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Mitogen-activated protein kinase 3

ERK1, extracellular signal-regulated kinase, p44, p42, Mitogen-Activated Protein Kinase 3, extracellular signal-regulated kinase 1
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ERK, V1a, p38, MAPK, Akt
Papers using ERK1 antibodies
A dual epigenomic approach for the search of obesity biomarkers: DNA methylation in relation to diet-induced weight loss
Dhar M. S. et al., In Journal of Nutrition and Metabolism, 2010
... Primary antibodies (p38, phospho-p38, JNK, phospho-JNK, p44/42, and phospho-p44/42) as well as the secondary antibody, horseradish peroxidase- (HRP-) conjugated anti-rabbit IgG, were obtained from Cell Signaling Technology (Danvers, MA) ...
zVAD-induced autophagic cell death requires c-Src-dependent ERK and JNK activation and reactive oxygen species generation.
Gires Olivier, In PLoS ONE, 2010
... chain 3 (LC3), Atg5, Atg7, Beclin-1, caspase 3, caspase 9, PARP, GAPDH, non-phospho- or phospho-MEK1/2 and ERK1/2 were from Cell Signaling Technology, Inc. ...
Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease
Yang James Y. et al., In Experimental Diabetes Research, 2009
... Antibodies were obtained from the following vendors, respectively: ERK1/2 and phospho-ERK1/2 (#9100), Cell Signaling (Beverly, Mass); PPAR ...
Characterization of Human Huntington's Disease Cell Model from Induced Pluripotent Stem Cells
Ellerby Lisa M. et al., In PLoS Currents, 2009
... were run on 4-12% bis-tris gel (Invitrogen), transferred to nitrocellulose membrane (Whatman), probed with anti-phospho-p44/42 (ERK1/2) (Thr202/Tyr204) antibody (Cell Signaling) and reprobed with anti-p44/42 ...
Partial loss of ataxin-1 function contributes to transcriptional dysregulation in spinocerebellar ataxia type 1 pathogenesis
MacKintosh Carol et al., In Biochemical Journal, 2009
... on ERK1/2 (#9101) and anti-ERK1/2 (#9102) were from Cell Signaling Technology ...
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Papers on ERK1
Nobiletin, a Polymethoxylated Flavone, Inhibits Glioma Cell Growth and Migration via Arresting Cell Cycle and Suppressing MAPK and Akt Pathways.
Lu et al., Taipei, Taiwan. In Phytother Res, 12 Dec 2015
Data from western blotting showed that nobiletin significantly attenuated the expression of cyclin D1, cyclin-dependent kinase 2, cyclin-dependent kinase 4, and E2 promoter-binding factor 1 (E2F1) and the phosphorylation of Akt/protein kinase B and mitogen-activated protein kinases, including p38, extracellular signal-regulated kinase, and c-Jun N-terminal kinase.
Survival analysis and microarray profiling identify Cd40 as a candidate for the Salmonella susceptibility locus, Ity5.
Malo et al., Montréal, Canada. In Genes Immun, 12 Dec 2015
In fact, CD40 signaling is altered in A/J mice as seen by impaired IgM upregulation during infection, decreased Ig class switching, neutropenia, reduced granulocyte recruitment in response to infection and inflammation, and decreased ERK1/2 activity.
Mechanism of metformin action in MCF-7 and MDA-MB-231 human breast cancer cells involves oxidative stress generation, DNA damage, and transforming growth factor β1 induction.
Cecchini et al., Londrina, Brazil. In Tumour Biol, 11 Dec 2015
The drug decreased cytoplasmic extracellular signal-regulated kinases 1 and 2 (ERK1/2) and AKT and increased nuclear p53 and cytoplasmic transforming growth factor β1 (TGF-β1) in both cell lines.
Restraint of Trophoblast Invasion of the Uterus by Decorin: Role in Pre-eclampsia.
Lala et al., London, Canada. In Am J Reprod Immunol, 11 Dec 2015
DCN blocked VEGFR-2 dependent EVT cell migration and endovascular differentiation by inhibiting P38MAPK and ERK1/2 pathways.We identified the avid VEGFR2 binding site in DCN protein as a 12 amino acids (LGTNPLKSSGIE) span in the Leucine-rich-repeat (LRR) 5 region of domain III.
Dual inhibition of histone deacetylases and phosphoinositide 3-kinases: effects on Burkitt lymphoma cell growth and migration.
Klumb et al., Rio de Janeiro, Brazil. In J Leukoc Biol, 11 Dec 2015
Moreover, histone deacetylase inhibitor/PI3K inhibitor cotreatment suppressed Burkitt lymphoma cell migration and decreased cell polarization, Akt and ERK1/2 phosphorylation, and leads to RhoB induction.
Phosphorylation of αB-crystallin: Role in stress, aging and patho- physiological conditions.
Rao et al., Hyderābād, India. In Biochim Biophys Acta, 25 Oct 2015
Phosphorylation of S45 is mediated by p44/42 MAP kinase, whereas S59 phosphorylation is mediated by MAPKAP kinase-2.
MEK1 and MEK2 inhibitors and cancer therapy: the long and winding road.
Cook et al., Cambridge, United Kingdom. In Nat Rev Cancer, 24 Oct 2015
The role of the ERK signalling pathway in cancer is thought to be most prominent in tumours in which mutations in the receptor tyrosine kinases RAS, BRAF, CRAF, MEK1 or MEK2 drive growth factor-independent ERK1 and ERK2 activation and thence inappropriate cell proliferation and survival.
Extreme Outlier Analysis Identifies Occult Mitogen-Activated Protein Kinase Pathway Mutations in Patients With Low-Grade Serous Ovarian Cancer.
Iyer et al., Houston, United States. In J Clin Oncol, Oct 2015
Functional characterization demonstrated that this mutant induced extracellular signal-regulated kinase pathway activation, promoted anchorage-independent growth and tumor formation in mice, and retained sensitivity to selumetinib.
Molecular Targeting of ERKs/RSK2 Signaling Axis in Cancer Prevention.
Cho et al., Puch'ŏn, South Korea. In J Cancer Prev, Sep 2015
RSK2 is a downstream signaling protein of ERK1 and ERK2 and plays a key role in physiological homeostasis.
An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ.
Spiegelman et al., Boston, United States. In Nature, Feb 2015
Unbiased proteomic studies show that extracellular signal-regulated kinase (ERK) kinases are activated in these knockout animals.
Systems biology. Accurate information transmission through dynamic biochemical signaling networks.
Wollman et al., San Diego, United States. In Science, Jan 2015
In the extracellular signal-regulated kinase (ERK), calcium (Ca(2+)), and nuclear factor kappa-B (NF-κB) pathways, response dynamics resulted in significantly greater information transmission capacities compared to nondynamic responses.
Dual Inhibition of MEK and PI3K Pathway in KRAS and BRAF Mutated Colorectal Cancers.
Shamseddine et al., Beirut, Lebanon. In Int J Mol Sci, Dec 2014
Amplification of the driving oncogene KRAS(13D), which increases signaling through the ERK1/2 pathway, upregulation of the noncanonical wingless/calcium signaling pathway (Wnt), and coexisting PIK3CA mutations have all been implicated with resistance against MEK inhibitor therapy in KRAS mutated CRC.
BRAF Mutation in Colorectal Cancer: An Update.
Barras, Lausanne, Switzerland. In Biomark Cancer, Dec 2014
Melanoma patients benefit from the combination of BRAF inhibitors with mitogen/extracellular signal-regulated kinase (MEK) inhibitors, among others.
Interleukin (IL)-1β Is a Strong Inducer of IL-36γ Expression in Human Colonic Myofibroblasts.
Andoh et al., Ōtsu, Japan. In Plos One, Dec 2014
The inhibitors for ERK1/2 (PD98059 and U0216) and a p38 MAPK (SB203580) significantly reduced the IL-1β-induced IL-36γ mRNA expression.
A new tumor suppressor role for the Notch pathway in bladder cancer.
Klinakis et al., Athens, Greece. In Nat Med, Oct 2014
We show that Notch activation in bladder cancer cells suppresses proliferation both in vitro and in vivo by directly upregulating dual-specificity phosphatases (DUSPs), thus reducing the phosphorylation of ERK1 and ERK2 (ERK1/2).
The role of Ras-ERK-IL-1β signaling pathway in upregulation of elastin expression by human coronary artery smooth muscle cells cultured in 3D scaffolds.
Mequanint et al., London, Canada. In Biomaterials, 2012
endogenous IL-1beta play a role in elastin gene upregulation and this upregulation is mediated by the Ras-ERK1/2 pathway in 3D cultures
Extracellular signal-regulated kinase 1/2 signaling promotes oligodendrocyte myelination in vitro.
Murray et al., Melbourne, Australia. In J Neurochem, 2012
Erk1/2 signaling within oligodendrocytes exerts an important and direct effect to promote myelination.
ERK1/2 activation is a therapeutic target in age-related macular degeneration.
Ambati et al., Lexington, United States. In Proc Natl Acad Sci U S A, 2012
ERK1/2 have roles in the pathogenesis of GA, a late stage of age-related macular degeneration
Dermokine-β impairs ERK signaling through direct binding to GRP78.
Saito et al., Ōsaka, Japan. In Febs Lett, 2012
Dermokine-beta impairs ERK signaling through direct binding to GRP78
ERK1/ERK2 MAPK signaling is required to increase myelin thickness independent of oligodendrocyte differentiation and initiation of myelination.
Bansal et al., Farmington, United States. In J Neurosci, 2012
These studies suggest that the predominant role of ERK1/ERK2 signaling in vivo is in promoting rapid myelin growth to increase its thickness, subsequent to oligodendrocyte differentiation and the initiation of myelination.
More papers using ERK1 antibodies
Sirolimus plus sorafenib in treating HCC recurrence after liver transplantation: a case report.
Guan Xin-yuan, In PLoS ONE, 2009
... Primary antibodies, AKT and phosphorylated AKT (p-AKT; S473); ERK1/2 and phosphorylated ERK1/2 (p-ERK1/2; T202/Y204); PDGFRβ and phosphorylated PDGFRβ (p-PDGFRβ; Y1021) were purchased from Cell Signaling Technology ...
Ras-related small GTPases RalA and RalB regulate cellular survival after ionizing radiation
Rodemann H Peter et al., In Breast Cancer Research : BCR, 2009
... Antibodies against phospho-YB-1 (S102) and YB-1, phospho-Akt (S473), phospho-ERK1/2 (T202/Y204) and ERK1/2 were purchased from Cell Signaling Technology (Frankfurt, Germany) ...
Oxidative stress induces lipid-raft-mediated activation of Src homology 2 domain-containing protein-tyrosine phosphatase 2 in astrocytes
Maudsley Stuart et al., In Journal of Signal Transduction, 2008
... Anti-active, (phosphor-)ERK1/2 antisera were obtained from Cell Signaling Technology (Danvers, MA) ...
Elevated CC chemokine level in bronchoalveolar lavage fluid is predictive of a poor outcome of idiopathic pulmonary fibrosis.
Sozzani Silvano, In PLoS ONE, 2008
... Antibodies: Phospho-p44/42 (Cell Signaling Technology (clone E10) cat ...
A hierarchy of neurobehavioral tasks discriminates between mild and moderate brain injury in rats.
Combs Colin, In PLoS ONE, 2008
... ), total ERK1/2 and double-cortin antibodies were purchased from Cell Signaling Technology (Danvers, MA) ...
Nuclear export of NF90 to stabilize IL-2 mRNA is mediated by AKT-dependent phosphorylation at Ser647 in response to CD28 costimulation
Hong Wanjin, In PLoS ONE, 2007
... Polyclonal antibodies raised against Akt, p38, ERK1/2 and their anti-phosphorylated counterparts were purchased from Cell Signaling (Beverly, MA, USA) ...
Age-related changes in the osteogenic differentiation potential of mouse bone marrow stromal cells.
Shi Songtao, In PLoS ONE, 2007
... from MBL International; Smurf1 (#AP2104a) and Smurf2 (#AP2105a) antibodies from Abgent Inc.; ERK1/2 (#9102) and phospho-ERK1/2 (#9106) antibodies from Cell Signaling Technology, Inc ...
Structure of a Shigella effector reveals a new class of ubiquitin ligases.
Häcker Georg, In PLoS ONE, 2007
... the dilution 1∶2000, anti-RSK1 was from Santa Cruz Bitotechnology and used in the dilution 1∶1000, anti-ERK1/2 was from Cell Signaling and used in the ...
Mechanisms of combined action of different chemopreventive dietary compounds: a review.
Kashanchi Fatah, In PLoS ONE, 2007
... for p38, p53, c-Jun N-terminal kinase (JNK1/2) (Thr183/Tyr185), p44/42 MAPK (Thr202/Tyr204) i.e extracellular signal-regulated kinase (ERK1/2) were purchased from Cell Signaling Technology (Beverly, USA) ...
Lysine acetylation: codified crosstalk with other posttranslational modifications
Sorkin Alexander et al., In The Journal of Cell Biology, 2007
... (pY1068), phospho-AKT (Ser473), phospho-ERK1/2 (Thr202/Tyr204), and polyclonal antibodies to phospho-EGFR (pY1045), total AKT, and total ERK1/2 were obtained from Cell Signaling Technology ...
Leukotriene E4 activates peroxisome proliferator-activated receptor gamma and induces prostaglandin D2 generation by human mast cells.
Linden Rafael, In PLoS ONE, 2007
... The phospho-Erk1/2 antibody was from New England BioLabs Inc, (Beverly, MA) ...
Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate.
Laudet Vincent, In PLoS ONE, 2007
... rabbit monoclonal antibodies raised against β-actin, c-fos and total or phosphorylated forms of IκBα and ERK1/2 and HRP-conjugated anti-rabbit polyclonal antibody were from Cell Signaling Technology (MA, USA) ...
Nuclear actin dynamics–from form to function.
Tyagi Anil Kumar, In PLoS ONE, 2007
... Phospho-specific and nonphospho-specific antibodies against ERK1/2, nonmuscle myosin II, and fluorescein isothiocyanate (FITC)-conjugated goat anti-mouse secondary and anti-FITC–HRP antibodies were obtained from Abcam.
The initial steps of ovarian cancer cell metastasis are mediated by MMP-2 cleavage of vitronectin and fibronectin
Jiang Bing-Hua et al., In International Journal of Molecular Sciences, 2007
... The antibodies against phospho-AKT (Ser473), total AKT, p70S6K1, β-actin and phospho-p44/42MAPK (Thr202/Tyr204) were purchased from Cell Signaling Technology (Beverly, MA, USA) ...
FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription.
Vanacker Jean-Marc, In PLoS ONE, 2007
... Abcam Inc., Cambridge, UK), Rp antibody against CXCR7 (ab12870; Abcam Inc.) and Rp antibody against ERK1 (sc-94; Santa Cruz Biotechnology).
DNMT1 as a molecular target in a multimodality-resistant phenotype in tumor cells
Berghe Wim Vanden et al., In Molecular Cancer, 2007
... (C19), anti-Fra1(H50), anti-Nrf2 (C10), anti-Bax antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA), anti-p38, anti-p44/42, anti-cfos, anti-cjun, anti-junB, anti-junD from Active Motif, anti-Sirt1 from Biomol, anti-Stat3 ...
Multiple variants of the RON receptor tyrosine kinase: biochemical properties, tumorigenic activities, and potential drug targets
Wang Ming-Hai et al., In Molecular Cancer, 2006
... Mouse mAb specific to phospho-tyrosine (PY-100), phospho-Erk1/2, and other signaling proteins were from Cell Signaling (Danvers, MA) ...
uPAR-induced cell adhesion and migration: vitronectin provides the key
Sidenius Nicolai et al., In The Journal of Cell Biology, 2006
... Antibodies against total and phosphorylated ERK1/2 were from Cell Signaling Technology ...
Rac1 signaling stimulates N-cadherin expression, mesenchymal condensation, and chondrogenesis.
Hotchin Neil, In PLoS ONE, 2006
... hybridoma HB-10494 (ATCC, American Type Culture Collection, Rockville Pike, MD); anti-phospho-p38, anti-p38 polyclonal Abs and anti-phospho-ERK1/2 mAb were from Cell Signaling Technology (Danvers, MA); anti-STAT ...
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases
Kühn Ralf et al., In Molecular Biotechnology, 2006
... in phosphate-buffered saline with 0.1% Tween 20 (PBS-T) for 24 h at 4°C, incubated with rabbit anti-ERK1/2 (1:1000, Cell Signaling Technology) 1 h at RT, ...
The integration of signaling by multiprotein complexes containing Raf kinases.
Schneider David S., In PLoS Pathogens, 2006
... Louis, Missouri) and polyclonal anti-ERK1/2 antibodies were purchased from Cell Signaling Technology (Charlottesville, Virginia) ...
Knocking out peroxisome proliferator-activated receptor (PPAR) alpha inhibits radiation-induced apoptosis in the mouse kidney through activation of NF-kappaB and increased expression of IAPs.
Ulasov Ilya, In PLoS ONE, 2006
... Antibodies for c-Jun (sc-45), phosphorylated c-Jun (Ser73, sc-7981), ERK1 (sc-94), phosphorylated ERK1/2 (Thr202/Thr204, sc-81492), phosphorylated MEK (sc-7995R), COX-2 (sc-1745) and HA (sc-7392) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia
Chen Jie et al., In Journal of Translational Medicine, 2006
... polyclonal anti-phosphorylated Ezrin (Tyr353), mouse monoclonal anti-AKT, anti-phospho-AKT (Ser473), anti-p44/42 MAPK (Erk1/2) and anti-phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) antibodies were purchased from Cell Signaling Technology (Beverly, MA, USA) ...
MST1 promotes apoptosis through regulating Sirt1-dependent p53 deacetylation.
Schneider-Stock Regine, In PLoS ONE, 2006
... (Sigma), Myc (Santa Cruz), PP1A (Epitomics), GST (Santa Cruz), YAP2 (Santa Cruz), Phospho-Ser127-YAP2 (Cell Signaling), Erk1/2 (Cell Signaling), Actin (SIGMA), GAPDH (SIGMA) ...
TOR signaling in growth and metabolism
Patel Tarun B. et al., In Oncogene, 2005
... Anti-phospho Src (Ser-416 and Ser-527), anti-phospho-Akt (Ser-473), anti-phospho-S6 kinase (Thr 389), anti-phospho-RSK (Thr-573), and anti-phospho-Erk1/2 (Thr-202/Tyr-204) antibodies were purchased from Cell Signaling (Beverly, MA) ...
Method of preparation of Curcurbitacin IIa as anti-cancer drugs
Lu Q et al., In British Journal of Cancer, 2005
... PARP, cleaved PARP, Histone H3, STAT3, phospho-STAT3 (tyrosine 705), JAK2, phospho-JAK2 (tyrosine 1007/1008), ERK1/2, and phospho-ERK1/2, were from Cell Signaling (Danvers, MA, USA) ...
Epigenetic and proteolytic inactivation of 14-3-3sigma in breast and prostate cancers.
Koch Karl-Wilhelm, In PLoS ONE, 2005
... Rabbit monoclonal anti-ERK1/2 and anti-phospho ERK1/2 antibodies were from Cell Signaling Technology (Pickering, ON, Canada) ...
Capsaicin, a component of red peppers, inhibits growth of androgen-independent, p53 mutant prostate cancer cells
Lu Qun et al., In Molecular Cancer, 2005
... Mouse anti-actin, histone-H3, and rabbit anti-Erk1/2 and survivin were from Cell Signaling (Boston, MA) ...
Cell adhesion to fibronectin (CAM-DR) influences acquired mitoxantrone resistance in U937 cells
Marincola Francesco M et al., In Journal of Translational Medicine, 2005
... anti-human caspase-3(E-8), mouse anti-Topoisomerase-alpa (Ki-S1), mouse anti-human β-actin monoclonal antibody and phosphorylated proteins of ERK1/2(p- ERK1/2(E-4)); Cy3-conjugated goat anti-mouse IgG, goat anti-rabbit immunoglobulin G (IgG) and goat anti-mouse IgG antibodies coupled to horseradish peroxidase were all from Santa Cruz Biotechnology (Santa Cruz, USA) ...
ERK regulates Golgi and centrosome orientation towards the leading edge through GRASP65
Seemann Joachim et al., In The Journal of Cell Biology, 2005
... ), ERK1 (C-16; Santa Cruz Biotechnology, Inc.), phospho-ERK1/2 (Cell Signaling ...
Performance comparison of one-color and two-color platforms within the MicroArray Quality Control (MAQC) project.
Pintus Gianfranco, In PLoS ONE, 2005
... Rabbit monoclonal antibodies (mAb) against ERK1/2 (#4695) and phospho-ERK1/2 (#4376) were purchased from Cell Signaling Technology (CST), and mAb ...
Signal transduction by VEGF receptors in regulation angiogenesis and lymphangiogenesis
Nör Jacques E. et al., In Cell death and differentiation, 2005
... Scientific Inc., San Diego, CA); 0-30 μM PD98059 (MEK-1 inhibitor, upstream of ERK1/2, Cell Signaling Technology, Inc, Danvers, MA); ...
PINCH-1 expression during early avian embryogenesis: implications for neural crest and heart development.
Jagetia Ganesh Chandra, In PLoS ONE, 2005
... Tyr410, Src Tyr416, ERK1/2, ERK1/2 Thr202/Tyr204 (Cell Signaling, Frankfurt, Germany), Paxillin, Paxillin ...
Binding of Par-4 to the actin cytoskeleton is essential for Par-4/Dlk-mediated apoptosis.
Harwood Adrian John, In PLoS ONE, 2004
... The following primary antibodies were used: rabbit polyclonal anti-caveolin-1 (Cell Signaling, Danvers, MA), mouse monoclonal anti-ERK1/2 (Cell Signaling), mouse monoclonal anti-phospho-ERK1/2 (Cell ...
Bioavailability and antioxidant effect of epigallocatechin gallate administered in purified form versus as green tea extract in healthy individuals
Hung Chi-Feng et al., In Molecular Vision, 2004
... (Minneapolis, MN); anti-phospho-ERK1/2, and anti-COX-2 were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
The signal transduction networks required for phosphorylation of STAT1 at Ser727 in mouse epidermal JB6 cells in the UVB response and inhibitory mechanisms of tea polyphenols
Verma Ajit K. et al., In Oncogene, 2004
... ERK1/2 siRNA, non-targeting siRNA and transfection reagent were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Phosphorylation of Ser-446 determines stability of MKP-7.
Blagosklonny Mikhail V., In PLoS ONE, 2004
... Antibodies against phospho-p38 MAPK (Thr180/Tyr182), phospho-JNK1/2 (Thr183/Tyr185), phospho-ERK1/2 (Thr202/Tyr204), phosphor-eIF2α (Ser51), and eIF2α were obtained from Cell Signaling Technology (Beverly, MA) ...
Functional analysis of PIK3CA gene mutations in human colorectal cancer.
Shellman Yiqun G., In PLoS ONE, 2004
... anti-phospho-HER2 antibodies were purchased from Upstate Biotechnology, Anti-phospho-EGFR, anti-EGFR, anti-phospho-HER3, anti-phospho-c-Met, anti-phospho-Akt, anti-Akt, anti-PTEN, anti-phospho-ERK1/2, anti-ERK1/2, and mutation-specific (L858R in exon 21 and deletion E746-A750 in exon 19) antibodies were from Cell Signaling Technology, anti-HER3 and anti-c-Met ...
Caveolin-1 expression is critical for vascular endothelial growth factor-induced ischemic hindlimb collateralization and nitric oxide-mediated angiogenesis
Vermes I. et al., In International Journal of Cell Biology, 2003
... following companies: caveolin-1 (Sigma, Mo, USA; C4490), Akt (Abcam (Cambridge, UK); ab28422), phospho-Akt (Abcam, ab27773), ERK1 (Abcam, ab9363), phospho-ERK (Santa Cruz, ...
Among circulating hematopoietic cells, BCLL uniquely expresses functional EPAC1, but EPAC1-mediated Rap1 activation does not account for PDE4 inhibitor-induced apoptosis
Kooijman R. et al., In Cellular and Molecular Life Sciences, 2003
... rabbit antibodies against Pp38, ERK1/2, P-JNK, JNK, P-CREB and CREB, and the mouse monoclonal against P-ERK1/2 were obtained from Cell Signaling (Beverly, Mass.) ...
Effect of exogenous kappa-opioid receptor activation in rat model of myocardial infarction
Lee Mi Young et al., In Korean Journal of Anesthesiology, 2003
... (a standard selective KOP agonist), LY294002 (a potent and selective PI3K inhibitor), and PD98059 (an ERK1/2 specific inhibitor) were purchased from Tocris Bioscience (Ellisville, MO) ...
Connective tissue growth factor and renal diseases: some answers, more questions
Zhang Zhi et al., In Respiratory Research, 2003
... Rabbit anti-Erk1/2 and rabbit anti-phosphorylated Erk1/2 polyclonal antibodies were purchased from New England Biolabs (Hertfordshire, UK) ...
Signaling endosome hypothesis: A cellular mechanism for long distance communication.
Linden Rafael, In PLoS ONE, 2003
... Antibodies: Anti-β-actin (AC-74) and anti-FLAG M2 (Sigma), anti-ERK1/2 and anti-phospho-ERK1/2(T202, Y204) (Cell Signaling Technologies; Danvers, MA), anti-HA-HRP ...
Acetylation of mitogen-activated protein kinase phosphatase-1 inhibits Toll-like receptor signaling
Lowenstein Charles J. et al., In The Journal of Experimental Medicine, 2002
... ERK1/2, phospho-ERK1/2, phospho-MEK1/2, phospho-Raf, phospho-Elk-1, phospho-p90, p38, phospho-p38, JNK, phospho-JNK, phospho-Raf and acetyl-K, phospho-MKK3/6, and MKK3 were purchased from Cell Signaling Technology ...
Mechanistic studies on protein tyrosine phosphatases
Janssens Veerle, In PLoS ONE, 2002
... Polyclonal anti-ERK1/2, anti-phospho-ERK1/2 antibodies were from Cell Signaling.
Acute antinociceptive responses in single and combinatorial opioid receptor knockout mice: distinct mu, delta and kappa tones
Panula Pertti et al., In BMC Neuroscience, 2002
... C-terminal and N-terminal anti-NPFF2R antibodies and blocking peptides from Novus Biologicals (Littleton, CO, USA), rabbit anti-phospho-ERK1/2 antibody from Cell Signaling Technology (Beverly, MA, USA), ...
Metalloproteinase expression in PMA-stimulated THP-1 cells. Effects of peroxisome proliferator-activated receptor-gamma (PPARγ) agonists and 9-cis-retinoic acid
Ramji Dipak P. et al., In The International Journal of Biochemistry & Cell Biology, 2002
... Antibodies were from Affinity Bioreagents (ADAMTS-4), Cell Signaling Technology (Smad2/3, p38MAPK, ERK1/2), Santa Cruz Biotechnology (c-Jun) and Sigma (β-actin) ...
BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury
Dryer Stuart E., In PLoS ONE, 2002
... Antibodies against phospho-Akt (Ser473), Akt, phospho-p38 (Thr180/Tyr182), p38, phospho-JNK1/2 (Thr183/Tyr185), JNK1/2, phospho-ERK1/2 (Thr202/Tyr204), ERK1/2 and IκBα were from Cell Signaling Technology ...
Monophosphothreonyl extracellular signal-regulated kinases 1 and 2 (ERK1/2) are formed endogenously in intact cardiac myocytes and are enzymically active
Clerk Angela et al., In Cellular Signalling, 2002
... The antibody against total ERK1/2 was a rabbit polyclonal from Cell Signaling Technology Inc ...
Functional P2Y2 nucleotide receptors mediate uridine s'-triphosphate-induced intimal hyperplasia in collared rabbit carotid arteries
Weisman Gary A. et al., In Purinergic Signalling, 2001
... Rabbit anti-rat ERK1/2, horseradish peroxidase (HRP)-conjugated goat anti-rabbit IgG, and HRP-conjugated goat anti-mouse IgG antibodies were obtained from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Poly(dimethylsiloxane) as a Material for Fabrication of Microfluidic Devices.
Holowka David, In PLoS ONE, 2001
... Mouse monoclonal anti-ERK1/2 (#L38C12) was obtained from Cell Signaling Technology Inc (Danvers, MA) ...
Critical role for scaffolding adapter Gab2 in FcγR-mediated phagocytosis
Neel Benjamin G. et al., In The Journal of Cell Biology, 2000
... Anti–phospho-Akt (Ser-473) and anti–phospho-Erk1/2 rabbit antibodies were purchased from Cell Signaling Technology ...
Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity
Levison Steven W et al., In Journal of Neuroinflammation, 2000
... STAT3 (9132), phospho-STAT3-tyr705 (9131), phospho-ERK1/2 (9101) and ERK1/2 (9102) antibodies were purchased from Cell Signaling Technologies (Beverly, MA) ...
A new mathematical model for relative quantification in real-time RT-PCR
Subbiah Elankumaran, In PLoS ONE, 2000
An antibody to phosphorylated ERK1/2 was obtained from Upstate (Lake Placid, NY), VSV-G protein from Alpha Diagnostic (San Antonio, TX), anti Ras antibody from Cell Signaling Technology (Danvers, MA) and ...
Early cell adhesion events differ between osteoporotic and non-osteoporotic osteoblasts
Cheng Cheng-Kung et al., In Journal of Bone and Mineral Research, 2000
... Mouse monoclonal antibodies (mAbs) against ERK2 (sc-1647) and phospho-ERK1/2 (sc-7383) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
SOCS proteins: negative regulators of cytokine signaling.
Hartl Dominik, In PLoS ONE, 2000
... 9131) and ERK1 antibody (Santa Cruz Biotechnology, CA, USA, Cat ...
VEGF receptor signal transduction.
Kume Tsutomu, In PLoS ONE, 2000
... The following commercially available antibodies were used: rabbit anti-phospho-ERK1/2 (Thr 202/Tyr 204, Cell Signaling #9101L); rabbit anti-ERK1/2 (Cell ...
Activation of ErbB2 receptor tyrosine kinase supports invasion of endothelial cells by Neisseria meningitidis
Bourdoulous Sandrine et al., In The Journal of Cell Biology, 2000
... Antiphospho Erk1/2 (Thr202/Tyr204) was from Cell Signaling Technology ...
The Helicobacter pylori Vacuolating Toxin Inhibits T Cell Activation by Two Independent Mechanisms
Baldari Cosima T. et al., In The Journal of Experimental Medicine, 2000
... Phosphospecific antibodies recognizing the active forms of p38, Erk1/2, and MKK 3/6 were from Cell Signaling Technology, anti-p38 and anti-Erk ...
Discrete Generation of Superoxide and Hydrogen Peroxide by T Cell Receptor Stimulation
Williams Mark S. et al., In The Journal of Experimental Medicine, 1999
... Antibodies to phosphorylated p44/42 ERK and pan-specific anti-ERK1/2 were obtained from Cell Signaling.
Intimate adhesion of Neisseria meningitidis to human epithelial cells is under the control of the crgA gene, a novel LysR-type transcriptional regulator.
Roy Craig R., In PLoS Pathogens, 1999
... Rabbit antibodies directed against JNK, p38 MAPK, Erk1/2, and their phosphorylated forms were obtained from Cell signaling.
Acute health effects of ambient air pollution: the ultrafine particle hypothesis
Huang Yuh-Chin T. et al., In Environmental Health Perspectives, 1999
... Monoclonal antibodies against phospho-p38, total extracellular signal-regulated kinases 1 and 2 (ERK1/2), total p38, and phospho-ERK1/2 were purchased from Cell Signaling Technology, Inc ...
CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis
Ghosh Sankar et al., In The Journal of Cell Biology, 1999
... The antibodies used were anti–phospho-Erk1/2 (Cell Signaling Technology), anti–phospho-Smad2 (Cell Signaling ...
Chemoprevention of aflatoxin B1 hepatocarcinogenesis by coumarins a natural benzo(a)pyrene that is a potent inducer of AFB1-aldehyde reductase, the glutathioneS- transferase A5 and P1 sub units and NAD(P)H quinone oxidoreductase in rat liver
Frédéric André, In PLoS ONE, 1999
... Akt (#4060; Ser 473)135/1136)nclear whether doses more than 1, anti-IRS1 (#2382), anti-Erk1/2 (#4695) and phosphorylated Erk1/2 (#9101; Thr 202/204) antibodies were purchased from Cell Signaling Technology (Beverly, MA, USA) ...
Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence
Sessa William C. et al., In The Journal of Cell Biology, 1999
... phospho-c-Raf (clone 56A6), Erk1/2, phosphor-Erk1/2 (clone E10) antibodies were obtained from Cell Signaling Technology ...
Regulation of Ras–MAPK pathway mitogenic activity by restricting nuclear entry of activated MAPK in endoderm differentiation of embryonic carcinoma and stem cells
Xu Xiang-Xi et al., In The Journal of Cell Biology, 1998
... Antibodies were obtained from multiple sources: Dab2/p96 monoclonal, clathrin heavy chain monoclonal, and Erk1 monoclonal (BD Biosciences); Elk-1 polyclonal, phospho-Elk-1 monoclonal, ...
NF-κB is a target of AKT in anti-apoptotic PDGF signalling
Kawakami Toshiaki et al., In The Journal of Experimental Medicine, 1998
... , anti-Syk (C-20), anti–PLC-γ2 (Q-20), anti-JNK1 (C-17), and anti-ERK1 (C-16) were from Santa Cruz Biotechnology, Inc.; antiphosphotyrosine mAb 4G10, ...
Specific SHP-2 partitioning in raft domains triggers integrin-mediated signaling via Rho activation
Mañes Santos et al., In The Journal of Cell Biology, 1998
... and anti-pan Src (Santa Cruz Biotechnology); anti-β1 integrin (Chemicon International); anti-TfR and -ERK1/2 (Zymed Labs); anti–phospho-ERK1/2 (Cell Signaling Technology); anti–phospho-FAK ( ...
Selective modulation of type 1 insulin-like growth factor receptor signaling and functions by β1 integrins
Languino Lucia R. et al., In The Journal of Cell Biology, 1997
... Cruz Biotechnology, Inc.); to phospho-Akt (Ser 473), to Akt, to phospho-Shp2 (Tyr542; Cell Signaling); to ERK1 (Santa Cruz Biotechnology, Inc.); to LN-1 described ...
A third-generation lentivirus vector with a conditional packaging system.
Lindenbach Brett D., In PLoS Pathogens, 1997
... ); P(S505)- PLA2G4A, ERK1/2, P-ERK1/2 (Cell Signaling ...
Rhamm−/− fibroblasts are defective in CD44-mediated ERK1,2 motogenic signaling, leading to defective skin wound repair
Turley Eva A. et al., In The Journal of Cell Biology, 1997
... muscle actin (immunohistochemistry), nonimmune IgG (Santa Cruz Biotechnology, Inc.), Ki67 (immunohistochemistry; DakoCytomation), tenascin (immunohistochemistry; Chemicon), phospho-ERK1,2 (immunohistochemistry/Western blot/immunofluorescence; Cell Signaling), CD44 (Western blot/immunofluorescence/blocking; IM7; ...
Activation of the Src/p21ras/Erk pathway by progesterone receptor via cross-talk with estrogen receptor
Gu Jian-xin et al., In Journal of Experimental & Clinical Cancer Research : CR, 1997
... Anti-phospho-ERK1/2 (Thr202/Tyr204) and anti-ERK1/2 antibodies were purchased from Cell Signaling Technology ...
MyD88 But Not TRIF Is Essential for Osteoclastogenesis Induced by Lipopolysaccharide, Diacyl Lipopeptide, and IL-1α
Udagawa Nobuyuki et al., In The Journal of Experimental Medicine, 1997
... Rabbit anti–mouse phospho-ERK1/2 (Thr202/Tyr204) antibody and rabbit anti–mouse ERK1/2 antibody were purchased from Cell Signaling Technology Inc ...
Cytokine production by human airway epithelial cells after exposure to an air pollution particle is metal-dependent.
Mohapatra Shyam S et al., In Respiratory Research, 1996
... Anti-ERK1/2 (p44/p42) polyclonal antibody, anti-phosphorylated ERK1/2 polyclonal antibody, and horseradish peroxidase (HRP)-conjugated goat anti-rabbit IgG were purchased from New England Biolabs (Beverly, MA, USA) ...
A human primary T-lymphocyte-derived human immunodeficiency virus type 1 Tat-associated kinase phosphorylates the C-terminal domain of RNA polymerase II and induces CAK activity
Kashanchi Fatah et al., In Virology Journal, 1996
... P44 peptide was synthesized from GenScript Corporation (Piscataway, USA) ...
A Synthetic Peptide Corresponding to the Extracellular Domain of Occludin Perturbs the Tight Junction Permeability Barrier.
Hotchin Neil, In PLoS ONE, 1996
... FAK, anti-Src, anti-ERK1/2 and anti-phospho ERK1/2 antibodies were from Cell Signaling Technology, Inc ...
AGN193109 is a highly effective antagonist of retinoid action in human ectocervical epithelial cells
Lucio-Cazana Francisco Javier et al., In Journal of Neuroinflammation, 1995
... Antibody against phosphorylated form of ERK1/2 was purchased from Cell Signaling Technology (Danvers, MA) and ...
Targeted over expression of luteinizing hormone in transgenic mice leads to infertility, polycystic ovaries, and ovarian tumors
Luthra Kalpana et al., In The Indian Journal of Medical Research, 1994
... Total ERK1/2 antibody and pERK1/2 antibody were procured from Cell Signaling Technology, USA ...
6-Isopropoxy-9-oxoxanthene-2-carboxylic acid (AH 6809), a human EP2 receptor antagonist
Jabbour Henry N. et al., In Molecular and Cellular Endocrinology, 1994
... Rabbit anti-phospho-p42/44 and mouse anti-p42/44 monoclonal antibodies were purchased from Cell Signaling Technologies (New England Biolabs, ...
Regulation of stably transfected platelet activating factor receptor in RBL-2H3 cells. Role of multiple G proteins and receptor phosphorylation.
Koch Karl-Wilhelm, In PLoS ONE, 1993
... Rabbit anti-ERK1 and anti-phospho-ERK1/2 antibodies were purchased from Cell Signaling (Beverly, MA) ...
Regulation of stably transfected platelet activating factor receptor in RBL-2H3 cells. Role of multiple G proteins and receptor phosphorylation.
Xue Chaoyang, In PLoS ONE, 1993
... Rabbit anti-ERK1/2 and anti-phospho-ERK1/2 antibodies were purchased from Cell Signaling (Beverly, MA) ...
Isolation of new ribozymes from a large pool of random sequences
Joyce Gerald, In PLoS Biology, 1992
... The primary antibodies used were anti-RET (C-19), anti-VGF (R-15), and anti-ERK1 (C-16) (all three, Santa Cruz Biotechnology, Santa Cruz, California, United ...
Glycosaminoglycans: Molecular properties, protein interactions, and role in physiological processes
Guicheux Jérôme et al., In Stem Cells (Dayton, Ohio), 1990
... (3101), phospho-extracellular signal-regulated kinase (ERK)1/2 (9101), phospho-c-Jun N-terminal kinase (JNK)1/2 (9251), phospho-p38 (9211), SMAD 2 (3102), ERK1/2 (9102), and goat anti-rabbit IgG horseradish peroxidase (HRP)–linked (7074) antibodies were purchased from Cell Signaling Inc ...
Cysteinyl leukotrienes enhance growth of human airway epithelial cells
Rovati G Enrico et al., In Respiratory Research, 1989
... Louis, MO); anti EGF-R, p-EGF-R (Tyr 1173) and ERK1/2 were from Santa Cruz Biotechnology (Santa Cruz, CA) ...
A new force field for molecular mechanical simulation of nucleic acids and proteins
Ling Ming Tat, In PLoS ONE, 1983
... Sources of antibodies include Santa Cruz Biotechnology (rabbit polyclonal anti-EphA2 and anti-ERK1, mouse anti-pERK1/2), Cell Signaling Technologies (anti-pS473-Akt and anti-Akt), ...
Hardie D Grahame et al., In Journal of Biology, 1983
... Anti-Erk1/2 antibodies were from Cell Signaling Technology (New England Biolabs, ...
Non–T Cell Activation Linker (NTAL)
Hořejší Václav et al., In The Journal of Experimental Medicine, 1980
... Rabbit polyclonal antibodies to Erk1/2 and phospho-Erk1/2 were from Promega and New England Biolabs, Inc., respectively.
An effect human leukaemic cell line: Reh
Naderi Soheil et al., In Molecular Cancer, 1976
... phospho-IκBα (S32; #2859), p65 (#3034), IKKα (#2682), IKKβ (#2684), phospho-IKKα/β (S176/S180; #2697), ERK1/2 (#9102), and phosphor-ERK1/2 (T202/Y204; #9101) were from Cell Signaling Technology ...
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