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V-ets erythroblastosis virus E26 oncogene homolog

ERG3, Ets-related
This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2012] (from NCBI)
Top mentioned proteins: CAN, ERG2, HAD, ACID, NET
Papers on ERG3
Gain of chromosome 21 or amplification of chromosome arm 21q is one mechanism for increased ERG expression in acute myeloid leukemia.
New
Schnittger et al., München, Germany. In Genes Chromosomes Cancer, Feb 2016
Increased expression of the ETS-related transcription factor gene ERG has been described in myeloid malignancies with chromosomal rearrangements involving chromosome band 21q22, but also in cytogenetically normal AML, where it is associated with adverse prognosis.
Recurrent CIC Gene Abnormalities in Angiosarcomas: A Molecular Study of 120 Cases With Concurrent Investigation of PLCG1, KDR, MYC, and FLT4 Gene Alterations.
New
Antonescu et al., Taipei, Taiwan. In Am J Surg Pathol, Feb 2016
All 3 CIC-rearranged AS cases lacked vasoformation and had a solid growth of round, epithelioid to rhabdoid cells, showing immunoreactivity for CD31 and Ets-related gene and sharing a transcriptional signature with other round cell sarcomas, including CIC-rearranged tumors.
Injury-Mediated Vascular Regeneration Requires Endothelial ER71/ETV2.
New
Choi et al., Atlanta, United States. In Arterioscler Thromb Vasc Biol, Jan 2016
The E-twenty six (ETS) factor Ets variant 2 (ETV2; aka Ets-related protein 71) is essential for the formation of hematopoietic and vascular systems.
Correlation of ERG immunohistochemistry with molecular detection of TMPRSS2-ERG gene fusion.
New
Kwon et al., Seoul, South Korea. In J Clin Pathol, Jan 2016
AIMS: TMPRSS2/E26 transformation-specific (ETS) family gene fusion in prostate carcinoma (PCa) can be detected by several methods including immunohistochemistry (IHC) for ETS-related gene (ERG), the diagnostic utility of which has not been clearly defined.
Elevated expression of microRNA-30b in osteoarthritis and its role in ERG regulation of chondrocyte.
New
Zhang et al., Suzhou, China. In Biomed Pharmacother, Dec 2015
ERG (ETS-related gene) belongs to the ETS family of transcription factors, and has been recently reported to contribute to homeostatic balance in skeleton cell plasticity.
The oncogene ERG: a key factor in prostate cancer.
Review
New
Ladomery et al., Bristol, United Kingdom. In Oncogene, May 2015
UNASSIGNED: ETS-related gene (ERG) is a member of the E-26 transformation-specific (ETS) family of transcription factors with roles in development that include vasculogenesis, angiogenesis, haematopoiesis and bone development.
Newly available antibodies with practical applications in surgical pathology.
Review
Chan, Hong Kong, Hong Kong. In Int J Surg Pathol, 2013
ERG (Ets-related gene) is an excellent marker for endothelium and vascular tumors as well as prostatic cancer (about 50% of cases).
miRNA and TMPRSS2-ERG do not mind their own business in prostate cancer cells.
Review
Farooqi et al., Lahore, Pakistan. In Immunogenetics, 2013
Accumulating evidence substantiates the fact that miRNAs translate into dose-dependent responsiveness of cells to signaling regulators in transmembrane protease serine 2:ETS-related gene (TMPRSS2-ERG)-positive cells.
Prognostic significance of combined MN1, ERG, BAALC, and EVI1 (MEBE) expression in patients with myelodysplastic syndromes.
GeneRIF
Heuser et al., Hannover, Germany. In Ann Hematol, 2012
A high MEBE (MN1,ERG, BAALC, EVI1) expression score is an unfavorable prognostic marker in Myelodysplastic syndrome and is associated with an increased risk for progression to Acute myeloid leukemia.
Combined analysis of TMPRSS2-ERG and TERT for improved prognosis of biochemical recurrence in prostate cancer.
GeneRIF
Lazutka et al., Vilnius, Lithuania. In Genes Chromosomes Cancer, 2012
Prostate specimens and urine sediments from 179 previously untreated patients with pT2-pT3 stage PCa were analyzed for expression of telomerase (TERT and TR) and the TMPRSS2-ERG fusion gene by means of reverse transcription PCR.
ERG rearrangement in local recurrences compared to distant metastases of castration-resistant prostate cancer.
GeneRIF
Perner et al., Tübingen, Germany. In Virchows Arch, 2012
The ERG rearrangement occurred at a lower frequency in distant metastatic prostate cancer compared to local recurrent castration-resistant prostate cancer.
Modulation of hERG potassium channel gating normalizes action potential duration prolonged by dysfunctional KCNQ1 potassium channel.
GeneRIF
Li et al., Baltimore, United States. In Proc Natl Acad Sci U S A, 2012
Modulation of hERG potassium channel gating normalizes action potential duration prolonged by dysfunctional KCNQ1 potassium channel.
Oncogene-mediated alterations in chromatin conformation.
GeneRIF
Rubin et al., New York City, United States. In Proc Natl Acad Sci U S A, 2012
Erg oncogenic transcription factor overexpression is associated with global, reproducible, and functionally coherent changes in chromatin organization.
The role of RhoJ in endothelial cell biology and angiogenesis.
Review
Heath et al., Birmingham, United Kingdom. In Biochem Soc Trans, 2011
It is expressed in both the developing mammalian vasculature and the vascular beds of a number of adult tissues, with its expression regulated by the endothelial transcription factor ERG (ETS-related gene).
[Advances of study on prognostic factors of molecular biology in acute myeloid leukemia with normal cytogenetics].
Review
Xu et al., Shanghai, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2010
The review focuses on research advances abroad in this field including gene mutations suggesting bad prognosis such as FMS-related tyrosine kinase 3 gene mutation, Baalc gene and ETS-related gene hyperexpression, Wilms' tumor gene mutation and other gene mutations as well as gene mutations suggesting good prognosis such as nucleophosmin gene mutation, mixed lineage leukemia-partial tandem duplication, CCAAT/enhancer-binding protein α gene mutation.
The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells.
Impact
GeneRIF
Kile et al., Australia. In Nat Immunol, 2008
Erg is required for definitive hematopoiesis, adult hematopoietic stem cell function
High expression levels of the ETS-related gene, ERG, predict adverse outcome and improve molecular risk-based classification of cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B Study.
Impact
Cancer and Leukemia Group B Study et al., Columbus, United States. In J Clin Oncol, 2007
PURPOSE: To validate ERG overexpression as an adverse predictor and assess its prognostic value in the context of other molecular markers in cytogenetically normal (CN) -acute myeloid leukemia (AML).
Overexpression of the ETS-related gene, ERG, predicts a worse outcome in acute myeloid leukemia with normal karyotype: a Cancer and Leukemia Group B study.
Impact
GeneRIF
Bloomfield et al., Columbus, United States. In J Clin Oncol, 2006
High ERG expression was associated with upregulation of 112 expressed-sequenced tags and named genes, many of which are involved in cell proliferation, differentiation, and apoptosis in acute myeloid leukemia
Segmental regulation of Hoxb-3 by kreisler.
Impact
Krumlauf et al., London, United Kingdom. In Nature, 1997
We identified additional sequences that contain an Ets-related activation site, required for both the activation and restriction to r5.
Regulation of the Ets-related transcription factor Elf-1 by binding to the retinoblastoma protein.
Impact
Leiden et al., Chicago, United States. In Science, 1993
The retinoblastoma gene product (Rb) is a nuclear phosphoprotein that regulates cell cycle progression.
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