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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Muscleblind-like

EXP, MBNL1, MBNL, Muscleblind-like 1
Top mentioned proteins: DM2, Angiotensin II, CAN, HAD, AT1
Papers on EXP
Oral administration of erythromycin decreases RNA toxicity in myotonic dystrophy.
New
Takahashi et al., Ōsaka, Japan. In Ann Clin Transl Neurol, Jan 2016
The transcripts containing an expanded CUG repeat (CUG (exp)) result in a toxic gain-of-function by forming ribonuclear foci that sequester the alternative splicing factor muscleblind-like 1 (MBNL1).
A genome landscape of SRSF3-regulated splicing events and gene expression in human osteosarcoma U2OS cells.
New
Zheng et al., Frederick, United States. In Nucleic Acids Res, Jan 2016
By global profiling of the SRSF3-regulated splicing events in human osteosarcoma U2OS cells, we found that SRSF3 regulates the expression of 60 genes including ERRFI1, ANXA1 and TGFB2, and 182 splicing events in 164 genes, including EP300, PUS3, CLINT1, PKP4, KIF23, CHK1, SMC2, CKLF, MAP4, MBNL1, MELK, DDX5, PABPC1, MAP4K4, Sp1 and SRSF1, which are primarily associated with cell proliferation or cell cycle.
Inhibition of duck hepatitis B virus replication by mimic peptides in vitro.
New
Zhou et al., Hangzhou, China. In Exp Ther Med, Nov 2015
The cells were divided into mimic peptide groups (EXP groups), an entecavir-treated group (positive control) and a negative control group.
Genomic profiling screens small molecules of metastatic prostate carcinoma.
New
Sun et al., Beijing, China. In Oncol Lett, Sep 2015
In addition, KPNA4, SYT1, PLCB1, SPRED1, MBNL2, RNF165, MEF2C, MBNL1, ZFP36L1 and CELF2, were found to be likely to play significant roles in the process of metastatic prostate carcinoma.
Developmental insights into the pathology of and therapeutic strategies for DM1: Back to the basics.
Review
New
Kalsotra et al., Champaign, United States. In Dev Dyn, Mar 2015
This expansion results in the expression of toxic gain-of-function RNA that forms ribonuclear foci and disrupts normal activities of RNA-binding proteins belonging to the MBNL and CELF families.
Therapeutic Approaches for Dominant Muscle Diseases: Highlight on Myotonic Dystrophy.
Review
Chuah et al., Paris, France. In Curr Gene Ther, 2014
Mutant RNAs containing CUG or CCUG expanded repeats, which are retained in the nuclei as aggregates alter activities of alternative splicing regulators such as MBNL proteins and CELF1.
Muscle wasting in myotonic dystrophies: a model of premature aging.
Review
López de Munain et al., San Sebastián, Spain. In Front Aging Neurosci, 2014
The expansions are transcribed into (CUG)n and (CCUG)n-containing RNA, respectively, which form secondary structures and sequester RNA-binding proteins, such as the splicing factor muscleblind-like protein (MBNL), forming nuclear aggregates known as foci.
MBNL1-mediated regulation of differentiation RNAs promotes myofibroblast transformation and the fibrotic response.
Molkentin et al., Cincinnati, United States. In Nat Commun, 2014
Here we perform a genome-wide screen for genes that control myofibroblast transformation, and identify the RNA-binding protein muscleblind-like1 (MBNL1).
Detection and replication of epistasis influencing transcription in humans.
Impact
Powell et al., Brisbane, Australia. In Nature, 2014
For example, MBNL1 is influenced by an additive effect at rs13069559, which itself is masked by trans-SNPs on 14 different chromosomes, with nearly identical genotype-phenotype maps for each cis-trans interaction.
MBNL proteins and their target RNAs, interaction and splicing regulation.
Review
Sobczak et al., Poznań, Poland. In Nucleic Acids Res, 2013
Muscleblind-like (MBNL) proteins are key regulators of precursor and mature mRNA metabolism in mammals.
MBNL proteins repress ES-cell-specific alternative splicing and reprogramming.
Impact
Blencowe et al., Toronto, Canada. In Nature, 2013
Here we identify the muscleblind-like RNA binding proteins, MBNL1 and MBNL2, as conserved and direct negative regulators of a large program of cassette exon alternative splicing events that are differentially regulated between ES cells and other cell types.
Evolutionary dynamics of gene and isoform regulation in Mammalian tissues.
Impact
Burge et al., Cambridge, United States. In Science, 2013
Thousands of previously unknown, lineage-specific, and conserved alternative exons were identified; widely conserved alternative exons had signatures of binding by MBNL, PTB, RBFOX, STAR, and TIA family splicing factors, implicating them as ancestral mammalian splicing regulators.
Mechanisms of RNA-induced toxicity in CAG repeat disorders.
Review
Krauss et al., Bonn, Germany. In Cell Death Dis, 2012
These include the sequestration of MBNL1, leading to misregulated splicing; sequestration of nucleolin, leading to reduced cellular rRNA; and sequestration of proteins of the siRNA machinery, resulting in the production of short silencing RNAs that affect gene expression.
Transcriptome-wide regulation of pre-mRNA splicing and mRNA localization by muscleblind proteins.
Impact
GeneRIF
Burge et al., Cambridge, United States. In Cell, 2012
This analysis identified several hundred splicing events whose regulation depended on Mbnl function in a pattern indicating functional interchangeability between Mbnl1 and Mbnl2.
Sequestration of MBNL1 in tissues of patients with myotonic dystrophy type 2.
GeneRIF
Hrabálková et al., Brno, Czech Republic. In Neuromuscul Disord, 2012
The present results show that the MBNL1 protein is expressed and more or less sequestered into the CCUGexp nuclear foci also in analyzed non-muscle tissues of DM2 patients.
A rapid immunohistochemical test to distinguish congenital myotonic dystrophy from X-linked myotubular myopathy.
GeneRIF
Holt et al., Oswestry, United Kingdom. In Neuromuscul Disord, 2012
congenital myotonic dystrophy muscle has nuclear foci that contain muscleblind-like 1 (MBNL1) protein.
Common variants near MBNL1 and NKX2-5 are associated with infantile hypertrophic pyloric stenosis.
Impact
GeneRIF
Melbye et al., Copenhagen, Denmark. In Nat Genet, 2012
Common variants near MBNL1 and NKX2-5 are associated with infantile hypertrophic pyloric stenosis.
Muscleblind-like 1 knockout mice reveal novel splicing defects in the myotonic dystrophy brain.
GeneRIF
Kimura et al., Nishinomiya, Japan. In Plos One, 2011
The sequestration of MBNL1 by CUG(exp) RNA results in aberrant splicing events in the Myotonic dystrophy type 1 brain.
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