Equilibrative Nucleoside Transporter 1
Biological activity of natural sesquiterpenoids containing a gem-dimethylcyclopropane unit.
Cadiz, Spain. In Nat Prod Rep, Aug 2015
The biological activities of aristolane, aromadendrane, ent-1,10-secoaromadendrane, 2,3-secoaromadendrane, ent-5,10-cycloaromadendrane, bicyclogermacrene, lepidozane, and maaliane terpenoids which contain the gem-dimethylcyclopropyl unit are described.
Clinical potential of elacytarabine in patients with acute myeloid leukemia.
Durham, United States. In Ther Adv Hematol, 2014
Elacytarabine, a lipophilic 5'-elaidic acid ester or nucleoside analogue of cytosine arabinoside, was created with the intent of overcoming resistance mechanisms including reduced expression of the human equilibrative nucleoside transporter 1 (hENT1) required for cytarabine entry into cells, as well as increased activity of cytidine deaminase (CDA) which breaks down the active metabolite of cytarabine, ara-CTP.
Purification and crystallization of yeast Ent1 ENTH domain.
Tel Aviv-Yafo, Israel. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012
X-ray analysis revealed that the crystallographic symmetry of Ent1 is primitive orthorhombic, space group P222, with unit-cell parameters a = 32.7, b = 35.5, c = 110.6 A and a diffraction limit of 2.3 A
Curvature of clathrin-coated pits driven by epsin.
Cambridge, United Kingdom. In Nature, 2002
An epsin 1 helix is inserted into one leaflet of the lipid bilayer, inducing curvature; on lipid monolayers epsin alone is sufficient to facilitate the formation of clathrin-coated invaginations