A PAK-activated linker for EGFR and FAKmore suppliers
In OncoTargets and therapy, 2009
... rabbit anti-human p130cas, rabbit anti-human p130cas(Y410) phosphorylation, rabbit anti-human ERK (ERK1 + ERK2), and rabbit anti-human ERK general phosphorylation (T185 + Y187 + T202 + Y204) antibodies were purchased from Abcam (Cambridge, MA) ...
Leptin signalling pathways in hypothalamic neurons.
Seoul, South Korea. In Cell Mol Life Sci, Feb 2016
The signaling pathways known to mediate the actions of leptin include JAK-STAT signaling, PI3K-Akt-FoxO1 signaling, SHP2-ERK signaling, AMPK signaling, and mTOR-S6K signaling.
MEK1 and MEK2 inhibitors and cancer therapy: the long and winding road.
Cambridge, United Kingdom. In Nat Rev Cancer, Oct 2015
The role of the ERK signalling pathway in cancer is thought to be most prominent in tumours in which mutations in the receptor tyrosine kinases RAS, BRAF, CRAF, MEK1 or MEK2 drive growth factor-independent ERK1 and ERK2 activation and thence inappropriate cell proliferation and survival.
MAPK-Activated Protein Kinases (MKs): Novel Insights and Challenges.
Hannover, Germany. In Front Cell Dev Biol, 2014
Downstream of MAPKs, such as classical/atypical ERKs and p38 MAPKs, but not of JNKs, signaling is often mediated by protein kinases which are phosphorylated and activated by MAPKs and, therefore, designated MAPK-activated protein kinases (MAPKAPKs).
Overview of fundamental study of pazopanib in cancer.
More papers using
Tianjin, China. In Thorac Cancer, 2014
In an vitro study, pazopanib exerted anti-tumor effect through mechanisms including the Raf-MAPK/ERK (MEK)-extracellular signal-regulated kinase (ERK) pathway, and directly targeted on v-raf murine sarcoma viral oncogene homolog B (B-raf) as well.
The vascular endothelial growth factor receptor (VEGFR-1) supports growth and survival of human breast carcinoma
In British Journal of Cancer, 2005
... p4EBP1, vascular endothelial growth factor receptor (VEGF), VEGFR-1, mTOR, PLD1, PLD2, S6K, pS6K, MEK, pMEK, ERK, pERK, ERα, and ERβ were purchased from Abcam (Cambridge, MA, USA) ... HDAC3 is crucial in shear- and VEGF-induced stem cell differentiation toward endothelial cells
In The Journal of Cell Biology, 2005
... antibodies against β-gal, CD31 (goat), CD144 (mouse), HDAC1, p21, p53, p-AktThr308, Akt1/2 (goat), pERK42/44, and ERK2 were obtained from Santa Cruz Biotechnology, Inc.; antibodies against eNOS, ... The comet assay: a method to measure DNA damage in individual cells
In Cell Death & Disease, 2005
... H2AX anti-rabbit antibody (pS139) (Epitomics, Burlingame, CA, USA), ERK2 (Santa Cruz, CA, USA), Topo IIα (Enzo Life Sciences, Lörrach, Germany), Topo IIβ antibody (Abcam, Cambridge, MA, USA), p-Chk1 ... Inhibition of mitogen-activated protein kinase enhances apoptosis induced by arsenic trioxide in human breast cancer MCF-7 cells.
In Environmental Health Perspectives, 2004
... c-Fos (H-125), β-actin (C-2), phosphorylated extracellular signal-regulated kinase 1/2 (p-ERK1/2; E-4), Egr-1 (588), CTGF (L-20), ERK2 (C-14), ERα (F-10), or GPR30 (N-15), all from Santa Cruz Biotechnology, DBA (Milan, Italy), or ... CD8+ T cells in autoimmunity
In Indian Journal of Human Genetics, 2004
... such as SB203580 (SB) for p38 kinase, SP600125 (SP) for JNK and PD98059 (PD) for ERK were purchased from BIOMOL (Plymouth Meeting, PA, USA) ... Acute antinociceptive responses in single and combinatorial opioid receptor knockout mice: distinct mu, delta and kappa tones
In BMC Neuroscience, 2002
... Biologicals (Littleton, CO, USA), rabbit anti-phospho-ERK1/2 antibody from Cell Signaling Technology (Beverly, MA, USA), mouse anti-ERK2 antibody from BD Transduction Laboratories (Becton Dickinson and Company, Franklin Lakes, ... Spatiotemporal Dynamics of CREB Phosphorylation: Transient versus Sustained Phosphorylation in the Developing Striatum.
In PLoS ONE, 1995
... anti-p-Akt1 (Ser47, sc-7985-R), anti-p-JNK (Thr183/Tyr185, sc-12882-R), anti-JNK (sc-572), anti-Actin (sc-10731), goat polyclonal anti-Akt (sc-7126), and anti-ERK (sc-94-G) antibodies were acquired from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...