Genetic alterations in chondrosarcomas - keys to targeted therapies?
New Haven, United States. In Cell Oncol (dordr), 2014
As they are not observed in malignant cells, mutations in the EXT1 and EXT2 genes are considered early-stage events providing an environment that alters IHH/PTHrP signaling, thereby inducing mutations in adjacent cells.
A genome-wide association study identifies novel risk loci for type 2 diabetes.
Montréal, Canada. In Nature, 2007
These loci include a non-synonymous polymorphism in the zinc transporter SLC30A8, which is expressed exclusively in insulin-producing beta-cells, and two linkage disequilibrium blocks that contain genes potentially involved in beta-cell development or function (IDE-KIF11-HHEX and EXT2-ALX4).