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Estrogen receptor 1

Estrogen Receptor, ERalpha
This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters. [provided by RefSeq, Jul 2008] (from NCBI)
Papers using Estrogen Receptor antibodies
Absorption and disposition of ginsenosides after oral administration of Panax notoginseng extract to rats
Okabe Tetsuro et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2008
... Estrogen receptor (ER) alpha and beta small interfering RNA (siRNA) were from Santa Cruz biotechnology.
The null genotype of glutathione s-transferase M1 and T1 locus increases the risk for thyroid cancer
DeMichele Angela et al., In Breast Cancer Research : BCR, 2001
... any possible differential effect of variable tamoxifen metabolism on outcome among patients whose tumors were estrogen-receptor positive.The ECOG Pathology Core Facility at Northwestern University extracted DNA from hematologic stem cells with the EZ1 system (Qiagen, Inc, Hilden, NW, Germany) ...
Enhancement of tumor growth and vascular density by transfection of vascular endothelial cell growth factor into MCF-7 human breast carcinoma cells.
Burow Matthew E. et al., In Environmental Health Perspectives, 1994
... Profiler PCR Array (Breast Cancer and Estrogen Receptor Signaling PCR Array; PAHS-005; QIAGEN).
Papers on Estrogen Receptor
Estrogen receptor-alpha gene PvuII (T/C) and XbaI (A/G) polymorphisms and endometriosis risk: a meta-analysis.
Li et al., Chengdu, China. In Gene, 2012
Estrogen receptor-alpha gene PvuII (T/C) and XbaI (A/G) polymorphisms are not associated with endometriosis risk.
Interplay between AP-1 and estrogen receptor α in regulating gene expression and proliferation networks in breast cancer cells.
Zhao et al., Huddinge, Sweden. In Carcinogenesis, 2012
show that c-Fos and ERalpha can cooperate in regulating E2F1 gene expression by binding to regulatory elements in the E2F1 promoter
Peptidylarginine deiminase 2-catalyzed histone H3 arginine 26 citrullination facilitates estrogen receptor α target gene activation.
Coonrod et al., Ithaca, United States. In Proc Natl Acad Sci U S A, 2012
17beta-estradiol stimulation induces the recruitment of PAD2 to target promoters by ERalpha, whereby PAD2 then citrullinates H3R26, which leads to local chromatin decondensation and transcriptional activation.
PES1 promotes breast cancer by differentially regulating ERα and ERβ.
Ye et al., Beijing, China. In J Clin Invest, 2012
expression of PES1 correlated positively with ERalpha expression and negatively with ERbeta expression and predicted good clinical outcome in breast cancer
[ESR1 gene allelic polymorphism analysis in population of Ukraine].
Livshyts' et al., In Tsitol Genet, 2012
Polymorphic variants of ESR1 gene with TA-repeats could be related to dysfunction of the ovaries and infertility, which requires additional studies.
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