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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Carboxylesterase 3

ES-31, CES3
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene is expressed in several tissues, particularly in colon, trachea and in brain, and the protein participates in colon and neural drug metabolism. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported, but the biological validity and/or full-length nature of some variants have not been determined.[provided by RefSeq, Jun 2010] (from NCBI)
Top mentioned proteins: ACID, Carboxylesterase, Phosphogluconate Dehydrogenase, Cic, SIMPLE
Papers on ES-31
Expression of proteins associated with adipocyte lipolysis was significantly changed in the adipose tissues of the obese spontaneously hypertensive/NDmcr-cp rat.
Ichihara et al., Tsu, Japan. In Diabetol Metab Syndr, 2013
Further analysis using the 2D-DIGE connected with MALDI-TOF/TOF analysis, the expression of monoglyceride lipase (MGLL) was significantly up-regulated and that of carboxylesterase 3 (CES3) was significantly down-regulated in 6- and 25-week-old CP compared with age-matched control (WKY and Lean rats).
Elisa protocol for rapid screening of potential anti-tubercular drugs based on antigenic reactivity of mycobacterial ES-31 serine protease - a drug target supported by axenic culture of Mycobacterium tuberculosis H37 Ra strain in the presence of inhibitor.
Harinath et al., India. In Indian J Tuberc, 2013
BACKGROUND: Mycobacterial ES-31 serine protease has been reported to be a drug target using protease and lipase inhibitors in axenic and macrophage cultures.
Fluoxetine induces hepatic lipid accumulation via both promotion of the SREBP1c-related lipogenesis and reduction of lipolysis in primary mouse hepatocytes.
Yang et al., Nanjing, China. In Cns Neurosci Ther, 2012
Oppositely, Fluoxetine significantly decreased the carboxylesterase 3 (CES3) and carboxylesterase 1 (CES1) expression, which are related to lipolysis.
Metabolomics identifies an inflammatory cascade involved in dioxin- and diet-induced steatohepatitis.
Impact
Gonzalez et al., Bethesda, United States. In Cell Metab, 2012
Serum metabolomics identified azelaic acid monoesters as significantly increased metabolites after TCDD treatment, due to downregulation of hepatic carboxylesterase 3 (CES3, also known as triglyceride hydrolase) expression in an arylhydrocarbon receptor (AhR)-dependent manner in mice.
Identification of a novel intracellular cholesteryl ester hydrolase (carboxylesterase 3) in human macrophages: compensatory increase in its expression after carboxylesterase 1 silencing.
GeneRIF
Ghosh et al., Richmond, United States. In Am J Physiol Cell Physiol, 2012
This study provides the first evidence of functional compensation whereby increased expression of CES3 restores intracellular cholesteryl ester hydrolytic activity and free cholesterol efflux in CES1-deficient cells.
Inhibitory effect of isoniazid and orlistat combination on mycobacterial ES-31 serine protease in vitro and on the growth of M.tb bacilli in axenic culture.
Harinath et al., Wardha, India. In Indian J Tuberc, 2012
BACKGROUND: Isoniazid and orlistat were reported to have inhibitory effect on mycobacterial ES-31 serine protease in vitro and bacterial cell growth in axenic culture.
Multi-antigen and antibody assays (SEVA TB ELISA) for the diagnosis of tuberculous pleural effusion.
Harinath et al., Wardha, India. In Indian J Tuberc, 2012
OBJECTIVE: Prospective evaluation of inhouse developed SEVA TB ELISA using cocktail of Mycobacterial antigens ES-31 and EST-6 (containing ES-38 and ES-41) and their specific antibodies in the diagnosis of Tuberculous pleural effusion was done in a tertiary care hospital.
Carboxylesterase expression in human dental pulp cells: role in regulation of BisGMA-induced prostanoid production and cytotoxicity.
Jeng et al., Taiwan. In Acta Biomater, 2012
This study found that human dental pulp cells expressed mainly carboxylesterase-2 (CES2) and smaller amounts of CES1A1 and CES3 isoforms.
A sensitive and specific ES-31 antigen detection based fluorometric assay for confirmation of Mycobacterium tuberculosis in cell culture.
Harinath et al., Wardha, India. In Indian J Exp Biol, 2011
The present study was undertaken to find the usefulness of mycobacterial ES-31 serine protease as a marker to detect tuberculosis bacilli using fluorescein isothiocyanate conjugated anti-ES-31 serine protease antibody.
Mammalian carboxylesterase 3: comparative genomics and proteomics.
GeneRIF
VandeBerg et al., San Antonio, United States. In Genetica, 2010
Studies indicate that CES3 mRNA isoform expression in several tissues, particularly in colon, trachea and in brain.
Potential of mycobacterial excretory secretory protein antigens (sevatb ES-31, ES-43, EST-6 and ES-20) as biomarkers to detect Mycobacterium tuberculosis bacilli.
Harinath et al., Wardha, India. In Indian J Clin Biochem, 2010
The utility of mycobacterial ES-31, ES-43, EST-6 or ES-20 antigen as a biomarker for differentiation of Mycobacterium tuberculosis bacilli from nontuberculous mycobacteria was explored using Fluorescein isothiocyanate conjugated antibodies against these antigens.
Human carboxylesterases: an update on CES1, CES2 and CES3.
Review
GeneRIF
Bosron et al., Indianapolis, United States. In Protein Pept Lett, 2008
CES3 seems to have a lower catalytic efficiency than the other two CESs for selected substrates.
Structure and characterization of human carboxylesterase 1A1, 1A2, and 1A3 genes.
GeneRIF
Yokoi et al., Kanazawa, Japan. In Pharmacogenet Genomics, 2008
pharmacogenomic characterization of human carboxylesterase 1A1, 1A2, and 1A3 genes
Immunodiagnosis of tuberculosis: An update.
Harinath et al., Wardha, India. In Indian J Clin Biochem, 2003
Indigenous immunoassay systems have explored excretory-secretory ES-31 mycobacterial antigen for immunodiagnosis of TB.
Analysis of SEVA TB ES-31 antigen specific immunoglobulins IgM, IgA and IgG in sera of sputum and culture positive pulmonary tuberculosis.
Harinath et al., Wardha, India. In Indian J Clin Biochem, 2002
SEVA TB ES-31 antigen has shown potential in detecting tuberculous IgG antibody in earlier studies from our laboratory.
Assay of tubercular antibody, circulating free and immune complexed antigen in the diagnosis of pulmonary tuberculosis.
Harinath et al., Wardha, India. In Indian J Clin Biochem, 2001
Analysis of tubercular antibody, circulating free and immune complexed antigen (CIC-Ag) was done in confimed pulmonary tuberculosis sera by ELISA, using ES-31 antigen and affinity purified anti ES-31 antibody.
Isolation ofMycobacterium Tuberculosis 31 kDa antigen protein of diagnostic interest from culture filtrate using anti-ES-31 antibody by affinity chromatography.
Harinath et al., Wardha, India. In Indian J Clin Biochem, 2001
Proteins secreted into the culture medium byMycobacterium tuberculosis (M.
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