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Ethanolamine kinase 1

ethanolamine kinase, EKI, EKI1
This gene encodes an ethanolamine kinase, which functions in the first committed step of the phosphatidylethanolamine synthesis pathway. This cytosolic enzyme is specific for ethanolamine and exhibits negligible kinase activity on choline. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, PI3K, STEP, ACID, V1a
Papers on ethanolamine kinase
Inhibition of oncogenic epidermal growth factor receptor kinase triggers release of exosome-like extracellular vesicles and impacts their phosphoprotein and DNA content.
New
Rak et al., Hamilton, Canada. In J Biol Chem, Nov 2015
The content of P-EGFR isoforms (Tyr-845, Tyr-1068, and Tyr-1173), ERK, and AKT varies between cells and their corresponding EVs and as a function of EKI treatment.
An ethanolamine kinase Eki1 affects radial growth and cell wall integrity in Trichoderma reesei.
New
Zhang et al., Tianjin, China. In Fems Microbiol Lett, Sep 2015
The functions of eki genes that encode ethanolamine kinase have been intensively studied in mammalian cells, fruit flies and yeast.
Choline metabolism-based molecular diagnosis of cancer: an update.
Review
New
Bhujwalla et al., Baltimore, United States. In Expert Rev Mol Diagn, Jun 2015
Molecular causes of abnormal choline metabolism are changes in choline kinase-α, ethanolamine kinase-α, phosphatidylcholine-specific phospholipase C and -D and glycerophosphocholine phosphodiesterases, as well as several choline transporters.
The Choline/Ethanolamine Kinase Family in Arabidopsis: Essential Role of CEK4 in Phospholipid Biosynthesis and Embryo Development.
New
Nakamura et al., Taipei, Taiwan. In Plant Cell, May 2015
The choline/ethanolamine kinase (CEK) family catalyzes the initial steps of phospholipid biosynthesis.
Design, synthesis and anti-leishmanial activity of novel symmetrical bispyridinium cyclophanes.
New
Campos et al., Granada, Spain. In Eur J Med Chem, Feb 2015
The anti-leishmanial activity of this macrocyclic salts is independent of the Leishmania enzymes ethanolamine kinase and choline/ethanolamine kinase.
Drosophila spermatid individualization is sensitive to temperature and fatty acid metabolism.
Steinhauer et al., New York City, United States. In Spermatogenesis, 2015
In contrast, modulating phospholipid levels by mutation of the phosphatidylcholine lipase Swiss cheese (Sws) or the ethanolamine kinase Easily shocked (Eas) does not perturb individualization, nor does Sws overexpression.
Expression profiling of choline and ethanolamine kinases in MCF7, HCT116 and HepG2 cells, and the transcriptional regulation by epigenetic modification.
Ling et al., Malaysia. In Mol Med Report, 2015
The function of choline kinase (CK) and ethanolamine kinase (EK) is to catalyse the phosphorylation of choline and ethanolamine, respectively, in order to yield phosphocholine (PCho) and phosphoethanolamine (PEtn).
Novel recurrent mutations in ethanolamine kinase 1 (ETNK1) gene in systemic mastocytosis with eosinophilia and chronic myelomonocytic leukemia.
Pardanani et al., Rochester, United States. In Blood Cancer J, 2014
In addition to KITD816V, we identified a somatic missense mutation in ethanolamine kinase 1 (ETNK1N244S) that was not present in 50 healthy controls.
Genome-wide association study for poor sperm motility in Holstein-Friesian bulls.
Kaminski et al., Olsztyn, Poland. In Anim Reprod Sci, 2014
The most significant SNP were located on chromosome 24 (rs110876480), 5 (rs110827324 and rs29011704), and 1 (rs110596818), in the close vicinity of melanocortin 4 receptor (MC4R), PDZ domain containing ring finger 4 (PDZRN4) and ethanolamine kinase 1 (ETNK1), olfactory receptor 5K3-like (LOC785875) genes, respectively.
Phospholipid homeostasis and lipotoxic cardiomyopathy: a matter of balance.
Bodmer et al., Los Angeles, United States. In Fly (austin), 2011
Fly mutants that bear perturbations in phosphatidylethanolamine (PE) biosynthesis, such as the easily-shocked (eas) mutants defective in ethanolamine kinase, incurred aberrant activation of the sterol regulatory element binding protein (SREBP) pathway, thereby causing chronic lipogenesis and cardiac steatosis that culminates in the development of lipotoxic cardiomyopathy.
Transcriptional control of genes involved in yeast phospholipid biosynthesis.
Shen et al., New York City, United States. In J Microbiol, 2011
Here, 22 out of 47 phospholipid biosynthetic genes were identified as UAS(INO)-containing genes, including EKI1, EPT1, INM1, IPK2, KCS1, PAH1, and PIK1 which have never been reported before.
Regulation of the Saccharomyces cerevisiae EKI1-encoded ethanolamine kinase by zinc depletion.
GeneRIF
Carman et al., New Brunswick, United States. In J Biol Chem, 2006
The zinc-mediated regulation of ethanolamine kinase and the synthesis of phospholipids via the CDP-ethanolamine branch of the Kennedy pathway were controlled in part by Zap1p.
[Identification of muscle-type carnitine palmitoyltransferase I and characterization of its gene structure].
Review
Yamazaki, Tokushima, Japan. In Yakugaku Zasshi, 2004
Isolation and characterization of a genomic DNA clone revealed that the gene for human M-CPTI consists of two 5'-noncoding exons, 18 coding exons, and one 3'-noncoding exon spanning approximately 10 kbp, and a gene encoding choline/ethanolamine kinase-beta (CK/EK-beta) was located about 300 bp upstream from the M-CPTI gene with the same strand direction.
Identification of muscle-type carnitine palmitoyltransferase I and characterization of its atypical gene structure.
Review
Yamazaki, Tokushima, Japan. In Biol Pharm Bull, 2004
Characterization of a genomic DNA clone revealed that the gene for human M-CPTI consists of two 5'-noncoding exons, 18 coding exons, and one 3'-noncoding exon spanning approximately 10 kbp, and a gene encoding choline/ethanolamine kinase-beta (CK/EK-beta) was located only about 300 bp upstream from the M-CPTI gene with the same strand direction.
Coamplification of DAD-R, SOX5, and EKI1 in human testicular seminomas, with specific overexpression of DAD-R, correlates with reduced levels of apoptosis and earlier clinical manifestation.
GeneRIF
Looijenga et al., Rotterdam, Netherlands. In Cancer Res, 2002
DAD-R, SOX5, and EKI1 map within region of chromosome 12p whose duplication is related to reduced apoptosis in human testicular seminomas.
Combinatorial chemoprevention of intestinal neoplasia.
Impact
Discafani et al., Baltimore, United States. In Nat Med, 2000
The second drug was EKI-569, a newly developed, irreversible inhibitor of the epidermal growth factor receptor kinase.
The Drosophila easily shocked gene: a mutation in a phospholipid synthetic pathway causes seizure, neuronal failure, and paralysis.
Impact
Tanouye et al., Berkeley, United States. In Cell, 1994
Molecular cloning, germline transformation, and biochemical experiments show that eas mutants are defective in the gene for ethanolamine kinase, which is required for a pathway of phosphatidylethanolamine synthesis.
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