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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Endothelin receptor type B

ETB, EDNRB, endothelin B receptor
The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011] (from NCBI)
Top mentioned proteins: endothelin-1, endothelin receptor, V1a, HAD, CAN
Papers on ETB
Reduced Mechanical Stretch Induces Enhanced Endothelin B Receptor-mediated Contractility via Activation of Focal Adhesion Kinase and Extra Cellular-regulated Kinase 1/2 in Cerebral Arteries from Rat.
New
Edvinsson et al., Glostrup, Denmark. In Basic Clin Pharmacol Toxicol, Feb 2016
UNASSIGNED: Cerebral ischaemia results in enhanced endothelin B (ETB ) receptor-mediated contraction and receptor protein expression in the affected cerebrovascular smooth muscle cells (SMC).
Endothelin Receptors, Mitochondria and Neurogenesis in Cerebral Ischemia.
New
Gulati, Downers Grove, United States. In Curr Neuropharmacol, Feb 2016
UNASSIGNED: The ET family consists of three isopeptides (ET-1, ET-2 and ET-3) that produce biological actions by acting on two types of receptors (ETA and ETB).
Endothelin-1 downregulates sperm phagocytosis by neutrophils in vitro: a physiological implication in bovine oviduct immunity.
New
Miyamoto et al., Obihiro, Japan. In J Reprod Dev, Feb 2016
Moreover, this suppression was eliminated by an ETB receptor antagonist (BQ-788).
Ovarian hormones modulate endothelin A and B receptor expression.
New
Pollock et al., Birmingham, United States. In Life Sci, Feb 2016
AIMS: The study aims to determine the modulatory roles of ovarian hormones, estrogen (E2) and progesterone (P), on the expression of endothelin A (ETA) and B (ETB) receptors in lung, liver and kidney tissues.
High salt intake increases endothelin B receptor function in the renal medulla of rats.
New
Pollock et al., Birmingham, United States. In Life Sci, Jan 2016
AIMS: Endothelin (ET)-1 promotes natriuresis via the endothelin B receptor (ETB) within the renal medulla.
Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes.
New
Impact
Tseng et al., Boston, United States. In Nat Med, Jul 2015
Knocking out the positive UCP1 regulators, PREX1 and EDNRB, in brown preadipocytes using CRISPR-Cas9 markedly abolished the high level of UCP1 in brown adipocytes differentiated from the preadipocytes.
Endothelin and tubulointerstitial renal disease.
Review
New
Hocher et al., Potsdam, Germany. In Semin Nephrol, Mar 2015
These studies have shown that a critical balance between ETA and ETB receptor action is necessary to maintain structure and function in the cystic kidney.
Endothelin and renal ion and water transport.
Review
New
Pollock et al., Birmingham, United States. In Semin Nephrol, Mar 2015
ET-1 inhibits Na(+) transport in all parts of the nephron through activation of the ETB receptor, and, to a minor extent, the ETA receptor.
Drug Discovery Opportunities at the Endothelin B Receptor-Related Orphan G Protein-Coupled Receptors, GPR37 and GPR37L1.
Review
Smith, Australia. In Front Pharmacol, 2014
Two promising orphan GPCRs are the endothelin B receptor-like proteins, GPR37 [ET(B)R-LP, Pael-R] and GPR37L1 [ET(B)R-LP-2].
Endothelin Blockade in Diabetic Kidney Disease.
Review
Soler et al., Barcelona, Spain. In J Clin Med, 2014
This review focuses on the localization of endothelin receptors (ETA and ETB) within the kidney, as well as the ET-1 functions through them.
The Genetics of Deafness in Domestic Animals.
Review
Strain, Baton Rouge, United States. In Front Vet Sci, 2014
Across species, the genes identified with deafness or white pigmentation patterns include MITF, PMEL, KIT, EDNRB, CDH23, TYR, and TRPM1 in dog, cat, horse, cow, pig, sheep, ferret, mink, camelid, and rabbit.
Aldosterone inactivates the endothelin-B receptor via a cysteinyl thiol redox switch to decrease pulmonary endothelial nitric oxide levels and modulate pulmonary arterial hypertension.
GeneRIF
Leopold et al., Boston, United States. In Circulation, 2012
Our findings demonstrate that aldosterone modulates an ET(B) cysteinyl thiol redox switch to decrease pulmonary endothelium-derived NO(.) and promote pulmonary arterial hypertension.
Non-endothelial cell endothelin-B receptors limit neointima formation following vascular injury.
GeneRIF
Hadoke et al., Edinburgh, United Kingdom. In Cardiovasc Res, 2012
results are consistent with ETB receptor activation playing an important role in limiting neointimal lesion formation following acute vascular injury
Endothelin-1 activation of ETB receptors leads to a reduced cellular proliferative rate and an increased cellular footprint.
GeneRIF
Polgar et al., Boston, United States. In Exp Cell Res, 2012
endothelin-1 activation of endothelin receptor type B leads to a reduction in cell number by end-point cell counting and a decrease in cell growth.
Endothelin induces rapid, dynamin-mediated budding of endothelial caveolae rich in ET-B.
GeneRIF
Schnitzer et al., San Diego, United States. In J Biol Chem, 2012
endothelin can engage ET-B already highly concentrated in caveolae of endothelial cells to induce very rapid caveolae fission and endocytosis
Expression of selected neuropeptides in pathogenesis of bullous pemphigoid and dermatitis herpetiformis.
GeneRIF
Waszczykowska et al., Łódź, Poland. In Pol J Pathol, 2012
results obtained give evidence of a possible participation of receptor for endothelin B in the pathogenesis of the itch in the dermatitis herpetiformis
Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy.
Impact
GeneRIF
Coukos et al., Philadelphia, United States. In Nat Med, 2008
Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors
Effects of G-protein mutations on skin color.
Impact
Barsh et al., Stanford, United States. In Nat Genet, 2004
We identified three of four such mutations as hypermorphic alleles of Gnaq and Gna11, which encode widely expressed Galphaq subunits, act in an additive and quantitative manner, and require Ednrb.
Spatiotemporal regulation of endothelin receptor-B by SOX10 in neural crest-derived enteric neuron precursors.
Impact
GeneRIF
Shin et al., Philadelphia, United States. In Nat Genet, 2004
regulation by SOX10 in the enteric nervous system
Endothelin-B receptor activation triggers an endogenous analgesic cascade at sites of peripheral injury.
Impact
GeneRIF
Davar et al., Boston, United States. In Nat Med, 2003
These results indicate the existence of an intrinsic feedback mechanism to control peripheral pain in skin, and establish keratinocytes as an endothelin(B) receptor-operated opioid pool.
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