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Excision repair cross-complementing rodent repair deficiency, complementation group 1

The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. [provided by RefSeq, Oct 2009] (from NCBI)
Papers using ERCC1 antibodies
A presumed DNA helicase encoded by ERCC-3 is involved in the human repair disorders xeroderma pigmentosum and Cockayne's syndrome.
Maizels Nancy, In PLoS Genetics, 1989
... ERCC1-His were used to transfect Sf9 insect cells, and to amplify the virus according to the manufacturer's instructions (BAC TO BAC system; Life Technologies).
Papers on ERCC1
Comparison of ERCC1/XPF genetic variation, mRNA and protein levels in women with advanced stage ovarian cancer treated with intraperitoneal platinum.
Niedernhofer et al., Washington, D.C., United States. In Gynecol Oncol, 2012
ERCC1 mRNA levels in tumors correlated with outcome in patients with epithelial ovarian cancer treated with intraperitoneal cisplatin.
ERCC1 expression in circulating tumor cells (CTCs) using a novel detection platform correlates with progression-free survival (PFS) in patients with metastatic non-small-cell lung cancer (NSCLC) receiving platinum chemotherapy.
Bruce et al., Stanford, United States. In Lung Cancer, 2012
Low expression of ERCC1 on circulating tumor cell (CTC) correlates with Progression-free survival (PFS) in patients with metastatic NSCLC receiving platinum-based therapy.
Fluorescence-based incision assay for human XPF-ERCC1 activity identifies important elements of DNA junction recognition.
McDonald et al., London, United Kingdom. In Nucleic Acids Res, 2012
XPF-ERCC1 has a preference for cleaving the phosphodiester bond positioned on the 3'-side of a T or a U, which is flanked by an upstream T or U suggesting that a T/U pocket may exist within the catalytic domain.
Multiple DNA binding domains mediate the function of the ERCC1-XPF protein in nucleotide excision repair.
Schärer et al., Stony Brook, United States. In J Biol Chem, 2012
Multiple DNA binding domains mediate the function of the ERCC1-XPF protein in nucleotide excision repair
ERCC1 expression in triple negative breast cancer.
Altundag et al., Ankara, Turkey. In J Buon, 2012
High ERCC1 expression is associated with triple negative breast cancer.
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