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Exportin, tRNA

Exportin-t, Exportin(tRNA), exportin-tRNA
This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Exportin-5, importin, RAN, HAD
Papers on Exportin-t
Exportin t and Exportin 5: tRNA and miRNA biogenesis - and beyond.
Review
Bohnsack et al., Frankfurt am Main, Germany. In Biol Chem, 2012
The nuclear export receptors Exportin-t (Exp-t) and Exportin 5 (Exp5), and their homologues, are involved in the export of transfer RNA to the cytoplasm.
Interaction of immobilized human exportin-t with calf liver tRNA.
GeneRIF
Sprinzl et al., Bayreuth, Germany. In Rna Biol, 2006
Exportin-t preferentially binds and exports those tRNAs that are rapidly consumed by the protein synthesis machinery.
DNA microarray analysis of changes in gene expression induced by 1,25-dihydroxyvitamin D3 in human promyelocytic leukemia HL-60 cells.
Isemura et al., Shizuoka, Japan. In Biomed Res, 2006
The present study revealed the down-regulated gene expression of importins and exportins 1, 5, 7, and exportin-tRNA.
1,25-Dihydroxyvitamin D3 suppresses exportin expression in human promyelocytic leukemia HL-60 cells.
GeneRIF
Isemura et al., Shizuoka, Japan. In Biomed Res, 2006
Results suggest that decreased expression of exportin-1 and exportin-t induced by 1alpha,25-dihydroxyvitamin D3 can be correlated to inhibition of the proliferation of HL-60 cells.
Nuclear processing and export of microRNAs in Arabidopsis.
Poethig et al., Philadelphia, United States. In Proc Natl Acad Sci U S A, 2005
In contrast, a mutation in PAUSED (PSD), the Arabidopsis ortholog of the tRNA export receptor, Exportin-t, interfered with the processing of tRNA-Tyr but did not affect the accumulation or nuclear export of miRNAs.
PAUSED, a putative exportin-t, acts pleiotropically in Arabidopsis development but is dispensable for viability.
Chen et al., United States. In Plant Physiol, 2003
Exportin-t was first identified in humans as a protein that mediates the export of tRNAs from the nucleus to the cytoplasm.
Recognition of engineered tRNAs with an extended 3' end by Exportin-t (Xpo-t) and transport of tRNA-attached ribozymes to the cytoplasm in somatic cells.
Taira et al., Tokyo, Japan. In Biomacromolecules, 2000
Our recent analysis indicates that the cytoplasmic localization of tRNA-attached ribozymes (tRNA-Rz) is critical for its high-level intracellular activity, suggesting that mature mRNAs in the cytoplasm are more accessible to ribozymes than pre-mRNAs in the nucleus (Kato et al.
The role of exportin-t in selective nuclear export of mature tRNAs.
Mattaj et al., Heidelberg, Germany. In Embo J, 1999
Exportin-t (Xpo-t) is a vertebrate nuclear export receptor for tRNAs that binds tRNA cooperatively with GTP-loaded Ran.
Identification of a nuclear export receptor for tRNA.
Mattaj et al., Heidelberg, Germany. In Curr Biol, 1998
We therefore name the protein Exportin(tRNA).
Identification of a tRNA-specific nuclear export receptor.
Görlich et al., Heidelberg, Germany. In Mol Cell, 1998
Here, we identify exportin-t as a specific mediator of tRNA export.
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