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Coagulation factor VIII-associated 1

F8A, factor VIII-associated protein, HAP40
This gene is contained entirely within intron 22 of the factor VIII gene; spans less than 2 kb, and is transcribed in the direction opposite of factor VIII. A portion of intron 22 (int22h), containing F8A, is repeated twice extragenically closer to the Xq telomere. Although its function is unknown, the observation that this gene is conserved in the mouse implies it has some function. Unlike factor VIII, this gene is transcribed abundantly in a wide variety of cell types. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, H1, CAN, c-Myc, MAX
Papers on F8A
An in vitro investigation of a detachable fork-like structure as efficient nuclear-targeted sub-unit in A2780 cell cultures.
Huang et al., Chengdu, China. In Int J Pharm, Feb 2016
To efficiently deliver drugs into cancer cell nucleus, in our previous study, a fork-like sub-unit, with one end conjugated with a targeting peptide named R8NLS (CRRRRRRRRPKKKRKV) and the other end conjugated with c-Myc oncogene inhibitor H1-S6A,F8A (H1) peptide, was linked onto the N-(2-hydroxypropyl) methacrylamide (HPMA) copolymer via an enzyme degradable glycylphenylalanylleucylglycine (GFLG) tetrapeptide spacer.
Binding modes of three inhibitors 8CA, F8A and I4A to A-FABP studied based on molecular dynamics simulation.
Zhu et al., Jinan, China. In Plos One, 2013
Molecular dynamics (MD) simulations coupled with solvated interaction energy method (SIE) were carried out to study the binding modes of three inhibitors 8CA, F8A and I4A to A-FABP.
Controlled release of ropinirole hydrochloride from a multiple barrier layer tablet dosage form: effect of polymer type on pharmacokinetics and IVIVC.
Kulkarni et al., Pune, India. In Aaps Pharmscitech, 2013
The formulations F8A and F9A having similar dissolution profiles among themselves and with Requip® XL™ (f 2 value 72, 77, 71 respectively) were evaluated.
Gene expression pattern contributing to prognostic factors in childhood acute lymphoblastic leukemia.
Tone et al., Ribeirão Preto, Brazil. In Leuk Lymphoma, 2013
The present study evaluated the expression profile of 19 genes previously reported in microarray studies and associated with resistance or sensitivity to vincristine (RPLP2, CD44, TCFL5, KCNN1, TRIM24), prednisolone (F8A, CDK2AP1, BLVRB, CD69), daunorubicin (MAP3K12, SHOC2, PCDH9, EGR1, KCNN4) and l-asparaginase (GPR56, MAN1A1, CLEC11A, IGFBP7, GATA3).
Antimicrobial HPA3NT3 peptide analogs: placement of aromatic rings and positive charges are key determinants for cell selectivity and mechanism of action.
Park et al., Kwangju, South Korea. In Biochim Biophys Acta, 2013
In the present study, we designed peptide analogs including HPA3NT3-F1A (-F1A), HPA3NT3-F8A (-F8A), HPA3NT3-F1AF8A (-F1AF8A), HPA3NT3-A1 (-A1) and HPA3NT3-A2 (-A2) in an effort to investigate the effects of amino acid substitutions in reducing their hydrophobicity or increasing their cationicity, and any resulting effects on their selectivity in their interactions with human cells and pathogens, as well as their mechanism of antimicrobial action.
Striatal synaptosomes from Hdh140Q/140Q knock-in mice have altered protein levels, novel sites of methionine oxidation, and excess glutamate release after stimulation.
DiFiglia et al., In J Huntingtons Dis, 2012
RESULTS: Striatal synaptosomes of 6 month old Hdh140Q/140Q mice had less DARPP32, syntaxin 1 and calmodulin compared to WT. Striatal synaptosomes of 12 month old Hdh140Q/140Q mice had lower levels of DARPP32, alpha actinin, HAP40, Na+/K+-ATPase, PSD95, SNAP-25, TrkA and VAMP1, VGlut1 and VGlut2, increased levels of VAMP2, and modifications in actin and calmodulin compared to WT.
Site-specific protein dynamics in communication pathway from sensor to signaling domain of oxygen sensor protein, HemAT-Bs: Time-resolved Ultraviolet Resonance Raman Study.
Kitagawa et al., Bochum, Germany. In J Biol Chem, 2012
The W16 and W3 Raman bands of Trp, the F8a band of Phe, and the Y8a band of Tyr increased in intensity at hundreds of nanoseconds after CO photodissociation, and this was followed by recovery in ∼50 μs.
[Effectors of GTPase Rab5 in endocytosis and signal transduction].
Miaczyńska et al., Warsaw, Poland. In Postepy Biochem, 2008
Small GTPase Rab5 is a multifunctional protein, which regulates early steps of endocytosis, due to its interactions with numerous effectors such as: Rabaptin-5/Rabex-5, EEA1, phosphatidylinositol 3-kinases hVPS34-p150 and p110beta-p85alpha, phosphatidylinositol 4- and 5-phosphatases, Rabenosyn-5/hVPS45, Rabankyrin-5, Huntingtin-HAP40, APPL1 and APPL2.
Protein S enhances the tissue factor pathway inhibitor inhibition of factor Xa but not its inhibition of factor VIIa-tissue factor.
Broze et al., In J Thromb Haemost, 2008
Protein S enhances the tissue factor pathway inhibitor inhibition of factor Xa but not its inhibition of factor VIIa-tissue factor
Rab5 modulates aggregation and toxicity of mutant huntingtin through macroautophagy in cell and fly models of Huntington disease.
Rubinsztein et al., Cambridge, United Kingdom. In J Cell Sci, 2008
The subcellular localisation of huntingtin and many of its interactors suggest a role in endocytosis, and recently it has been shown that huntingtin interacts indirectly with the early endosomal protein Rab5 through HAP40.
Identification of residues contributing to A2 domain-dependent structural stability in factor VIII and factor VIIIa.
Fay et al., Rochester, United States. In J Biol Chem, 2008
analysis of the residues contributing to A2 domain-dependent structural stability in factor VIII and factor VIIIa
Regulation of endosome dynamics by Rab5 and Huntingtin-HAP40 effector complex in physiological versus pathological conditions.
Zerial et al., Dresden, Germany. In Methods Enzymol, 2007
We have recently identified Huntingtin (Htt) and Huntingtin associated protein of 40 kDa (HAP40) as a novel Rab5 effector complex that regulates endosome motility.
A1 subunit-mediated regulation of thrombin-activated factor VIII A2 subunit dissociation.
Lollar et al., Atlanta, United States. In J Biol Chem, 2006
cupredoxin-like A1 subdomains in fVIII contain inter-species differences that are a result of selective pressure on the dissociation rate constant
[Linkage analysis of five genes in pigs using radiation hybrid clone panel].
Jiang et al., Nanjing, China. In Yi Chuan, 2006
In this study, based on the information of five human genes (FMR1, IDS, FATE, BGN, F8A) on the X chromosome, the linkage relationship of these five genes in pigs were analyzed by a panel of 96 radiation hybrid cell lines.
Huntingtin-HAP40 complex is a novel Rab5 effector that regulates early endosome motility and is up-regulated in Huntington's disease.
Zerial et al., Dresden, Germany. In J Cell Biol, 2006
In this study, we have identified Htt-associated protein 40 (HAP40) as a novel effector of the small guanosine triphosphatase Rab5, a key regulator of endocytosis.
Application of thermally responsive polypeptides directed against c-Myc transcriptional function for cancer therapy.
Raucher et al., Jackson, United States. In Mol Cancer Ther, 2005
The coding sequence for elastin-like polypeptide was modified by the addition of the membrane translocating sequence penetratin and a peptide derived from helix 1 of the helix-loop-helix region of c-Myc (H1-S6A,F8A), known to inhibit c-Myc transcriptional function.
Clustered basic residues within segment 484-510 of the factor VIIIa A2 subunit contribute to the catalytic efficiency for factor Xa generation.
Fay et al., Rochester, United States. In J Thromb Haemost, 2004
The mutation Arg489Ala/Arg490Ala/Lys493Ala (489-3A) possessed near-normal affinity for FIXa and showed no effect on the Km for Factor X.
Inversion mutation analysis in hemophilia a by restriction enzyme analysis and southern blotting.
Jenkins et al., London, United Kingdom. In Methods Mol Med, 1998
These regions are termed intron 22 homologous regions (int22h) (1) and contain the Factor VIII associated gene (F8A).
[Molecular genetics of hemophilia A].
Larripa et al., Buenos Aires, Argentina. In Medicina (b Aires), 1995
The copies of a particular DNA sequence (termed F8A gene).
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