Gene expression pattern contributing to prognostic factors in childhood acute lymphoblastic leukemia.
Ribeirão Preto, Brazil. In Leuk Lymphoma, 2013
The present study evaluated the expression profile of 19 genes previously reported in microarray studies and associated with resistance or sensitivity to vincristine (RPLP2, CD44, TCFL5, KCNN1, TRIM24), prednisolone (F8A, CDK2AP1, BLVRB, CD69), daunorubicin (MAP3K12, SHOC2, PCDH9, EGR1, KCNN4) and l-asparaginase (GPR56, MAN1A1, CLEC11A, IGFBP7, GATA3).
Striatal synaptosomes from Hdh140Q/140Q knock-in mice have altered protein levels, novel sites of methionine oxidation, and excess glutamate release after stimulation.
In J Huntingtons Dis, 2012
RESULTS: Striatal synaptosomes of 6 month old Hdh140Q/140Q mice had less DARPP32, syntaxin 1 and calmodulin compared to WT. Striatal synaptosomes of 12 month old Hdh140Q/140Q mice had lower levels of DARPP32, alpha actinin, HAP40, Na+/K+-ATPase, PSD95, SNAP-25, TrkA and VAMP1, VGlut1 and VGlut2, increased levels of VAMP2, and modifications in actin and calmodulin compared to WT.
[Effectors of GTPase Rab5 in endocytosis and signal transduction].
Warsaw, Poland. In Postepy Biochem, 2008
Small GTPase Rab5 is a multifunctional protein, which regulates early steps of endocytosis, due to its interactions with numerous effectors such as: Rabaptin-5/Rabex-5, EEA1, phosphatidylinositol 3-kinases hVPS34-p150 and p110beta-p85alpha, phosphatidylinositol 4- and 5-phosphatases, Rabenosyn-5/hVPS45, Rabankyrin-5, Huntingtin-HAP40, APPL1 and APPL2.