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Exportin 5

Exportin-5, Exp5
This gene encodes a member of the karyopherin family that is required for the transport of small RNAs and double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The encoded protein translocates cargo through the nuclear pore complex in a RanGTP-dependent process. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: CAN, RAN, Dicer, Exportin-t, OUT
Papers using Exportin-5 antibodies
Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins
Supplier
Macara Ian G. et al., In The Journal of Cell Biology, 1997
... The entire exportin-5 cDNA was sequenced and then moved into pKmyc, pKH3, pGBT10, and pQE60 (QIAGEN).
Papers on Exportin-5
Characterization of miRNA processing machinery in the embryonic chick lung.
New
Correia-Pinto et al., Braga, Portugal. In Cell Tissue Res, Dec 2015
The present work characterizes the expression pattern of drosha, dgcr8, exportin-5 and dicer1 in early stages of the embryonic chick lung by whole mount in situ hybridization and cross-section analysis.
Adenovirus VA RNA: An essential pro-viral non-coding RNA.
New
Conn et al., Atlanta, United States. In Virus Res, Jul 2015
Following transcription by cellular RNA polymerase III, VA RNAs saturate the nuclear export protein Exportin 5 (Exp5) and the cellular endoribonculease Dicer, interfering with pre-micro (mi)RNA export and miRNA biogenesis, respectively.
In vivo biochemical analyses reveal distinct roles of β-importins and eEF1A in tRNA subcellular traffic.
New
Hopper et al., Columbus, United States. In Genes Dev, May 2015
Our studies provide the first in vivo biochemical evidence that two β-importin family members, Los1 (exportin-t) and Msn5 (exportin-5), serve overlapping but distinct roles in tRNA nuclear export.
Disruption of microRNA nuclear transport in human cancer.
Review
Esteller et al., Houston, United States. In Semin Cancer Biol, 2014
Small RNAs such as precursors of miRNAs (pre-miRNAs) are transported out of the nucleus by a specific nuclear transport receptor, exportin-5 (XPO5).
Mammalian 5'-capped microRNA precursors that generate a single microRNA.
Impact
Steitz et al., New Haven, United States. In Cell, 2014
MicroRNAs (miRNAs) are short RNA gene regulators typically produced from primary transcripts that are cleaved by the nuclear microprocessor complex, with the resulting precursor miRNA hairpins exported by exportin 5 and processed by cytoplasmic Dicer to yield two (5p and 3p) miRNAs.
Genetic variants in microRNA machinery genes are associated [corrected] with idiopathic recurrent pregnancy loss risk.
Kim et al., Seoul, South Korea. In Plos One, 2013
Genotypes of miRNA machinery genes, including DICER rs3742330, DROSHA rs10719, RAN GTPase (RAN) rs14035, and exportin-5 (XPO5) rs11077 were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay.
Single nucleotide polymorphisms of microRNA processing machinery genes and outcome of hepatocellular carcinoma.
Zhao et al., Shijiazhuang, China. In Plos One, 2013
We examined 6 miR-SNPs in miRNA processing machinery genes including exportin 5 (XPO5) (rs11077), Ran-GTPase (RAN) (rs14035), Dicer (rs3742330), Trinucleotide Repeat Containing 6B (TNRC6B) (rs9623117), GEMIN3 (rs197412), GEMIN4 (rs2740348) in 108 surgically resected HCC patients and evaluated the impact of these miR-SNPs on HCC outcome.
Impact of MiRSNPs on survival and progression in patients with multiple myeloma undergoing autologous stem cell transplantation.
GeneRIF
Bladé et al., Barcelona, Spain. In Clin Cancer Res, 2012
overall survival was significantly longer in multiple myeloma patients with C/C or A/C variant in the XPO5 gene single nucleotide polymorphism site rs11077
Exportin t and Exportin 5: tRNA and miRNA biogenesis - and beyond.
Review
Bohnsack et al., Frankfurt am Main, Germany. In Biol Chem, 2012
The nuclear export receptors Exportin-t (Exp-t) and Exportin 5 (Exp5), and their homologues, are involved in the export of transfer RNA to the cytoplasm.
Nucleocytoplasmic transport of microRNAs and related small RNAs.
Review
Yoneda et al., Suita, Japan. In Traffic, 2011
In conventional linear processing pathways, precursors of miRNAs are transported out of the nucleus by the specific nuclear transport receptor, exportin-5.
Competition for XPO5 binding between Dicer mRNA, pre-miRNA and viral RNA regulates human Dicer levels.
GeneRIF
Benkirane et al., Montpellier, France. In Nat Struct Mol Biol, 2011
Exportin-5 controls Dicer1 expression post-transcriptionally.
Selective nuclear export mechanism of small RNAs.
Review
Tsukihara et al., Ch'ŏngju, South Korea. In Curr Opin Struct Biol, 2011
Since the 2004 publication of the first exportin structure, Cse1p, the X-ray structures of exportin-5 complexed with pre-microRNA, exportin-t complexed with tRNA, and three CRM1-related structures have revealed the binding mechanism involved in specific cargo recognition.
A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cells.
Impact
GeneRIF
Esteller et al., Barcelona, Spain. In Cancer Cell, 2010
The restoration of XPO5 functions reverses the impaired export of pre-miRNAs and has tumor-suppressor features.
Steroidal regulation of uterine miRNAs is associated with modulation of the miRNA biogenesis components Exportin-5 and Dicer1.
GeneRIF
Hong et al., Kansas City, United States. In Endocrine, 2010
miRNA biogenesis components Drosha, Dgcr8, Exportin-5 and Dicer1 are expressed in the mouse uterus and that Exportin-5 and Dicer1 appear to be the major steroid regulated components in the miRNA biogenesis pathway
A protein inventory of human ribosome biogenesis reveals an essential function of exportin 5 in 60S subunit export.
GeneRIF
Kutay et al., Zürich, Switzerland. In Plos Biol, 2009
Data show a requirement for the export receptor Exportin 5 in nuclear export of 60S subunits in human cells, and that Exp5 binds to pre-60S particles in a RanGTP-dependent manner.
A high-resolution structure of the pre-microRNA nuclear export machinery.
Impact
GeneRIF
Tsukihara et al., Suita, Japan. In Science, 2009
2.9 angstrom structure of the pre-miRNA nuclear export machinery formed by pre-miRNA complexed with Exp-5 and RanGTP; RNA recognition by Exp-5:RanGTP does not depend on RNA sequence, implying that Exp-5:RanGTP can recognize a variety of pre-miRNAs
Role of miRNA in carcinogenesis and biomarker selection: a methodological view.
Review
Ahmed, Greenville, United States. In Expert Rev Mol Diagn, 2007
Pre-miRNA is then exported to the cytoplasm by exportin-5.
Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways.
Impact
Kay et al., Stanford, United States. In Nature, 2006
In vitro and in vivo shRNA transfection studies implied that one such factor, shared by the shRNA/miRNA pathways and readily saturated, is the nuclear karyopherin exportin-5.
Nuclear export of microRNA precursors.
Impact
GeneRIF
Kutay et al., Madison, United States. In Science, 2004
exportin-5 is key to microRNA biogenesis and may help coordinate nuclear and cytoplasmic processing steps
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