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EPS8-like 1

Eps8L1, Eps8-like, epidermal growth factor receptor pathway substrate 8-like protein
This gene encodes a protein that is related to epidermal growth factor receptor pathway substrate 8 (EPS8), a substrate for the epidermal growth factor receptor. The function of this protein is unknown. At least two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Eps8, Actin, Eps8L2, Src, CD3epsilon
Papers on Eps8L1
Progressive hearing loss and gradual deterioration of sensory hair bundles in the ears of mice lacking the actin-binding protein Eps8L2.
Marcotti et al., United Kingdom. In Proc Natl Acad Sci U S A, 2013
We show that the actin-binding protein epidermal growth factor receptor pathway substrate 8 (Eps8)L2, a member of the Eps8-like protein family, is a newly identified hair bundle protein that is localized at the tips of stereocilia of both cochlear and vestibular hair cells.
Structural basis of PxxDY motif recognition in SH3 binding.
Permi et al., Helsinki, Finland. In J Mol Biol, 2008
The CD3epsilon peptide binds Eps8L1 SH3 in a class II orientation, but neither adopts a polyproline II helical conformation nor engages the first proline-binding pocket of the SH3 ligand binding interface.
Eps8 is increased in pancreatic cancer and required for dynamic actin-based cell protrusions and intercellular cytoskeletal organization.
Schmidt et al., Heidelberg, Germany. In Cancer Lett, 2007
Eps8 is essential for actin dynamics and cell interactions, independent of Eps8-like gene products.
Simultaneous detection of amide and methyl correlations using a time shared NMR experiment: application to binding epitope mapping.
Permi et al., Helsinki, Finland. In J Biomol Nmr, 2007
Experimental verification of proposed time-shared approach for simultaneous detection amide (15)N, (1)H and methyl (13)C, (1)H correlations has been carried out with three proteins, human ubiquitin, SH3 domain of human epidermal growth factor receptor pathway substrate 8-like protein (Eps8L1) and maltose binding protein complex with beta-Cyclodextrin.
Reciprocal regulation of SH3 and SH2 domain binding via tyrosine phosphorylation of a common site in CD3epsilon.
Saksela et al., Helsinki, Finland. In J Immunol, 2007
This screening identified Eps8L1 (epidermal growth factor receptor pathway substrate 8-like 1) together with the N-terminal SH3 domain of Nck1 and Nck2 as its preferred SH3 partners.
The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway.
Scita et al., Milano, Italy. In Mol Biol Cell, 2004
Here, we describe the identification and characterization of a family of eps8-related proteins, comprising three novel gene products, named eps8L1, eps8L2, and eps8L3.
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