GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Mitogen-activated protein kinase 1
ERK, Mitogen-Activated Protein Kinase 1, ERK2
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jul 2008] (from
NCBI)
Papers using
ERK
antibodies
Galectin-3 mediates cross-talk between K-Ras and Let-7c tumor supressor micro RNA
Supplier
In PLoS ONE, 2010
PKC-1 acts with the ERK MAPK signaling pathway to regulate Caenorhabditis elegans mechanosensory response
Supplier
In Journal of Biomedical Science, 2009
... PD98059 (selective inhibitor of ERK signaling pathway) and CGP53353 (selective inhibitor of PKCβII signaling pathway) were obtained from TOCRIS Bioscience Company (Bristol, UK) ...
A PAK-activated linker for EGFR and FAK
Supplier
In OncoTargets and therapy, 2009
... rabbit anti-human p130cas, rabbit anti-human p130cas(Y410) phosphorylation, rabbit anti-human ERK (ERK1 + ERK2), and rabbit anti-human ERK general phosphorylation (T185 + Y187 + T202 + Y204) antibodies were purchased from Abcam (Cambridge, MA) ...
Circulating mitochondrial DAMPs cause inflammatory responses to injury
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In The Journal of Cell Biology, 2009
Connexin 43 mimetic peptide Gap27 reveals potential differences
in the role of Cx43 in wound repair between diabetic and non-diabetic
cells.
more suppliersSupplier
In PLoS ONE, 2009
Papers on
ERK
Angiotensin-(1-7): beyond the cardio-renal actions.
Review
New
Belo Horizonte, Brazil. In Clin Sci (lond), 30 Apr 2013
The interaction Ang-(1-7)/Mas regulates different signalling pathways, such as PI3K (phosphoinositide 3-kinase)/AKT and ERK (extracellularsignal-regulated kinase) pathways and involves downstream effectors such as NO, FOXO1 (forkhead box O1) and COX-2 (cyclo-oxygenase-2).
Protein kinase Cδ is required for ErbB2-driven mammary gland tumorigenesis and negatively correlates with prognosis in human breast cancer.
New
Aurora, United States. In Oncogene, 11 Apr 2013
Depletion of PKCδ with short hairpin RNA inhibited ligand-induced growth in both two-dimensional (2D) (plastic) and three-dimensional (3D) (Matrigel) culture, and correlated with decreased phosphorylation of the ErbB2 receptor and reduced activation of Src and MAPK/ERK pathways.
Suppression of Toll-like receptor 4 activation by endogenous oxidized phosphatidylcholine, KOdiA-PC by inhibiting LPS binding to MD2.
New
Puch'ŏn, South Korea. In Inflamm Res, 09 Apr 2013
RESULTS: KOdiA-PC prevented the activation of TLR4-signaling components including ERK, JNK, p38, NF-κB, and IRF3 leading to decrease of TNF-α, IFN-β, and COX-2 expression.
Genetic Correction of a LRRK2 Mutation in Human iPSCs Links Parkinsonian Neurodegeneration to ERK-Dependent Changes in Gene Expression.
New
Impact
Germany. In Cell Stem Cell, 07 Apr 2013
LRRK2 G2019S induced increased extracellular-signal-regulated kinase 1/2 (ERK) phosphorylation.
MiR-21 involve in ERK- mediated upregulation of MMP9 in the rat hippocampus following cerebral ischemia.
New
Nanjing, China. In Brain Res Bull, 06 Apr 2013
Matrix metallinoprotease-9 (MMP9) plays a key role in the pathogenesis of post-ischemic blood brain barrier (BBB) disruption and the formation of lesions after cerebral ischemia In this study we investigate the effect of brain-specific miRNAs on MMP-9 protein level in the rat hippocampus following cerebral ischemia and its underlying mechanism Cerebral ischemia significantly upregulated miR-21 and -224 in the hippocampus; however, expression of miR-122 and -338-3p was not significantly affected by ischemia Silencing of miR-21, but not -224, reduced MMP9 protein level after cerebral ischemia Downregulation of extracellular signal-regulated kinase (ERK) signaling using the ERK inhibitor U0126 and the calcium-channel blocker ketamine inhibited the upregulation of miR-21 expression and MMP9 protein level after cerebral ischemia The study suggests that cerebral ischemia up-regulates expression level of miR-21, which is involved in ERK-stimulated upregulation of MMP9 following cerebral ischemia via a calcium-dependent mechanism.
Chronic Akt Activation Attenuated Lipopolysaccharide-Induced Cardiac Dysfunction via Akt/GSK3β-Dependent Inhibition of Apoptosis and ER Stress.
New
Xi'an, China. In Biochim Biophys Acta, 06 Apr 2013
Akt signaling cascade (Akt, PTEN, GSK3β), stress signal (ERK, JNK, p38), apoptotic markers (BAX, caspase-3/-9), ER stress markers (GRP78, GADD153, eIF2α), inflammatory markers (TNFα, IL-1β, IL-6) and autophagic markers (Beclin-1, LC3B, Atg7 and p62) were evaluated.
IGF1 Promotes Osteogenic Differentiation of Mesenchymal Stem Cells Derived from Rat Bone Marrow by Increasing TAZ Expression.
New
Shijiazhuang, China. In Biochem Biophys Res Commun, 05 Apr 2013
Moreover, UO126 (MEK-ERK inhibitor), not LY294002 (PI3K-Akt inhibitor), inhibited the IGF1 induced increase in TAZ expression.
Reduced dosage of ERF causes complex craniosynostosis in humans and mice and links ERK1/2 signaling to regulation of osteogenesis.
New
Impact
Oxford, United Kingdom. In Nat Genet, 31 Mar 2013
The extracellular signal-related kinases 1 and 2 (ERK1/2) are key proteins mediating mitogen-activated protein kinase signaling downstream of RAS: phosphorylation of ERK1/2 leads to nuclear uptake and modulation of multiple targets.
Encoding and Transducing the Synaptic or Extrasynaptic Origin of NMDA Receptor Signals to the Nucleus.
New
Impact
Magdeburg, Germany. In Cell, 28 Mar 2013
Long-distance trafficking of Jacob from synaptic, but not extrasynaptic, sites depends on ERK activity, and association with fragments of the intermediate filament α-internexin hinders dephosphorylation of the Jacob/ERK complex during nuclear transit.
Interaction domains of sos1/grb2 are finely tuned for cooperative control of embryonic stem cell fate.
New
Impact
Toronto, Canada. In Cell, 28 Mar 2013
The Ras guanine nucleotide exchange factor (RasGEF) Sos1 and its adaptor Grb2 are multidomain proteins that couple fibroblast growth factor (FGF) signaling to activation of the Ras-Erk pathway during mammalian development and drive embryonic stem cells toward the primitive endoderm (PrE) lineage.
The BAFF Receptor Transduces Survival Signals by Co-opting the B Cell Receptor Signaling Pathway.
New
Impact
London, United Kingdom. In Immunity, 26 Mar 2013
Genetic rescue studies demonstrated that Syk transduces BAFFR survival signals via ERK and PI3 kinase.
Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance.
Review
New
Greenville, United States. In Oncotarget, Oct 2012
The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by genetic alterations in upstream signaling molecules such as receptor tyrosine kinases (RTK).
Mind the gap; regulation of gap junctional, intercellular communication by the SRC oncogene product and its effectors.
Review
New
Kingston, Canada. In Anticancer Res, Oct 2012
However, Src activates multiple signalling pathways such as the Ras/Raf/Erk and PLCγ/protein kinase C, which can also phosphorylate Cx43 and interrupt communication.
Deregulation of signalling pathways in prognostic subtypes of hepatocellular carcinoma: novel insights from interspecies comparison.
Review
New
Sassari, Italy. In Biochim Biophys Acta, Aug 2012
Mounting evidence emphasises the role of up-regulation of RAS/ERK, P13K/AKT, IKK/NF-kB, WNT, TGF-ß, NOTCH, Hedgehog, and Hippo signalling pathways as well as of aberrant proteasomal activity in hepatocarcinogenesis. Signalling deregulation often occurs in preneoplastic stages of rodent and human hepatocarcinogenesis and progressively increases in carcinomas, being most pronounced in more aggressive tumours.
Stimulating healthy tissue regeneration by targeting the 5-HT₂B receptor in chronic liver disease.
Impact
GeneRIF
Newcastle upon Tyne, United Kingdom. In Nat Med, 2011
5-HT2B blockade enhances liver regeneration by inhibiting induction of TGF-beta1 expression by hepatic stellate cells that is dependent on 5-HT, ERK and JunD.
Endocrine-disrupting chemicals: associated disorders and mechanisms of action.
Review
Gent, Belgium. In J Environ Public Health, 2011
Endocrine disruptors can act through classical nuclear receptors, but also through estrogen-related receptors, membrane-bound estrogen-receptors, and interaction with targets in the cytosol resulting in activation of the Src/Ras/Erk pathway or modulation of nitric oxide.
The Ebolavirus VP24 protein blocks phosphorylation of p38 mitogen-activated protein kinase.
GeneRIF
Madison, United States. In J Infect Dis, 2011
It was shown that VP24 interferes with the p38 MAP kinase pathway by blocking IFN-beta-stimulated phosphorylation of p38-alpha.
Parathyroid hormone (PTH) regulates the sodium chloride cotransporter via Ras guanyl releasing protein 1 (Ras-GRP1) and extracellular signal-regulated kinase (ERK)1/2 mitogen-activated protein kinase (MAPK) pathway.
GeneRIF
Chicago, United States. In Transl Res, 2011
Gene silencing of Ras-GRP1 prevented the PTH-mediated suppression of NCC activity, the activation of the H-Ras isoform of Ras, and the activation of ERK1/2 MAPK
Ephrin-A5 suppresses neurotrophin evoked neuronal motility, ERK activation and gene expression.
GeneRIF
Tübingen, Germany. In Plos One, 2010
These data suggest an interaction of ephrin-As and neurotrophin signaling pathways converging at ERK signaling and nuclear gene activity.
Null mutations in EphB receptors decrease sharpness of frequency tuning in primary auditory cortex.
More papers using
ERK
antibodies
GeneRIF
Irvine, United States. In Plos One, 2010
These results demonstrate that EphB receptors influence auditory cortical responses, and suggest that EphB signaling has multiple functions in auditory system development.
Estriol acts as a GPR30 antagonist in estrogen receptor-negative breast cancer cells.
Supplier
In PLoS ONE, 2009
... TX); ERβ (Oncogene Research Products, San Diego, CA); phospho-p42/p44 ERK/MAPK (Cell Signaling, Beverly, MA); ERK1, ERK2, (Santa Cruz Biotechnology, Santa Cruz, CA); GPR30 ...
Pseudohypoparathyroidism and GNAS epigenetic defects: clinical evaluation of Albright hereditary osteodystrophy and molecular analysis in 40 patients
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In Journal of Bone and Mineral Research, 2009
A solution for stripping antibodies from polyvinylidene fluoride immunoblots for multiple reprobing.
Supplier
In PLoS ONE, 2008
... or Alexa594-conjugated secondary antibodies (Molecular Probes); β-tubulin, cyclin D1, PCNA, RACK-1, transglutaminase 1 (Tgase 1), ERK-1, p(T202/Y204)-ERK1/ERK2 and HRP-conjugated secondary antibodies (Santa Cruz Biotechnology); PKC isotypes (BD Biosciences); ...
beta-1 and beta-2, but not alpha-1 and alpha-2, adrenoceptor blockade delays rat cutaneous wound healing
Supplier
In OncoTargets and therapy, 2008
... against phospho-ERK, Akt and phospho-Akt were purchased from Cell Signalling (Danvers, MA, USA), the polyclonal anti-ERK antibody was from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Systems biology of growth factor-induced receptor endocytosis
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In Molecular Systems Biology, 2008
Estrogen receptor-alpha (ER-alpha) suppresses expression of its variant ER-alpha 36
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In Oncogene, 2008
Osteopontin promotes vascular endothelial growth factor-dependent breast tumor growth and angiogenesis via autocrine and paracrine mechanisms
Supplier
In Molecular Cancer, 2007
... Rabbit polyclonal anti-ICAM-1, goat polyclonal anti-actin, mouse monoclonal anti-p70S6 kinase, mouse anti-p-ERK1/2 and rabbit anti-ERK2 antibodies were purchased from Santa Cruz Biotechnology.
Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals.
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In PLoS ONE, 2007
Increased expression of the gamma-secretase components presenilin-1 and nicastrin in activated astrocytes and microglia following traumatic brain injury
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In Journal of Neuroinflammation, 2007
... Anti-α2 integrin antibody, anti-α1 integrin antibody, anti-β1 integrin antibody, anti-phospho-ERK, anti-ERK2 antibody, and Protein A/G PLUS-Agarose beads were from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Resistance of human glioblastoma multiforme cells to growth factor inhibitors is overcome by blockade of inhibitor of apoptosis proteins
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In Breast Cancer Research : BCR, 2007
Eph receptors in breast cancer: roles in tumor promotion and tumor suppression
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In PLoS ONE, 2007
A paxillin tyrosine phosphorylation switch regulates the assembly and form of cell-matrix adhesions
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In British Journal of Cancer, 2006
... Antibodies to Akt1, phospho-Akt (Ser473), ERK1/2, and phospho-ERK (Tyr202/Tyr204) were from Cell Signaling Technology (Beverly, MA, USA) ...
Chlamydia pneumoniae directly interferes with HIF-1alpha stabilization in human host cells.
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In PLoS Pathogens, 2006
Abundance, complexation, and trafficking of Wnt/beta-catenin signaling elements in response to Wnt3a
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In Journal of Molecular Signaling, 2006
... Mouse anti-AKAP5, anti-pERK monoclonal antibody, rabbit anti-ERK, goat anti-mouse IgG-HRP, and goat anti-rat IgG-HRP were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Real-time imaging reveals that noninvasive mammary epithelial acini can contain motile cells
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In The Journal of Cell Biology, 2006
... Antibodies used were c-Fos, vimentin, MLC2 (sc-28329 and sc-15370), and ERK2 (Santa Cruz Biotechnology, Inc.); α ...
Mitogen activated protein (MAP) kinases: development of ATP and non-ATP dependent inhibitors
2
Supplier
In Journal of Molecular Signaling, 2005
The vascular endothelial growth factor receptor (VEGFR-1) supports growth and survival of human breast carcinoma
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In British Journal of Cancer, 2005
... p4EBP1, vascular endothelial growth factor receptor (VEGF), VEGFR-1, mTOR, PLD1, PLD2, S6K, pS6K, MEK, pMEK, ERK, pERK, ERα, and ERβ were purchased from Abcam (Cambridge, MA, USA) ...
Phospholipase D1 regulates cell migration in a lipase activity-independent manner.
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In PLoS ONE, 2005
... Polyclonal anti-pAMPK antibody (Thr-172), anti-pERK (Thr-202/Tyr-204) antibody and anti-ERK antibody were purchased from Cell Signaling.
Regulation of angiogenesis and tumor growth by p110 alpha and AKT1 via VEGF expression.
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In PLoS ONE, 2005
... Antibodies against ERK2 were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Enhancement of antitumor activity of the anti-EGF receptor monoclonal antibody cetuximab/C225 by perifosine in PTEN-deficient cancer cells.
Supplier
In PLoS ONE, 2005
... c-Jun, poly(ADP-ribose) polymerase (PARP), and ubiquitin (all from Cell Signaling Technology, Inc., Danvers, MA); T202/Y204-phosphorylated Erk (Santa Cruz Biotechnology, Santa Cruz, CA) ...
A role for the mitogen-activated protein kinase kinase kinase 1 in epithelial wound healing.
Supplier
In PLoS ONE, 2005
... The chemical inhibitors for JNK (SP600125), p38 (SB202190), ERK (PD98059) were obtained from Calbiochem (Gibbstown, NJ); and the inhibitor for IKKβ (TPCA-1) was from Tocris Bioscience (Ellisville, Missouri) ...
Adaptation of enterocytic Caco-2 cells to glucose modulates triacylglycerol-rich lipoprotein secretion through triacylglycerol targeting into the endoplasmic reticulum lumen.
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In PLoS ONE, 2005
Prostaglandin J2 alters pro-survival and pro-death gene expression patterns and 26 S proteasome assembly in human neuroblastoma cells
Supplier
In Oncogene, 2005
HDAC3 is crucial in shear- and VEGF-induced stem cell differentiation toward endothelial cells
Supplier
In The Journal of Cell Biology, 2005
... antibodies against β-gal, CD31 (goat), CD144 (mouse), HDAC1, p21, p53, p-AktThr308, Akt1/2 (goat), pERK42/44, and ERK2 were obtained from Santa Cruz Biotechnology, Inc.; antibodies against eNOS, ...
Inactivation of MAPK in mature oocytes triggers progression into mitosis via a Ca2+-dependent pathway but without completion of S phase
Supplier
In Developmental Biology, 2005
... U0126, polyclonal anti-ERK and anti-active ERK antibodies were obtained from Promega; MBP and monoclonal anti-active ERK antibody from New England Biolabs; Hoechst 33342 dye from ...
The anti-angiogenic peptide anginex disrupts the cell membrane
Supplier
In Cell Death & Disease, 2005
... Antibodies to phospho-histone H2AX (Ser139), phospho-Raf-1, Raf-1, phospho-p42/44 ERK, and p42/44 ERK were purchased from Cell Signaling Technology (Beverly, MA, USA) ...
The comet assay: a method to measure DNA damage in individual cells
Supplier
In Cell Death & Disease, 2005
... H2AX anti-rabbit antibody (pS139) (Epitomics, Burlingame, CA, USA), ERK2 (Santa Cruz, CA, USA), Topo IIα (Enzo Life Sciences, Lörrach, Germany), Topo IIβ antibody (Abcam, Cambridge, MA, USA), p-Chk1 ...
Low molecular weight fucoidan increases VEGF165-induced endothelial cell migration by enhancing VEGF165 binding to VEGFR-2 and NRP1.
Supplier
In PLoS ONE, 2005
... The ERK inhibitor PD98059 (Merck KGaA) was used in ...
Oncogenic PI3K and its role in cancer
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In PLoS ONE, 2005
... Antibodies were obtained from following commercial sources: anti-Par-4, anti-MMP-2, anti-Akt, anti-ERK, and anti-TIMP-1 from Santa Cruz Biotechnology (Santa Cruz, CA), anti-p-Akt ...
Cells migrating to sites of tissue damage in response to the danger signal HMGB1 require NF-κB activation
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In The Journal of Cell Biology, 2004
Cholesterol targeting alters lipid raft composition and cell survival in prostate cancer cells and xenografts
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In Journal of Biomedical Science, 2004
... Polyclonal anti-Met (C12), anti-EGFR (1005), and anti-ERK were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo
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In The American Journal of Pathology, 2004
Inhibition of mitogen-activated protein kinase enhances apoptosis induced by arsenic trioxide in human breast cancer MCF-7 cells.
Supplier
In Environmental Health Perspectives, 2004
... c-Fos (H-125), β-actin (C-2), phosphorylated extracellular signal-regulated kinase 1/2 (p-ERK1/2; E-4), Egr-1 (588), CTGF (L-20), ERK2 (C-14), ERα (F-10), or GPR30 (N-15), all from Santa Cruz Biotechnology, DBA (Milan, Italy), or ...
Soluble Abeta oligomers ultrastructurally localize to cell processes and might be related to synaptic dysfunction in Alzheimer's disease brain
Supplier
In Journal of Neuroinflammation, 2004
... Anti-Lyn, anti-Syk, anti-COX-2, anti-phospho-ERK, anti-ERK2 antibody, horseradish peroxidase conjugated secondary antibodies, and protein A/G PLUS-Agarose beads were from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Diallyl trisulfide-induced G(2)-M phase cell cycle arrest in human prostate cancer cells is caused by reactive oxygen species-dependent destruction and hyperphosphorylation of Cdc 25 C
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In European Journal of Nutrition, 2004
... The antibodies against ERK, P-ERK, were from Cell Signaling Technology, and actin was ...
Membrane estrogen receptor-alpha levels in MCF-7 breast cancer cells predict cAMP and proliferation responses
Supplier
In Environmental Health Perspectives, 2004
Clostridium difficile toxin A induces expression of the stress-induced early gene product RhoB.
Supplier
In PLoS ONE, 2004
... ERK2 antibody used in this study was obtained from Santa Cruz (Heidelberg, Germany), antibody for phosphorylated IκBα (p-IκBα) originated from New England Biolabs (Frankfurt am Main, Germany) ...
CD8+ T cells in autoimmunity
Supplier
In Indian Journal of Human Genetics, 2004
... such as SB203580 (SB) for p38 kinase, SP600125 (SP) for JNK and PD98059 (PD) for ERK were purchased from BIOMOL (Plymouth Meeting, PA, USA) ...
Fibronectin stimulates human lung carcinoma cell proliferation by suppressing p21 gene expression via signals involving Erk and Rho kinase
Supplier
In Breast Cancer Research : BCR, 2004
... (OP64-100UG) (Oncogene Research Products, Cambridge, MA, USA); ERK and P-ERK (Thr202/Tyr204) (Cell Signaling Technology, Danvers, MA, USA); ...
PPARγ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors
Supplier
In PPAR Research, 2003
The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL–C3G-mediated activation of Rap1
Supplier
In The Journal of Cell Biology, 2003
... The antibodies for phospho-CrkL (Y207), phospho-PLCγ1 (Y783), phospho-Pak1 Thr423 (Mst1 Thr183), total Mst1, and Erk were obtained from Cell Signaling Technology ...
Inefficient replication of Listeria innocua in the cytosol of mammalian cells.
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In PLoS Pathogens, 2003
Cleavage of Mcl-1 by caspases impaired its ability to counteract Bim-induced apoptosis
Supplier
In Oncotarget, 2003
Acute antinociceptive responses in single and combinatorial opioid receptor knockout mice: distinct mu, delta and kappa tones
Supplier
In BMC Neuroscience, 2002
... Biologicals (Littleton, CO, USA), rabbit anti-phospho-ERK1/2 antibody from Cell Signaling Technology (Beverly, MA, USA), mouse anti-ERK2 antibody from BD Transduction Laboratories (Becton Dickinson and Company, Franklin Lakes, ...
Farnesyltransferase inhibitors as anticancer agents: current status
Supplier
In British Journal of Cancer, 2002
... and anti-p42MAPK/ERK2 rabbit polyclonal antibodies were from Santa Cruz Biotechnology Inc ...
Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells
Supplier
In Journal of Veterinary Science, 2002
... Anti-Bid, anti-Bax, anti-Bcl-xL, anti-Akt, anti-phospho-Akt Thr-308, Ser-473, anti-ERK and anti-phospho-ERK antibodies for Western blot analysis were purchased from Santa Cruz Biotechnology (USA) ...
Metalloproteinase expression in PMA-stimulated THP-1 cells. Effects of peroxisome proliferator-activated receptor-gamma (PPARγ) agonists and 9-cis-retinoic acid
Supplier
In The International Journal of Biochemistry & Cell Biology, 2002
... Human recombinant TGF-β1 was from Peprotech, validated Smad-2, c-Jun and extracellular signal-regulated kinase (ERK) 1/2 small interfering RNA (siRNA) was from Qiagen and validated Smad-3 and ...
Nesca, a novel adapter, translocates to the nuclear envelope and regulates neurotrophin-induced neurite outgrowth
Supplier
In The Journal of Cell Biology, 2001
... used were EGFR and GFP (Santa Cruz Biotechnology, Inc.), phospho-p44/42 MapK (New England Biolabs, Inc.), Erk2 (BD Biosciences), and RC20 (Transduction Laboratories) ...
c-myc is a downstream target of the Smad pathway
Supplier
In British Journal of Cancer, 2001
... , anti-p53, anti-Cdk2, anti-Cdk4, anti-Cyclin D1, ERK and anti-Rb antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Influence of the structural diversity of data sets on the statistical quality of three-dimensional quantitative structure-activity relationship (3D-QSAR) models: predicting the estrogenic activity of xenoestrogens
Supplier
In Environmental Health Perspectives, 2001
Mitogen-activated protein kinases and nuclear factor-κB regulate Helicobacter pylori-mediated interleukin-8 release from macrophages
Supplier
In Journal of Clinical Biochemistry and Nutrition, 2001
... IκB-α was purchased from Cell Signaling Technology (Danvers, MA), and antibody for ERK2 and phosphorylated ERK2 was purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Akt activation protects hippocampal neurons from apoptosis by inhibiting transcriptional activity of p53
Supplier
In BMC Cell Biology, 2000
... (2 μg; measured using Bio-Rad Protein assay Kit, Biorad, CA) was incubated with MAP kinase (Erk2, 10 Units, New England Biolabs, MA), Protein Kinase A (Catalytic ...
The high molecular weight urinary matrix metalloproteinase (MMP) activity is a complex of gelatinase B/MMP-9 and neutrophil gelatinase-associated lipocalin (NGAL). Modulation of MMP-9 activity by NGAL.
Supplier
In PLoS ONE, 2000
... Western Blotting Luminol Reagent, HRP-conjugated donkey anti-goat secondary antibody, rabbit polyclonal antibodies against human ERK2, PKC βI, βII, δ and goat polyclonal antibody against human PKCθ were from Santa Cruz Biotechnology.
The Helicobacter pylori Vacuolating Toxin Inhibits T Cell Activation by Two Independent Mechanisms
Supplier
In The Journal of Experimental Medicine, 2000
... active forms of p38, Erk1/2, and MKK 3/6 were from Cell Signaling Technology, anti-p38 and anti-Erk antibodies were from Santa Cruz Biotechnology, antiphosphotyrosine mAb, anti–cyclooxygenase (COX)-2 ...
A conserved docking motif in MAP kinases common to substrates, activators and regulators.
Supplier
In PLoS ONE, 1999
... Cobb) or ERK2 mutants C38A, C214A and C214E (Genscript, Piscataway, NJ, USA), with ...
Phosphorylation of actopaxin regulates cell spreading and migration
Supplier
In The Journal of Cell Biology, 1999
... Active Erk2 was obtained from New England Biolabs, Inc ...
The B Cell Antigen Receptor Controls Integrin Activity through Btk and PLCγ2
Supplier
In The Journal of Experimental Medicine, 1999
... phospho-p44/42 MAP kinase [T202/Y204] against ERK1 and 2 and phospho-Akt [Ser473] against PKB/Akt (New England Biolabs); anti-ERK2 (C-14) and anti-Akt1/2 (H-136; Santa Cruz Biotechnology); the mouse monoclonal IgG1 ...
Impairment of erbb1 receptor and fluid-phase endocytosis and associated mitogenic signaling by inositol hexaphosphate in human prostate carcinoma du145 cells
Supplier
In Frontiers in Oncology, 1999
Nerve growth factor- and epidermal growth factor-regulated gene transcription in PC12 pheochromocytoma and INS-1 insulinoma cells.
Supplier
In PLoS ONE, 1999
... Polyclonal antibodies to EGR1 and ERK 1/2 were obtained from Santa Cruz Biotechnology (Santa Cruz, CA) ...
An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin–polymerizing machine
Supplier
In The Journal of Cell Biology, 1998
... ) sera; rabbit polyclonals anti–Sos-1, anti-Grb2, and anti–ERK-1, (Santa Cruz Biotechnology, Inc.); monoclonals anti-myc and ...
A novel role for FGF and extracellular signal–regulated kinase in gap junction–mediated intercellular communication in the lens
Supplier
In The Journal of Cell Biology, 1998
... forms of ERK) and the antiphospho-p44/42 MAP kinase E10 monoclonal mouse antibody (specific for activated ERK) were purchased from New England Biolabs, Inc ...
The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells
Supplier
In The Journal of Cell Biology, 1998
... Flag tag from Sigma-Aldrich, antibodies to active Akt pS473 from Cell Signaling, and anti–Akt-PKBα and pan–Erk antibodies from BD Biosciences.
Differential αv integrin–mediated Ras-ERK signaling during two pathways of angiogenesis
Supplier
In The Journal of Cell Biology, 1997
Merlin/NF-2 mediates contact inhibition of growth by suppressing recruitment of Rac to the plasma membrane
Supplier
In The Journal of Cell Biology, 1997
STAT3 mediates the survival signal in oncogenic ras-transfected intestinal epithelial cells
Supplier
In British Journal of Cancer, 1997
Compartmentalization of integrin α6β4 signaling in lipid rafts
Supplier
In The Journal of Cell Biology, 1997
... (anti-phospho-ERK), Santa Cruz Biotechnology, Inc ...
Differential regulation of Pyk2 and focal adhesion kinase (FAK)
Supplier
In The Journal of Cell Biology, 1997
... Polyclonal antibodies to JNK1/2 (sc-572) and to ERK2 (c-14) were purchased from Santa Cruz Biotechnology, Inc., and antibodies to ...
The NS5A/NS5 Proteins of Viruses from Three Genera of the Family Flaviviridae Are Phosphorylated by Associated Serine/Threonine Kinases.
Supplier
In PLoS ONE, 1997
... ERK-1 mAb was from BD Biosciences (San Jose, CA), MEK1/2 ...
Avian neural crest-derived neurogenic precursors undergo apoptosis on the lateral migration pathway
Supplier
In The Journal of Cell Biology, 1997
... Bcl-2, MEK, ERK, and CAS specific antibodies were from Santa Cruz Biotechnology, and anti-Crk was from ...
Active MAP kinase in mitosislocalization at kinetochores and association with the motor protein CENP-E
Supplier
In The Journal of Cell Biology, 1997
... Lamin B (M-20), pY ERK (E-4), ERK1 (C-16), ERK2 (C-14), and MKK1 (C-18) antibodies were purchased from Santa Cruz Biotechnology, Inc ...
Receptor tyrosine kinase c-ros knockout mice as a model for the study of epididymal regulation of sperm function
Supplier
In The Journal of Cell Biology, 1997
Analyzing chemotaxis using the Dunn direct-viewing chamber
Supplier
In The Journal of Cell Biology, 1996
... 05-180; Millipore), α-tubulin DM1A clone (T6199; Sigma-Aldrich), and rabbit polyclonal extracellular signal–regulated kinase (ERK), K-23 (sc-94; Santa Cruz Biotechnology).
Raf-1 activation disrupts its binding to keratins during cell stress
Supplier
In The Journal of Cell Biology, 1996
... Additional Abs used were directed to: 14-3-3ζ, Raf-1, Raf pS259, Raf pS621, and Erk (Santa Cruz Biotechnology, Inc.); mAb 4.62, which ...
Signal characteristics of G protein-transactivated EGF receptor
Supplier
In Purinergic Signalling, 1996
Detection of ERK activation by a novel monoclonal antibody
Supplier
In The Journal of Cell Biology, 1996
... Immunoblots were also probed using a rabbit polyclonal antibody recognizing the COOH terminus of ERK2 (C-14; Santa Cruz Biotechnology ...
Distinct organ-dependent mechanisms for the control of murine cytomegalovirus infection by natural killer cells
Supplier
In The Journal of Experimental Medicine, 1996
... The affinity-purified antiserum against Erk2 was obtained from Santa Cruz Biotechnology, Inc. ...
Association of CSK-homologous kinase (CHK) (formerly MATK) with HER-2/ErbB-2 in breast cancer cells
Supplier
In The Journal of Cell Biology, 1996
... Rabbit antibodies to the ErbB1, -2, -3, -4, p130CAS, and ERK2 were from Santa Cruz Biotechnology, Inc ...
Negative Regulation of Immunoglobulin E–dependent Allergic Responses by Lyn Kinase
Supplier
In The Journal of Experimental Medicine, 1996
... ), Hck (M28), Src (N16), Csk-binding protein (Cbp), Csk, ERK2, and p38MAPK were from Santa Cruz Biotechnology, Inc ...
Peptidase inhibitors improve recovery of substance P and calcitonin gene-related peptide release from rat spinal cord slices
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In Molecular Pain, 1995
Spatiotemporal Dynamics of CREB Phosphorylation: Transient versus Sustained Phosphorylation in the Developing Striatum.
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In PLoS ONE, 1995
... anti-p-Akt1 (Ser47, sc-7985-R), anti-p-JNK (Thr183/Tyr185, sc-12882-R), anti-JNK (sc-572), anti-Actin (sc-10731), goat polyclonal anti-Akt (sc-7126), and anti-ERK (sc-94-G) antibodies were acquired from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E–cdk2, and phosphorylation of the retinoblastoma protein
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In The Journal of Cell Biology, 1995
... monoclonal antibody 9E10 against the Myc epitope (BAbCo) and a monoclonal antibody against the phosphorylated Thr202/Tyr204 ERK activation epitope (New England Biolabs, Inc.) ...
Differential damage to auditory neurons and hair cells by ototoxins and neuroprotection by specific neurotrophins in rat cochlear organotypic cultures
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In Environmental Health Perspectives, 1995
... Caspase-3, caspase-9, cyt c, phosphorylated-ERK (p-ERK), and total-ERK antibodies were obtained from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
AGN193109 is a highly effective antagonist of retinoid action in human ectocervical epithelial cells
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In Journal of Neuroinflammation, 1995
... Primary antibodies against COX-1, COX-2, RAR-β and total ERK2 were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways
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In The Journal of Cell Biology, 1995
... MEK inhibitor PD98059, anti–phospho-ERK and anti–IκB-α antibodies were purchased from New England Biolabs, Inc., anti–v-src antibody (clone ...
A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-gamma 2
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In Journal of Inflammation (London, England), 1995
... Antibodies against p-JNK, PLC-γ2, ERK-2 and phosphotyrosine as well as HRP conjugated secondary antibodies, were from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Overexpression of Rad inhibits glucose uptake in cultured muscle and fat cells.
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In PLoS ONE, 1995
... pACC (Ser79), ACC were purchased from Cell Signaling Technology (Beverly, MA), LKB1, Tubulin, Akt and Erk were from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Continuous HGF supply from HGF-expressing fibroblasts transplanted into spleen prevents CCl4-induced acute liver injury in rats.
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In PLoS ONE, 1995
Modulation of flagellar expression in Escherichia coli by acetyl phosphate and the osmoregulator OmpR.
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In PLoS ONE, 1994
Growth factor–induced shedding of syndecan-1 confers glypican-1 dependence on mitogenic responses of cancer cells
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In The Journal of Cell Biology, 1994
Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase
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In PLoS ONE, 1994
... Rabbit anti-human phosphor-Erk1 (pT202/pY204)/Erk2 (pT185/pY187)Epitomics, Inc. ...
Demonstration that mutation of the type II transforming growth factor beta receptor inactivates its tumor suppressor activity in replication error-positive colon carcinoma cells
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In Molecular Cancer, 1994
Integrin-dependent activation of MAP kinasea link to shape-dependent cell proliferation
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In The Journal of Cell Biology, 1994
... (1249 and mAb E-12), PLC-γ2 (Q20 and mAb B-10), phospho–extracellular signal–regulated kinase (ERK) (E-4), and ERK2 (C-14) were from Santa Cruz Biotechnology, Inc ...
Integrin-dependent activation of MAP kinase: a link to shape-dependent cell proliferation
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In The Journal of Cell Biology, 1994
... A rabbit polyclonal antibody, C-14, raised against rat ERK2 was used for immunoprecipitation and Western blotting (Santa Cruz Biotechnology ...
The alpha 5 beta 1 integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expression
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In The Journal of Cell Biology, 1994
... The anti–phospho-p44/42 MAPK antibody E10, which recognizes the active form of Erk, was from New England Biolabs, Inc., and the anti-Erk2 ...
Osteopontin-stimulated vascular smooth muscle cell migration is mediated by β3 integrin
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In The Journal of Cell Biology, 1993
... Anti-ERK polyclonal antibody for Western blotting was from Santa Cruz Biotechnology, Inc ...
NMR View: A computer program for the visualization and analysis of NMR data.
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In PLoS ONE, 1993
Disruption by interferon-alpha of an autocrine interleukin-6 growth loop in IL-6-dependent U266 myeloma cells by homologous and heterologous downregulation of the IL-6 receptor αand β chains.
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In Cancer Cell International, 1993
... Anti-ERK and phospho-ERK antibodies was purchased from Santa Cruz Biotechnology (USA) ...
Structure of the HMG box motif in the B-domain of HMG1
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In The Journal of Cell Biology, 1992
... The monoclonal mouse antiphosphorylated MAP kinases (ERK 1 and 2) was from New England Biolabs, Inc ...
The mechanism of activation of protein kinase C: a biophysical perspective
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In Acta Histochemica et Cytochemica, 1991
... Anti-phosphorylated-Raf (p-Raf), MEK, p-MEK, p-ERK and ERK antibodies were purchased from New England Biolabs, Inc ...
Identification and characterization of a novel cytoskeleton-associated pp60src substrate.
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In PLoS ONE, 1990
... Arlinet Kierbel (Montevideo Pasteur Institute, Montevideo, Uruguay), and mouse monoclonal anti-phosphoERK1/2 (Tyr204) and rabbit polyclonal anti-ERK antibodies were purchased from Santa Cruz Biotechnology (California, USA) ...
The serum response factor is extensively modified by phosphorylation following its synthesis in serum-stimulated fibroblasts
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In The Journal of Experimental Medicine, 1990
... Polyclonal antibodies against Vav, Raf-1, STAT3, STAT5a, STAT5b, and c-myc, and a monoclonal anti-Erk2 antibody were obtained from Santa Cruz Biotechnology ...
Ligand-induced transformation by a noninternalizing epidermal growth factor receptor
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In British Journal of Cancer, 1989
Primary structure of human fibronectin: differential splicing may generate at least 10 polypeptides from a single gene.
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In BMC Cell Biology, 1984
... Anti-phospho-p44/42 MAPK polyclonal antibody and anti-p44/42 ERK polyclonal antibody were purchased from New England Biolabs.
The cysteine rich region of Raf-1 kinase contains zinc, translocates to liposomes, and is adjacent to a segment that binds GTP-Ras
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In The Journal of Experimental Medicine, 1982
... Antibodies to phosphorylated and nonphosphorylated extracellular signal–regulated kinase (ERK)1 and 2 were from New England Biolabs, Inc ...
