GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Thyroid hormone receptor, alpha
erbA, c-erbA, TRalpha
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] (from
NCBI)
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Papers on
erbA
Thyroid hormone receptor (TR)alpha and TRbeta expression in breast cancer.
New
München, Germany. In Histol Histopathol, 28 Feb 2013
Results: Both TRalpha and TRbeta were expressed in the nuclei of breast cancer cells.
Multiple novel signals mediate thyroid hormone receptor nuclear import and export.
New
United States. In J Biol Chem, Oct 2012
Along with the known nuclear localization signal in the hinge domain, we identified a novel nuclear localization signal in the A/B domain of thyroid hormone receptor α1 that is absent in thyroid hormone receptor β1 and inactive in the oncoprotein v-ErbA.
Thyroid hormone limits postnatal Sertoli cell proliferation in vivo by activation of its alpha1 isoform receptor (TRalpha1) present in these cells and by regulation of Cdk4/JunD/c-myc mRNA levels in mice.
New
France. In Biol Reprod, Jul 2012
Thus, after crossing with the AMH-Cre line, we generated and analyzed a new line that expressed a dominant-negative TRalpha1 isoform (TRalpha(AMI)) in SCs only.
Association between a thyroid hormone receptor-α gene polymorphism and blood pressure but not with coronary heart disease risk.
GeneRIF
Lille, France. In Am J Hypertens, 2011
our study showed associations between the THRA rs939348 polymorphism and systolic blood pressure and the risk of hypertension but not with coronary heart disease.
Severe impairment of cerebellum development in mice expressing a dominant-negative mutation inactivating thyroid hormone receptor alpha1 isoform.
GeneRIF
Lyon, France. In Dev Biol, 2011
Severe impairment of cerebellum development supporting the view that TRalpha1 isoform is specifically required for proper cerebellum development
Mutant thyroid hormone receptors (TRs) isolated from distinct cancer types display distinct target gene specificities: a unique regulatory repertoire associated with two renal clear cell carcinomas.
GeneRIF
Davis, United States. In Mol Endocrinol, 2011
TR mutations from renal clear cell carcinoma and hepatocellular carcinoma may play tissue-specific roles in carcinogenesis.
Type-2 iodothyronine 5'deiodinase (D2) in skeletal muscle of C57Bl/6 mice. II. Evidence for a role of D2 in the hypermetabolism of thyroid hormone receptor alpha-deficient mice.
GeneRIF
Springfield, United States. In Endocrinology, 2011
enhanced D2 activity in Thra-0/0 plays a critical role in their alternate form of facultative thermogenesis.
The oligomeric state of thyroid receptor regulates hormone binding kinetics.
GeneRIF
San Francisco, United States. In J Endocrinol, 2011
investigation of association/dissociation kinetics for recombinant TRalpha and ligand (125I-T3)
Short-term effects of thyroid hormones during development: Focus on signal transduction.
Review
Roma, Italy. In Steroids, 2010
However, also other thyroid hormone receptors can produce nongenomic effects, including the cytoplasmic TRalpha and TRbeta receptors and probably also a G protein-coupled membrane receptor, and increasing importance is now given to thyroid hormone metabolites like 3,5-diiodothyronine and reverse T(3) that can mimick some nongenomic effects of T(3) and T(4).
Cardiac hypertrophy and thyroid hormone signaling.
Review
San Diego, United States. In Heart Fail Rev, 2010
These multiple thyroid hormone effects are largely mediated by the action of nuclear based thyroid hormone receptors (TR) the thyroid hormone receptor alpha and beta.
Actions of thyroid hormones in bone.
Review
London, United Kingdom. In Endokrynol Pol, 2009
Studies in mutant mice have demonstrated that T(3) action in bone is mediated principally by T(3) receptor alpha (TRalpha).
Thyroid receptor: roles in cancer.
Review
Madrid, Spain. In Trends Endocrinol Metab, 2009
The thyroid hormone receptors, encoded by the TRalpha and TRbeta genes, are ligand-dependent transcription factors that belong to the nuclear receptor superfamily.
Thyroid hormone antagonists: potential medical applications and structure activity relationships.
Review
Uppsala, Sweden. In Curr Med Chem, 2008
No TRalpha-selective ligands have been prepared up to this date, ligands that potentially would further ameliorate the problem with cardiac disease connected with hyperthyroidism and maybe cardiac arrhythmia.
Thyroid hormones and the central nervous system of mammals (Review).
Palermo, Italy. In Mol Med Report, 2008
Most of the effects of THs are mediated by two classes of nuclear receptors (α and β isoforms), which belong to the c-erbA superfamily of transcriptional regulators and are expressed in a tissue-specific and developmentally regulated manner.
Nuclear receptor expression links the circadian clock to metabolism.
Impact
Los Angeles, United States. In Cell, 2006
While thyroid hormones are generally constant, we find that TRalpha and beta dramatically cycle, suggesting that fundamental concepts such as "basal metabolism" may require reexamination.
A transcription factor response element for gene expression during circadian night.
Impact
Tsukuba, Japan. In Nature, 2002
Here we demonstrate the role of the Rev-ErbA/ROR response element in gene expression during circadian night, which is in phase with Bmal1 and in antiphase to Per2 oscillations.
The v-erba oncogene - a superb tool for dissecting the involvement of nuclear hormone receptors in differentiation and neoplasia (review).
In Int J Oncol, 1995
It is derived from the c-erbA protooncogene which encodes the alpha form of the nuclear receptor for the thyroid hormone triiodothyronine (T3R).
A novel cis element mediating ligand-independent activation by c-ErbA: implications for hormonal regulation.
Impact
San Diego, United States. In Cell, 1994
Unlike classical HREs, this element, RSV-T3RE (found in Rous sarcoma virus-long terminal repeat), mediates strong activation by the c-ErbA alpha thyroid hormone (T3) receptor in the absence of T3, and addition of T3 reverses this response.
Sequencing the erbA gene of avian erythroblastosis virus reveals a new type of oncogene.
Impact
In Science, 1984
Avian erythroblastosis virus (AEV) contains two distinct oncogenes, erbA and erbB .
A new avian erythroblastosis virus, AEV-H, carries erbB gene responsible for the induction of both erythroblastosis and sarcomas.
Impact
In Cell, 1983
Using DNA probes specific for the LTR sequence of SR-RSV-A, and for the erbA gene and the erbB gene of the ES4 strain of AEV, we have shown that the genome of AEV-H is 35S in size and carries the erbB gene but not the erbA gene.
