Receptors of thyroid hormones.
Madrid, Spain. In Pediatr Endocrinol Rev, Sep 2013
The important physiological actions of the thyroid hormones are mediated by binding to nuclear thyroid hormone receptors (TRs), encoded by two genes TRalpha and TRbeta.
Short-term effects of thyroid hormones during development: Focus on signal transduction.
Roma, Italy. In Steroids, 2010
However, also other thyroid hormone receptors can produce nongenomic effects, including the cytoplasmic TRalpha and TRbeta receptors and probably also a G protein-coupled membrane receptor, and increasing importance is now given to thyroid hormone metabolites like 3,5-diiodothyronine and reverse T(3) that can mimick some nongenomic effects of T(3) and T(4).
Actions of thyroid hormones in bone.
London, United Kingdom. In Endokrynol Pol, 2009
Studies in mutant mice have demonstrated that T(3) action in bone is mediated principally by T(3) receptor alpha (TRalpha).
Thyroid receptor: roles in cancer.
Madrid, Spain. In Trends Endocrinol Metab, 2009
The thyroid hormone receptors, encoded by the TRalpha and TRbeta genes, are ligand-dependent transcription factors that belong to the nuclear receptor superfamily.