Novel genetic tools facilitate the study of cortical neuron migration.
Cincinnati, United States. In Mamm Genome, Jan 2016
To address both of these unresolved issues, we report here the creation of a novel conditional allele of the Reelin gene and showcase the use of an Etv1-GFP transgenic line highlighting a subpopulation of the cortex: layer V pyramidal neurons.
β-Cell Insulin Secretion Requires the Ubiquitin Ligase COP1.
San Francisco, United States. In Cell, Jan 2016
Here, we show that post-translational regulation of the transcription factors ETV1, ETV4, and ETV5 by the ubiquitin ligase COP1 (also called RFWD2) in β cells is critical for insulin secretion.
The Molecular Taxonomy of Primary Prostate Cancer.
In Cell, Dec 2015
Our results revealed a molecular taxonomy in which 74% of these tumors fell into one of seven subtypes defined by specific gene fusions (ERG, ETV1/4, and FLI1) or mutations (SPOP, FOXA1, and IDH1).
Landscape of gene fusions in epithelial cancers: seq and ye shall find.
Ann Arbor, United States. In Genome Med, 2014
Tumor-specific gene fusions can serve as diagnostic biomarkers or help define molecular subtypes of tumors; for example, gene fusions involving oncogenes such as ERG, ETV1, TFE3, NUT, POU5F1, NFIB, PLAG1, and PAX8 are diagnostically useful.
ETS fusion genes in prostate cancer.
Rotterdam, Netherlands. In Endocr Relat Cancer, 2014
During the last few years, novel concepts of the process of gene fusion have emerged, and initial experimental results explaining the function of the ETS genes ERG and ETV1 in prostate cancer have been published.
ETS gene fusions in prostate cancer.
Male, Maldives. In Nat Rev Urol, 2009
Fusions involving ETV1, ETV4 and ETV5 occur less frequently but exhibit greater variability in fusion structure with 12 unique 5' fusion partners identified so far.