eukaryotic translation initiation factor 2
Unfolded protein response is activated in aged retinas.
Birmingham, United States. In Neurosci Lett, Dec 2015
Using western blotting, we determined that the hallmarks of the UPR PERK arm, phosphorylated (p) eIF2a, ATF4, and GADD34, were significantly altered in aged vs. young rat retinas.
Integrated stress response-altered pro-inflammatory signals in mucosal immune-related cells.
Yangsan, South Korea. In Immunopharmacol Immunotoxicol, 2013
Various cells are associated with the integrated stress response (ISR) that leads to translation arrest via phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2. Pathogenic insults or nutritional imbalance in the mucosal tissues including the intestinal, airway, and genitourinary epithelia can cause ISRs, which have been linked to different mucosal inflammatory responses and subsequent systemic diseases.
Translational control in Plasmodium and toxoplasma parasites.
New York City, United States. In Eukaryot Cell, 2013
This review focuses on the mechanisms that regulate translational control in Plasmodium and Toxoplasma, with a particular emphasis on the phosphorylation of the α subunit of eukaryotic translation initiation factor 2 (eIF2α).
Selective small molecule activator of the apoptotic arm of the UPR
Bethesda, United States. In Unknown Journal, 2012
The progenitor of this probe was identified through a high-throughput screen of the NIH Molecular Libraries Small Molecule Repository (MLSMR) of >350,000 compounds through complementary cell-based reporter assays using stably transfected CHO-K1 cells that specifically identify activators of the PERK/eIF2a/CHOP (apoptotic), but not the IRE1/XBP1 (adaptive) UPR subpathways.
Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans.
Atlanta, United States. In Nat Immunol, 2009
Computational analyses identified a gene signature, including complement protein C1qB and eukaryotic translation initiation factor 2 alpha kinase 4-an orchestrator of the integrated stress response-that correlated with and predicted YF-17D CD8(+) T cell responses with up to 90% accuracy in an independent, blinded trial.