Endosidin2 targets conserved exocyst complex subunit EXO70 to inhibit exocytosis.
Praha, Czech Republic. In Proc Natl Acad Sci U S A, Feb 2016
We discovered that the small molecule Endosidin2 (ES2) binds to the EXO70 (exocyst component of 70 kDa) subunit of the exocyst complex, resulting in inhibition of exocytosis and endosomal recycling in both plant and human cells and enhancement of plant vacuolar trafficking.
[Neurophysiological studies of headaches].
Zaragoza, Spain. In Rev Neurol, 1997
The electromyogram and Muscle Reflexes have been used in the study of Tension Type Headaches, ES2 changes, showing brainstem antinociceptive reflexes support the participation of a central factor in the origin of chronic Tension Headache.