Utility of CD99 Paranuclear Expression in the Differential Diagnosis of Merkel Cell Carcinoma.
Mexico. In Int J Surg Pathol, Feb 2016
MATERIAL AND METHODS: We explore paranuclear dot-like CD99 expression in several small, round blue cell neoplasms, including neuroendocrine neoplasms, Ewing sarcomas/primitive neuroectodermal tumors (EWS/PNET), melanomas, small cell lung carcinomas (SCC), lymphoblastic lymphoma/leukemia, and rhabdomyosarcomas, in comparison with 33 cases of MCC, to determine the specificity of the paranuclear dot-like CD99 expression in MCC.
Advances in the Clinicopathologic and Molecular Classification of Cutaneous Mesenchymal Neoplasms.
Dublin, Ireland. In Histopathology, Feb 2016
Genetic characterization of several soft tissue tumour types that occur in the skin has resulted in the identification of diagnostically useful markers: ALK gene rearrangement with corresponding ALK protein expression by immunohistochemistry in epithelioid fibrous histiocytoma; WWTR1-CAMTA1 fusion gene with CAMTA1 protein expression in epithelioid haemangioendothelioma; MYC amplification and overexpression in radiation-associated angiosarcoma; and EWSR1 gene rearrangement in cutaneous myoepithelial tumours.
microRNA and Bone Cancer.
Dublin, Ireland. In Adv Exp Med Biol, 2014
The EWS-FLI1 fusion protein produced in Ewing sarcoma has been shown to induce changes in miRNA expression.
ChIP-ping away at EWS/ETS transcription networks.
Los Angeles, United States. In Cancer Cell, 2014
In this issue of Cancer Cell, Riggi and colleagues use a genomic approach to define two distinct molecular mechanisms through which the chimeric EWS/FLI1 oncoprotein regulates target genes in Ewing sarcoma, expanding a framework upon which to model the target gene network and test strategies for antagonizing growth of this tumor.