Short-term effects of thyroid hormones during development: Focus on signal transduction.
Roma, Italy. In Steroids, 2010
However, also other thyroid hormone receptors can produce nongenomic effects, including the cytoplasmic TRalpha and TRbeta receptors and probably also a G protein-coupled membrane receptor, and increasing importance is now given to thyroid hormone metabolites like 3,5-diiodothyronine and reverse T(3) that can mimick some nongenomic effects of T(3) and T(4).
Cardiac hypertrophy and thyroid hormone signaling.
San Diego, United States. In Heart Fail Rev, 2010
These multiple thyroid hormone effects are largely mediated by the action of nuclear based thyroid hormone receptors (TR) the thyroid hormone receptor alpha and beta.
Actions of thyroid hormones in bone.
London, United Kingdom. In Endokrynol Pol, 2009
Studies in mutant mice have demonstrated that T(3) action in bone is mediated principally by T(3) receptor alpha (TRalpha).
Thyroid receptor: roles in cancer.
Madrid, Spain. In Trends Endocrinol Metab, 2009
The thyroid hormone receptors, encoded by the TRalpha and TRbeta genes, are ligand-dependent transcription factors that belong to the nuclear receptor superfamily.
Thyroid hormones and the central nervous system of mammals (Review).
Palermo, Italy. In Mol Med Report, 2008
Most of the effects of THs are mediated by two classes of nuclear receptors (α and β isoforms), which belong to the c-erbA superfamily of transcriptional regulators and are expressed in a tissue-specific and developmentally regulated manner.