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Estrogen-related receptor gamma

This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: ERRalpha, orphan nuclear receptor, CAN, PGC-1alpha, Estrogen Receptor
Papers on ERRgamma
MiR-940 inhibits hepatocellular carcinoma growth and correlates with prognosis of hepatocellular carcinoma patients.
Luo et al., Chengdu, China. In Cancer Sci, Jul 2015
Estrogen-related receptor gamma (ESRRG) was targeted by miR-940, and suppression of ESRRG inhibited HCC cell lines growth and induced cell apoptosis.
Derivatives containing both coumarin and benzimidazole potently induce caspase-dependent apoptosis of cancer cells through inhibition of PI3K-AKT-mTOR signaling.
She et al., Augusta, United States. In Anticancer Drugs, Jul 2015
Real-time reverse transcriptase PCR analyses of 26 cancer-related genes revealed that seven genes (NPPB, ATF3, DDIT4, CDH10, TSPAN14, TXNIP, and AXL) were significantly upregulated and nine genes (PAGE4, LRP8, SNCAIP, IGFBP5, SLCO2A1, CLDN2, ESRRG, D2HGDH, and PDGFRA) were significantly downregulated.
Differential network analysis reveals dysfunctional regulatory networks in gastric carcinogenesis.
Li et al., Shanghai, China. In Am J Cancer Res, 2014
Based on our inferred differential networking information and known signaling pathways, we generated testable hypotheses on the roles of GATA6, ESRRG and their signaling pathways in gastric carcinogenesis.
Cytoplasmic PELP1 and ERRgamma protect human mammary epithelial cells from Tam-induced cell death.
Ostrander et al., Durham, United States. In Plos One, 2014
Furthermore, PELP1-cyto signaling through estrogen-related receptor gamma (ERRγ) promoted cell survival in the presence of Tam.
ERRγ target genes are poor prognostic factors in Tamoxifen-treated breast cancer.
Riggins et al., Washington, D.C., United States. In J Exp Clin Cancer Res, 2014
Estrogen-related receptor gamma (ESRRG, ERRγ) is an orphan nuclear receptor with broad, structural similarities to classical ER that is widely implicated in the transcriptional regulation of energy homeostasis.
Risk miRNA screening of ovarian cancer based on miRNA functional synergistic network.
Xu et al., Shenyang, China. In J Ovarian Res, 2013
Other TFs, such as BIN1, FOXN3, FOXK1, FOXP2, and ESRRG with high degrees may be inhibited in ovarian cancer.
The miR-545/374a cluster encoded in the Ftx lncRNA is overexpressed in HBV-related hepatocellular carcinoma and promotes tumorigenesis and tumor progression.
Qin et al., Jinan, China. In Plos One, 2013
One of these targets, namely estrogen-related receptor gamma (ESRRG) was inversely correlated with miR-545 expression.
Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9.
Rao et al., Saint Louis, United States. In Front Genet, 2012
Index SNPs in 20 other loci exhibited suggestive (p-value ≤ 1E-06) associations with BP traits by the 1 df interaction test or joint 2 df test, including 3 rare variants, one low-frequency variant, and SNPs near/in genes ESRRG, FAM179A, CRIPT-SOCS5, KAT2B, ADCY2, GLI3, ZNF716, SLIT1, PDE3A, KERA-LUM, RNF219-AS1, CLEC3A, FBXO15, and IGSF5.
Orphan nuclear receptor estrogen-related receptor γ (ERRγ) is key regulator of hepatic gluconeogenesis.
Choi et al., Kwangju, South Korea. In J Biol Chem, 2012
Orphan nuclear receptor estrogen-related receptor gamma (ERRgamma) is key regulator of hepatic gluconeogenesis
Disorder-to-order transition underlies the structural basis for the assembly of a transcriptionally active PGC-1α/ERRγ complex.
Spiegelman et al., Boston, United States. In Proc Natl Acad Sci U S A, 2011
Disorder-to-order transition underlies the structural basis for the assembly of a transcriptionally active PGC-1alpha/ERRgamma complex
Estrogen-related receptor γ (ERRγ) is a novel transcriptional regulator of phosphatidic acid phosphatase, LIPIN1, and inhibits hepatic insulin signaling.
Choi et al., Kwangju, South Korea. In J Biol Chem, 2011
Estrogen-related receptor gamma (ERRgamma) is a novel transcriptional regulator of phosphatidic acid phosphatase, LIPIN1, and inhibits hepatic insulin signaling
Estrogen-related receptor gamma (ERRgamma) mediates oxygen-dependent induction of aromatase (CYP19) gene expression during human trophoblast differentiation.
Mendelson et al., Dallas, United States. In Mol Endocrinol, 2011
These novel findings identify ERRgamma as an O(2)-dependent transcription factor and HIF-1alpha target gene that serves a critical role in the induction of hCYP19 expression during human trophoblast differentiation.
Nuclear receptor SHP inhibition of Dnmt1 expression via ERRγ.
Wang et al., Salt Lake City, United States. In Febs Lett, 2011
Study provides evidence for nuclear receptor mediated regulation of Dnmt1 expression through ERRgamma and SHP crosstalk.
Orphan nuclear receptors in breast cancer pathogenesis and therapeutic response.
Clarke et al., Washington, D.C., United States. In Endocr Relat Cancer, 2010
Here, we review the emerging role(s) of orphan nuclear receptors in breast cancer, with a particular focus on two of the estrogen-related receptors (ERRalpha and ERRgamma) and several others implicated in clinical outcome and response or resistance to cytotoxic or endocrine therapies, including the chicken ovalbumin upstream promoter transcription factors, nerve growth factor-induced B, DAX-1, liver receptor homolog-1, and retinoic acid-related orphan receptor alpha.
PPAR transcriptional activator complex polymorphisms and the promise of individualized therapy for heart failure.
Cresci et al., Saint Louis, United States. In Heart Fail Rev, 2010
This review focuses on the transcription factors that comprise the PPAR transcriptional activator complex--the PPARs (PPARalpha, PPARbeta, or PPARgamma), PPAR heterodimeric partners, such as RXRalpha, and PPAR co-activators, such as PPARgamma coactivator 1alpha (PGC-1alpha) and the estrogen-related receptors (ERRalpha, ERRbeta, and ERRgamma).
Transcriptional control of energy homeostasis by the estrogen-related receptors.
Giguère, Montréal, Canada. In Endocr Rev, 2008
Estrogen-related receptor (ERR) alpha, ERRbeta, and ERRgamma are nuclear receptors that have yet to be associated with a natural ligand and are thus considered as orphan receptors.
ERRgamma directs and maintains the transition to oxidative metabolism in the postnatal heart.
Evans et al., Los Angeles, United States. In Cell Metab, 2007
Disruption of the ERRgamma gene (Esrrg), which is expressed at high levels in the fetal and postnatal mouse heart, blocks this switch, resulting in lactatemia, electrocardiographic abnormalities, and death during the first week of life.
Estrogen-related receptors as emerging targets in cancer and metabolic disorders.
Jordan et al., Philadelphia, United States. In Curr Top Med Chem, 2005
The ERRs, comprising ERRalpha, ERRbeta and ERRgamma, bind and regulate transcription via estrogen response elements (EREs) and extended ERE half-sites termed ERR response elements (ERREs), but do not bind endogenous estrogens.
The orphan nuclear receptor SHP regulates PGC-1alpha expression and energy production in brown adipocytes.
Moore et al., Kansas City, United States. In Cell Metab, 2005
The orphan nuclear receptor ERRgamma is expressed in BAT and its transactivation of the PGC-1alpha promoter is potently inhibited by SHP.
Estrogen receptor-related receptors: orphan receptors desperately seeking a ligand.
Vanacker et al., Lyon, France. In J Mol Endocrinol, 2003
Moreover recent data analyzing ERR expression in human breast tumors have proposed ERRalpha and ERRgamma as prognostic markers of these cancers.
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