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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

MPK6 mitogen-activated protein kinase 6

ERK3, Mitogen-Activated Protein Kinase 6, MPK6, MAPK6, Extracellular signal-regulated kinase 3, AtMPK6
Encodes a MAP kinase induced by pathogens, ethylene biosynthesis, oxidative stress and osmotic stress.Also involved in ovule development. Homozygous mutants in a MPK3 heterozygous background are female sterile due to defects in integument development.MPK6 appears to be associated with the microsomal compartment and may be involved in mediating secretory processes. (from NCBI)
Top mentioned proteins: MAPK, ACID, CAN, V1a, ERK1
Papers on ERK3
The innate immune signaling system as a regulator of disease resistance and ISR activity against Verticillium dahliae.
New
Tjamos et al., Athens, Greece. In Mol Plant Microbe Interact, Feb 2016
Tests with Arabidopsis mutants impaired in several regulators of the early steps of the innate immune responses, including fls2, efr-1, bak1-4, mpk3, mpk6, wrky22 and wrky29 showed that FLS2 and WRKY22 have a central role in the K165-triggered ISR, while EFR1, MPK3 and MPK6 are possible susceptibility factors for V. dahliae and bak1 shows a tolerance phenomenon.
Attenuation of pattern recognition receptor signaling is mediated by a MAP kinase kinase kinase.
New
Menke et al., Utrecht, Netherlands. In Embo Rep, Feb 2016
MKKK7 attenuates MPK6 activity and defense gene expression.
ERK3 regulates TDP2-mediated DNA damage response and chemoresistance in lung cancer cells.
New
Long et al., Xi'an, China. In Oncotarget, Jan 2016
In the current study, we have found that ERK3, an atypical MAPK, phosphorylates TDP2 at S60 and regulates TDP2's phosphodiesterase activity, thereby cooperatively protecting lung cancer cells against Top2 inhibitors-induced DNA damage and growth inhibition.
Protein-protein interactions in plant mitogen-activated protein kinase cascades.
Review
New
Harmon et al., Gainesville, United States. In J Exp Bot, Jan 2016
This review surveys various technologies used for characterizing MAPK-substrate interactions and presents case studies of MPK4 and MPK6, highlighting the multiple functions of MAPKs.
Comparative phospho-proteomics analysis of salt-responsive phosphoproteins regulated by the MKK9-MPK6 cascade in Arabidopsis.
New
Ren et al., Beijing, China. In Plant Sci, Dec 2015
Our studies showed that mkk9 and mpk6 null mutant seedlings are hyposensitive to salt stress.
New insights into the activation, interaction partners and possible functions of MK5/PRAK.
New
Seternes et al., Tromsø, Norway. In Front Biosci, Dec 2015
However, since the discovery that MK5 is a bona fide interaction partner of the atypical MAP kinases ERK3 and ERK4 and that this interaction leads to both the activation and subcellular relocalisation of MK5, there has been considerable debate as to the relative roles of these MAPK pathways in mediating the activation and biological functions of MK5.
Cellular reprogramming through mitogen-activated protein kinases.
Review
Scheel et al., Halle, Germany. In Front Plant Sci, 2014
In our work, we mimicked in vivo activation of two stress-activated MAPKs, MPK3 and MPK6, through transgenic manipulation of Arabidopsis thaliana and used phosphoproteomics analysis to identify potential novel MAPK substrates.
Analysis of ERK3 intracellular localization: dynamic distribution during mitosis and apoptosis.
Bottone et al., Pavia, Italy. In Eur J Histochem, 2014
Extracellular signal-regulated kinases (ERK) 1, 2 and 3 are involved in cell proliferation and differentiation, and apoptosis; although ERK1/2 have been widely studied, limited knowledge on ERK3 is available.
Mitogen-activated protein kinase signal transduction in solid tumors.
Review
Wang et al., Nanchang, China. In Asian Pac J Cancer Prev, 2013
There are 5 main subgroups manipulating by a set of sequential actions: ERK(ERK1/ ERK2), c-Jun N(JNK/SAPK), p38 MAPK(p38α, p38β, p38γ and p38δ), and ERK3/ ERK4/ ERK5.
Determination of primary sequence specificity of Arabidopsis MAPKs MPK3 and MPK6 leads to identification of new substrates.
GeneRIF
Andreasson et al., Lund, Sweden. In Biochem J, 2012
Data suggest that amino acids surrounding the phosphorylated serine residue of peptide substrates contribute to MPK6/MPK3 substrate specificity; MPK6/MPK3 activities appear to be important in growth of plant stomata.
MAP Kinase 6-mediated activation of vacuolar processing enzyme modulates heat shock-induced programmed cell death in Arabidopsis.
GeneRIF
Xing et al., Guangzhou, China. In New Phytol, 2012
MAP Kinase 6-mediated activation of vacuolar processing enzyme modulates heat shock-induced programmed cell death in Arabidopsis
Dual-level regulation of ACC synthase activity by MPK3/MPK6 cascade and its downstream WRKY transcription factor during ethylene induction in Arabidopsis.
GeneRIF
Zhang et al., Hohhot, China. In Plos Genet, 2012
direct binding of WRKY33 to the W-boxes in the promoters of ACS2 and ACS6 genes in vivo, suggesting that WRKY33 is directly involved in the activation of ACS2 and ACS6 expression downstream of MPK3/MPK6 cascade in response to pathogen invasion
Phosphorylation by AtMPK6 is required for the biological function of AtMYB41 in Arabidopsis.
GeneRIF
Chung et al., Chinju, South Korea. In Biochem Biophys Res Commun, 2012
These results indicate that the phosphorylation of MYB41 by MPK6 is required for the biological function of MYB41 in salt tolerance.
ERK3 signals through SRC-3 coactivator to promote human lung cancer cell invasion.
GeneRIF
O'Malley et al., Houston, United States. In J Clin Invest, 2012
A previously unknown role for ERK3 in promoting lung cancer cell invasiveness by phosphorylating SRC-3 and regulating SRC-3 proinvasive activity by site-specific phosphorylation.
The multifaceted function of BAK1/SERK3: plant immunity to pathogens and responses to insect herbivores.
Review
Wu et al., Jena, Germany. In Plant Signal Behav, 2011
BAK1 rapidly binds to certain receptors for pathogen/microbeassociated molecular patterns (PAMPs/MAMPs) after the perception of pathogen elicitors and is required for the full elicitation of pathogen-induced defense responses, such as the activation of the mitogen-activated protein kinase 6 (MPK6) and production of reactive oxygen species.
Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases.
Review
Roux et al., Montréal, Canada. In Microbiol Mol Biol Rev, 2011
There are additional, atypical MAPK enzymes, including ERK3/4, ERK7/8, and Nemo-like kinase (NLK), which have distinct regulation and functions.
Dual control of nuclear EIN3 by bifurcate MAPK cascades in C2H4 signalling.
Impact
Sheen et al., Boston, United States. In Nature, 2008
By combining systematic cellular and genetic screens, here we uncover a previously unexpected MKK9-MPK3/MPK6 cascade promoting ethylene-insensitive 3 (EIN3)-mediated transcription in ethylene signalling.
OXI1 kinase is necessary for oxidative burst-mediated signalling in Arabidopsis.
Impact
Knight et al., Oxford, United Kingdom. In Nature, 2004
OXI1 is required for full activation of the mitogen-activated protein kinases (MAPKs) MPK3 and MPK6 after treatment with AOS or elicitor and is necessary for at least two very different AOS-mediated processes: basal resistance to Peronospora parasitica infection, and root hair growth.
MAP kinase signalling cascade in Arabidopsis innate immunity.
Impact
Sheen et al., Boston, United States. In Nature, 2002
Here we identify a complete plant MAP kinase cascade (MEKK1, MKK4/MKK5 and MPK3/MPK6) and WRKY22/WRKY29 transcription factors that function downstream of the flagellin receptor FLS2, a leucine-rich-repeat (LRR) receptor kinase.
ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF.
Impact
Yancopoulos et al., Dallas, United States. In Cell, 1991
We now describe cloning and characterization of two ERK1-related kinases, ERK2 and ERK3, and provide evidence suggesting that there are additional ERK family members.
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