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Estrogen receptor 1
Estrogen Receptor, ERalpha
This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters. [provided by RefSeq, Jul 2008] (from
DeMichele Angela et al., In Breast Cancer Research : BCR, 2001
... any possible differential effect of variable tamoxifen metabolism on outcome among patients whose tumors were estrogen-receptor positive.The ECOG Pathology Core Facility at Northwestern University extracted DNA from hematologic stem cells with the EZ1 system (Qiagen, Inc, Hilden, NW, Germany) ...
Coonrod et al., Ithaca, United States. In Proc Natl Acad Sci U S A, 2012
17beta-estradiol stimulation induces the recruitment of PAD2 to target promoters by ERalpha, whereby PAD2 then citrullinates H3R26, which leads to local chromatin decondensation and transcriptional activation.