gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Mitogen-activated protein kinase 15

ERK7, ERK8, Extracellular signal-regulated kinase 7, Extracellular signal-regulated kinase 8
activity; localization, and function is regulated by the C-terminal tail [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: MAPK, ERK, CAN, ERK1, AP-1
Papers on ERK7
ERK8 is a novel HuR kinase that regulates tumour suppressor PDCD4 through a miR-21 dependent mechanism.
Holcik et al., Ottawa, Canada. In Oncotarget, Dec 2015
Importantly, we identify HuR as a novel substrate of the ERK8 kinase pathway in response to H2O2 treatment.
MAPK15 mediates BCR-ABL1-induced autophagy and regulates oncogene-dependent cell proliferation and tumor formation.
Chiariello et al., Siena, Italy. In Autophagy, Nov 2015
Here, we investigated a possible role for the MAPK15/ERK8 kinase in BCR-ABL1-dependent autophagy, a key process for oncogene-induced leukemogenesis.
Luciferin and derivatives as a DYRK selective scaffold for the design of protein kinase inhibitors.
Svendsen et al., Tromsø, Norway. In Eur J Med Chem, May 2015
Inhibition profiling of D-luciferin over a 103-protein kinase panel showed significant inhibition of a small set of protein kinases, in particular the DYRK-family, but also other members of the CMGC-group, including ERK8 and CK2.
ERK7 regulates ciliogenesis by phosphorylating the actin regulator CapZIP in cooperation with Dishevelled.
Nishida et al., Kyoto, Japan. In Nat Commun, 2014
Here, we identify ERK7, an atypical mitogen-activated protein kinase, as a key regulator of ciliogenesis.
p53- and ERK7-dependent ribosome surveillance response regulates Drosophila insulin-like peptide secretion.
Hietakangas et al., Helsinki, Finland. In Plos Genet, 2014
A downstream effector of this growth inhibitory response is an atypical MAP kinase ERK7 (ERK8/MAPK15), which is upregulated in the IPCs following impaired ribosome biogenesis as well as starvation.
In silico identification and characterization of the MAPK family members of unicellular model eukaryote Tetrahymena thermophila.
Arslanyolu et al., İstanbul, Turkey. In Eur J Protistol, 2014
Phylogenetic analysis assigned the TtMPKs into two major groups, ERK1/2-like (TtMPK1, 2, 3, 5, 6, 7, 8, and 9) as stress-responsive MAPKs for biotic and abiotic stresses, and ERK7/8-like (TtMPK4, 10, and 11) as cell-cycle-associated protein kinases for biotic factors.
Response of Adipose Tissue-Derived Stromal Cells in Tissue-Related O2 Microenvironment to Short-Term Hypoxic Stress.
Buravkova et al., Moscow, Russia. In Cells Tissues Organs, 2013
Up-regulation of ERK7, MEK1 and c-fos, and down-regulation of MKK6, p53, CCNA2, CCNB1 and CCNB2 were observed after 24 h of oxygen deprivation.
ERK8 is a negative regulator of O-GalNAc glycosylation and cell migration.
Bard et al., Singapore, Singapore. In Elife, 2013
ERK8, an atypical MAPK with high basal kinase activity, is a strong hit and is partially localised at the Golgi.
The distribution and possible role of ERK8 in mouse oocyte meiotic maturation and early embryo cleavage.
Sun et al., Guangzhou, China. In Microsc Microanal, 2013
It is well known that extracellular signal-regulated kinase 8 (ERK8) plays pivotal roles in various mitotic events.
Structure prediction and validation of the ERK8 kinase domain.
Chiariello et al., Siena, Italy. In Plos One, 2012
Extracellular signal-regulated kinase 8 (ERK8) has been already implicated in cell transformation and in the protection of genomic integrity and, therefore, proposed as a novel potential therapeutic target for cancer.
Extracellular signal-regulated kinase 8 (ERK8) controls estrogen-related receptor α (ERRα) cellular localization and inhibits its transcriptional activity.
Chiariello et al., Siena, Italy. In J Biol Chem, 2011
a novel function for ERK8 as a bona fide ERRalpha corepressor, involved in control of its cellular localization by nuclear exclusion, and suggest a key role for this MAP kinase in the regulation of the biological activities of this nuclear receptor.
Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases.
Roux et al., Montréal, Canada. In Microbiol Mol Biol Rev, 2011
There are additional, atypical MAPK enzymes, including ERK3/4, ERK7/8, and Nemo-like kinase (NLK), which have distinct regulation and functions.
ATP site-directed inhibitors of protein kinase CK2: an update.
Pinna et al., Padova, Italy. In Curr Top Med Chem, 2010
The observation that CK2 inhibitors with medium/high promiscuity scores share the ability to inhibit a group of protein kinases as effectively as CK2 discloses the possibility of using their scaffolds for the rational development of selective inhibitors of these kinases, with special reference to PIMs, DYRKs, HIPK2, PKD and ERK8.
A chromatin-bound kinase, ERK8, protects genomic integrity by inhibiting HDM2-mediated degradation of the DNA clamp PCNA.
Lannigan et al., Charlottesville, United States. In J Cell Biol, 2010
Data show that ERK8 prevents HDM2-mediated PCNA destruction by inhibiting the association of PCNA with HDM2, and implicate ERK8 in the regulation of genomic stability.
Extracellular signal-regulated kinase 8-mediated c-Jun phosphorylation increases tumorigenesis of human colon cancer.
Dong et al., Austin, United States. In Cancer Res, 2010
Extracellular signal-regulated kinase 8-mediated c-Jun phosphorylation increases tumorigenesis of human colon cancer
The signaling pathway leading to extracellular signal-regulated kinase 5 (ERK5) activation via G-proteins and ERK5-dependent neurotrophic effects.
Nakahata et al., Sendai, Japan. In Mol Pharmacol, 2010
The MAPK family includes ERK1/2, c-Jun NH(2)-terminal kinases 1, 2, and 3, p38MAPK alpha, beta, gamma, and -delta, and ERK5 as conventional MAPKs and ERK3, ERK4 NLK, and ERK7 as atypical MAPKs.
Regulation of the activity and expression of ERK8 by DNA damage.
Cohen et al., Dundee, United Kingdom. In Febs Lett, 2009
Regulation of the activity and expression of DERK8 by DNA damage are reported.
Atypical mitogen-activated protein kinases: structure, regulation and functions.
Meloche et al., Montréal, Canada. In Biochim Biophys Acta, 2007
Atypical MAP kinases include ERK3/ERK4, NLK and ERK7.
Differential regulation and properties of MAPKs.
Cobb et al., Dallas, United States. In Oncogene, 2007
ERK3, ERK5 and ERK7 are other MAPKs that have distinct regulation and functions.
ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5.
Abe et al., Chicago, United States. In J Biol Chem, 2006
human ERK8 has a role as a negative regulator of human GRalpha, acting through Hic-5
share on facebooktweetadd +1mail to friends