gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Ets variant gene 2

ER71, Etsrp, Etv2, Ets1-related protein, Etsrp71
Top mentioned proteins: CK7, FATE, CAN, NET, vascular endothelial growth factor
Papers on ER71
Injury-Mediated Vascular Regeneration Requires Endothelial ER71/ETV2.
Choi et al., Atlanta, United States. In Arterioscler Thromb Vasc Biol, Jan 2016
The E-twenty six (ETS) factor Ets variant 2 (ETV2; aka Ets-related protein 71) is essential for the formation of hematopoietic and vascular systems.
LSD1/KDM1A promotes hematopoietic commitment of hemangioblasts through downregulation of Etv2.
Kobayashi et al., Tsukuba, Japan. In Proc Natl Acad Sci U S A, Dec 2015
Surprisingly, the hematopoietic defects in lsd1(it627) embryos were rescued by the gene knockdown of the Ets variant 2 gene (etv2), an essential regulator for vasculogenesis.
Integrin α6β1 Expressed in ESCs Instructs the Differentiation to Endothelial Cells.
Malik et al., Chicago, United States. In Stem Cells, Jun 2015
We observed that α6β1 binding to LN1 was required for differentiation to ECs. α6β1 functioned by recruiting the adaptor tetraspanin protein CD151, which activated FAK and Akt signaling and mediated the EC lineage-specifying transcription factor Er71.
Induction of hematopoietic and endothelial cell program orchestrated by ETS transcription factor ER71/ETV2.
Choi et al., Saint Louis, United States. In Embo Rep, May 2015
The ETS factor ETV2 (aka ER71) is essential for the generation of the blood and vascular system, as ETV2 deficiency leads to a complete block in blood and endothelial cell formation and embryonic lethality in the mouse.
Etv2 and fli1b function together as key regulators of vasculogenesis and angiogenesis.
Sumanas et al., Vilnius, Lithuania. In Arterioscler Thromb Vasc Biol, Apr 2015
OBJECTIVE: The E26 transformation-specific domain transcription factor Etv2/Etsrp/ER71 is a master regulator of vascular endothelial differentiation during vasculogenesis, although its later role in sprouting angiogenesis remains unknown.
Cyclosporin A induces cardiac differentiation but inhibits hemato-endothelial differentiation of P19 cells.
Lim et al., Seoul, South Korea. In Plos One, 2014
In contrast, mRNA expression levels of hematopoietic and endothelial lineage markers, including Flk1 and Er71, were severely reduced in CsA-treated P19 cells.
OVOL2 is a critical regulator of ER71/ETV2 in generating FLK1+, hematopoietic, and endothelial cells from embryonic stem cells.
Park et al., Atlanta, United States. In Blood, 2014
In this study, we report that OVOL2, a C2H2 zinc finger protein, is a novel binding protein of ER71, which is a critical transcription factor for blood and vessel development.
Direct conversion of adult skin fibroblasts to endothelial cells by defined factors.
Kim et al., Seoul, South Korea. In Circulation, 2014
Serial stepwise screening revealed 5 key factors (Foxo1, Er71, Klf2, Tal1, and Lmo2) that were required for efficient reprogramming of skin fibroblasts into Tie2-GFP(+) cells (4%).
Transcriptional inhibition of etv2 expression is essential for embryonic cardiac development.
Ramchandran et al., Milwaukee, United States. In Dev Biol, 2014
E-twenty six variant 2 (Etv2) transcription factor participates in cardiac, vascular-endothelial and blood cell lineage specification decisions during embryonic development.
Distinct regulation of the anterior and posterior myeloperoxidase expression by Etv2 and Gata1 during primitive Granulopoiesis in zebrafish.
Sumanas et al., Cincinnati, United States. In Dev Biol, 2014
An ETS-family transcription factor Etsrp/Etv2/ER71 has been implicated in vasculogenesis and hematopoiesis in multiple vertebrates.
Post-transcriptional mechanisms contribute to Etv2 repression during vascular development.
Lawson et al., Worcester, United States. In Dev Biol, 2014
etv2 is an endothelial-specific ETS transcription factor that is essential for vascular differentiation and morphogenesis in vertebrates.
Mesp1 patterns mesoderm into cardiac, hematopoietic, or skeletal myogenic progenitors in a context-dependent manner.
Kyba et al., Minneapolis, United States. In Cell Stem Cell, 2013
Remarkably, instead of promoting cardiac differentiation in the initial wave of mesoderm, Mesp1 binds to the Tal1 (Scl) +40 kb enhancer and generates Flk-1+ precursors expressing Etv2 (ER71) and Tal1 that undergo hematopoietic differentiation.
Enhanced hemangioblast generation and improved vascular repair and regeneration from embryonic stem cells by defined transcription factors.
Choi et al., Saint Louis, United States. In Stem Cell Reports, 2012
ER71/ETV2, GATA2, and SCL form a core transcriptional network in hemangioblast development.
Flk1+ and VE-cadherin+ endothelial cells derived from iPSCs recapitulates vascular development during differentiation and display similar angiogenic potential as ESC-derived cells.
Malik et al., Chicago, United States. In Plos One, 2012
Emergence of Flk1(+)VE-cadherin(+) cells entailed expression of the vascular developmental transcription factor Er71, which bound identically to Flk1, VE-cadherin, and CD31 promoters in both populations.
Transcription factors ER71/ETV2 and SOX9 participate in a positive feedback loop in fetal and adult mouse testis.
Janknecht et al., Los Angeles, United States. In J Biol Chem, 2012
Data suggest a mechanism by which SRY induces Sox9 and Er71 transcription early in testis differentiation.
The Flk1-Cre-mediated deletion of ETV2 defines its narrow temporal requirement during embryonic hematopoietic development.
Kouskoff et al., Manchester, United Kingdom. In Stem Cells, 2012
Data establish that ETV2 is required very transiently to specify mesodermal precursors to hematopoiesis and vasculogenesis and that SCL is one of the key downstream targets of ETV2 in controlling hematopoietic specification.
ER71 specifies Flk-1+ hemangiogenic mesoderm by inhibiting cardiac mesoderm and Wnt signaling.
Choi et al., Saint Louis, United States. In Blood, 2012
ER71-deficient Flk-1(+) mesoderm displayed enhanced Wnt signaling, which was reduced by ER71 re-introduction.
PKA/CREB signaling triggers initiation of endothelial and hematopoietic cell differentiation via Etv2 induction.
Yamashita et al., Kyoto, Japan. In Stem Cells, 2012
These data indicated that PKA/CREB pathway is a critical regulator for the initiation of EC/HPC differentiation via Etv2 transcription.
Identification of vascular and hematopoietic genes downstream of etsrp by deep sequencing in zebrafish.
Lin et al., Los Angeles, United States. In Plos One, 2011
substantially increased number of candidate genes regulated by etsrp in vascular cells
ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification.
Choi et al., Taejŏn, South Korea. In Cell Stem Cell, 2008
Inhibition of BMP, Notch, and Wnt signaling pathways greatly decreased the generation of FLK1(+) mesoderm and expression of the Ets transcription factor Er71. Enforced expression of ER71 in ESCs resulted in a robust induction of FLK1(+) mesoderm; rescued the generation of FLK1(+) mesoderm when blocked by BMP, Notch, and Wnt inhibition; and enhanced hematopoietic and endothelial cell generation.
share on facebooktweetadd +1mail to friends