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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Enhancer of zeste homolog 2

EZH2, enhancer of zeste homolog 2
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Feb 2011] (from NCBI)
Papers using EZH2 antibodies
Fate tracing reveals the endothelial origin of hematopoietic stem cells
Supplier
Nizetic D et al., In Oncogene, 2007
... Mouse monoclonal anti-hRUNX1 antibody and rabbit polyclonal anti-mouse EZH2 antibody were from Abcam (Cambridge, UK) ...
Endothelial barrier disruption by VEGF-mediated Src activity potentiates tumor cell extravasation and metastasis
Supplier
Oshima Robert G. et al., In Oncogene, 2003
... (Covance, PRB-155P); CD31 (Pharmingen, 01951D, BD Bioscience), PCNA (Sigma, P8825), smooth muscle actin (Sigma, C6198), EZH2 (6A10, Novocastra and AC22, Cell Signaling).
Papers on EZH2
Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia.
GeneRIF
Iwama et al., Chiba, Japan. In Blood, 2012
Ezh2 inhibits differentiation programs in leukemic stem cells, thereby augmenting their leukemogenic activity.
Cancer angiogenesis induced by Kaposi sarcoma-associated herpesvirus is mediated by EZH2.
GeneRIF
Gao et al., Minneapolis, United States. In Cancer Res, 2012
Taken together, our findings indicate that KSHV regulates the host epigenetic modifier EZH2 to promote angiogenesis.
Intronic RNAs mediate EZH2 regulation of epigenetic targets.
GeneRIF
Esteller et al., Barcelona, Spain. In Nat Struct Mol Biol, 2012
Overexpression of EZH2-bound intronic RNA for the H3K4 methyltransferase gene SMYD3 is concomitant with an increase in EZH2 occupancy throughout the corresponding genomic fragment and is sufficient to reduce levels of the endogenous transcript and protein
The enhancer of zeste homolog 2 (EZH2), a potential therapeutic target, is regulated by miR-101 in renal cancer cells.
GeneRIF
Tomita et al., Yamagata, Japan. In Biochem Biophys Res Commun, 2012
these results show nuclear EZH2 as a prognostic marker of worse survival in human RCC, and identify miR-101 as a negative regulator of EZH2 expression and renal cancer cell proliferation.
Notch1 intracellular domain increases cytoplasmic EZH2 levels during early megakaryopoiesis.
GeneRIF
Banerjee et al., Calcutta, India. In Cell Death Dis, 2011
Interaction of EZH2 with LIMK1 changed the activity of cofilin (a downstream target of LIMK1) towards actin filaments, thereby leading to lower filamentous actin content within these cells.
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