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Estrogen receptor 1

Estrogen Receptor, ERalpha
This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, V1a, erbB-2, AGE
Papers using Estrogen Receptor antibodies
Absorption and disposition of ginsenosides after oral administration of Panax notoginseng extract to rats
Supplier
Okabe Tetsuro et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2008
... Estrogen receptor (ER) alpha and beta small interfering RNA (siRNA) were from Santa Cruz biotechnology.
The null genotype of glutathione s-transferase M1 and T1 locus increases the risk for thyroid cancer
Supplier
DeMichele Angela et al., In Breast Cancer Research : BCR, 2001
... any possible differential effect of variable tamoxifen metabolism on outcome among patients whose tumors were estrogen-receptor positive.The ECOG Pathology Core Facility at Northwestern University extracted DNA from hematologic stem cells with the EZ1 system (Qiagen, Inc, Hilden, NW, Germany) ...
Enhancement of tumor growth and vascular density by transfection of vascular endothelial cell growth factor into MCF-7 human breast carcinoma cells.
Supplier
Burow Matthew E. et al., In Environmental Health Perspectives, 1994
... Profiler PCR Array (Breast Cancer and Estrogen Receptor Signaling PCR Array; PAHS-005; QIAGEN).
Papers on Estrogen Receptor
A Phase I Study of the AKT Inhibitor MK-2206 in Combination with Hormonal Therapy in Postmenopausal Women with Estrogen Receptor Positive Metastatic Breast Cancer.
New
Ellis et al., Soe, Indonesia. In Clin Cancer Res, Feb 2016
PURPOSE: Phosphatidylinositol-3-kinase (PI3K)/AKT pathway activation is an important endocrine resistance mechanism in estrogen receptor positive (ER+) breast cancer.
Nudging Oligodendrocyte Intrinsic Signaling to Remyelinate and Repair: Estrogen Receptor Ligand Effects.
Review
New
Tiwari-Woodruff et al., Riverside, United States. In J Steroid Biochem Mol Biol, Feb 2016
Our previous work has shown that therapeutic treatment with the modestly selective generic estrogen receptor (ER) β agonist diarylpropionitrile (DPN) confers functional neuroprotection in a chronic experimental autoimmune encephalomyelitis (EAE) mouse model of MS by stimulating endogenous myelination.
Identification of Distinct Breast Cancer Stem Cell Populations Based on Single-Cell Analyses of Functionally Enriched Stem and Progenitor Pools.
New
Landberg et al., Göteborg, Sweden. In Stem Cell Reports, Feb 2016
Estrogen receptor (ER)α+ tumors featured a clear hierarchical organization with switch-like and gradual transitions between different clusters, illustrating how breast cancer cells transfer between discrete differentiation states in a sequential manner.
The removal of estrogenic activity with UV/chlorine technology and identification of novel estrogenic disinfection by-products.
New
Lu et al., Beijing, China. In J Hazard Mater, Feb 2016
Estrogen receptor based affinity chromatography was used to isolate the specific estrogenic DBPs, and a novel product, with high estrogenic activity compared to E2, Δ9(11)-dehydro-estradiol, was identified.
Trichostatin A Enhances Estrogen Receptor-Alpha Repression in MCF-7 Breast Cancer Cells under Hypoxia.
New
Lee et al., Seoul, South Korea. In Biochem Biophys Res Commun, Feb 2016
UNASSIGNED: Estrogen receptor (ER) is a crucial determinant of resistance to endocrine therapy, which may change during the progression of breast cancer.
Estrogen receptor beta as target for colorectal cancer prevention.
Review
New
Gustafsson et al., Houston, United States. In Cancer Lett, Jan 2016
A large body of evidence from preclinical studies indicates that expression of the estrogen receptor beta (ERβ/ESR2) demonstrates an inverse relationship with the presence of colorectal polyps and stage of tumors, and can mediate a protective response.
Estrogen Receptor β Modulates Apoptosis Complexes and the Inflammasome to Drive the Pathogenesis of Endometriosis.
New
Impact
O'Malley et al., Houston, United States. In Cell, Dec 2015
In addition to higher estrogen receptor (ER) β levels, enhanced ERβ activity was detected in endometriotic tissues, and the inhibition of enhanced ERβ activity by an ERβ-selective antagonist suppressed mouse ectopic lesion growth.
Cancer therapy using natural ligands that target estrogen receptor beta.
Review
New
Vadlamudi et al., San Antonio, United States. In Chin J Nat Med, Nov 2015
Estrogen receptor beta (ERβ) is one of the two key receptors (ERα, ERβ) that facilitate biological actions of 17β-estradiol (E2).
Improvements in US Breast Cancer Survival and Proportion Explained by Tumor Size and Estrogen-Receptor Status.
New
Impact
Gail et al., Seoul, South Korea. In J Clin Oncol, Oct 2015
We estimated the proportion of improvements in stage- and age-specific breast cancer survival in the United States explained by tumor size or estrogen receptor (ER) status.
International Union of Basic and Clinical Pharmacology. XCVII. G Protein-Coupled Estrogen Receptor and Its Pharmacologic Modulators.
Review
New
Impact
Arterburn et al., Albuquerque, United States. In Pharmacol Rev, Jul 2015
Estrogens mediate their effects through multiple cellular receptors, including the nuclear receptor family (ERα and ERβ) and the G protein-coupled receptor (GPCR) family (GPR30/G protein-coupled estrogen receptor [GPER]).
Evaluation of the stage IB designation of the American Joint Committee on Cancer staging system in breast cancer.
New
Impact
Hunt et al., San Antonio, United States. In J Clin Oncol, May 2015
Estrogen receptor (ER) status and grade significantly stratified patients with stage I disease with respect to RFS, DSS, and OS.
Mature Testicular Teratoma with Positive Estrogen Receptor Beta Expression in a Transgendered Individual on Cross-Sex Hormonal Therapy: A Case Report.
New
Okada et al., Koshigaya, Japan. In Lgbt Health, Mar 2015
In the human testis, estrogen receptor beta (ER-β) mediates the physiological action of estrogen.
Aberrant Splicing of Estrogen Receptor, HER2, and CD44 Genes in Breast Cancer.
Review
Fry et al., Winston-Salem, United States. In Genet Epigenet, 2014
Established biomarkers, such as hormone receptors (estrogen receptor [ER]/progesterone receptor) and human epidermal growth factor receptor 2 (HER2), play significant roles in the selection of patients for endocrine and trastuzumab therapies.
Association between Estrogen Receptor-α Gene XbaI and PvuII Polymorphisms and Periodontitis Susceptibility: A Meta-Analysis.
Review
Niu et al., Shiyan, China. In Dis Markers, 2014
Certain studies have previously explored the association between the estrogen receptor-α (ER-α) gene polymorphisms and periodontitis susceptibility, although the current results are controversial.
Genome-wide association studies identify four ER negative-specific breast cancer risk loci.
Impact
Kraft et al., United Kingdom. In Nat Genet, 2013
Estrogen receptor (ER)-negative tumors represent 20-30% of all breast cancers, with a higher proportion occurring in younger women and women of African ancestry.
Estrogen receptor-alpha gene PvuII (T/C) and XbaI (A/G) polymorphisms and endometriosis risk: a meta-analysis.
GeneRIF
Li et al., Chengdu, China. In Gene, 2012
Estrogen receptor-alpha gene PvuII (T/C) and XbaI (A/G) polymorphisms are not associated with endometriosis risk.
Interplay between AP-1 and estrogen receptor α in regulating gene expression and proliferation networks in breast cancer cells.
GeneRIF
Zhao et al., Huddinge, Sweden. In Carcinogenesis, 2012
show that c-Fos and ERalpha can cooperate in regulating E2F1 gene expression by binding to regulatory elements in the E2F1 promoter
Peptidylarginine deiminase 2-catalyzed histone H3 arginine 26 citrullination facilitates estrogen receptor α target gene activation.
GeneRIF
Coonrod et al., Ithaca, United States. In Proc Natl Acad Sci U S A, 2012
17beta-estradiol stimulation induces the recruitment of PAD2 to target promoters by ERalpha, whereby PAD2 then citrullinates H3R26, which leads to local chromatin decondensation and transcriptional activation.
PES1 promotes breast cancer by differentially regulating ERα and ERβ.
GeneRIF
Ye et al., Beijing, China. In J Clin Invest, 2012
expression of PES1 correlated positively with ERalpha expression and negatively with ERbeta expression and predicted good clinical outcome in breast cancer
[ESR1 gene allelic polymorphism analysis in population of Ukraine].
GeneRIF
Livshyts' et al., In Tsitol Genet, 2012
Polymorphic variants of ESR1 gene with TA-repeats could be related to dysfunction of the ovaries and infertility, which requires additional studies.
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