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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

EPS8-like 2

This gene encodes a member of the EPS8 gene family. The encoded protein, like other members of the family, is thought to link growth factor stimulation to actin organization, generating functional redundancy in the pathways that regulate actin cytoskeletal remodeling. [provided by RefSeq, Dec 2008] (from NCBI)
Top mentioned proteins: Eps8, Eps8L1, Actin, cis-2, Eps8L3
Papers on Eps8L2
EPS8L2 is a new causal gene for childhood onset autosomal recessive progressive hearing loss.
Petit et al., Bab Ezzouar, Algeria. In Orphanet J Rare Dis, 2014
RESULTS: A frame-shift variant (c.1014delC; p.Ser339Alafs*15) was identified in EPS8L2, encoding Epidermal growth factor receptor Pathway Substrate 8 L2, a protein of hair cells' stereocilia previously implicated in progressive deafness in the mouse.
Progressive hearing loss and gradual deterioration of sensory hair bundles in the ears of mice lacking the actin-binding protein Eps8L2.
Marcotti et al., United Kingdom. In Proc Natl Acad Sci U S A, 2013
In the cochlea, whereas Eps8 is essential for the initial elongation of stereocilia, Eps8L2 is required for their maintenance in adult hair cells.
Molecular markers of endometrial carcinoma detected in uterine aspirates.
Gil-Moreno et al., Barcelona, Spain. In Int J Cancer, 2011
We identified ACAA1, AP1M2, CGN, DDR1, EPS8L2, FASTKD1, GMIP, IKBKE, P2RX4, P4HB, PHKG2, PPFIBP2, PPP1R16A, RASSF7, RNF183, SIRT6, TJP3, EFEMP2, SOCS2 and DCN as differentially expressed in ECs.
Reciprocal regulation of SH3 and SH2 domain binding via tyrosine phosphorylation of a common site in CD3epsilon.
Saksela et al., Helsinki, Finland. In J Immunol, 2007
CD3epsilon bound well also to Eps8 and Eps8L3, and modestly to Eps8L2, but not detectably to other SH3 domains tested.
Manipulation of thyroid status and/or GH injection alters hepatic gene expression in the juvenile chicken.
Cogburn et al., Newark, United States. In Cytogenet Genome Res, 2006
Several genes were identified which have not been previously ascribed as T3 responsive (e.g., DEFB9, EPS8L2, ARHGAP1, LASS2, INHBC).
A p53-dominant transcriptional response to cisplatin in testicular germ cell tumor-derived human embryonal carcinoma.
Spinella et al., United States. In Oncogene, 2005
Interestingly, in p53 knockdown cells nearly the entire set of identified cisplatin targets fail to respond or have a diminished response to cisplatin, suggesting that many are new direct or indirect targets of p53 including GPR87, STK17A, INPP5D, FLJ11259, and EPS8L2.
The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway.
Scita et al., Milano, Italy. In Mol Biol Cell, 2004
Here, we describe the identification and characterization of a family of eps8-related proteins, comprising three novel gene products, named eps8L1, eps8L2, and eps8L3.
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