
New
Impact
Real et al., Madrid, Spain. In Nat Genet, Dec 2013
A discovery exome sequencing screen (n = 17), followed by a prevalence screen (n = 60), identified new genes mutated in this tumor coding for proteins involved in chromatin modification (MLL2, ASXL2 and BPTF), cell division (STAG2, SMC1A and SMC1B) and DNA repair (ATM, ERCC2 and FANCA).
Amino acid profiles in term and preterm human milk through lactation: a systematic review.
Review
New
Lőnnerdal et al., Urbana, United States. In Nutrients, Dec 2013
We report a systematic review of total amino acid (TAA) and free amino acid (FAA) profiles, in term and preterm HM derived from 13 and 19 countries, respectively.
The Fanconi anemia DNA repair pathway: structural and functional insights into a complex disorder.
Review
New
Deans et al., Dundee, United Kingdom. In Annu Rev Biophys, Dec 2013
Mutations in any of at least sixteen FANC genes (FANCA-Q) cause Fanconi anemia, a disorder characterized by sensitivity to DNA interstrand crosslinking agents.
Reprogramming fibroblasts into bipotential hepatic stem cells by defined factors.
New
Impact
Hu et al., Shanghai, China. In Cell Stem Cell, Oct 2013
In the injured liver of fumarylacetoacetate hydrolase (Fah)-deficient mice, repopulating iHepSCs become hepatocyte-like cells.
Hereditary breast and ovarian cancer susceptibility genes (review).
Review
New
Matsuura et al., Kashihara, Japan. In Oncol Rep, Sep 2013
Mutations in BRCA genes cannot account for all cases of HBOC, indicating that the remaining cases can be attributed to the involvement of constitutive epimutations or other cancer susceptibility genes, which include Fanconi anemia (FA) cluster (FANCD2, FANCA and FANCC), mismatch repair (MMR) cluster (MLH1, MSH2, PMS1, PMS2 and MSH6), DNA repair cluster (ATM, ATR and CHK1/2), and tumor suppressor cluster (TP53, SKT11 and PTEN).
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration.
New
Impact
Clevers et al., Utrecht, Netherlands. In Nature, Mar 2013
Such clonal organoids can be induced to differentiate in vitro and to generate functional hepatocytes upon transplantation into Fah(-/-) mice.
Differential expression of DNA repair genes in Hispanic women with breast cancer.
New
Suarez et al., Ponce, Puerto Rico. In Mol Cancer Biol, Mar 2013
Statistically significant positive correlations between DRC level and gene expression were found for the RAD51, FANCB and FANCA genes.
Recommendations for the management of tyrosinaemia type 1.
Review
Spiekerkötter et al., Brussels, Belgium. In Orphanet J Rare Dis, 2012
The management of tyrosinaemia type 1 (HT1, fumarylacetoacetase deficiency) has been revolutionised by the introduction of nitisinone but dietary treatment remains essential and the management is not easy.
Fanconi anemia complementation group A (FANCA) protein has intrinsic affinity for nucleic acids with preference for single-stranded forms.
GeneRIF
Zhang et al., Miami, United States. In J Biol Chem, 2012
the nucleic acid-binding domain of FANCA is located primarily at its C terminus, where most disease-causing mutations are found.
Evidence for complete epistasis of null mutations in murine Fanconi anemia genes Fanca and Fancg.
GeneRIF
Arwert et al., Amsterdam, Netherlands. In Dna Repair (amst), 2012
null mutations in Fanca or Fancg are fully epistatic
Identification of mutations causing hereditary tyrosinemia type I in patients of Middle Eastern origin.
GeneRIF
Al-Sayed et al., Riyadh, Saudi Arabia. In Mol Genet Metab, 2011
We detected 11 novel and 6 previously described pathogenic mutations in the fumarylacetoacetase gene in a cohort of 43 patients originating from the Middle East with the acute form hereditary tyrosinemia type I
Hepatorenal tyrosinemia.
Review
Kitagawa, Tokyo, Japan. In Proc Jpn Acad Ser B Phys Biol Sci, 2011
They suggested that the primary enzyme deficiency in patients with HRT was fumarylacetoacetate hydrolase, and this was soon confirmed.
Evaluation of Fanconi anaemia genes FANCA, FANCC and FANCL in cervical cancer susceptibility.
GeneRIF
Gyllensten et al., Uppsala, Sweden. In Gynecol Oncol, 2011
genetic diversity in FANCA, FANCC and FANCL does not support an association of these genes with cervical cancer susceptibility in the Swedish population.
Origin, functional role, and clinical impact of Fanconi anemia FANCA mutations.
GeneRIF
Surrallés et al., Barcelona, Spain. In Blood, 2011
All missense mutations studied lead to an altered FANCA protein that is unable to relocate to the nucleus and activate the FA/BRCA pathway.
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