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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

ESX homeobox 1

Esx1, ESX1L, ESXR1
This gene encodes a dual-function 65 kDa protein that undergoes proteolytic cleavage to produce a 45 kDa N-terminal fragment with a paired-like homeodomain and a 20 kDa C-terminal fragment with a proline-rich domain. The C-terminal fragment localizes to the cytoplasm while the N-terminal fragment localizes exclusively to the nucleus. In contrast to human, the mouse homolog has a novel PN/PF motif in the C-terminus and is paternally imprinted in placental tissue. This gene likely plays a role in placental development and spermatogenesis. [provided by RefSeq, Jan 2010] (from NCBI)
Top mentioned proteins: BIRC5, CAN, V1a, Mtb, ACID
Papers on Esx1
Separable roles for Mycobacterium tuberculosis ESX-3 effectors in iron acquisition and virulence.
New
Jacobs et al., Shanghai, China. In Proc Natl Acad Sci U S A, Feb 2016
Mycobacterium tuberculosis (Mtb) encodes five type VII secretion systems (T7SS), designated ESX-1-ESX-5, that are critical for growth and pathogenesis.
Mycobacterial pan-genome analysis suggests important role of plasmids in the radiation of type VII secretion systems.
New
Sapriel et al., Saint-Quentin, France. In Genome Biol Evol, Feb 2016
Our phylogenetic and gene-order-analyses revealed two main groups of ESX types: i) ancestral types, including ESX-4 and ESX-4-like systems from mycobacterial and non-mycobacterial actinobacteria, and ii) mycobacteria-specific ESX systems, including ESX-1-2-3-5 systems and the plasmid-encoded ESX types.
Mechanism of ESAT-6 membrane interaction and its roles in pathogenesis of Mycobacterium tuberculosis.
New
Sun et al., Wuhan, China. In Toxicon, Nov 2015
ESAT-6 is secreted through the ESX-1 secretion system (Type VII) of M. tuberculosis and has been implicated to mediate mycobacterial cytosolic translocation within the host macrophages by rupturing the phagosomal membranes.
Myeloid Growth Factors Promote Resistance to Mycobacterial Infection by Curtailing Granuloma Necrosis through Macrophage Replenishment.
New
Ramakrishnan et al., Cambridge, United Kingdom. In Cell Host Microbe, Aug 2015
The mycobacterial ESX-1 virulence locus accelerates macrophage recruitment to the forming tuberculous granuloma.
Release of mycobacterial antigens.
Review
New
Brosch et al., Paris, France. In Immunol Rev, Mar 2015
The importance of specific mycobacterial antigen release is probably best exemplified by the striking differences observed between the cellular events during infection with the ESX-1-deficient, attenuated Mycobacterium bovis BCG compared to the virulent M. tuberculosis, which are clearly important for design of more specific diagnostics and more efficient vaccines.
RD-1 encoded EspJ protein gets phosphorylated prior to affect the growth and intracellular survival of mycobacteria.
Srivastava et al., Lucknow, India. In Sci Rep, 2014
The present study describes STPK modulated modification in one of the hypothetical proteins of the RD1 region; EspJ (ESX-1 secretion associated protein), which is predicted to be involved in virulence of MTB.
Take five - Type VII secretion systems of Mycobacteria.
Review
Bitter et al., Amsterdam, Netherlands. In Biochim Biophys Acta, 2014
Pathogenic mycobacteria, such as the notorious pathogen Mycobacterium tuberculosis, have up to five of these secretion systems, named ESX-1 to ESX-5.
Distributive Conjugal Transfer: New Insights into Horizontal Gene Transfer and Genetic Exchange in Mycobacteria.
Review
Gray et al., In Microbiol Spectr, 2014
The mating identity genes map to the esx1 locus, expanding the central role of ESX-1 function in conjugation.
Targeting type VII/ESX secretion systems for development of novel antimycobacterial drugs.
Review
Manganelli et al., Padova, Italy. In Curr Pharm Des, 2013
The genome of M. tuberculosis encodes 5 of such systems (ESX-1 to -5), three of which have been characterized and shown to be essential for viability (ESX-3, ESX-5) or virulence (ESX-1, ESX-5).
ESX-1-induced apoptosis during mycobacterial infection: to be or not to be, that is the question.
Review
Pardo et al., Zaragoza, Spain. In Front Cell Infect Microbiol, 2012
The major Mycobacterium tuberculosis virulence factor ESAT-6 exported by the ESX-1 secretion system has been described as a pro-apoptotic factor by several independent groups in recent years, sustaining a role for apoptosis in M. tuberculosis pathogenesis.
Extracellular M. tuberculosis DNA targets bacteria for autophagy by activating the host DNA-sensing pathway.
Impact
Cox et al., San Francisco, United States. In Cell, 2012
Here we show that phagosomal permeabilization mediated by the bacterial ESX-1 secretion system allows cytosolic components of the ubiquitin-mediated autophagy pathway access to phagosomal M. tuberculosis.
Mycobacterial secretion systems ESX-1 and ESX-5 play distinct roles in host cell death and inflammasome activation.
GeneRIF
Peters et al., Amsterdam, Netherlands. In J Immunol, 2011
Use of wild-type and ESX-1-deficient mycobacterial strains demonstrates that mycobacterial type 7 secretion system (T7SS) differentially affects macrophage cell death and interleukin (IL)-1b secretion.
ESX1 gene expression as a robust marker of residual spermatogenesis in azoospermic men.
GeneRIF
Miozzo et al., Milano, Italy. In Hum Reprod, 2010
ESX1 emerges as a potentially reliable molecular marker of residual spermatogenesis in azoospermic men
Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors.
Impact
Ko et al., Baltimore, United States. In Cell Stem Cell, 2009
Of the 50 TFs, Cdx2 provoked the most extensive transcriptome perturbation in ESCs, followed by Esx1, Sox9, Tcf3, Klf4, and Gata3.
Infection by tubercular mycobacteria is spread by nonlytic ejection from their amoeba hosts.
Impact
Soldati et al., Genève, Switzerland. In Science, 2009
This conserved nonlytic spreading mechanism requires a cytoskeleton regulator from the host and an intact mycobacterial ESX-1 secretion system.
The role of the granuloma in expansion and dissemination of early tuberculous infection.
Impact
Ramakrishnan et al., Atlanta, United States. In Cell, 2009
Intracellular mycobacteria use the ESX-1/RD1 virulence locus to induce recruitment of new macrophages to, and their rapid movement within, nascent granulomas.
Secreted transcription factor controls Mycobacterium tuberculosis virulence.
Impact
Cox et al., San Francisco, United States. In Nature, 2008
The ESX-1 protein secretion system of Mycobacterium tuberculosis-the causative agent of the human disease tuberculosis-delivers bacterial proteins into host cells during infection and is critical for virulence, but how it is regulated is unknown.
Homeobox gene ESX1L expression is decreased in human pre-term idiopathic fetal growth restriction.
GeneRIF
Kalionis et al., Melbourne, Australia. In Mol Hum Reprod, 2006
In FGR-affected placentae, ESX1L levels were lower than in gestation-matched controls, indicating a potential role for the ESX1L gene within the growth control mechanism of the fetus, through its effect on placental function.
Stage-dependent expression of extra-embryonic tissue-spermatogenesis-homeobox gene 1 (ESX1) protein, a candidate marker for X chromosome-bearing sperm.
GeneRIF
Lo et al., Taiwan. In Reprod Fertil Dev, 2004
ESX1 existed in the testes after 3 weeks of age, coincident with the appearance of round spermatids.ESX1 expression became more abundant in the seminiferous tubules as the development of round spermatids progressed into spermatozoa.
Molecular and morphologic analyses of expression of ESX1L in different stages of human placental development.
GeneRIF
Porto et al., Rio de Janeiro, Brazil. In J Cell Mol Med, 2004
ESX1L is expressed during all stages of placental development and is localized to sparse areas of trophoblast in terminal villi in association with cytotrophoblastic cells
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