Epigenetic silencing of EYA2 in pancreatic adenocarcinomas promotes tumor growth.
Baltimore, United States. In Oncotarget, 2014
To identify potentially important genes dysregulated in pancreatic cancer, we analyzed genome-wide transcriptional analysis of pancreatic cancers and normal pancreatic duct samples and identified the transcriptional coactivator, EYA2 (Drosophila Eyes Absent Homologue-2) as silenced in the majority of pancreatic cancers.
G(z) signaling: emerging divergence from G(i) signaling.
Hong Kong, Hong Kong. In Oncogene, 2001
Functional interactions of the alpha subunit of G(z) (Galpha(z)) with the NKR-P1 receptor, Galpha(z)-specific regulator of G protein signaling, p21-activated kinase, G protein-regulated inducers of neurite outgrowth, and the Eya2 transcription cofactor have been demonstrated.