Novel treatment of acute promyelocytic leukemia: As₂O₃, retinoic acid and retinoid pharmacology.
Beijing, China. In Curr Pharm Biotechnol, 31 Oct 2014
Here, like v-erbA, PML/RARa is a (strong) transcriptional repressor of the RA receptor (RAR) complex, and PML/RARa fusion receptor gene act as conditional oncogenic receptor (translocated chimeric retinoic acid a signaling) or oncogenic PML/RARa may participate in leukemogenesis of APL through blocking RA-mediated promyelocytic differentiation.
Minireview: role of orphan nuclear receptors in cancer and potential as drug targets.
Houston, United States. In Mol Endocrinol, 28 Feb 2014
The nuclear orphan receptors for which endogenous ligands have not been identified include nuclear receptor (NR)0B1 (adrenal hypoplasia congenita critical region on chromosome X gene), NR0B2 (small heterodimer partner), NR1D1/2 (Rev-Erbα/β), NR2C1 (testicular receptor 2), NR2C2 (testicular receptor 4), NR2E1 (tailless), NR2E3 (photoreceptor-specific NR [PNR]), NR2F1 chicken ovalbumin upstream promoter transcription factor 1 (COUP-TFI), NR2F2 (COUP-TFII), NR2F6 (v-erbA-related protein), NR4A1 (Nur77), NR4A2 (Nurr1), NR4A3 (Nor1), and NR6A1 (GCNF).
Receptors of thyroid hormones.
Madrid, Spain. In Pediatr Endocrinol Rev, Sep 2013
The important physiological actions of the thyroid hormones are mediated by binding to nuclear thyroid hormone receptors (TRs), encoded by two genes TRalpha and TRbeta.
Thyroid hormone receptor-α and vascular function.
Chicago, United States. In Am J Physiol Cell Physiol, 2012
found that TRalpha is the predominant TR in mouse coronary smooth muscle cells (SMCs). Coronary SMCs isolated from TRalpha knockout mice exhibited a significant decrease in K(+) channel activity
Short-term effects of thyroid hormones during development: Focus on signal transduction.
Roma, Italy. In Steroids, 2010
However, also other thyroid hormone receptors can produce nongenomic effects, including the cytoplasmic TRalpha and TRbeta receptors and probably also a G protein-coupled membrane receptor, and increasing importance is now given to thyroid hormone metabolites like 3,5-diiodothyronine and reverse T(3) that can mimick some nongenomic effects of T(3) and T(4).
Actions of thyroid hormones in bone.
London, United Kingdom. In Endokrynol Pol, 2009
Studies in mutant mice have demonstrated that T(3) action in bone is mediated principally by T(3) receptor alpha (TRalpha).
Thyroid receptor: roles in cancer.
Madrid, Spain. In Trends Endocrinol Metab, 2009
The thyroid hormone receptors, encoded by the TRalpha and TRbeta genes, are ligand-dependent transcription factors that belong to the nuclear receptor superfamily.