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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Runt-related transcription factor 1; translocated to, 1

ETO, CDR, CDR1, 3-alpha-Hydroxysteroid Dehydrogenase
This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010] (from NCBI)
Top mentioned proteins: CAN, AML1, ACID, HAD, CDR2
Papers on ETO
Differences in memory function between 5-HT1A receptor genotypes in patients with major depressive disorder.
New
Koblan et al., Marlborough, United States. In Cns Spectr, Feb 2016
They had enrolled into a clinical trial and were tested prior to dosing on the baseline study day using the CDR System, an integrated set of 3 attention tests, 2 working memory tests, and 4 episodic memory tests.
In vitro study of human mutL homolog 1 hypermethylation in inducing drug resistance of esophageal carcinoma.
New
Li et al., Zaozhuang, China. In Ir J Med Sci, Feb 2016
RESULTS: Stronger methylation status of hMLH1 promoter, lower hMLH1 mRNA and protein expression were found in both drug-resistance cell lines; after removing methylated bands using 5-aza-2'-deoxycytidine(5-Aza-CdR) in drug-resistance cell lines, hMLH1 mRNA and protein expression were restored and drug-resistance abilities declined nearly by half.
Identification and functional characterization of Penicillium marneffei pleiotropic drug resistance transporters ABC1 and ABC2.
New
Kajiwara et al., Tokyo, Japan. In Med Mycol, Feb 2016
PmABC1 and PmABC2 were most similar to the archetype Candida albicans multidrug efflux pump gene CDR1.
Emodin enhances the demethylation by 5-Aza-CdR of pancreatic cancer cell tumor-suppressor genes P16, RASSF1A and ppENK.
New
Chen et al., Jiaxing, China. In Oncol Rep, Feb 2016
UNASSIGNED: 5-Aza-2'-deoxycytidine (5-Aza-CdR) is currently acknowledged as a demethylation drug, and causes a certain degree of demethylation in a variety of cancer cells, including pancreatic cancer cells.
Decreased expression of MEG3 contributes to retinoblastoma progression and affects retinoblastoma cell growth by regulating the activity of Wnt/β-catenin pathway.
Review
New
Lu et al., Guangzhou, China. In Tumour Biol, Jan 2016
We also observed that MEG3 expression can be modulated by DNA methylation by using 5-aza-CdR treatment.
Synthetic lethal targeting of oncogenic transcription factors in acute leukemia by PARP inhibitors.
New
Impact
So et al., Hong Kong, Hong Kong. In Nat Med, Dec 2015
Here we demonstrate that AML driven by repressive transcription factors, including AML1-ETO (encoded by the fusion oncogene RUNX1-RUNX1T1) and PML-RARα fusion oncoproteins (encoded by PML-RARA) are extremely sensitive to poly (ADP-ribose) polymerase (PARP) inhibition, in part owing to their suppressed expression of key homologous recombination (HR)-associated genes and their compromised DNA-damage response (DDR).
Mycologic Endocrinology.
Review
New
Stevens et al., San Jose, United States. In Adv Exp Med Biol, Dec 2015
Genome expression profiles of C. albicans in the presence of estradiol or progesterone, and S. cerevisiae with progesterone, indicate major up-regulation of various drug resistance pumps, like CDR1, and CDR2, can affect antifungal susceptibility.
The role of evolutionarily conserved germ-line DH sequence in B-1 cell development and natural antibody production.
Review
New
Schroeder et al., Rio de Janeiro, Brazil. In Ann N Y Acad Sci, Dec 2015
Because of N addition and variation in the site of VDJ joining, the third complementarity-determining region of the heavy chain (CDR-H3) is the most diverse component of the initial immunoglobulin antigen-binding site repertoire.
Candida Efflux ATPases and Antiporters in Clinical Drug Resistance.
Review
New
Shah et al., New Delhi, India. In Adv Exp Med Biol, Dec 2015
For example, the azole resistant (AR) clinical isolates of the opportunistic human fungal pathogen Candida albicans show an overexpression of CDR1 and/or CaMDR1 belonging to ABC and MFS, superfamilies, respectively.
Effect on Multipotency and Phenotypic Transition of Unrestricted Somatic Stem Cells from Human Umbilical Cord Blood after Treatment with Epigenetic Agents.
New
Santourlidis et al., Düsseldorf, Germany. In Stem Cells Int, Dec 2015
Here we document that USSCs drastically change their phenotype after treatment by a new elaborated cultivation protocol which utilizes the DNA hypomethylating compound 5'-aza-2-deoxycytidine (5-Aza-CdR) and the histone deacetylase inhibitor trichostatin A (TSA).
DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts.
New
Impact
De Carvalho et al., Toronto, Canada. In Cell, Sep 2015
Using a combination of experimental and bioinformatics analyses in colorectal cancer cells, we demonstrate that low-dose 5-AZA-CdR targets colorectal cancer-initiating cells (CICs) by inducing viral mimicry.
Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors.
New
Impact
Kwong et al., Bethesda, United States. In Cell, Jul 2015
The 16 antibodies segregated by recognition mode and developmental ontogeny into two types: CDR H3-dominated and VH-gene-restricted.
Interplay between Transcription Factors and the Epigenome: Insight from the Role of RUNX1 in Leukemia.
Review
Holloway et al., Hobart, Australia. In Front Immunol, 2014
Here, we will highlight how these factors normally co-operate to establish and maintain the transcriptional and epigenetic landscape of cells, and how this is reprogramed in cancer, focusing on the RUNX1 transcription factor and oncogenic derivative RUNX1-ETO in leukemia as paradigms of transcriptional and epigenetic reprograming.
5-Aza-CdR delivers a gene body blow.
Impact
Henikoff et al., Seattle, United States. In Cancer Cell, 2014
In this issue of Cancer Cell, Yang et al.
Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies.
Impact
Mascola et al., Bethesda, United States. In Nature, 2014
Twelve somatically related neutralizing antibodies (CAP256-VRC26.01-12) were isolated from donor CAP256 (from the Centre for the AIDS Programme of Research in South Africa (CAPRISA)); each antibody contained the protruding tyrosine-sulphated, anionic antigen-binding loop (complementarity-determining region (CDR) H3) characteristic of this category of antibodies.
Depletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding.
GeneRIF
Bonifer et al., Leeds, United Kingdom. In Leukemia, 2012
selective removal of RUNX1/ETO leads to a widespread reversal of epigenetic reprogramming and a genome-wide redistribution of RUNX1 binding, resulting in the inhibition of leukemic proliferation and self-renewal, and the induction of differentiation.
PRMT1 interacts with AML1-ETO to promote its transcriptional activation and progenitor cell proliferative potential.
GeneRIF
Zhang et al., San Diego, United States. In Blood, 2012
PRMT1 interacts with AML1-ETO to promote its transcriptional activation and progenitor cell proliferative potential.
Sensitivity of acute myeloid leukemia Kasumi-1 cells to binase toxic action depends on the expression of KIT and АML1-ETO oncogenes.
GeneRIF
Makarov et al., Moscow, Russia. In Cell Cycle, 2012
The cooperative effect of the expression of mutated KIT and AML1-ETO oncogenes is crucial for selective toxic action of binase on malignant cells.
RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis.
Review
GeneRIF
Zhang et al., San Diego, United States. In Front Biosci, 2011
In this review, we detail the structural features, functions, and models used to study both RUNX1 and RUNX1-ETO in hematopoiesis over the past two decades
Molecular cloning of rat liver 3α-hydroxysteroid dehydrogenase and identification of structurally related proteins from rat lung and kidney.
GeneRIF
Cheng, New York City, United States. In J Steroid Biochem Mol Biol, 1992
characterization of recombinant 3-alpha-hydroxysteroid dehydrogenase from liver: molecular weight; amino acid sequence; sequence alignment and homology with similar enzymes; inhibition by indomethacin
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