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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Endoplasmic reticulum aminopeptidase 1

ERAP1, adipocyte-derived leucine aminopeptidase, A-LAP, ARTS1, ERAAP
The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene.[provided by RefSeq, Oct 2010] (from NCBI)
Top mentioned proteins: aminopeptidase, MHC, HLA-B, ERAP2, CAN
Papers on ERAP1
Interactions of the Immune System with Skin and Bone Tissue in Psoriatic Arthritis: A Comprehensive Review.
Review
New
Maverakis et al., Sacramento, United States. In Clin Rev Allergy Immunol, Feb 2016
In addition, there are numerous other genetic susceptibility loci (LCE3, CARD14, NOS2, NFKBIA, PSMA6, ERAP1, TRAF3IP2, IL12RB2, IL23R, IL12B, TNIP1, TNFAIP3, TYK2) and geoepidemiologic factors that contribute to the wide variability seen in psoriasis.
The T210M Substitution in the HLA-a*02:01 gp100 Epitope Strongly Affects Overall Proteasomal Cleavage Site Usage and Antigen Processing.
New
Mishto et al., Berlin, Germany. In J Biol Chem, Jan 2016
The T210M exchange revealed no effect on ERAP1-mediated N-terminal trimming of the precursor peptides.
The proteasome immunosubunits, PA28 and ER-aminopeptidase 1 protect melanoma cells from efficient MART-126-35 -specific T-cell recognition.
New
Seifert et al., Berlin, Germany. In Eur J Immunol, Dec 2015
Here, we demonstrate that in addition the IFN-γ-inducible proteasome subunit β2i/MECL-1 (multicatalytic endopeptidase complex-like 1), proteasome activator 28 (PA28), and ER-resident aminopeptidase 1 (ERAP1) impair MART-126-35 epitope generation.
The genetic associations of acute anterior uveitis and their overlap with the genetics of ankylosing spondylitis.
New
Australasian Osteoporosis Genetics Consortium AOGC et al., Brisbane, Australia. In Genes Immun, Dec 2015
Heterogeneity testing showed that rs30187 in ERAP1 has a larger effect on AAU compared with that in AS alone.
The immunogenetics of Behçet's disease: A comprehensive review.
Review
New
Remmers et al., Bethesda, United States. In J Autoimmun, Nov 2015
Genome-wide association studies have identified associations with genome-wide significance (P < 5 × 10(-8)) in the IL23R-IL12RB2, IL10, STAT4, CCR1-CCR3, KLRC4, ERAP1, TNFAIP3, and FUT2 loci.
The immunogenetics of Psoriasis: A comprehensive review.
Review
New
Bowcock et al., New York City, United States. In J Autoimmun, Nov 2015
These genes span an array of functions that involve antigen presentation (HLA-Cw6, ERAP1, ERAP2, MICA), the IL-23 axis (IL12Bp40, IL23Ap19, IL23R, JAK2, TYK2), T-cell development and T-cells polarization (RUNX1, RUNX3, STAT3, TAGAP, IL4, IL13), innate immunity (CARD14, c-REL, TRAF3IP2, DDX58, IFIH1), and negative regulators of immune responses (TNIP1, TNFAIP3, NFKBIA, ZC3H12C, IL36RN, SOCS1).
Association of ERAP1 Gene Polymorphisms With Behçet's Disease in Han Chinese.
New
Yang et al., Chongqing, China. In Invest Ophthalmol Vis Sci, Sep 2015
The endoplasmic reticulum aminopeptidase 1 (ERAP1), has a significant influence on the stability and immunological properties of MHC-I loaded peptides.
Endoplasmic reticulum aminopeptidases in the pathogenesis of ankylosing spondylitis.
Review
New
Haroon et al., Brisbane, Australia. In Rheumatology (oxford), Sep 2015
There appears to be a genetic as well as a functional interaction of ERAP1 and 2 with HLA-B27 based on the known functions of these molecules.
Pathogenesis of Behçet's disease: autoinflammatory features and beyond.
Review
New
Gül, İstanbul, Turkey. In Semin Immunopathol, Jul 2015
Non-HLA genetic associations such as endoplasmic reticulum aminopeptidase 1 (ERAP1), interleukin 23 receptor (IL23R) and IL10 variations suggest that BD shares susceptibility genes and inflammatory pathways with spondyloarthritis.
Association between ERAP1 gene polymorphisms and ankylosing spondylitis susceptibility in Han population.
Gao et al., Hangzhou, China. In Int J Clin Exp Pathol, 2014
PURPOSES: The present study was designed to investigate the relationship between endoplasmic reticulum amino peptidase 1 (ERAP1) gene polymorphisms and ankylosing spondylitis (AS) in Han population of Shaanxi province.
A large-scale screen for coding variants predisposing to psoriasis.
Impact
Zhang et al., Hefei, China. In Nat Genet, 2014
We discovered two independent missense SNVs in IL23R and GJB2 of low frequency and five common missense SNVs in LCE3D, ERAP1, CARD14 and ZNF816A associated with psoriasis at genome-wide significance.
Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1.
Impact
Kastner et al., Bethesda, United States. In Nat Genet, 2013
Additionally, two SNPs in ERAP1, encoding ERAP1 p.Asp575Asn and p.Arg725Gln alterations, recessively conferred disease risk.
Nonclassical MHC class Ib-restricted cytotoxic T cells monitor antigen processing in the endoplasmic reticulum.
Impact
GeneRIF
Shastri et al., Berkeley, United States. In Nat Immunol, 2012
MHC class Ib-restricted cytolytic effector cells specifically eliminated ERAAP-deficient cells in vitro and in vivo.
The crystal structure of human endoplasmic reticulum aminopeptidase 2 reveals the atomic basis for distinct roles in antigen processing.
GeneRIF
Mavridis et al., Athens, Greece. In Biochemistry, 2012
The overall ERAP2 domain organization is highly similar to that of the recently determined structure of ERAP1 in its closed conformation. A large internal cavity adjacent to the catalytic site can accommodate large peptide substrates.
A functional variant in ERAP1 predisposes to multiple sclerosis.
GeneRIF
Sironi et al., Milano, Italy. In Plos One, 2011
A functional variant in ERAP1 predisposes to multiple sclerosis.
Exon 10 coding sequence is important for endoplasmic reticulum retention of endoplasmic reticulum aminopeptidase 1.
GeneRIF
Tsujimoto et al., Wako, Japan. In Biol Pharm Bull, 2011
The amino acid coding sequence of Exon 10 of ERAP1 is found to be important for endoplasmic reticulum retention
Associations between ERAP1 polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis.
GeneRIF
Song et al., Seoul, South Korea. In Inflamm Res, 2011
the rs27044, rs17482078, rs10050860, rs30187, and rs2287987 polymorphisms of ERAP1 are associated with the development of AS in Europeans
Human cytomegalovirus microRNA miR-US4-1 inhibits CD8(+) T cell responses by targeting the aminopeptidase ERAP1.
Impact
Ahn et al., Seoul, South Korea. In Nat Immunol, 2011
Precursors of MHC class I-presented peptides are trimmed to mature epitopes by the aminopeptidase ERAP1.
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.
Impact
Wellcome Trust Case Control Consortium 2 (WTCCC2) et al., Bristol, United Kingdom. In Nat Genet, 2011
We also show that polymorphisms of ERAP1, which encodes an endoplasmic reticulum aminopeptidase involved in peptide trimming before HLA class I presentation, only affect ankylosing spondylitis risk in HLA-B27-positive individuals.
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