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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Solute carrier family 29

Equilibrative Nucleoside Transporter 1, ENT1, epsin 1, rENT1
This gene is a member of the equilibrative nucleoside transporter family. The gene encodes a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium. The protein is categorized as an equilibrative (as opposed to concentrative) transporter that is sensitive to inhibition by nitrobenzylthioinosine (NBMPR). Nucleoside transporters are required for nucleotide synthesis in cells that lack de novo nucleoside synthesis pathways, and are also necessary for the uptake of cytotoxic nucleosides used for cancer and viral chemotherapies. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: V1a, ACID, HAD, CAN, CNT2
Papers on Equilibrative Nucleoside Transporter 1
Human Equilibrative Nucleoside Transporter 1 Expression in Endoscopic Ultrasonography-Guided Fine-Needle Aspiration Biopsy Samples Is a Strong Predictor of Clinical Response and Survival in the Patients With Pancreatic Ductal Adenocarcinoma Undergoing Gemcitabine-Based Chemoradiotherapy.
New
Isaji et al., Suzuka, Japan. In Pancreas, Feb 2016
OBJECTIVES: This study aimed to clarify whether pretreatment human equilibrative nucleoside transporter (hENT1) expressions in endoscopic ultrasonography-guided fine-needle aspiration biopsy (EUS-FNAB) specimens obtained from resectable, borderline resectable, and locally advanced unresectable pancreatic ductal adenocarcinoma (PDAC) are concordant with those in the resected specimen after gemcitabine-based chemoradiotherapy (Gem-CRT) and to validate the utility of hENT1 expression using EUS-FNAB samples as a prognostic marker.
Effects of P2Y12 receptor antagonists beyond platelet inhibition - comparison of ticagrelor with thienopyridines.
Review
New
Schulz et al., Mölndal, Sweden. In Br J Pharmacol, Feb 2016
In addition to P2Y12 receptor blockade ticagrelor is unique in having the only well documented additional target inhibition, the equilibrative nucleoside transporter 1.
Effect of Hypoxanthine on Functional Activity of Nucleoside Transporters ENT1 and ENT2 in Caco-2 Polar Epithelial Intestinal Cells.
New
Tonevitskaya et al., Moscow, Russia. In Bull Exp Biol Med, Nov 2015
We studied regulation of hypoxanthine transport depending on its concentration in the culture medium.
Cytidine Deaminase as a Molecular Predictor of Gemcitabine Response in Patients with Biliary Tract Cancer.
New
Lee et al., South Korea. In Oncology, Nov 2015
Potential biomarkers for gemcitabine response include the activities of cytidine deaminase (CDA), human equilibrative nucleoside transporter 1 (hENT1), deoxycytidine kinase (DCK), and ribonucleotide reductase M1 (RRM1).
Altered Hypoxic-Adenosine Axis and Metabolism in Group III Pulmonary Hypertension.
New
Karmouty-Quintana et al., Houston, United States. In Am J Respir Cell Mol Biol, Oct 2015
METHODS AND RESULTS: Explanted lung tissue was analyzed for markers of the hypoxic-adenosine axis including expression levels of HIF-1A, ADORA2B, CD73 and ENT-1.
Prognostic effect of hENT1, dCK and HuR expression by morphological type in periampullary adenocarcinoma, including pancreatic cancer.
New
Eberhard et al., Lund, Sweden. In Acta Oncol, Oct 2015
The most studied biomarker is human equilibrative nucleoside transporter 1 (hENT1), and the activating enzyme deoxycytidine kinase (dCK) has also been linked to treatment response.
Disrupted sleep-wake regulation in type 1 equilibrative nucleoside transporter knockout mice.
New
Basheer et al., Boston, United States. In Neuroscience, Oct 2015
The type 1 equilibrative nucleoside transporter (ENT1) is implicated in regulating levels of extracellular adenosine ([AD]ex).
Quantitative Targeted Proteomics of Pancreatic Cancer: Deoxycytidine Kinase Protein Level Correlates to Progression-Free Survival of Patients Receiving Gemcitabine Treatment.
New
Terasaki et al., Sendai, Japan. In Mol Pharm, Oct 2015
Protein expression levels of deoxycytidine kinase (dCK), uridine monophosphate-cytidine monophosphate (UMP-CMP) kinase, cytosolic nucleotidase III (cN-III), and equilibrative nucleoside transporter 1 (ENT1) were significantly correlated with IC50 or 1/IC50 in five cell lines with different sensitivities to dFdC (p < 0.05).
Low expression of equilibrative nucleoside transporter 1 is associated with poor prognosis in chemotherapy-naïve pT2 gallbladder adenocarcinoma patients.
New
Nervi et al., Santiago, Chile. In Histopathology, Sep 2015
AIMS: Equilibrative nucleoside transporter 1 (ENT1) is the major transporter of the chemotherapeutic drug gemcitabine, the current therapy for advanced gallbladder cancer (GBC).
Biological activity of natural sesquiterpenoids containing a gem-dimethylcyclopropane unit.
Review
New
Hernández-Galán et al., Cadiz, Spain. In Nat Prod Rep, Aug 2015
The biological activities of aristolane, aromadendrane, ent-1,10-secoaromadendrane, 2,3-secoaromadendrane, ent-5,10-cycloaromadendrane, bicyclogermacrene, lepidozane, and maaliane terpenoids which contain the gem-dimethylcyclopropyl unit are described.
Equilibrative Nucleoside Transporters 1 and 4: Which One Is a Better Target for Cardioprotection Against Ischemia-Reperfusion Injury?
Review
New
Leung et al., Kunming, China. In J Cardiovasc Pharmacol, Jun 2015
Equilibrative nucleoside transporter (ENT) inhibitors may be an alternative.
Cellular Uptake of Decitabine by Equilibrative Nucleoside Transporters in HCT116 Cells.
Iwakawa et al., Kōbe, Japan. In Biol Pharm Bull, 2014
Real-time polymerase chain reaction analysis revealed that ENT1 mRNA was the most abundant among the nucleoside transporters examined in HCT116 cells.
Clinical potential of elacytarabine in patients with acute myeloid leukemia.
Review
Rizzieri et al., Durham, United States. In Ther Adv Hematol, 2014
Elacytarabine, a lipophilic 5'-elaidic acid ester or nucleoside analogue of cytosine arabinoside, was created with the intent of overcoming resistance mechanisms including reduced expression of the human equilibrative nucleoside transporter 1 (hENT1) required for cytarabine entry into cells, as well as increased activity of cytidine deaminase (CDA) which breaks down the active metabolite of cytarabine, ara-CTP.
hENT1 expression is predictive of gemcitabine outcome in pancreatic cancer: a systematic review.
Review
Andersson et al., Lund, Sweden. In World J Gastroenterol, 2014
High human equilibrative nucleoside transporter 1 (hENT1)-expression has shown a survival benefit in pancreatic cancer patients treated with gemcitabine in several studies.
Levels of gemcitabine transport and metabolism proteins predict survival times of patients treated with gemcitabine for pancreatic adenocarcinoma.
GeneRIF
Van Laethem et al., Brussels, Belgium. In Gastroenterology, 2012
High levels of hENT1 in pancreatic ductal adenocarcinoma predict longer survival times in patients treated with adjuvant gemcitabine.
Purification and crystallization of yeast Ent1 ENTH domain.
GeneRIF
Prag et al., Tel Aviv-Yafo, Israel. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012
X-ray analysis revealed that the crystallographic symmetry of Ent1 is primitive orthorhombic, space group P222, with unit-cell parameters a = 32.7, b = 35.5, c = 110.6 A and a diffraction limit of 2.3 A
PPARα and PPARγ regulate the nucleoside transporter hENT1.
GeneRIF
Leisewitz et al., Santiago, Chile. In Biochem Biophys Res Commun, 2012
PPARalpha and PPARgamma activation modulate hENT1 expression
Expression of equilibrative nucleoside transporter type 1 protein in elderly patients with schizophrenia.
GeneRIF
McCullumsmith et al., Birmingham, United States. In Neuroreport, 2012
ENT1 expression is decreased in the superior temporal gyrus in patients with schizophrenia, demonstrating altered glutamate transport in this illness.
Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice.
GeneRIF
Eltzschig et al., Aurora, United States. In J Clin Invest, 2012
These studies identify ENT1 and adenosine receptors as key to the process of reestablishing renal perfusion following ischemic acute kidney injury.
Curvature of clathrin-coated pits driven by epsin.
Impact
GeneRIF
McMahon et al., Cambridge, United Kingdom. In Nature, 2002
An epsin 1 helix is inserted into one leaflet of the lipid bilayer, inducing curvature; on lipid monolayers epsin alone is sufficient to facilitate the formation of clathrin-coated invaginations
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