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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

TEA domain family member 2

ETF, Tead2
specific electron acceptor for several dehydrogenases, including acyl-coA dehyrogenases, glutaryl-coA and sarcosine dehydrogenase; transfers electrons to the main mitochondrial respiratory chain [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: ACID, Presenilin-1, MADD, oxidoreductase, CAN
Papers on ETF
Palmitoylation of TEAD Transcription Factors Is Required for Their Stability and Function in Hippo Pathway Signaling.
New
Cunningham et al., San Francisco, United States. In Structure, Feb 2016
We show that human TEADs are palmitoylated at a universally conserved cysteine, and report the crystal structures of the human TEAD2 and TEAD3 YAP-binding domains in their palmitoylated forms.
Search for regulatory factors of the pituitary-specific transcription factor PROP1 gene.
New
Kato et al., Japan. In J Reprod Dev, Jan 2016
Furthermore, a synergy effect with SOX2 was observed for an additional 10 factors, FOXJ1, HES1, HEY1, HEY2, KLF6, MSX1, RUNX1, TEAD2, YBX2 and ZFP36Ll, which did not show substantial independent action.
Comparative Protein Profiling of Intraphagosomal Expressed Proteins of Mycobacterium bovis BCG.
New
Bisht et al., Āgra, India. In Protein Pept Lett, Dec 2015
These were - a precursor of alanine and proline-rich secreted protein apa, isoforms of malate dehydrogenase, large subunit alpha (Alpha-ETF) of electron transfer flavoprotein, immunogenic protein MPB64 precursor, UPF0036 protein, and two proteins with unknown function.
The influence of alternative pathways of respiration that utilize branched-chain amino acids following water shortage in Arabidopsis.
New
Fernie et al., Potsdam, Germany. In Plant Cell Environ, Dec 2015
UNASSIGNED: During dark-induced senescence isovaleryl-CoA dehydrogenase (IVDH) and D-2-hydroxyglutarate dehydrogenase (D-2HGDH) act as alternate electron donors to the ubiquinol pool via the electron-transfer flavoprotein/ electron-transfer flavoprotein:ubiquinone oxidoreductase (ETF/ETFQO) pathway.
Targeting the Central Pocket in Human Transcription Factor TEAD as a Potential Cancer Therapeutic Strategy.
New
Poulsen et al., Singapore, Singapore. In Structure, Dec 2015
Our X-ray crystallography studies reveal that flufenamic acid, a non-steroidal anti-inflammatory drug (NSAID), binds to the central pocket of TEAD2 YBD.
An electron transfer flavoprotein is essential for viability and its depletion causes a rod-to-sphere change in Burkholderia cenocepacia.
New
Cardona et al., Winnipeg, Canada. In Microbiology, Oct 2015
We further demonstrated that the two subunits EtfA and EtfB interact with each other, and that cells depleted of ETF are non-viable and lack redox potential.
Plants Possess a Cyclic Mitochondrial Metabolic Pathway similar to the Mammalian Metabolic Repair Mechanism Involving Malate Dehydrogenase and l-2-Hydroxyglutarate Dehydrogenase.
New
Maurino et al., Düsseldorf, Germany. In Plant Cell Physiol, Sep 2015
Using loss-of-function mutants, we show that the electrons produced in the l-2HGDH reaction are transferred to the mitochondrial electron transport chain through the electron transfer protein (ETF).
Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese.
Gao et al., Hong Kong, Hong Kong. In Nat Commun, 2014
Another novel gene, TEAD2, is found to be associated with high-density lipoprotein cholesterol through gene-based association analysis.
Coexpression Network Analysis of miRNA-142 Overexpression in Neuronal Cells.
Bastola et al., Omaha, United States. In Biomed Res Int, 2014
Larger differences in the enriched networks revealed that the nervous system development related genes such as TEAD2, PLEKHA6, and POGLUT1 were greatly impacted due to miRNA-142 overexpression.
Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer.
Impact
DePinho et al., Houston, United States. In Cell, 2014
Functional studies established the role of Yap1 and the transcriptional factor Tead2 in driving Kras(G12D)-independent tumor maintenance.
Riboflavin-responsive multiple Acyl-CoA dehydrogenation deficiency in 13 cases, and a literature review in mainland Chinese patients.
Review
Hong et al., Nanchang, China. In J Hum Genet, 2014
ETF:QO expression from the muscle specimens was significantly decreased in all patients.
Energy conservation via electron bifurcating ferredoxin reduction and proton/Na(+) translocating ferredoxin oxidation.
Review
Thauer et al., Marburg an der Lahn, Germany. In Biochim Biophys Acta, 2013
In analogy to the bifurcating complex III of the mitochondrial respiratory chain and with the help of the structure of the human ETF, we propose a conformational change by which γ-FADH(-) in EtfBC approaches β-FAD to enable the bifurcating one-electron transfer.
Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP.
GeneRIF
Pan et al., United States. In Genes Dev, 2012
These findings provide proof of principle that inhibiting TEAD-YAP interactions is a pharmacologically viable strategy against the YAP oncoprotein.
Regulation of mouse embryonic stem cell self-renewal by a Yes-YAP-TEAD2 signaling pathway downstream of LIF.
GeneRIF
Annerén et al., Uppsala, Sweden. In J Cell Sci, 2011
YAP, TEAD2 and Yes are highly expressed in self-renewing embryonic stem cells, and are activated by LIF.
Transcription factors ETF, E2F, and SP-1 are involved in cytokine-independent proliferation of murine hepatocytes.
GeneRIF
Gebhardt et al., Leipzig, Germany. In Hepatology, 2010
The transcription factors ETF, E2F1, and SP-1 seem to play a pronounced role in mediating proliferation-dependent differential gene expression in liver.
The electron transfer flavoprotein: ubiquinone oxidoreductases.
Review
Frerman et al., Norwich, United Kingdom. In Biochim Biophys Acta, 2010
Electron transfer flavoprotein: ubiqionone oxidoreductase (ETF-QO) is a component of the mitochondrial respiratory chain that together with electron transfer flavoprotein (ETF) forms a short pathway that transfers electrons from 11 different mitochondrial flavoprotein dehydrogenases to the ubiquinone pool.
Structural and functional analysis of the YAP-binding domain of human TEAD2.
GeneRIF
Luo et al., Dallas, United States. In Proc Natl Acad Sci U S A, 2010
structural and functional analysis of the YAP-binding domain of human TEAD2
Redundant roles of Tead1 and Tead2 in notochord development and the regulation of cell proliferation and survival.
GeneRIF
Sasaki et al., Kōbe, Japan. In Mol Cell Biol, 2008
Tead1 and Tead2 are functionally redundant, use YAP as a major coactivator, and support notochord maintenance as well as cell proliferation and survival in development.
Dynamics driving function: new insights from electron transferring flavoproteins and partner complexes.
Review
Scrutton et al., Manchester, United Kingdom. In Febs J, 2007
ETF is positioned at a key metabolic branch point, responsible for transferring electrons from up to 10 primary dehydrogenases to the membrane-bound respiratory chain.
Enteral nutritional support in prevention and treatment of pressure ulcers: a systematic review and meta-analysis.
Review
Elia et al., Southampton, United Kingdom. In Ageing Res Rev, 2005
METHODS: Fifteen studies (including eight randomised controlled trials (RCTs)) of oral nutritional supplements (ONS) or enteral tube feeding (ETF), identified using electronic databases (including Pub Med and Cochrane) and bibliography searches, were included in the systematic review.
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