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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Discoidin, CUB and LCCL domain containing 2

Top mentioned proteins: Neuropilin-1, V1a, NET, Ubiquitin, Src
Papers on ESDN
EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis.
Cheng et al., In J Clin Invest, 2014
Here, we determined that the discoidina neuropilin-like membrane protein DCBLD2 is upregulated in clinical specimens of glioblastomas and head and neck cancers (HNCs) and is required for EGFR-stimulated tumorigenesis.
A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus.
Hagoort et al., Beijing, China. In Genes Brain Behav, 2014
The most significant association was found between right HG area and SNP rs72932726 close to gene DCBLD2 (3q12.1;
Identification of tumour suppressive microRNA-451a in hypopharyngeal squamous cell carcinoma based on microRNA expression signature.
Seki et al., Chiba, Japan. In Br J Cancer, 2014
Our data demonstrated that the gene coding for endothelial and smooth muscle cell-derived neuropilin-like molecule (ESDN/DCBLD2) was a direct target of miR-451a regulation.
Transmembrane protein ESDN promotes endothelial VEGF signaling and regulates angiogenesis.
Sadeghi et al., In J Clin Invest, 2013
Endothelial and smooth muscle cell-derived neuropilin-like protein (ESDN) is a neuropilin-related transmembrane protein expressed in ECs; however, its potential effect on VEGF responses remains undefined.
Tyrosine phosphorylation of the orphan receptor ESDN/DCBLD2 serves as a scaffold for the signaling adaptor CrkL.
Ballif et al., Burlington, United States. In Febs Lett, 2013
A quantitative proteomics screen to identify substrates of the Src family of tyrosine kinases (SFKs) whose phosphorylation promotes CrkL-SH2 binding identified the known Crk-associated substrate (Cas) of Src as well as the orphan receptor endothelial and smooth muscle cell-derived neuropilin-like protein (ESDN).
Ensemble of gene signatures identifies novel biomarkers in colorectal cancer activated through PPARγ and TNFα signaling.
Ceccarelli et al., Benevento, Italy. In Plos One, 2012
AKAP12, DCBLD2, NT5E and SPON1 are particularly represented in the signatures and selected for validation in vivo on two independent patients cohorts comprising 140 tumor tissues and 60 matched normal tissues.
DCBLD2 gene variations correlate with nasal polyposis in Korean asthma patients.
Shin et al., Seoul, South Korea. In Lung, 2012
These findings suggest that DCBLD2 could be a potential marker and drug target for treatment of nasal polyposis in Korean asthma patients.
Potential association of DCBLD2 polymorphisms with fall rates of FEV(1) by aspirin provocation in Korean asthmatics.
Shin et al., Seoul, South Korea. In J Korean Med Sci, 2012
Seven SNPs (rs1371687, rs7615856, rs828621, rs828618, rs828616, rs1062196, and rs8833) and one haplotype (DCBLD2-ht1) show associations with susceptibility to AERD.
Pseudoachondroplasia and multiple epiphyseal dysplasia: a 7-year comprehensive analysis of the known disease genes identify novel and recurrent mutations and provides an accurate assessment of their relative contribution.
Briggs et al., Manchester, United Kingdom. In Hum Mutat, 2012
Since 2003, the European Skeletal Dysplasia Network (ESDN) has used an on-line review system to efficiently diagnose cases referred to the network prior to mutation analysis.
Long signal peptides of RGMa and DCBLD2 are dissectible into subdomains according to the NtraC model.
Starzinski-Powitz et al., Frankfurt am Main, Germany. In Mol Biosyst, 2011
The full-length signal peptides of DCBLD2 is functional and furthermore that the C-domains are sufficient and essential for ER targeting, whereas the N-domains are dispensable. Thus, the N-domains are available for additional functions.
Identification of functional TFAP2A and SP1 binding sites in new TFAP2A-modulated genes.
Taverna et al., Torino, Italy. In Bmc Genomics, 2009
The direct binding of TFAP2A or SP1 to a random subset of TFAP2A-modulated genes was demonstrated by Chromatin ImmunoPrecipitation (ChIP) assay and the TFAP2A-driven regulation of DCBLD2/ESDN/CLCP1 gene studied in details.
Endothelial and smooth muscle-derived neuropilin-like protein regulates platelet-derived growth factor signaling in human vascular smooth muscle cells by modulating receptor ubiquitination.
Sadeghi et al., New Haven, United States. In J Biol Chem, 2009
ESDN modulates PDGF signaling in VSMCs via regulation of PDGFR beta surface levels.
Functional genomics in zebrafish permits rapid characterization of novel platelet membrane proteins.
Bloodomics Consortium et al., Cambridge, United Kingdom. In Blood, 2009
We identified a putative role for BAMBI and LRRC32 in promotion and DCBLD2 and ESAM in inhibition of thrombus formation.
Identification of novel neuroendocrine-specific tumour genes.
Thommesen et al., Trondheim, Norway. In Br J Cancer, 2008
In addition to potential new diagnostic markers (NEFM, CLDN4, PEROX2), the results point to genes that may be involved in the tumorigenesis (BEX1, TMEPAI, FOSL1, RAB32), and in the processes of invasion, progression and metastasis (MME, STAT3, DCBLD2) of NETs.
AP-2alpha and AP-2gamma regulate tumor progression via specific genetic programs.
Taverna et al., Torino, Italy. In Faseb J, 2008
In particular, we showed that ESDN, EREG, and CXCL2 play a major role in AP-2 controlled migration, as ablation of any of these genes severely altered migration.
Epigenetic down-regulation and suppressive role of DCBLD2 in gastric cancer cell proliferation and invasion.
Kim et al., Taejŏn, South Korea. In Mol Cancer Res, 2008
These data suggest that down-regulation of DCBLD2, often associated with promoter hypermethylation, is a frequent event that may be related to the development of gastric cancer.
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