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Estrogen receptor 2

ERbeta, Erb
This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Estrogen Receptor, CAN, V1a, HAD, AGE
Papers on ERbeta
Identification of a novel circadian clock modulator controlling BMAL1 expression through a ROR/REV-ERB-response element-dependent mechanism.
New
Kim et al., Seoul, South Korea. In Biochem Biophys Res Commun, Feb 2016
BMAL1, a core clock gene, is controlled by a ROR/REV-ERB-response element (RORE)-dependent mechanism, which plays an important role in stabilizing the period of the molecular circadian clock.
Stimulation of nuclear receptor REV-ERBs regulates tumor necrosis factor-induced expression of proinflammatory molecules in C6 astroglial cells.
New
Nakata et al., Hiroshima, Japan. In Biochem Biophys Res Commun, Feb 2016
Treatment with either REV-ERB agonists GSK4112 or SR9009 significantly blocked TNF-induced upregulation of CCL2 mRNA and MMP-9 mRNA, but not IL-6 mRNA and iNOS mRNA expression.
Coactivator-Dependent Oscillation of Chromatin Accessibility Dictates Circadian Gene Amplitude via REV-ERB Loading.
New
O'Malley et al., Houston, United States. In Mol Cell, Jan 2016
We demonstrate that ROR and/or BMAL1 promote global chromatin decondensation during the activation phase of the circadian cycle to actively facilitate REV-ERB loading for repression of circadian gene expression.
MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells.
New
Impact
Dang et al., Philadelphia, United States. In Cell Metab, Jan 2016
We report here that deregulated expression of MYC or N-MYC disrupts the molecular clock in vitro by directly inducing REV-ERBα to dampen expression and oscillation of BMAL1, and this could be rescued by knockdown of REV-ERB.
Circadian clock: Time for novel anticancer strategies?
Review
New
Grimaldi et al., Genova, Italy. In Pharmacol Res, Oct 2015
In this review, we focus on the functions of the druggable circadian nuclear receptors, REV-ERBα and REV-ERBβ, in cancer cell survival and describe the potential development of small molecule compounds that modulate REV-ERB activity as novel anticancer therapeutics.
The expression and localization of estrogen receptor beta in hyperplastic and neoplastic prostate lesions.
New
Sabo et al., In Vojnosanit Pregl, Oct 2015
Considering literature data for ER-beta.
Segregation of Clock and Non-Clock Regulatory Functions of REV-ERB.
New
Impact
Burris et al., Saint Louis, United States. In Cell Metab, Sep 2015
The molecular clock is a master controller of circadian cellular processes that affect growth, metabolic homeostasis, and behavior.
BTG1 potentiates apoptosis and suppresses proliferation in renal cell carcinoma by interacting with PRMT1.
New
Chen et al., Nanjing, China. In Oncol Lett, Aug 2015
UNASSIGNED: B-cell translocation gene 1 (BTG1) is a member of the BTG/transducer of Erb family.
Emerging models for the molecular basis of mammalian circadian timing.
Review
New
Partch et al., Santa Cruz, United States. In Biochemistry, Feb 2015
At its core, the heterodimeric transcription factor CLOCK:BMAL1 activates expression of Period, Cryptochrome, and Rev-Erb genes, which feed back to repress transcription and create oscillations in gene expression that confer circadian timing cues to cellular processes.
Nuclear receptors in acute and chronic cholestasis.
Review
Chignard et al., Paris, France. In Dig Dis, 2014
Likewise, NRs from other physiological clusters with low hepatic expression, such as estrogen receptor α (ERα) or reverse-Erb α/β (REV-ERB α/β), may also control pathophysiological processes in cholestasis.
Astrocytic estrogen receptors and impaired neurotrophic responses in a rat model of perimenopause.
Review
Finch et al., Los Angeles, United States. In Front Aging Neurosci, 2014
In a perimenopausal model of middle-aged rats, the astrocyte estrogen receptor-alpha (ERa): ER-beta (ERb) ratio increased with the onset of acyclicity (constant estrus, CE) in association with impaired neurotrophic responses to estradiol (E2).
Ulcerative colitis: from inflammation to cancer. Do estrogen receptors have a role?
Review
Di Leo et al., Bari, Italy. In World J Gastroenterol, 2014
The estrogen receptors (ER) alpha/beta balance seems to have a relevant influence on colorectal carcinogenesis and ER beta appears to parallel apoptosis, and hence an anti-carcinogenic effect.
REV-ERB and ROR nuclear receptors as drug targets.
Review
Impact
Burris et al., Jupiter, United States. In Nat Rev Drug Discov, 2014
The nuclear receptors REV-ERB (consisting of REV-ERBα and REV-ERBβ) and retinoic acid receptor-related orphan receptors (RORs; consisting of RORα, RORβ and RORγ) are involved in many physiological processes, including regulation of metabolism, development and immunity as well as the circadian rhythm.
Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription.
Impact
Glass et al., San Diego, United States. In Nature, 2013
Rev-Erb-α and Rev-Erb-β are nuclear receptors that regulate the expression of genes involved in the control of circadian rhythm, metabolism and inflammatory responses.
The ESR2 AluI 1730G>A (rs4986938) gene polymorphism is associated with fibrinogen plasma levels in postmenopausal women.
GeneRIF
Caccamo et al., Messina, Italy. In Gene, 2012
ESR2 AluI 1730G>A (rs4986938) gene polymorphism is associated with high fibrinogen plasma levels and cardiovascular disease.
Aggressive prostate cancer is prevented in ERαKO mice and stimulated in ERβKO TRAMP mice.
GeneRIF
Lubahn et al., Columbia, United States. In Endocrinology, 2012
Aggressive prostate cancer is prevented in ERalphaKO mice and stimulated in ERbetaKO TRAMP mice
Distribution and estrogen regulation of membrane progesterone receptor-β in the female rat brain.
GeneRIF
Mani et al., Phoenix, United States. In Endocrinology, 2012
Findings demonstrate a wide distribution of mPRbeta in the rodent brain that may contribute to functions affecting behavioral, endocrine, motor, and sensory systems.
PES1 promotes breast cancer by differentially regulating ERα and ERβ.
GeneRIF
Ye et al., Beijing, China. In J Clin Invest, 2012
expression of PES1 correlated positively with ERalpha expression and negatively with ERbeta expression and predicted good clinical outcome in breast cancer
Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β.
Impact
Evans et al., Los Angeles, United States. In Nature, 2012
Although the nuclear receptors REV-ERB-α and REV-ERB-β have been proposed to form an accessory feedback loop that contributes to clock function, their precise roles and importance remain unresolved.
Estrogen receptor 2 expression in back muscles of girls with idiopathic scoliosis - relation to radiological parameters.
GeneRIF
Kotwicka et al., Poznań, Poland. In Stud Health Technol Inform, 2011
Patients with ESR2 (convex/concave) ratio >/= 1 presented positive correlation between ESR2 ratio and Cobb angle
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