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Epidermal growth factor receptor pathway substrate 8

Eps8, epidermal growth factor receptor pathway substrate 8
This gene encodes a member of the EPS8 family. This protein contains one PH domain and one SH3 domain. It functions as part of the EGFR pathway, though its exact role has not been determined. Highly similar proteins in other organisms are involved in the transduction of signals from Ras to Rac and growth factor-mediated actin remodeling. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Actin, Src, CAN, EGFR, Akt
Papers using Eps8 antibodies
Phospholipase D2-generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos
Supplier
Choi Eui-Ju et al., In The Journal of Cell Biology, 2006
... Rabbit polyclonal antibodies to CIIA, SOS1, and EPS8 were obtained from Santa Cruz Biotechnology, Inc ...
Papers on Eps8
The actin-binding protein EPS8 binds VE-cadherin and modulates YAP localization and signaling.
New
Dejana et al., Milano, Italy. In J Cell Biol, Jan 2016
We show that EPS8, a signaling adapter regulating actin dynamics, is a novel partner of VE-cadherin and is able to modulate YAP activity.
Identification of human leukemia antigen A*0201-restricted epitopes derived from epidermal growth factor pathway substrate number 8.
New
Li et al., Guangzhou, China. In Mol Med Report, Aug 2015
Epidermal growth factor receptor pathway substrate 8 (EPS8), whose function is pivotal for tumor proliferation, progression and metastasis, has been found to be overexpressed in most human tumor types, while its expression in normal tissue is low.
Formin 1 Regulates Ectoplasmic Specialization in the Rat Testis Through Its Actin Nucleation and Bundling Activity.
New
Cheng et al., Hong Kong, Hong Kong. In Endocrinology, Aug 2015
This disruptive effect on the tight junction barrier was mediated by a loss of actin microfilament bundling and actin polymerization capability mediated by changes in the localization of branched actin-inducing protein Arp3 (actin-related protein 3), and actin bundling proteins Eps8 (epidermal growth factor receptor pathway substrate 8) and palladin, thereby disrupting cell adhesion.
Overexpression of EPS8 is associated with poor prognosis in patients with acute lymphoblastic leukemia.
New
Li et al., Guangzhou, China. In Leuk Res, Jun 2015
A novel gene, epidermal growth factor receptor pathway substrate 8 (EPS8), is often over-expressed and associated with poor outcome in some solid tumor types.
Generation of cytotoxic T lymphocytes specific for native or modified peptides derived from the epidermal growth factor receptor pathway substrate 8 antigen.
New
He et al., Guangzhou, China. In Cancer Immunol Immunother, Feb 2015
The epidermal growth factor receptor pathway substrate 8 gene (Eps8) might be an effective antigen for cancer immunotherapy as it is overexpressed in a variety of cancer cells but not in normal tissues.
The angiopoietin1-Akt pathway regulates barrier function of the cultured spinal cord microvascular endothelial cells through Eps8.
Yuan et al., Shenyang, China. In Exp Cell Res, 2014
Besides, these roles of Ang1 in the BSCB in vitro were found to be accompanied with an increasing expression of epidermal growth factor receptor pathway substrate 8 (Eps8), an F-actin bundling protein.
The actin-binding proteins eps8 and gelsolin have complementary roles in regulating the growth and stability of mechanosensory hair bundles of mammalian cochlear outer hair cells.
Brown et al., Sheffield, United Kingdom. In Plos One, 2013
Gelsolin is part of a whirlin scaffolding protein complex at the stereocilia tip, which has been shown to interact with other actin regulatory molecules such as Eps8.
EPS8, encoding an actin-binding protein of cochlear hair cell stereocilia, is a new causal gene for autosomal recessive profound deafness.
Petit et al., Paris, France. In Orphanet J Rare Dis, 2013
RESULTS: A biallelic nonsense mutation, c.88C >‚ÄČT (p.Gln30*), was identified in EPS8 that encodes epidermal growth factor receptor pathway substrate 8, a 822 amino-acid protein involved in actin dynamics.
Novel oncoprotein EPS8: a new target for anticancer therapy.
Review
Du et al., Guangzhou, China. In Future Oncol, 2013
EPS8 was first identified as a tyrosine kinase substrate, that plays a role in EGFR-mediated mitogenic signaling.
Real-time quantitative polymerase chain reaction assay for detecting the eps8 gene in acute myeloid leukemia.
Li et al., Guangzhou, China. In Clin Lab, 2012
BACKGROUND: Eps8 is a novel proto-oncogene related to the tumorigenesis, proliferation, metastasis, chemo-resistance, and prognosis of many human solid cancers.
Silencing of Eps8 blocks migration and invasion in human glioblastoma cell lines.
GeneRIF
Vicentini et al., Milano, Italy. In Exp Cell Res, 2012
silencing of the protein by siRNA abrogated the migratory and invasive capacity of three different glioblastoma cell lines both in 2-dimensional and 3-dimensional in vitro assays.
Eps8 protein facilitates phagocytosis by increasing TLR4-MyD88 protein interaction in lipopolysaccharide-stimulated macrophages.
GeneRIF
Leu et al., Tainan City, Taiwan. In J Biol Chem, 2012
Eps8 is a key regulator of the LPS-stimulated TLR4-MyD88 interaction and contributes to macrophage phagocytosis
The signaling adaptor Eps8 is an essential actin capping protein for dendritic cell migration.
Impact
GeneRIF
Scita et al., Milano, Italy. In Immunity, 2011
identified Eps8 as a unique actin capping protein specifically required for Dendritic cell migration
The Eps8/IRSp53/VASP network differentially controls actin capping and bundling in filopodia formation.
GeneRIF
Ciliberto et al., Milano, Italy. In Plos Comput Biol, 2011
Studied generation of filopodia with regards to the dynamic interaction established by Eps8, IRSp53 and VASP with actin filaments.
Regulation of spermiogenesis, spermiation and blood-testis barrier dynamics: novel insights from studies on Eps8 and Arp3.
Review
Mruk et al., New York City, United States. In Biochem J, 2011
In the present review, we critically evaluate these and other findings in the literature as they relate to the restricted temporal and spatial expression of two actin regulatory proteins, namely Eps8 (epidermal growth factor receptor pathway substrate 8) and Arp3 (actin-related protein 3), which regulate these events.
Eps8 regulates hair bundle length and functional maturation of mammalian auditory hair cells.
GeneRIF
Marcotti et al., Sheffield, United Kingdom. In Plos Biol, 2011
epidermal growth factor receptor pathway substrate 8 is critical in coordinating the development and functionality of mammalian auditory hair cells
The myotubularin family of lipid phosphatases in disease and in spermatogenesis.
Review
Cheng et al., New York City, United States. In Biochem J, 2011
We also describe a working model to explain how MTMR2 interacts with other proteins such as c-Src, dynamin 2, EPS8 (growth factor receptor pathway substrate 8) and ARP2/3 (actin-related protein 2/3) at the apical ES and the apical TBC (tubulobulbar complex; tubular-like invaginations that function in the disassembly of the apical ES and in the recycling of its components) to regulate spermiation at late stage VIII of the seminiferous epithelial cycle.
Meta-analysis and meta-review of thyroid cancer gene expression profiling studies identifies important diagnostic biomarkers.
Review
Impact
Wiseman et al., Vancouver, Canada. In J Clin Oncol, 2006
A review of the top 12 candidates revealed well known thyroid cancer markers such as MET, TFF3, SERPINA1, TIMP1, FN1, and TPO as well as relatively novel or uncharacterized genes such as TGFA, QPCT, CRABP1, FCGBP, EPS8 and PROS1.
A novel actin barbed-end-capping activity in EPS-8 regulates apical morphogenesis in intestinal cells of Caenorhabditis elegans.
Impact
Di Fiore et al., Milano, Italy. In Nat Cell Biol, 2004
This is the case for Eps8, a receptor tyrosine kinase (RTK) substrate that participates in the activation of the Rac-specific guanine nucleotide-exchange function of Sos1 (refs 2-5), thereby regulating actin remodelling by RTKs.
EPS8 and E3B1 transduce signals from Ras to Rac.
Impact
Di Fiore et al., Milano, Italy. In Nature, 1999
Eps8 (relative molecular mass 97,000) is a substrate of receptors with tyrosine kinase activity which binds, through its SH3 domain, to a protein designated E3b1/Abi-1.
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