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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Erythropoietin receptor

erythropoietin receptor, EpoR
This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010] (from NCBI)
Top mentioned proteins: erythropoietin, CAN, JAK2, HAD, V1a
Papers on erythropoietin receptor
Delayed hemoglobin switching and perinatal neocytolysis in mice with gain-of-function erythropoietin receptor.
Yoon et al., Olomouc, Czech Republic. In J Mol Med (berl), Jan 2016
UNASSIGNED: Mutations of the truncated cytoplasmic domain of human erythropoietin receptor (EPOR) result in gain-of-function of erythropoietin (EPO) signaling and a dominantly inherited polycythemia, primary familial and congenital polycythemia (PFCP).
New genetic and physiological factors for excessive erythrocytosis and Chronic Mountain Sickness.
Villafuerte, Lima, Peru. In J Appl Physiol, Jan 2016
The different physiological patterns in the Epo-EpoR system found among Andeans, even among highlanders with CMS, together with their different degrees of erythropoietic response, might indicate specific underlying genetic backgrounds, which in turn might reflect different levels of adaptation to lifelong high-altitude hypoxia.
The systemic vascular resistance response: a cardiovascular response modulating blood viscosity with implications for primary hypertension and certain anemias.
St Cyr et al., Philadelphia, United States. In Ther Adv Cardiovasc Dis, Dec 2015
We suggest that an increase in blood viscosity is detected by mechanoreceptors in the left ventricle which upregulate expression of cardiac natriuretic peptides and soluble erythropoietin receptor.
Analysis of the erythropoietin of a Tibetan Plateau schizothoracine fish (Gymnocypris dobula) reveals enhanced cytoprotection function in hypoxic environments.
Chen et al., Shanghai, China. In Bmc Evol Biol, Dec 2015
The presence of potentially positive selection sites in both EPO and EPOR in G. dobula suggest possible adaptive evolution in the ligand-receptor binding activity of the EPO signaling cascade in G. dobula.
Erythropoietin Stimulates Tumor Growth via EphB4.
Sood et al., Houston, United States. In Cancer Cell, Dec 2015
A lack of correlation between expression of the canonical EpoR and rhEpo's effects on cancer cells prompted us to consider the existence of an alternative Epo receptor.
A Mechanical Switch Couples T Cell Receptor Triggering to the Cytoplasmic Juxtamembrane Regions of CD3ζζ.
Kuhns et al., Tucson, United States. In Immunity, Sep 2015
Using three in situ proximity assays based on ID-PRIME, FRET, and EPOR activity, we determined that the cytosolic juxtamembrane regions of the CD3ζζ subunits are spread apart upon assembly into the TCR-CD3 complex.
Emerging EPO and EPO receptor regulators and signal transducers.
Wojchowski et al., West Scarborough, United States. In Blood, Jul 2015
Early investigations defined basic mechanisms for hypoxia-inducible factor induction of EPO expression, and within erythroid progenitors EPOR engagement of canonical Janus kinase 2/signal transducer and activator of transcription 5 (JAK2/STAT5), rat sarcoma/mitogen-activated protein kinase/extracellular signal-regulated kinase (RAS/MEK/ERK), and phosphatidylinositol 3-kinase (PI3K) pathways.
Review of STAT3 (Signal Transducers and Activators of Transcription) in head and neck cancer.
Mali, India. In Oral Oncol, Jun 2015
STATs can be activated by a number of signal transduction pathways, including the epidermal growth factor receptor (EGFR), nicotinic receptor, interleukin (IL) receptor, and erythropoietin receptor pathways.
Tuning cytokine receptor signaling by re-orienting dimer geometry with surrogate ligands.
Garcia et al., Stanford, United States. In Cell, Apr 2015
We utilized diabodies (DA) as surrogate ligands in a prototypical dimeric receptor-ligand system, the cytokine Erythropoietin (EPO) and its receptor (EpoR), to dimerize EpoR ectodomains in non-native architectures.
Erythropoietin alleviates hepatic insulin resistance via PPARγ-dependent AKT activation.
Zhu et al., Nanjing, China. In Sci Rep, 2014
Here, we report that EPO administration promoted phosphatidylinositol 3-kinase (PI3K)/AKT pathway activation in palmitic acid (PA)-treated HepG2 cells and in the liver of high-fat diet (HFD)-fed mice, whereas adenovirus-mediated silencing of the erythropoietin receptor (EPOR) blocked EPO-induced AKT signalling in HepG2 cells.
Expressions of CD96 and CD123 in Bone Marrow Cells of Patients with Myelodysplastic Syndromes.
Liu et al., In Clin Lab, 2014
CD114 (GCSFR), EPOR, and CD110 (TPOR) expression on their CD34+CD38-CD96+ and CD34+CD38-CD96- BMC and these cells' apoptosis (Annexin V) were also detected by FACS.
Agonists of the tissue-protective erythropoietin receptor in the treatment of Parkinson's disease.
Spencer et al., Menlo Park, United States. In Curr Top Med Chem, 2014
The tissue-protective erythropoietin (EPO) receptor, EPOR/CD131, has emerged as one promising target for disease-modifying therapies.
Randomized Controlled Trial of Darbepoetin α Versus Continuous Erythropoietin Receptor Activator Injected Subcutaneously Once Every Four Weeks in Patients with Chronic Kidney Disease at the Pre-Dialysis Stage.
Maruyama et al., Tokyo, Japan. In Int J Mol Sci, 2014
Continuous erythropoietin receptor activator (CERA) seems to maintain a stable hemoglobin (Hb) level because its half-life is longer than darbepoetin α (DA).
Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.
Mullighan et al., Memphis, United States. In N Engl J Med, 2014
Kinase-activating alterations were identified in 91% of patients with Ph-like ALL; rearrangements involving ABL1, ABL2, CRLF2, CSF1R, EPOR, JAK2, NTRK3, PDGFRB, PTK2B, TSLP, or TYK2 and sequence mutations involving FLT3, IL7R, or SH2B3 were most common.
Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia.
Mullighan et al., Memphis, United States. In Cancer Cell, 2012
We performed transcriptome and whole genome sequencing on 15 cases of Ph-like ALL and identified rearrangements involving ABL1, JAK2, PDGFRB, CRLF2, and EPOR, activating mutations of IL7R and FLT3, and deletion of SH2B3, which encodes the JAK2-negative regulator LNK.
The SH2B1 adaptor protein associates with a proximal region of the erythropoietin receptor.
Barber et al., Toronto, Canada. In J Biol Chem, 2012
enhanced activation of signaling pathways downstream of the EPO-receptor, indicate that SH2B1 is a negative regulator of EPO signaling.
Peginesatide and erythropoietin stimulate similar erythropoietin receptor-mediated signal transduction and gene induction events.
Young et al., Palo Alto, United States. In Exp Hematol, 2012
Peginesatide and erythropoietin stimulate similar erythropoietin receptor-mediated signal transduction and gene induction events.
Location and the functionality of erythropoietin receptor(s) in A2780 cells.
Sytkowski et al., Košice, Slovakia. In Oncol Rep, 2012
the biology of the EpoR in ovarian cancer cells
Spry1 as a novel regulator of erythropoiesis, EPO/EPOR target, and suppressor of JAK2.
Wojchowski et al., West Scarborough, United States. In Blood, 2012
Studies implicate Spry1 as a novel regulator of erythropoiesis during anemia, transducer of EPO/EPOR signals, and candidate suppressor of Jak2 activity.
Erythropoietin receptor signaling is membrane raft dependent.
List et al., Tampa, United States. In Plos One, 2011
a critical role for membrane raft in recruitment and assembly of Epo-R and signal intermediates into discrete membrane signaling units
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