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DiGeorge syndrome critical region gene 14

ES2
This gene is located within the minimal DGS critical region (MDGCR) thought to contain the gene(s) responsible for a group of developmental disorders. These disorders include DiGeorge syndrome, velocardiofacial syndrome, conotruncal anomaly face syndrome, and some familial or sporadic conotruncal cardiac defects which have been associated with microdeletion of 22q11.2. The encoded protein may be a component of C complex spliceosomes, and the orthologous protein in the mouse localizes to the nucleus. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, ACID, V1a, Akt
Papers on ES2
Nilotinib reduced the viability of human ovarian cancer cells via mitochondria-dependent apoptosis, independent of JNK activation.
New
Chen et al., Taipei, Taiwan. In Toxicol In Vitro, Mar 2016
AMN induction of apoptosis with increased intracellular peroxide production and JNK protein phosphorylation was also identified in human A2780 ovarian cancer cells, cisplatin-resistant A2780CP cells, and clear ES-2 cells.
Endosidin2 targets conserved exocyst complex subunit EXO70 to inhibit exocytosis.
New
Raikhel et al., Praha, Czech Republic. In Proc Natl Acad Sci U S A, Feb 2016
We discovered that the small molecule Endosidin2 (ES2) binds to the EXO70 (exocyst component of 70 kDa) subunit of the exocyst complex, resulting in inhibition of exocytosis and endosomal recycling in both plant and human cells and enhancement of plant vacuolar trafficking.
Lipocalin 2 attenuates iron-related oxidative stress and prolongs the survival of ovarian clear cell carcinoma cells by up-regulating the CD44 variant.
New
Shiozawa et al., Matsumoto, Japan. In Free Radic Res, Feb 2016
Therefore, we herein examined the roles of LCN2 in the regulation of intracellular iron concentrations, oxidative stress, DNA damage, and anti-oxidative functions using LCN2-overexpressing (ES2), and LCN2-silenced (RMG-1) CCC cell lines.
Inhibition of human telomerase reverse transcriptase in vivo and in vitro for retroviral vector-based antisense oligonucleotide therapy in ovarian cancer.
New
Mi et al., Tianjin, China. In Cancer Gene Ther, Jan 2016
The vector was introduced into ES-2 by lipofectamine-mediated gene transfection.
Coumestrol Suppresses Proliferation of ES2 Human Epithelial Ovarian Cancer Cells.
New
Song et al., Seoul, South Korea. In J Endocrinol, Jan 2016
In the present study, we demonstrated that coumestrol inhibited viability and invasion, and induced apoptosis of ES2 (clear cell-/serous carcinoma origin) cells.
Delphinidin suppresses proliferation and migration of human ovarian clear cell carcinoma cells through blocking AKT and ERK1/2 MAPK signaling pathways.
New
Song et al., Seoul, South Korea. In Mol Cell Endocrinol, Jan 2016
Results of present study revealed that cell survival rates of ES2 cells from ovarian CCC treated with delphinidin decreased in a dose-dependent manner.
Inhibition of leucine aminopeptidase 3 suppresses invasion of ovarian cancer cells through down-regulation of fascin and MMP-2/9.
New
Fang et al., Weifang, China. In Eur J Pharmacol, Jan 2016
In this study, we used ES-2 ovarian cancer cell line as a model system to explore the role of LAP3 in regulation of cancer cell invasion by employing a natural LAP3 inhibitor bestatin and LAP3 siRNA.
HNF1β drives glutathione (GSH) synthesis underlying intrinsic carboplatin resistance of ovarian clear cell carcinoma (OCCC).
New
Serpa et al., Lisbon, Portugal. In Tumour Biol, Dec 2015
Metabolic profiles, GSH quantification, HNF1β, and γ-glutamylcysteine ligase catalytic subunit (GCLC) and modifier subunit (GCLM) expression, cell cycle, and death were assessed in ES2 cell line (OCCC) and OVCAR3 cell line (OSC); HNF1β knockdown was performed in ES2 and murine model of subcutaneous and peritoneal OCCC tumors was established to test buthionine sulphoxamine (BSO), as a sensitizer to carboplatin.
Multiplexed tracking of combinatorial genomic mutations in engineered cell populations.
New
Impact
Gill et al., Boulder, United States. In Nat Biotechnol, Jun 2015
Combinatorial mutations in the human ES2 ovarian carcinoma cell line were also assessed with TRACE.
D-Cys-D-Asp-Gly-HCit-Gly-Pro-Gln-D-Cys-Ebes-Lys-polyethylene glycol-cholic acids-Cy5.5 telodendrimer nanoparticles
Review
Leung, Bethesda, United States. In Unknown Journal, 2012
OA02-Cy5.5 was found to have a high specific accumulation in α3β1-positve ES-2 human ovarian tumor cells in nude mice.
LYP, a bestatin dimethylaminoethyl ester, inhibited cancer angiogenesis both in vitro and in vivo.
Review
Qu et al., Jinan, China. In Microvasc Res, 2011
Our previous study revealed that LYP, a bestatin dimethylaminoethyl ester, inhibited the growth of human ovarian carcinoma ES-2 xenografts in mice and suppressed aminopeptidase N (APN/CD13) activity more potently than bestatin.
Loss of Goosecoid-like and DiGeorge syndrome critical region 14 in interpeduncular nucleus results in altered regulation of rapid eye movement sleep.
GeneRIF
Yanagisawa et al., Dallas, United States. In Proc Natl Acad Sci U S A, 2010
results indicate that the absence of Gscl and Dgcr14 in the IP results in altered regulation of REM sleep
D-Cys-D-Asp-Gly-HCit-Gly-Pro-Gln-D-Cys-Ebes-Ebes-Lys-Cy5.5
Review
Leung, Bethesda, United States. In Unknown Journal, 2007
OA02-Cy5.5 was found to have a high specific accumulation in α3β1-positve ES-2 human ovarian tumor cells in nude mice.
Protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer.
Impact
Lee et al., Hamilton, Canada. In Nat Genet, 2002
In addition, EEF1A2 expression made NIH3T3 fibroblasts tumorigenic and increased the growth rate of ES-2 ovarian carcinoma cells xenografted in nude mice.
Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.
GeneRIF
Moore et al., Waltham, United States. In Rna, 2002
The human ortholog of Es2el co-purifies with C-complex spliceosomes
[Neurophysiological studies of headaches].
Review
Muñoz-Farjas, Zaragoza, Spain. In Rev Neurol, 1997
The electromyogram and Muscle Reflexes have been used in the study of Tension Type Headaches, ES2 changes, showing brainstem antinociceptive reflexes support the participation of a central factor in the origin of chronic Tension Headache.
[Exteroceptive suppression of activity of the temporal muscle. Principles and applications].
Review
Dworschak et al., Kiel, Germany. In Nervenarzt, 1996
The exteroceptive suppression period (ES) of the temporalis muscle activity is a trigemino-trigeminal brain stem reflex.
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