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Dopamine receptor D3

Essential Tremor, DRD3
This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: AGE, HAD, DRD2, CAN, DRD4
Papers on Essential Tremor
Review on clinical update of essential tremor.
Zheng et al., Chongqing, China. In Neurol Sci, Feb 2016
UNASSIGNED: Essential tremor (ET) is considered a benign disease without any pathological changes.
Effect of Primidone on Dentate Nucleus γ-Aminobutyric Acid Concentration in Patients With Essential Tremor.
Dydak et al., New Haven, United States. In Clin Neuropharmacol, Jan 2016
This is an important potential confound in studies of the pathophysiology of essential tremor (ET), one of the most common neurological diseases.
Linking Essential Tremor to the Cerebellum-Animal Model Evidence.
Handforth, Los Angeles, United States. In Cerebellum, Jan 2016
We begin by considering the harmaline model of essential tremor (ET), which has ET-like anatomy and pharmacology.
The Role of β-Carboline Alkaloids in the Pathogenesis of Essential Tremor.
Duez et al., Cluj-Napoca / Kolozsvár, Romania. In Cerebellum, Jan 2016
UNASSIGNED: Essential tremor (ET) is one of the most prevalent neurological disorders in the world.
Functional assessment and quality of life in essential tremor with bilateral or unilateral DBS and focused ultrasound thalamotomy.
Elias et al., Charlottesville, United States. In Mov Disord, Dec 2015
BACKGROUND: Thalamic deep brain stimulation (DBS) has largely replaced radiofrequency thalamotomy as the treatment of choice for disabling, medication-refractory essential tremor.
Implementation of a smartphone wireless accelerometer platform for establishing deep brain stimulation treatment efficacy of essential tremor with machine learning.
Peduto et al., In Conf Proc Ieee Eng Med Biol Soc, Aug 2015
Essential tremor (ET) is a highly prevalent movement disorder.
Differentiating tremor patients using spiral analyses.
Deuschl et al., In Conf Proc Ieee Eng Med Biol Soc, Aug 2015
Essential tremor follows an autosomal dominant type of inheritance in the majority of patients, yet its genetic basis has not been identified.
Alprazolam for essential tremor.
Colosimo et al., Catania, Italy. In Cochrane Database Syst Rev, 2014
BACKGROUND: Essential tremor (ET) is one of the most common movement disorders.
Non-invasive Central and Peripheral Stimulation: New Hope for Essential Tremor?
Ayache et al., Créteil, France. In Front Neurosci, 2014
Essential tremor (ET) is among the most frequent movement disorders.
Isolated vocal tremor as a focal phenotype of essential tremor: a retrospective case review.
Frucht et al., New York City, United States. In J Clin Mov Disord, 2014
BACKGROUND: Essential tremor (ET) is a common condition associated with significant physical and psychosocial disability.
A pilot study of focused ultrasound thalamotomy for essential tremor.
Wintermark et al., Charlottesville, United States. In N Engl J Med, 2013
This preliminary study investigates the use of transcranial MRI-guided focused ultrasound thalamotomy for the treatment of essential tremor.
MR-guided focused ultrasound thalamotomy for essential tremor: a proof-of-concept study.
Lozano et al., Toronto, Canada. In Lancet Neurol, 2013
BACKGROUND: Essential tremor is the most common movement disorder and is often refractory to medical treatment.
Dopamine receptor D3 regulates endocytic sorting by a Prazosin-sensitive interaction with the coatomer COPI.
Eggert et al., Boston, United States. In Proc Natl Acad Sci U S A, 2012
Dopamine receptor D3 regulates endocytic sorting by a Prazosin-sensitive interaction with the coatomer COPI.
Evidence that sleep deprivation downregulates dopamine D2R in ventral striatum in the human brain.
Ferré et al., Bethesda, United States. In J Neurosci, 2012
Downregulation of ventral striatum D2/D3 receptors with sleep deprivation may contribute to the associated decreased wakefulness.
In vivo mesolimbic D2/3 receptor binding predicts posttherapeutic clinical responses in restless legs syndrome: a positron emission tomography study.
Harada et al., Hamamatsu, Japan. In J Cereb Blood Flow Metab, 2012
alterations in mesolimbic D2/3 receptor function reflect the pathophysiology of iRLS, and the baseline availability of D2/3 receptors may predict the clinical outcome after D2/3 agonist treatment.
Lentiviral-mediated gene delivery reveals distinct roles of nucleus accumbens dopamine D2 and D3 receptors in novelty- and light-induced locomotor activity.
Desrivières et al., London, United Kingdom. In Eur J Neurosci, 2012
The results of this study suggested that D2R and D3R, expressed in the NAcc, have both shared and non-overlapping roles in transduction of alerting signals elicited by potentially important sensory and environmental cues.
Functional homomers and heteromers of dopamine D2L and D3 receptors co-exist at the cell surface.
Milligan et al., Glasgow, United Kingdom. In J Biol Chem, 2012
Dopamine D2L and D3 recepto form both homomers and heteromers at the cell surface.
Treatment of patients with essential tremor.
Elble et al., Kiel, Germany. In Lancet Neurol, 2011
Essential tremor is a common movement disorder.
Essential tremor: evolving clinicopathological concepts in an era of intensive post-mortem enquiry.
Louis, New York City, United States. In Lancet Neurol, 2010
Essential tremor (ET) is one of the most common neurological disorders.
Atypical RNA polymerase subunits required for RNA-directed DNA methylation.
Matzke et al., Vienna, Austria. In Nat Genet, 2005
We report here that DRD2 and DRD3 correspond to the second-largest subunit and largest subunit, respectively, of a fourth class of DNA-dependent RNA polymerase (polymerase IV) that is unique to plants.
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