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Dopamine receptor D3

Essential Tremor, DRD3
This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008] (from NCBI)
Papers on Essential Tremor
Dopamine receptor D3 regulates endocytic sorting by a Prazosin-sensitive interaction with the coatomer COPI.
Eggert et al., Boston, United States. In Proc Natl Acad Sci U S A, 2012
Dopamine receptor D3 regulates endocytic sorting by a Prazosin-sensitive interaction with the coatomer COPI.
Evidence that sleep deprivation downregulates dopamine D2R in ventral striatum in the human brain.
Ferré et al., Bethesda, United States. In J Neurosci, 2012
Downregulation of ventral striatum D2/D3 receptors with sleep deprivation may contribute to the associated decreased wakefulness.
In vivo mesolimbic D2/3 receptor binding predicts posttherapeutic clinical responses in restless legs syndrome: a positron emission tomography study.
Harada et al., Hamamatsu, Japan. In J Cereb Blood Flow Metab, 2012
alterations in mesolimbic D2/3 receptor function reflect the pathophysiology of iRLS, and the baseline availability of D2/3 receptors may predict the clinical outcome after D2/3 agonist treatment.
Lentiviral-mediated gene delivery reveals distinct roles of nucleus accumbens dopamine D2 and D3 receptors in novelty- and light-induced locomotor activity.
Desrivières et al., London, United Kingdom. In Eur J Neurosci, 2012
The results of this study suggested that D2R and D3R, expressed in the NAcc, have both shared and non-overlapping roles in transduction of alerting signals elicited by potentially important sensory and environmental cues.
Functional homomers and heteromers of dopamine D2L and D3 receptors co-exist at the cell surface.
Milligan et al., Glasgow, United Kingdom. In J Biol Chem, 2012
Dopamine D2L and D3 recepto form both homomers and heteromers at the cell surface.
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