Human telomere structure and biology.
Philadelphia, United States. In Annu Rev Genomics Hum Genet, 2007
One recently described family of (UUAGGG)n-containing subterminal RNAs appears to be critical for telomere integrity; these RNAs associate with telomeric chromatin and are regulated by RNA surveillance factors including human homologs of the yeast Est1p protein.
The yeast Pif1p helicase removes telomerase from telomeric DNA.
Princeton, United States. In Nature, 2005
In vivo, overexpression of Pif1p reduces telomerase association with telomeres, whereas depleting cells of Pif1p increases the levels of telomere-bound Est1p, a telomerase subunit that is present on the telomere when telomerase is active.
Telomerase: what are the Est proteins doing?
Princeton, United States. In Curr Opin Cell Biol, 2003
Yeast telomerase is thought to be a holoenzyme containing Est2p and TLC1 RNA, the catalytic subunit and its intrinsic template, respectively, as well as the TLC1-RNA-associated factors Est1p and Est3p.
The role of the EST genes in yeast telomere replication.
Houston, United States. In Ciba Found Symp, 1996
From this screen; 22 mutants were identified that mapped to three genes, called EST1, EST2 and EST3, as well as a novel EST-like mutation in a fourth gene, previously identified as CDC13.
Telomerase in yeast.
San Francisco, United States. In Science, 1995
The S. cerevisiae activity required the telomerase RNA gene TLC1 but not the EST1 gene, both of which are required for normal telomere maintenance in vivo.
Genetic variability for esterase enzyme in Onobrychis species.
Lubbock, United States. In Theor Appl Genet, 1990
Three regions of banding were observed in all the materials tested, with the number of bands varying from 0 to 3, 3 to 14, and 1 to 2 bands in each of these zones, which have been designated EST1, EST2, and EST3 respectively.