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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Exportin 4

Exportin 4, xPO4, Exp4
XPO4 belongs to a large family of karyopherins (see MIM 602738) that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments (Lipowsky et al., 2000 [PubMed 10944119]).[supplied by OMIM, Mar 2009] (from NCBI)
Top mentioned proteins: importin, EXP, HAD, Exportin 7, CAN
Papers using Exportin 4 antibodies
The karyopherin Kap142p/Msn5p mediates nuclear import and nuclear export of different cargo proteins
Rottier Robbert J. et al., In The Journal of Cell Biology, 2000
... S1 c), commercial anti-Exp4 was used (V-18; Santa Cruz Biotechnology, Inc.) ...
Papers on Exportin 4
SIRT6 deacetylates PKM2 to suppress its nuclear localization and oncogenic functions.
Das et al., New Delhi, India. In Proc Natl Acad Sci U S A, Feb 2016
We further have identified exportin 4 as the specific transporter mediating PKM2 nuclear export.
Genetic modifiers of response to glucose-insulin-potassium (GIK) infusion in acute coronary syndromes and associations with clinical outcomes in the IMMEDIATE trial.
Peter et al., New York City, United States. In Pharmacogenomics J, Dec 2015
The 'G' allele of rs12641551, near ACSL1, as well as the 'A' allele of XPO4 rs2585897 were associated with a differential glucose response (P for 2 degrees of freedom test, P2df⩽4.75 × 10(-7)) and infarct size with GIK (P2df<0.05).
Chelating effect of citric acid is negligible for development of enamel erosions.
Attin et al., Zürich, Switzerland. In Clin Oral Investig, Dec 2015
EXP-4: CA concentrations (56-1.75
A phase-transfer assisted solvo-thermal strategy for low-temperature synthesis of Na3(VO1-xPO4)2F1+2x cathodes for sodium-ion batteries.
Dai et al., Beijing, China. In Chem Commun (camb), May 2015
We demonstrate that a series of high-performance cathode materials, sodium vanadium polyanionic compounds, Na3(VO1-xPO4)2F1+2x (x = 0, 0.5 and 1), can be synthesized by a phase-transfer assisted solvo-thermal strategy at a rather low temperature (80-140 °C) in one simple step, exhibiting a high Na storage capacity of ca.
Copy number variation in exportin-4 (XPO4) gene and its association with histological severity of non-alcoholic fatty liver disease.
Mohamed et al., Kuala Lumpur, Malaysia. In Sci Rep, 2014
duplication in the exportin-4 (XPO4) gene to be associated with non-alcoholic steatohepatitis (NASH).
Exportin 4 gene expression and DNA promoter methylation status in chronic hepatitis B virus infection.
Wang et al., Jinan, China. In J Viral Hepat, 2014
Exportin 4 (XPO4) is a novel identified candidate tumour-suppressor gene involved in the pathogenesis of hepatocellular carcinoma (HCC).
Redox centers evolution in phospho-olivine type (LiFe0.5Mn0.5 PO4) nanoplatelets with uniform cation distribution.
George et al., Genova, Italy. In Nano Lett, 2014
In the case of LiFexMn1-xPO4, for example, in micrometer-sized particles synthesized via hydrothermal route, two separate redox centers corresponding to Fe(2+)/Fe(3+) (3.5 V vs Li/Li(+)) and Mn(2+)/Mn(3+) (4.1 V vs Li/Li(+)), due to the collective Mn-O-Fe interactions in the olivine lattice, are commonly observed in the electrochemical measurements.
Genome-wide analysis of copy number variation identifies candidate gene loci associated with the progression of non-alcoholic fatty liver disease.
Mohamed et al., Kuala Lumpur, Malaysia. In Plos One, 2013
respectively, harbour the exportin 4 (XPO4) and phosphodiesterase 1B (PDE1B) genes which are already known to be involved in the etiology of liver cirrhosis and HCC.
The role of Importin-βs in the maintenance and lineage commitment of mouse embryonic stem cells.
Yoneda et al., Suita, Japan. In Febs Open Bio, 2013
Furthermore, we demonstrated that knockdown of XPO4, RanBP17, RanBP16, or IPO7 differentially affected the lineage selection of differentiating mESCs.
Evaluation of TGFβ, XPO4, elF5A2 and ANGPTL4 as biomarkers in HCC.
Gu et al., Shanghai, China. In Exp Ther Med, 2013
To evaluate potential biomarkers in HCC, we employed multiple methods in this study, including qPCR, immunostaining methods and tissue microarrays (TMAs), as well as histological and pathological analysis, to assess TGFβ, XPO4, elF5A2 and ANGPTL4 in cancerous and paracancerous liver tissues from 280 patients suffering from liver cancer.
Decreased expression of XPO4 is associated with poor prognosis in hepatocellular carcinoma.
Xia et al., Guangzhou, China. In J Gastroenterol Hepatol, 2011
Data suggest that XPO4 could be involved in the progression of human hepatocellular carcinoma.
Exportin 4 interacts with Sox9 through the HMG Box and inhibits the DNA binding of Sox9.
Hiraoka et al., Suita, Japan. In Plos One, 2010
These results demonstrate that Exp4 acts as a Sox9 co-regulator that directly regulates binding of Sox9 to its target genes.
Hot colors: the nature and specificity of color-induced nasal thermal sensations.
Prud'hon et al., Lyon, France. In Behav Brain Res, 2010
Subjects were required to fixate a bottle containing a red or green solution presented centrally (Exp1 and Exp4) or laterally (Exp2) and to sniff another bottle, always the same one, but which they were not allowed to see, containing 10 ml of a colorless, odorless and trigeminal-free solution.
Exportin 4 mediates a novel nuclear import pathway for Sox family transcription factors.
Rottier et al., Rotterdam, Netherlands. In J Cell Biol, 2009
Exp4 (exportin 4) is an interaction partner of Sox2 in mouse embryonic stem cells and neural progenitors.
An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer.
Lowe et al., New York City, United States. In Cell, 2008
One gene, XPO4, encodes a nuclear export protein whose substrate, EIF5A2, is amplified in human tumors, is required for proliferation of XPO4-deficient tumor cells, and promotes hepatocellular carcinoma in mice.
Lactococcus lactis, an efficient cell factory for recombinant protein production and secretion.
Poquet et al., Jouy-le-Moutier, France. In J Mol Microbiol Biotechnol, 2007
Furthermore, our lactococcal expression/secretion system, using both P(Zn)zitR, an expression cassette tightly controlled by environmental zinc, and a consensus signal peptide, SP(Exp4), allows efficient production and secretion of the staphylococcal nuclease, as evidenced by protein yields (protein amount/biomass) comparable to those obtained using NICE or P170 expression systems under similar laboratory conditions.
The mechanism of nuclear export of Smad3 involves exportin 4 and Ran.
Moustakas et al., Uppsala, Sweden. In Mol Cell Biol, 2006
A short peptide representing the minimal interaction domain in Smad3 effectively competes with Smad3 association to exportin 4 and blocks nuclear export of Smad3 in vivo.
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