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V-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog

erbB-2, HER2, c-erbB-2, HER-2/neu
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, CAN, EGFR, AGE, Akt
Papers using erbB-2 antibodies
Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium.
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Peterlongo Paolo, In PLoS ONE, 2010
... HER2 positivity was determined by IHC 3+ (HerceptTest, DAKO, Denmark) or fluorescence ...
Prognostic value of androgen receptor expression in operable triple-negative breast cancer: a retrospective analysis based on a tissue microarray
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Lazutka Juozas et al., In Diagnostic Pathology, 2010
... Paraffin sections of the TMAs were cut for IHC (3 μm-thick) and HER2 FISH testing (4 μm-thick).IHC was performed on the TMA sections using Ultraview DAB detection kit on Ventana BenchMark XT staining system (Ventana Medical Systems, Tucson, Arizona, USA) [ ...
Genomic profiles specific to patient ethnicity in lung adenocarcinoma
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Lamy Pierre-Jean et al., In Breast Cancer Research : BCR, 2010
... Patients with primary HER-2-negative breast cancer were initially selected based on the level of HER-2 protein expression by IHC using the A485 monoclonal antibody (Dako A/S, Glostrup, Denmark) ...
American Society of Clinical Oncology/College of American Pathologists Guideline Recommendations for Immunohistochemical Testing of Estrogen and Progesterone Receptors in Breast Cancer
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Shu Xiao Ou et al., In BMC Cancer, 2009
... The modified staining protocol for HER2/PR based on the DAKO EnVision™ G|2 Doublestain kit.
Identification of subtypes in human epidermal growth factor receptor 2--positive breast cancer reveals a gene signature prognostic of outcome
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Serrano María José et al., In Breast Cancer Research : BCR, 2009
... HER2 status was determined by IHC by using Herceptest (Dako) in all patients and ...
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Papers on erbB-2
Engineering of a bispecific affibody molecule towards HER2 and HER3 by addition of an albumin-binding domain allows for affinity purification and in vivo half-life extension.
New
Löfblom et al., Stockholm, Sweden. In Biotechnol J, 30 Sep 2014
Affinity-purified bispecific Affibody molecules, targeting HER2 and HER3, showed simultaneous binding to the three target proteins (HER2, HER3, and albumin) when investigated in biosensor assays.
Pathological complete response and long-term clinical benefit in breast cancer: the CTNeoBC pooled analysis.
New
Impact
von Minckwitz et al., Silver Spring, United States. In Lancet, Aug 2014
The association between pathological complete response and long-term outcomes was strongest in patients with triple-negative breast cancer (EFS: HR 0·24, 95% CI 0·18-0·33; OS: 0·16, 0·11-0·25) and in those with HER2-positive, hormone-receptor-negative tumours who received trastuzumab (EFS: 0·15, 0·09-0·27; OS: 0·08, 0·03, 0·22).
Effect of adjuvant/neoadjuvant trastuzumab on clinical outcomes in patients with HER2-positive metastatic breast cancer.
New
Esteva et al., Houston, United States. In Cancer, Aug 2014
BACKGROUND: The purpose of the current study was to describe the outcomes of patients with human epidermal growth factor receptor 2 (HER2)-overexpressed/amplified (HER2+) early breast cancer who received adjuvant or neoadjuvant trastuzumab-based therapy and were subsequently retreated with trastuzumab for metastatic disease.
HER2 aberrations in cancer: implications for therapy.
Review
New
Kurzrock et al., United States. In Cancer Treat Rev, Jul 2014
Although anti-HER2 (human epidermal growth factor receptor 2) therapy is currently approved for breast, gastric, and gastroesophageal cancers overexpressing the HER2 protein or amplified for the HER2 gene, HER2 aberrations (gene amplification, gene mutations, and protein overexpression) are reported in other diverse malignancies.
Met in lung cancer.
Review
New
Dent, Richmond, United States. In Cancer Biol Ther, Jul 2014
(1) Thus expression of mutant active EGFR but in general not wild-type EGFR predisposes NSCLC cells to inhibitors of EGFR/ErbB2.
Neoadjuvant and adjuvant trastuzumab in patients with HER2-positive locally advanced breast cancer (NOAH): follow-up of a randomised controlled superiority trial with a parallel HER2-negative cohort.
New
Impact
Baselga et al., Milano, Italy. In Lancet Oncol, May 2014
BACKGROUND: In our randomised, controlled, phase 3 trial NeOAdjuvant Herceptin (NOAH) trial in women with HER2-positive locally advanced or inflammatory breast cancer, neoadjuvant trastuzumab significantly improved pathological complete response rate and event-free survival.
XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway.
New
Impact
Glimcher et al., New York City, United States. In Nature, May 2014
Triple-negative breast cancer (TNBC)--a form of breast cancer in which tumour cells do not express the genes for oestrogen receptor, progesterone receptor and HER2 (also called ERBB2 or NEU)--is a highly aggressive malignancy with limited treatment options.
Double-blind, placebo-controlled, multicenter, randomized, phase IIb neoadjuvant study of letrozole-lapatinib in postmenopausal hormone receptor-positive, human epidermal growth factor receptor 2-negative, operable breast cancer.
New
Impact
Conte et al., Modena, Italy. In J Clin Oncol, May 2014
PURPOSE: This is a randomized, double-blind, placebo-controlled study aimed to evaluate the clinical and biologic effects of letrozole plus lapatinib or placebo as neoadjuvant therapy in hormone receptor (HR) -positive/human epidermal growth factor receptor 2 (HER2) -negative operable breast cancer.
Examining ERBB2 as a candidate gene for susceptibility to leprosy (Hansen's disease) in Brazil.
New
Jeronimo et al., Natal, Brazil. In Mem Inst Oswaldo Cruz, Apr 2014
ErbB2 is a receptor for leprosy bacilli entering Schwann cells, which mediates Mycobacterium leprae-induced demyelination and the ERBB2 gene lies within a leprosy susceptibility locus on chromosome 17q11-q21.
Epiregulin: roles in normal physiology and cancer.
Review
New
Cullum et al., Auburn, United States. In Semin Cell Dev Biol, Apr 2014
Epiregulin binds to the EGF receptor (EGFR/ErbB1) and ErbB4 (HER4) and can stimulate signaling of ErbB2 (HER2/Neu) and ErbB3 (HER3) through ligand-induced heterodimerization with a cognate receptor.
Alternating current electrohydrodynamics induced nanoshearing and fluid micromixing for specific capture of cancer cells.
New
Trau et al., In Chemistry, Apr 2014
Under the optimal experimental conditions, we achieved high capture efficiency (e.g., approximately 90%; %RSD=2, n=3) with a 10-fold reduction in nonspecific adsorption of non-target cells for the detection of whole cells expressing Human Epidermal Growth Factor Receptor 2 (HER2).
A150: Control of Cell Proliferation in Lupus Nephritis: The Role of miRNAs and HER2.
New
Sullivan et al., Philadelphia, United States. In Arthritis Rheumatol, Mar 2014
Based on these results, we examined HER2 expression, a protein that regulates miR-26a and miR-30b levels in breast cancer cell lines.
The immune system and response to HER2-targeted treatment in breast cancer.
Review
New
Impact
Gianni et al., Milano, Italy. In Lancet Oncol, Feb 2014
The monoclonal antibody trastuzumab targets the growth factor receptor HER2 and has profoundly improved the course of disease and survival of women with HER2-overexpressing breast cancer.
Molecular markers for breast cancer: prediction on tumor behavior.
Review
New
Watanabe et al., Londrina, Brazil. In Dis Markers, Dec 2013
The most well-established breast molecular markers with prognostic and/or therapeutic value like hormone receptors, HER-2 oncogene, Ki-67, and p53 proteins, and the genes for hereditary breast cancer will be presented.
Targeted therapy in HER2-positive breast cancer.
Review
New
Li et al., Jinan, China. In Biomed Rep, Jul 2013
An important molecular determinant of therapy is the human epidermal growth factor receptor 2 (HER2) positivity of the tumor, which has been identified in 20-25% of breast cancers and is a prognostic marker of poor outcome.
Quantitation of the effect of ErbB2 on epidermal growth factor receptor binding and dimerization.
GeneRIF
Pike et al., Saint Louis, United States. In J Biol Chem, 2012
a molecular explanation for the apparent preference of the EGF receptor for dimerizing with ErbB2 and suggest that the phosphorylation of ErbB2 occurs largely in the context of the EGFR/ErbB2 heterodimer
Predictive value of HER2 serum levels in patients treated with lapatinib or trastuzumab -- a translational project in the neoadjuvant GeparQuinto trial.
GeneRIF
Müller et al., Hamburg, Germany. In Br J Cancer, 2012
Results show that elevated baseline sHER2 levels (>15 ng ml(1)) and a decrease of sHER2 levels (>20%) early after therapy initiation are both relevant criteria to predict response to lapatinib-based treatment.
HER2 status determination using RNA-ISH--a rapid and simple technique showing high correlation with FISH and IHC in 141 cases of breast cancer.
GeneRIF
García-Caballero et al., Santiago de Compostela, Spain. In Histol Histopathol, 2012
The probe developed for RNA-ISH represents a viable, effective possible alternative to FISH and IHC for analysing HER2 status in primary breast tumours.
[HER-2/neu-testing in breast cancer: is the immunocytochemistry competent?].
GeneRIF
Povilaĭtite et al., In Arkh Patol, 2012
Her-2/neu-testing in breast cancer: is the immunocytochemistry competent
[Different Her-2 status in infiltrative and intraductal components of the breast cancer].
GeneRIF
Petrov et al., In Arkh Patol, 2012
Different Her-2 status in infiltrative and intraductal components of the breast cancer
More papers using erbB-2 antibodies
Treatment of eccrine porocarcinoma with metastasis to the parotid gland using intensity-modulated radiation therapy: a case report
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Hoque Mohammad O., In PLoS ONE, 2009
... Tucson, AZ), PR (1E2, prediluted, Ventana Medical Systems), EGFR (3C6, prediluted, Ventana Medical Systems), and HER2 (4B5, prediluted, Ventana Medical Systems).
Novel design principles enable specific targeting of imaging and therapeutic agents to necrotic domains in breast tumors.
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Lebedeva Irina V., In PLoS ONE, 2009
... In these experiments, two different Affibody® molecules (Affibody, Stockholm, Sweden) were used: HER2-specific Affibody (His6-Z ...
p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC
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Vyzula Rostislav et al., In Diagnostic Pathology, 2009
... The expression of HER2 protein was determined by DAKO Herceptest (DAKO, Sweden) and ...
Overall survival analysis of a phase II randomized controlled trial of a Poxviral-based PSA-targeted immunotherapy in metastatic castration-resistant prostate cancer
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Chen Wei et al., In Breast Cancer Research : BCR, 2009
... Phospho-specific HER2 antibodies (Y877, Y1221/1222 and Y1248) were also purchased from Cell Signaling.
Integrated miRNA and mRNA expression profiling of the inflammatory breast cancer subtype.
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Falciani Francesco, In PLoS ONE, 2009
... Immunohistochemistry (IHC) status was available on most samples for ER (positivity cut-off: 10%), ERBB2 (0–3+ score, DAKO HercepTest, with >1+ defined ...
Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid
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Brünner Nils et al., In Histopathology, 2008
... The investigated antibodies are components of different IHC-based HER2 tests: PATHWAY® HER2 (clone 4B5; Ventana Medical Systems Inc., Tucson, AZ, USA), ...
Response to neoadjuvant therapy with cisplatin in BRCA1-positive breast cancer patients
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Richardson Andrea L et al., In Breast Cancer Research : BCR, 2008
... (SP1 antibody, Neomarkers, Fremont, CA, USA), PR (PgR 636 antibody, Dako, Carpinteria, CA, USA) and HER2 (A085 antibody, Dako).
Pharmacokinetics and metabolism of the putative cancer chemopreventive agent cyanidin-3-glucoside in mice
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Luo Jia et al., In Molecular Cancer, 2008
... and ErbB2 (polyclonal) antibodies were purchased from Cell Signaling Technology Inc ...
The protein-tyrosine kinase Syk interacts with TRAF-interacting protein TRIP in breast epithelial cells
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Harrison D J et al., In British Journal of Cancer, 2008
... HER2 FISH PharmDx; Dako, Ely, Cambridge, UK) ...
Multiphoton time-domain fluorescence lifetime imaging microscopy: practical application to protein–protein interactions using global analysis
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Kong Anthony et al., In Oncotarget, 2008
... Anti-HER2 antibodies recognizing the intracellular residues were obtained from Cell Signaling Technology ...
Prediction of BRCA1-association in hereditary non-BRCA1/2 breast carcinomas with array-CGH
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Domagala Wenancjusz et al., In Virchows Archiv, 2008
... Expression of HER-2 and c-kit was tested using the HercepTest kit (Dako) and c-kit pharmDx kit ...
HER2 status and benefit from adjuvant trastuzumab in breast cancer
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Erşahin Çağatay et al., In Pathology Research International, 2007
... IHC analysis of ER, PR, and HER2 was performed on the Benchmark XT staining module (Ventana Medical Systems Inc, Tucson, AZ) ...
Capecitabine vs. capecitabine + trastuzumab in patients with HER2-positive metastatic breast cancer progressing during trastuzumab treatment: The TBP phase III study (GBG 26/BIG 3-05) [abstract]
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De Laurentiis Michele et al., In Breast Cancer Research : BCR, 2007
... HER2 expression was assessed by immunohistochemistry with the polyclonal Dako test (Dako, Glostrup, Denmark) ...
The t10,c12 isomer of conjugated linoleic acid stimulates mammary tumorigenesis in transgenic mice over-expressing erbB2 in the mammary epithelium.
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Bauer Joseph Alan, In PLoS ONE, 2006
... Antibodies against HER2 were obtained from Abcam (Cambridge, MA) for Western ...
Standardization of HER2 testing: results of an international proficiency-testing ring study
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Kay Elaine et al., In Histopathology, 2006
... The cases supplied from Beaumont Hospital were assessed for HER-2 protein expression using Dako HercepTest® ( ...
A case of primary small cell carcinoma of the breast
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Bergkvist Leif et al., In Pathology Research International, 2006
... antibodies were used: estrogen receptor (Novocastra, clone 6F11, 1 : 100), progesterone receptor (Novocastra, clone 16, 1 : 100), c-erbB-2 oncoprotein (Dako, HER-2), mammoglobin (Dako, clone ...
Pterostilbene induces apoptosis and cell cycle arrest in human gastric carcinoma cells
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Chen Wei-Jen et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2006
... -actin, HER3 and HER2 were obtained from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
LIV-1 suppression inhibits HeLa cell invasion by targeting ERK1/2-Snail/Slug pathway
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Brandt B H et al., In British Journal of Cancer, 2006
... ductal invasive grade 2 and 3 breast cancer cases with very similar protein expression pattern (ER-positive, PR-positive, erbB2 0–2, Dako-Score/no-erbB2-amplification, EGFR-negative, p53 0–1, Ck ...
Prediction of breast tumor size by mammography and sonography--A breast screen experience
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Flynn Edward R et al., In Breast Cancer Research : BCR, 2006
... Anti-Her2 antibody was purchased from Bender MedSystems (now part of eBioscience, ...
Lowering of tumor interstitial fluid pressure reduces tumor cell proliferation in a xenograft tumor model.
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Najbauer Joseph, In PLoS ONE, 2005
... HER2- and Taq-specific Affibody Cloning, Overexpression, and Purification ...
Lapatinib plus capecitabine for HER2-positive advanced breast cancer
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Kiessling Rolf et al., In Journal of Translational Medicine, 2005
... Her2 status was routinely determined by immunohistochemistry using the antibodies CB11 (Ventana, and from 2007 Novocastra Leica, Wetzal, Germany), A485 (DAKO, ...
A Rac-Pak signaling pathway is essential for ErbB2-mediated transformation of human breast epithelial cancer cells
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Chernoff Jonathan et al., In Oncogene, 2005
... Monoclonal anti-ErbB2 was from Ventana Medical Systems, monoclonal anti-hemagglutinin (HA) (12CA5) ...
OLINDA/EXM: the second-generation personal computer software for internal dose assessment in nuclear medicine
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Capala Jacek et al., In European Journal of Nuclear Medicine and Molecular Imaging, 2004
... HER2:342–Cys Affibody molecule was conjugated with ...
Induction of androgen receptor expression by phosphatidylinositol 3-kinase/Akt downstream substrate, FOXO3a, and their roles in apoptosis of LNCaP prostate cancer cells
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Brodie A M H et al., In British Journal of Cancer, 2004
... The p-HER2 was purchased from Upstate (Temecula, CA, USA) and AR (SC-441) was obtained from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Hsp90 restrains ErbB-2/HER2 signalling by limiting heterodimer formation.
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Koch Karl-Wilhelm, In PLoS ONE, 2003
... Polyclonal rabbit anti phosphorylated ErbB1 (Tyr1068) and phosphorylated ErbB2 (Tyr1248) were purchased from Cell Signaling technology ...
Expression of luminal and basal cytokeratins in human breast carcinoma
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Pogoda Katarzyna et al., In Journal of Neuro-Oncology, 2003
... 6F11, Novocastra, dilution scale 1:100); against PR (Clone 16, Novocastra, dilution scale 1:200) and against HER2 (Polyclonal Hercep Test, DAKO).
PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients
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Anderson Steven M et al., In Breast Cancer Research : BCR, 2003
... The MMTV-c-ErbB2 (line 202) transgenic mice [ ...
Overexpression of the cell adhesion molecules DDR1, Claudin 3, and Ep-CAM in metaplastic ovarian epithelium and ovarian cancer
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Marcelo Aldaz C et al., In BMC Medical Genomics, 2003
... The data provided represent the statistical analysis of SAGE libraries from p53-Null, MMTV-erbB2 and C3(1)/SV40 transgenic mice mammary cancer models ...
The annexins
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Nenutil Rudolf et al., In Breast Cancer Research : BCR, 2003
... HER2/neu immunohistochemistryDako, polyclonal ...
Hsp90 (Heat Shock Protein 90) Inhibitor Occupancy Is a Direct Determinant of Client Protein Degradation and Tumor Growth Arrest in Vivo*
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Fritz Christian C. et al., In The Journal of Biological Chemistry, 2002
... Anti-Hsp90α antibody (clone 68) was from BD Biosciences; anti-Hsp90β antibody (clone H-114) and anti-HER2 (C-18) from Santa Cruz Biotechnology; and anti-EGFR, Akt (protein ...
Relationship between HER2 status and proliferation rate in breast cancer assessed by immunohistochemistry, fluorescence in situ hybridisation and standardised AgNOR analysis
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Ashankyty Ibraheem M. et al., In Pathology Research International, 2002
... hours in a humidity chamber using the following dilutions: p53 (clone DO-7, titer 1 : 50, Dako, Denmark), HER-2/neu (titer 1 : 50, Dako, Denmark), ER (clone 1D5, ...
Trastuzumab and vinorelbine as first-line therapy for HER2-overexpressing metastatic breast cancer: multicenter phase II trial with clinical outcomes, analysis of serum tumor markers as predictive factors, and cardiac surveillance algorithm
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Ghani Farooq et al., In Breast Cancer Research, 2002
... Patients eligible for participation were women with metastatic breast cancer who had HER2/neu overexpression as determined by immunohistochemistry (scores of 2+ or 3+ on the Dako Herceptest, Dako Corp, Carpinteria, ...
MHC class I negative phenotype of disseminated tumor cells in bone marrow is associated with poor survival in R0M0 breast cancer patients
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Kono K et al., In British Journal of Cancer, 2000
... Phycoerythrin (PE)-conjugated mouse anti-HER2/neu antibody (Becton Dickinson, Franklin Lakes, NJ, USA), ...
EGFR related peptides and their cognate receptors in breast cancer
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Thomas Shaji et al., In International Journal of Breast Cancer, 2000
... Immunohistochemistry for HER2-neu (Diagnostic biosystems HER2-neu, CD11 clone) ...
Untangling the ErbB signalling network
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Agus D B et al., In British Journal of Cancer, 2000
... Antibodies were purchased as follows: EGFR (#2232), HER2 (#2242), pEGFR (#2236), pHER2 (#2249) and pMAPK (#9101) from Cell Signaling Technology (Beverly, MA, USA), ...
Assessment of methods for tissue-based detection of the Her-2/neu alteration in human breast cancer: a direct comparison of fluorescence in situ hybridization and immunohistochemistry
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Vijay Anand Reddy P. et al., In The Indian Journal of Medical Research, 1999
... immunostaining was performed using rabbit anti-human c-erbB-2 oncoprotein as primary antibody (Dako, Copenhagen, Denmark) at 1 : ...
A graphical method to assess treatment-covariate interactions using the Cox model on subsets of the data
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Bertucci François et al., In Breast Cancer Research : BCR, 1999
... The HER2 status was evaluated with the Dako scale (HercepTest kit scoring ...
Increased AKT activity contributes to prostate cancer progression by dramatically accelerating prostate tumor growth and diminishing p27Kip1 expression
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Eppenberger-Castori Serenella et al., In Breast Cancer Research, 1999
... EIA ErbB-2 positive samples correlate strongly with DAKO 3+ and with ErbB-2 ...
Endostatin inhibits VEGF-induced endothelial cell migration and tumor growth independently of zinc binding.
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Lamartiniere Coral A. et al., In Environmental Health Perspectives, 1998
... A colony of mouse mammary tumor virus (MMTV)-erbB2/neu transgenic mice [FVB/N-TgN(MMTV-neu202Mul)] was established ...
c-Src is required for oxidative stress-mediated activation of big mitogen-activated protein kinase 1.
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Blagosklonny Mikhail V., In PLoS ONE, 1996
... HER2 was analyzed using the Dako Herceptest kit (DakoCytomation, Carpinteria, ...
Mechanisms of cellular penetration and nuclear localization of an anti-double strand DNA autoantibody
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Kim Yong-Sung et al., In Nucleic Acids Research, 1995
... and Her218 was placed between the ATG start codon and EGFP coding sequence in the pEGFP-N1 plasmid (Clontech), resulting in pG ...
Prognostic significance of HER-2 oncoprotein expression in breast cancer: a 30-year follow-up
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Meneses-Garcia A. et al., In ISRN Oncology, 1991
... Immunohistochemical staining for the HER2 protein was performed using the DAKO HercepTest immunocyto-chemical assay (DAKO, ...
Human breast cancer: identification of populations with a high risk of early relapse in relation to both oestrogen receptor status and c-erbB-2 overexpression
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Hamad Mohammad Al et al., In Breast Cancer Research, 1989
... primary antibodies against ER and PR (Biogenex, San Ramon, Ca, USA) was 1:130, and for Her-2/neu (Dako, Carpintera, Ca, USA) 1:50 ...
Immunogenicity of premalignant lesions is the primary cause of general cytotoxic T lymphocyte unresponsiveness
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Blankenstein Thomas et al., In The Journal of Experimental Medicine, 1989
... Myeloid cell expansion elicited by the progression of spontaneous mammary carcinomas in c-erbB-2 transgenic BALB/c mice suppresses immune ...
Integration and generalization of Kappa for multiple raters
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Kreipe H. H. et al., In Virchows Archiv, 1979
... IHC immunostaining was conducted using HercepTest™ (Dako Denmark A/S, Glostrup, Denmark) and/or the PATHWAY® HER2/neu (4B5) antibody (Ventana Medical Systems SA, Illkirch, France) ...
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