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Coagulation factor XII

F12, Hageman factor, coagulation factor XII
This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Kallikrein, ACID, Plasminogen, CAN, HAD
Papers using F12 antibodies
Radiation-induced Reprograming of Breast Cancer Cells.
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Tan Ming, In PLoS ONE, 2011
... SUM159PT cells were cultured in log-growth phase in F12 Medium (Invitrogen, Carlsbad, CA) supplemented with 5% fetal bovine serum (Sigma Aldrich, St Louis, MO), penicillin ...
Patient-specific induced pluripotent stem-cell models for long-QT syndrome
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Wu Qiang, In PLoS ONE, 2009
... medium was composed of DMEM/F12 (Invitrogen #21331-020), 2 mM L-glutamine (PAA, as not contained in the DMEM/F12 used), 1x ITS (BD Biosciences #354351), 0.1% HSA (Biological ...
IL-23 drives pathogenic IL-17-producing CD8+ T cells
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Hizawa Nobuyuki et al., In Journal of Allergy, 2008
... A bronchial epithelial cell line, BEAS-2B, was cultured in Hanks' F12/DMEM (Biofluids, Rockville, Md, USA) with 10% heat-inactivated FBS, 100 U/mL penicillin, and 100 ng/mL streptomycin (Life Technologies-BRL, Gaithersburg, Md, USA) ...
Elite and stochastic models for induced pluripotent stem cell generation.
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Verfaillie Catherine M., In PLoS ONE, 2008
... (WiCell) hESCs were grown on irradiated mouse embryonic fibroblast feeder cells in hESC feeder-dependent medium (DMEM-F12, 20% Knockout Serum Replacement, 0.1 mM nonessential amino acids (all Life Technologies), 2 mM glutamine (Hyclone), 0.1 ...
Modulation of calcium oxalate dihydrate growth by selective crystal-face binding of phosphorylated osteopontin and polyaspartate peptide showing occlusion by sectoral (compositional) zoning
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Yang Ru-E et al., In International Journal of Nanomedicine, 2008
... Dulbecco’s modified Eagle medium: nutrient mixture F12 was from Thermo Scientific HyClone (Logan, UT), and ...
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Papers on F12
The contact activation and kallikrein/kinin systems: pathophysiologic and physiologic activities.
Review
New
Schmaier, Cleveland, United States. In J Thromb Haemost, Jan 2016
However, the absence of bleeding states with deficiencies of factor XII (FXII), prekallikrein (PK) and high-molecular-weight kininogen indicates that the CAS and KKS do not contribute to hemostasis.
The Alzheimer's disease peptide Aβ promotes thrombin generation through activation of coagulation factor XII.
New
Strickland et al., New York City, United States. In J Thromb Haemost, Dec 2015
The plasma protein factor XII (FXII) triggers clot formation via the intrinsic coagulation cascade and has been implicated in thrombosis.
Kinetics and mechanisms of surface-dependent coagulation factor XII activation.
New
Panteleev et al., Moscow, Russia. In J Theor Biol, Nov 2015
Surface-induced activation of factor XII is critical part of the intrinsic pathway of blood coagulation.
Negatively charged silver nanoparticles cause retinal vascular permeability by activating plasma contact system and disrupting adherens junction.
New
Jiang et al., Beijing, China. In Nanotoxicology, Oct 2015
In vitro tests revealed that MUA@AgNPs activated the plasma kallikrein-kinin system (KKS) by triggering Hageman factor autoactivation.
Defective glycosylation of coagulation factor XII underlies hereditary angioedema type III.
New
Renné et al., In J Clin Invest, Sep 2015
Hereditary angioedema type III (HAEIII) is a rare inherited swelling disorder that is associated with point mutations in the gene encoding the plasma protease factor XII (FXII).
The role of activated coagulation factor XII in overall clot stability and fibrinolysis.
New
Govers-Riemslag et al., Maastricht, Netherlands. In Thromb Res, Aug 2015
Activated coagulation factor XII (α-FXIIa) is able to bind to fibrin(ogen) and increases the density and stiffness of the fibrin clot.
In vivo activation and functions of the protease factor XII.
Review
Renné et al., Stockholm, Sweden. In Thromb Haemost, 2014
Factor XII (FXII, Hageman factor) is a plasma protease that initiates the contact system.
Role of the kallikrein-kinin system in traumatic brain injury.
Review
Sirén et al., Würzburg, Germany. In Front Cell Neurosci, 2013
Selective and specific kinin receptor antagonists and inhibitors of plasma kallikrein and coagulation factor XII have been developed, and have already shown therapeutic efficacy in animal models of stroke and TBI.
The bradykinin-forming cascade: a historical perspective.
Review
Kaplan, Charleston, United States. In Chem Immunol Allergy, 2013
The formation of bradykinin in plasma requires interaction of three proteins, namely coagulation factor XII (Hageman factor), prekallikrein and high-molecular-weight kininogen (HK).
Contact system activation in patients with HAE and normal C1 inhibitor function.
Review
Drouet et al., Grenoble, France. In Immunol Allergy Clin North Am, 2013
This relates to contact phase activation with exaggerated kinin formation, and mutations in the coagulation factor XII gene have been identified in some affected families, but the cause of the disease has remained elusive in a majority of families.
Clinical, biochemical, and genetic characterization of type III hereditary angioedema in 13 Northwest Spanish families.
GeneRIF
López-Trascasa et al., Pontevedra, Spain. In Ann Allergy Asthma Immunol, 2012
All studied patients with type III hereditary angioedema in 13 Northwest Spanish families had the c.1032C>A, Thr309Lys mutation in the factor XII gene.
Activated plasma coagulation β-Factor XII-induced vasoconstriction in rats.
GeneRIF
Floras et al., Toronto, Canada. In Clin Sci (lond), 2012
beta-FXIIa infusion induces both adrenal catecholamine-mediated and adrenally independent increases in peripheral resistance
Selective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding.
GeneRIF
MacLeod et al., Carlsbad, United States. In Blood, 2011
PKK or fXII deficiency reduced thrombus formation in both arterial and venous thrombosis models, without an apparent effect on hemostasis.
Factor XIIa regulates the structure of the fibrin clot independently of thrombin generation through direct interaction with fibrin.
GeneRIF
Ariëns et al., Maastricht, Netherlands. In Blood, 2011
These data demonstrate that FXIIa modulates fibrin clot structure independently of thrombin generation through direct binding of the N-terminus of FXIIa to fibrin(ogen).
A novel mutation in the coagulation factor 12 gene in subjects with hereditary angioedema and normal C1-inhibitor.
GeneRIF
Witzke et al., Mainz, Germany. In Clin Immunol, 2011
a novel factor 12 gene mutation, the deletion of 72 base pairs (bp) (c.971_1018+24del72*), was identified in a family of Turkish origin, in two sisters with recurrent skin swellings and abdominal pain attacks and in their symptom-free father
Hageman factor deficiency and oral contraceptives.
Impact
Naiman et al., In Lancet, 1980
Hageman factor, a coagulation factor (Factor 12) is reported to be deficient in users of OCs (oral contraceptives) in this letter to the editor.
Hypotension associated with prekallikrein activator (Hageman-factor fragments) in plasma protein fraction.
Impact
Finlayson et al., In N Engl J Med, 1978
The prekallikrein activator was identified as Hageman-factor fragments by molecular weight (35,000 as estimated by gel chromatography), isoelectric point (4.2 to 4.4), and inhibition by antibody to Hageman factor.
Hageman factor (factor XII) deficiency in marine mammals.
Impact
Aggeler et al., In Science, 1970
These animals differed from other mammals in that the Hageman factor (factor XII) was absent and this absence caused marked prolongation of coagulation.
Activation of Hageman factor by L-homocystine.
Impact
Ratnoff, In Science, 1968
L-Homocystine activates Hageman factor, as demonstrated by its capacity to initiate clotting and to induce the evolution of plasma kinins.
Hageman factor: alterations in physical properties during activation.
Impact
Ratnoff et al., In Science, 1965
Highly purified preparations of Hageman factor, a potent clotpromoting agent in normal mammalian plasma, had a sedimentation coefficient of approximately 5S before activation.
More papers using F12 antibodies
Multicellular dynamics during epithelial elongation
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Tanoue Takuji et al., In The Journal of Cell Biology, 2007
... DLD-1 cells, human colon epithelial cells, were cultured in a 1:1 mixture of DME and Ham’s F12 medium (Wako Chemicals USA) supplemented with 10% ...
A fast thresholded landweber algorithm for wavelet-regularized multidimensional deconvolution
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Khachigian Levon M., In PLoS ONE, 2007
... D-glucose and sodium pyruvate, DMEM GlutaMAX containing 4.5 mg/L D-glucose and sodium pyruvate, RPMI-1640 GlutaMAX, F12 containing L-glutamine, MCDB-131, fetal bovine serum (FBS), phosphate buffered saline (PBS), and Gentamycin (50 mg/mL) were from Gibco and provided by Invitrogen Life Technologies Corporation (Cergy Pontoise, France) ...
Second-Generation Difluorinated Cyclooctynes for Copper-Free Click Chemistry
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Bertozzi Carolyn R. et al., In Journal of the American Chemical Society, 2007
... saline (PBS) and fetal bovine serum (FBS) were purchased from HyClone Laboratory, and RPMI-1640 and F12 media were obtained from Invitrogen Life Technologies, Inc ...
A piRNA pathway primed by individual transposons is linked to De Novo DNA methylation in mice
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Chen Runsheng et al., In International Journal of Cell Biology, 2007
... MCF-10A cells were cultured in DMEM-F12 (Life Technologies) supplemented with 5% horse ...
The upregulation of glial glutamate transporter-1 participates in the induction of brain ischemic tolerance in rats.
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Levison Steven W et al., In ASN NEURO, 2006
... Eagle's minimum essential media and DMEM/F12 [DMEM (Dulbecco's modified Eagle's medium) with nutrient F12 mixture in the ratio 1:1] were purchased from Mediatech/Life Technologies (Fisher Scientific) ...
BCCIP regulates homologous recombination by distinct domains and suppresses spontaneous DNA damage.
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Cookson Mark R., In PLoS ONE, 2006
... (Invitrogen Life Technologies); T98G in Ham's F-10/DMEM (10∶1) medium (Invitrogen Life Technologies); and MCF-10A in DMEM/F12 (Invitrogen Life Technologies) supplemented with 5% donor ...
Metabolic instability of type 2 deiodinase is transferable to stable proteins independently of subcellular localization
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Williams Graham R. et al., In Bone, 2005
... ATDC5 cells were maintained in DMEM/Ham's F12 (Life Technologies, Paisley, UK) containing 5% ...
Neuronal PTP1B regulates body weight, adiposity and leptin action. Nat.Med.
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Federici Massimo, In PLoS ONE, 2005
... DMEM/F12, Opti-MEM, penicillin and streptomycin, glutamine as well as Lipofectamine 2000 and Lipofectamine RNAiMAX were purchased from Invitrogen (Invitrogen by Life Technologies, Darmstadt, Germany) ...
Covert human immunodeficiency virus replication in dendritic cells and in DC-SIGN-expressing cells promotes long-term transmission to lymphocytes.
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Speck Roberto F., In PLoS ONE, 2004
... enzymatic digestion to isolate epithelial cells from uterine tissues, cells were washed, resuspended in complete DMEM/F12 medium without phenol red (Invitrogen Life Technologies, Carlsbad, CA) supplemented with ...
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
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Ouellette Michel M., In PLoS ONE, 2003
... The cells were maintained in DMEM/F12 medium supplemented with 10% fetal calf serum, 1% sodium pyruvate, and 1% penicillin/streptomycin (Thermo Scientific Inc., Waltham, MA) ...
Tcf binding sequence and position determines beta-catenin and Lef-1 responsiveness of MMP-7 promoters
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Li Jun, In PLoS ONE, 2003
... The mammary cell line MCF-7 (ATCC) and HUVECs were grown in Dulbecco's modified Eagle's medium/F12 (Life Technologies, Grand Island, NY, USA) ...
Endometrial cells derived from donor stem cells in bone marrow transplant recipients
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Groothuis P. et al., In Cellular and Molecular Life Sciences, 2003
... size, 30 mm diameter; Millipore, France) in 6-well plates containing 1.2 ml phenol red-free DMEM/Ham’s F12 medium (Life Technologies, Grand Island, NY), supplemented ...
Bone sialoprotein, matrix metalloproteinase 2, and alpha(v)beta3 integrin in osteotropic cancer cell invasion.
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Ramqvist Torbjorn, In PLoS ONE, 2003
... All cell lines were routinely cultured as monolayer in DMEM/F12 medium containing 10% FBS (Invitrogen, Carlsbad, CA) supplemented with 1% Penicillin/Streptomycin and 500 ng/ml Hydrocortisone (Sigma Aldrich, St ...
Assessment of the ultrastructural and proliferative properties of human embryonic stem cell-derived cardiomyocytes
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Palecek Sean P. et al., In International Journal of Cell Biology, 2002
... feeder layers every 5-6 days by exposure to 1 mg/mL collagenase type IV (Life Technologies) in DMEM/F12 (Life Technologies) for 3 minutes at 37°C, ...
Untangling the ErbB signalling network
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Baselga J et al., In Oncogene, 2000
... Type Culture Collection (Rockville, MD, USA) and maintained in Dulbecco's modified Eagle medium/Ham F12 1:1 (DMEM/F12) supplemented with 10% fetal bovine serum and 2 m-glutamine (Life Technologies, Inc ...
Assaying mitochondrial respiratory complex activity in mitochondria isolated from human cells and tissues.
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Chung Sookja, In PLoS ONE, 2000
... Dulbecco's Modified Eagle Medium+GlutaMAX™-1 Nutrient Mixture F-12 (DMEM-F12), fetal bovine serum (FBS), penicillin-streptomycin, Opti-MEM, Lipofectamine™ 2000, pcDNA3.1(+)expression
Microarrays of cells expressing defined cDNAs
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Brown Patrick O et al., In Molecular Systems Biology, 2000
... The next day, one-fourth of the medium was replaced with serum-free growth medium containing DMEM/F12 (Mediatech Inc.), 10% BIT9500 solution (StemCell Technologies), and 20 ng/ml each ...
Dexamethasone-induced insulin resistance in 3T3-L1 adipocytes is due to inhibition of glucose transport rather than insulin signal transduction.
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Calbet Jose A. L., In PLoS ONE, 1999
... Cells were cultured in basal SGBS medium consisting of DMEM/Ham F12 medium (Life Technologies, Karlsruhe, Germany) supplemented with ...
Encapsulation of plasmid DNA in biodegradable poly(D,L-lactic-co-glycolic acid) microspheres as a novel approach for immuno-gene delivery
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Grassi M et al., In International Journal of Nanomedicine, 1998
... Medium (Promocell, Heidelberg, Germany), one third Waymouth Medium MB 752/1, and one third Nutrient Mixture F12 supplemented with 15% fetal calf serum (FCS) and 1% penicillin/streptomycin (Life technologies, Gaithersburg, MD, USA) ...
Evidence of blood-brain barrier dysfunction in human cerebral malaria.
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Paul Rick Edward, In PLoS ONE, 1998
... HBEC-5i were grown to confluence in DMEM/F12 medium containing 15 mmol/L HEPES and L-glutamine pH 7.4 (Gibco Life Technologies, Carlsbad USA) supplemented with ...
Serum protects protein-free competent Chinese hamster ovary cells against apoptosis induced by nutrient deprivation in batch culture
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Grillari Johannes et al., In Journal of Biotechnology, 1998
... Recombinant antibody producing CHO-K1 cells (ECACC 85051005) were serum-free adapted and cultivated in 1:1 DMEM/Ham's F12 supplemented with 2 mM methionine-sulfoximine (MSX), 0.25% soy peptone, 0.1% Pluronic F68 (BASF, Germany), PF supplement (Polymun Scientific, Austria) and GS supplement ...
Effects of glucocorticoids on maturation of pig oocytes and their subsequent fertilizing capacity in vitro
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Michael A E et al., In The Journal of Endocrinology, 1998
... Percoll, human granulosa–lutein cells were cultured for 48 h in 1:1 Dulbecco's modified Eagle's medium (DMEM):Ham's F12 medium supplemented with 10% (v/v) fetal calf serum (Invitrogen Life Technologies), 2 mM ...
Organization of mammary epithelial cells into 3D acinar structures requires glucocorticoid and JNK signaling
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Martin Finian et al., In The Journal of Cell Biology, 1998
... growth factor (Promega), 5 μg/ml insulin (Sigma-Aldrich), 1 μg/ml hydrocortisone (Sigma-Aldrich), and 50 μg/ml gentamycin (Sigma-Aldrich) in F12 medium (Life Technologies, Inc.) ...
Nitric oxide inhibits rhinovirus-induced cytokine production and viral replication in a human respiratory epithelial cell line.
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Chu Hong Wei, In PLoS ONE, 1997
... The culture media consisted of a 1∶1 mix of DMEM:F12 (Life Technologies, CA, USA), 100 U/ml ...
Induction of apoptosis after expression of PYK2, a tyrosine kinase structurally related to focal adhesion kinase
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Schäfer Beat W. et al., In The Journal of Cell Biology, 1996
... DME supplemented with 10% FBS (Life Technologies), except for primary myoblasts, which were cultured in F12 medium with 15% FBS; both media contained 100 U/ml penicillin and 100 μg/ml streptomycin (Life Technologies).
Expression of the inducible form of nitric oxide synthase by reactive astrocytes after transient global ischemia
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Feinstein Douglas L et al., In Journal of Neuroinflammation, 1993
... Fetal calf serum (FCS) and DMEM-F12 were from GIBCO Life Technologies.
Divalent cation-dependent regulation of rat alveolar epithelial cell adhesion and spreading
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Schwarz Margaret A et al., In Respiratory Research, 1993
... Freshly isolated AT II cells were plated in a minimal defined serum-free medium (MDSF), (DMEM/F12 1:1, Sigma Aldrich, St ...
Recombinant human interferon gamma in the treatment of rheumatoid arthritis: double blind placebo controlled study
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Williams Anwen S et al., In Arthritis Research & Therapy, 1991
... at a 1:1 ratio, supplemented with 10% bovine fetal calf serum, antibiotics, L-glutamine, insulin and transferrin (DMEM/F12) (Life Technologies Invitrogen, Paisley, UK) ...
Cell locomotion and chemotaxis
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Tournier Jean-Marie et al., In The Journal of Cell Biology, 1988
... Immediately after excision, the samples were immersed in a Ham's F12/DME (1:3, vol/vol) (GIBCO BRL) supplemented with 80 U/ml penicillin, 80 μg/ml streptomycin (GIBCO BRL), and 50 μg/ml gentamicin (Sigma Aldrich Chimie) ...
Relationship between cell shape and type of collagen synthesised as chondrocytes lose their cartilage phenotype in culture
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Matsusue Yoshitaka et al., In Acta Orthopaedica, 1976
... saline (PBS) for 20 min and then 0.25% collagenase (Worthington Biochemical, Lakewood, NJ) in Ham's F12 medium (MP Biomedicals, Solon, OH) supplemented with ...
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