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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

EST1 Est1p

Est1, Est1p
glutathione S-conjugate transporting ATPase (AtMRP1) mRNA. The expression of this gene is upregulated by herbicide safeners such as benoxacor and fenclorim. (from NCBI)
Top mentioned proteins: CAN, ESI, ACID, telomerase reverse transcriptase, Stn1
Papers on Est1
Comparison of genetic structures and biochemical properties of tandem cutinase-type polyesterases from Thermobifida alba AHK119.
New
Kawai et al., Hat Yai, Thailand. In J Biosci Bioeng, Nov 2015
This study described the genetic map of tandem genes (est1 and est119) encoding cutinase-type polyesterases in Thermobifida alba AHK119 and comparison of wild type and mutant enzymes of Est1 and Est119.
Heterologous production of a feruloyl esterase from Pleurotus sapidus synthesizing feruloyl-saccharide esters.
New
Berger et al., Hannover, Germany. In Biotechnol Appl Biochem, Sep 2015
UNASSIGNED: The feruloyl esterase (FAE) gene EST1 from the basidiomycete Pleurotus sapidus was heterologously expressed in Escherichia coli and Pichia pastoris.
Once-weekly muscle endurance and strength training prevents deterioration of muscle oxidative function and attenuates the degree of strength decline during 3-week forearm immobilization.
New
Katsumura et al., Kusatsu, Japan. In Eur J Appl Physiol, Mar 2015
METHODS: Twenty-seven, healthy, male volunteers were divided into four groups: immobilization only (IMM); immobilization with endurance and strength training, once-weekly (IMM + EST1) or twice-weekly (IMM + EST2); and control, without immobilization or training (CNT).
Comparative analysis of blood and saliva expression profiles in chronic and refractory periodontitis patients.
He et al., Wuhan, China. In Bmc Oral Health, 2014
In addition, CD24, EST1, MTSS1, ING3, CCND2 and SYNE2 might be potential targets for diagnosis and treatment of CP.
Normal telomere length maintenance in Saccharomyces cerevisiae requires nuclear import of the ever shorter telomeres 1 (Est1) protein via the importin alpha pathway.
Friedman et al., Nashville, United States. In Eukaryot Cell, 2014
The Est1 (ever shorter telomeres 1) protein is an essential component of yeast telomerase, a ribonucleoprotein complex that restores the repetitive sequences at chromosome ends (telomeres) that would otherwise be lost during DNA replication.
Yeast telomere maintenance is globally controlled by programmed ribosomal frameshifting and the nonsense-mediated mRNA decay pathway.
Dinman et al., College Park, United States. In Translation (austin), 2013
Functional -1 PRF signals were identified in the mRNAs encoding two components of yeast telomerase, EST1 and EST2, and in mRNAs encoding proteins involved in recruiting telomerase to chromosome ends, STN1 and CDC13.
The telomeric Cdc13 protein interacts directly with the telomerase subunit Est1 to bring it to telomeric DNA ends in vitro.
GeneRIF
Zakian et al., Princeton, United States. In Proc Natl Acad Sci U S A, 2012
the telomeric Cdc13 protein interacts directly with the telomerase subunit Est1 to bring it to telomeric DNA ends in vitro
Est1 protects telomeres and inhibits subtelomeric y'-element recombination.
GeneRIF
Zhou et al., Shanghai, China. In Mol Cell Biol, 2011
These results demonstrate that one major functional role that Est1 brings to the telomerase complex is the capping or protection of telomeres.
Arsenic tolerance in Arabidopsis is mediated by two ABCC-type phytochelatin transporters.
GeneRIF
Martinoia et al., South Korea. In Proc Natl Acad Sci U S A, 2011
AtABCC1 and AtABCC2 are the long-sought and major vacuolar phytochelatin transporters
The TPR-containing domain within Est1 homologs exhibits species-specific roles in telomerase interaction and telomere length homeostasis.
GeneRIF
Harrington et al., Toronto, Canada. In Bmc Mol Biol, 2010
The tricotetrapeptide repeat of Est1 is required for Est2-mediated telomere length maintenance.
AP-1/sigma1B-adaptin mediates endosomal synaptic vesicle recycling, learning and memory.
GeneRIF
Schu et al., Münster, Germany. In Embo J, 2010
Synaptic vesicle reformation in cultured neurons from adaptor protein complex AP-1 sigma-1B-deficient mice is reduced upon stimulation, and large endosomal intermediates accumulate.
Human telomere structure and biology.
Review
Riethman, Philadelphia, United States. In Annu Rev Genomics Hum Genet, 2007
One recently described family of (UUAGGG)n-containing subterminal RNAs appears to be critical for telomere integrity; these RNAs associate with telomeric chromatin and are regulated by RNA surveillance factors including human homologs of the yeast Est1p protein.
The yeast Pif1p helicase removes telomerase from telomeric DNA.
Impact
Zakian et al., Princeton, United States. In Nature, 2005
In vivo, overexpression of Pif1p reduces telomerase association with telomeres, whereas depleting cells of Pif1p increases the levels of telomere-bound Est1p, a telomerase subunit that is present on the telomere when telomerase is active.
RPA regulates telomerase action by providing Est1p access to chromosome ends.
Impact
Géli et al., Marseille, France. In Nat Genet, 2004
Cells carrying rfa2Delta40 show impaired binding of the protein Est1p, which is required for telomerase action.
Telomerase: what are the Est proteins doing?
Review
Zakian et al., Princeton, United States. In Curr Opin Cell Biol, 2003
Yeast telomerase is thought to be a holoenzyme containing Est2p and TLC1 RNA, the catalytic subunit and its intrinsic template, respectively, as well as the TLC1-RNA-associated factors Est1p and Est3p.
Est1p as a cell cycle-regulated activator of telomere-bound telomerase.
Impact
Zakian et al., Princeton, United States. In Science, 2002
In Saccharomyces cerevisiae, the telomerase components Est2p, TLC1 RNA, Est1p, and Est3p are thought to form a complex that acts late during chromosome replication (S phase) upon recruitment by Cdc13p, a telomeric DNA binding protein.
The role of the EST genes in yeast telomere replication.
Review
Lundblad et al., Houston, United States. In Ciba Found Symp, 1996
From this screen; 22 mutants were identified that mapped to three genes, called EST1, EST2 and EST3, as well as a novel EST-like mutation in a fourth gene, previously identified as CDC13.
Telomerase in yeast.
Impact
Blackburn et al., San Francisco, United States. In Science, 1995
The S. cerevisiae activity required the telomerase RNA gene TLC1 but not the EST1 gene, both of which are required for normal telomere maintenance in vivo.
An alternative pathway for yeast telomere maintenance rescues est1- senescence.
Impact
Blackburn et al., San Francisco, United States. In Cell, 1993
Yeast cells lacking a functional EST1 gene show progressive shortening of the terminal G1-3T telomeric repeats and a parallel increase in the frequency of cell death.
Genetic variability for esterase enzyme in Onobrychis species.
Nunna et al., Lubbock, United States. In Theor Appl Genet, 1990
Three regions of banding were observed in all the materials tested, with the number of bands varying from 0 to 3, 3 to 14, and 1 to 2 bands in each of these zones, which have been designated EST1, EST2, and EST3 respectively.
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