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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Estrogen-related receptor alpha

ERRalpha
The protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. A processed pseudogene of ESRRA is located on chromosome 13q12.1. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PGC-1alpha, PGC, Estrogen Receptor, ERRgamma, CAN
Papers on ERRalpha
[XCT790 inhibits rat vascular smooth muscle cells proliferation through down-regulating the expression of estrogen-related receptor alpha].
Shi et al., In Yao Xue Xue Bao, 2014
In this study, the effects of XCT790, a potent and selective inverse agonist of estrogen-related receptor alpha (ERRalpha), on rat VSMCs proliferation and related signal pathways were investigated.
PGC-1β regulates mouse carnitine-acylcarnitine translocase through estrogen-related receptor α.
GeneRIF
Relat et al., Barcelona, Spain. In Biochem Biophys Res Commun, 2012
the 50-flanking region of the Cact gene contains a consensus sequence for ERRalpha. This sequence binds ERRa both in vivo and in vitro and is required for the activation of Cact expression by the PGC-1/ERR axis
Estrogen-related receptor α regulates osteoblast differentiation via Wnt/β-catenin signaling.
GeneRIF
Martinez et al., Cambridge, United States. In J Mol Endocrinol, 2012
Data identify ERRalpha as a new regulator of the Wnt-signaling pathway during osteoblast differentiation, through a cell-intrinsic mechanism not affecting beta-catenin nuclear translocation.
Negative regulation of ERRα by a novel nucleolar protein.
GeneRIF
Kim et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2012
these data suggest that RaRF sequesters ERRalpha in the nucleolus through a specific interaction, thereby inhibiting its transcriptional activity.
Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation.
GeneRIF
Rathmell et al., Durham, United States. In Proc Natl Acad Sci U S A, 2011
ERRalpha is a selective transcriptional regulator of Teff metabolism that may provide a metabolic means to modulate immunity
[Role of estrogen-related receptor alpha in adipocyes lipolysis].
Yang et al., China. In Sheng Wu Gong Cheng Xue Bao, 2011
Estrogen-related receptor a (ERRalpha) is a key regulator for energy metabolism and adipogenesis.
Transcriptional control of the ERBB2 amplicon by ERRalpha and PGC-1beta promotes mammary gland tumorigenesis.
GeneRIF
Giguère et al., Montréal, Canada. In Cancer Res, 2011
ERRalpha and PGC-1beta are key players in the etiology of breast cancer by coordinating the transcriptional regulation of genes located in the 17q12 region, a process that also involves interference with the repressive function of ERalpha on ERBB2 expression.
Immune response and mitochondrial metabolism are commonly deregulated in DMD and aging skeletal muscle.
GeneRIF
Pereon et al., Nantes, France. In Plos One, 2010
Data observed in DMD and aging skeletal muscle enrichment in motifs for candidate transcription factors that may coordinate either the immune/fibrosis responses (ETS1, IRF1, NF1) or the mitochondrial metabolism (ESRRA).
Synthesis and characterization of liquid chromatographic columns containing the immobilized ligand binding domain of the estrogen related receptor alpha and estrogen related receptor gamma.
Wainer et al., Baltimore, United States. In J Pharm Biomed Anal, 2010
The ligand binding domains of the estrogen related receptors, ERRalpha and ERRgamma were covalently immobilized onto the surface of an aminopropyl silica liquid chromatography stationary phase to create the ERRalpha-silica and ERRgamma-silica columns and onto the surface of open tubular capillaries to create the ERRalpha-OT and ERRgamma-OT columns.
Orphan nuclear receptors in breast cancer pathogenesis and therapeutic response.
Review
Clarke et al., Washington, D.C., United States. In Endocr Relat Cancer, 2010
Here, we review the emerging role(s) of orphan nuclear receptors in breast cancer, with a particular focus on two of the estrogen-related receptors (ERRalpha and ERRgamma) and several others implicated in clinical outcome and response or resistance to cytotoxic or endocrine therapies, including the chicken ovalbumin upstream promoter transcription factors, nerve growth factor-induced B, DAX-1, liver receptor homolog-1, and retinoic acid-related orphan receptor alpha.
Impairment of PGC-1alpha expression, neuropathology and hepatic steatosis in a transgenic mouse model of Huntington's disease following chronic energy deprivation.
Beal et al., New York City, United States. In Hum Mol Genet, 2010
In the striatum of the HD mice, the baseline levels of PGC-1alpha, NRF1, NRF2, Tfam, COX-II, PPARdelta, CREB and ERRalpha mRNA and mitochondrial DNA (mtDNA), were significantly reduced.
The estrogen-related receptor alpha: the oldest, yet an energetic orphan with robust biological functions.
Review
GeneRIF
Ranhotra, Shillong, India. In J Recept Signal Transduct Res, 2010
This review focuses on the overall developments and recent advances in understanding the role of ERRalpha in metabolism and other biological functions, including its role in human diseases.
PGC1beta mediates PPARgamma activation of osteoclastogenesis and rosiglitazone-induced bone loss.
Impact
Wan et al., Dallas, United States. In Cell Metab, 2010
Using mouse models with genetically altered PPARgamma, PGC1beta, or ERRalpha, here we show that PGC1beta is required for the resorption-enhancing effects of rosiglitazone.
PPAR transcriptional activator complex polymorphisms and the promise of individualized therapy for heart failure.
Review
Cresci et al., Saint Louis, United States. In Heart Fail Rev, 2010
This review focuses on the transcription factors that comprise the PPAR transcriptional activator complex--the PPARs (PPARalpha, PPARbeta, or PPARgamma), PPAR heterodimeric partners, such as RXRalpha, and PPAR co-activators, such as PPARgamma coactivator 1alpha (PGC-1alpha) and the estrogen-related receptors (ERRalpha, ERRbeta, and ERRgamma).
Sirtuin 3, a new target of PGC-1alpha, plays an important role in the suppression of ROS and mitochondrial biogenesis.
Chang et al., Beijing, China. In Plos One, 2009
Chromatin immunoprecipitation and electrophoretic mobility shift assays confirmed that ERRalpha bound to the identified ERRE and PGC-1alpha co-localized with ERRalpha in the mSirt3 promoter.
ERRalpha: a metabolic function for the oldest orphan.
Review
GeneRIF
Kralli et al., Barcelona, Spain. In Trends Endocrinol Metab, 2008
The importance of ERRalpha for adaptive energy metabolism suggest that strategies targeting ERRalpha may be useful in fighting metabolic diseases.
Transcriptional control of energy homeostasis by the estrogen-related receptors.
Review
Impact
Giguère, Montréal, Canada. In Endocr Rev, 2008
In particular, functional genomics and biochemical studies have shown that ERRalpha and ERRgamma operate as the primary conduits for the activity of members of the family of PGC-1 coactivators.
Transcriptional paradigms in mammalian mitochondrial biogenesis and function.
Review
Impact
Scarpulla, Chicago, United States. In Physiol Rev, 2008
Nucleomitochondrial interactions depend on the interplay between transcription factors (NRF-1, NRF-2, PPARalpha, ERRalpha, Sp1, and others) and members of the PGC-1 family of regulated coactivators (PGC-1alpha, PGC-1beta, and PRC).
Large-scale chemical dissection of mitochondrial function.
Impact
Mootha et al., Cambridge, United States. In Nat Biotechnol, 2008
Mining the resulting compendium revealed, first, that protein synthesis inhibitors can decouple coordination of nuclear and mtDNA transcription; second, that a subset of HMG-CoA reductase inhibitors, combined with propranolol, can cause mitochondrial toxicity, yielding potential clues about the etiology of statin myopathy; and, third, that structurally diverse microtubule inhibitors stimulate OXPHOS transcription while suppressing reactive oxygen species, via a transcriptional mechanism involving PGC-1alpha and ERRalpha, and thus may be useful in treating age-associated degenerative disorders.
The nuclear receptor ERRalpha is required for the bioenergetic and functional adaptation to cardiac pressure overload.
Impact
Kelly et al., Saint Louis, United States. In Cell Metab, 2007
We hypothesized that the estrogen-related receptor alpha (ERRalpha), which recruits PGC-1alpha to metabolic target genes in heart, exerts protective effects in the context of stressors known to cause heart failure.
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