gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Epidermal growth factor receptor pathway substrate 15-like 1

Eps15R
Top mentioned proteins: Eps15, Epidermal Growth Factor, Ubiquitin, V1a, p15
Papers using Eps15R antibodies
The mitotic spindle matrix: a fibro-membranous lamin connection
Supplier
Zheng Yixian et al., In The Journal of Cell Biology, 2005
... monoclonal antibody against clathrin heavy chain (BD) and Eps15 (BD), and rabbit monoclonal antibody against Eps15R (Epitomics, Inc.) were used at ...
Clathrin-independent endocytosis of ubiquitinated cargos.
Supplier
Gruenberg Jean, In PLoS ONE, 2004
... Rabbit anti-Eps15R and anti-Epsin1 polyclonal Abs were from Epitomics (Burlingame, CA, USA) ...
Papers on Eps15R
Eps15R is required for bone morphogenetic protein signalling and differentially compartmentalizes with Smad proteins.
Thomsen et al., Cambridge, United Kingdom. In Open Biol, 2012
The endocytic adaptor protein Eps15R, or 'epidermal growth factor (EGF) receptor pathway substrate 15-related protein' is a component of EGF signal transduction, mediating internalization of the EGF receptor.
Eps15: a multifunctional adaptor protein regulating intracellular trafficking.
van Bergen En Henegouwen, Utrecht, Netherlands. In Cell Commun Signal, 2008
It is proposed that Eps15 and its family members Eps15R and Eps15b are involved in the regulation of membrane morphology, which is required for intracellular vesicle formation and trafficking.
Lipid raft-dependent FcepsilonRI ubiquitination regulates receptor endocytosis through the action of ubiquitin binding adaptors.
Paolini et al., Roma, Italy. In Plos One, 2008
Notably, the triple depletion of Eps15, Eps15R and Epsin1 negatively affects the early steps of Ag-induced receptor endocytosis, whereas Hrs depletion retains ubiquitinated receptors into early endosomes and partially prevents their sorting into lysosomes for degradation.
The in vivo phosphorylation sites in multiple isoforms of amphiphysin I from rat brain nerve terminals.
Robinson et al., Sydney, Australia. In Mol Cell Proteomics, 2008
Multiple phosphosites from amphI-co-migrating synaptosomal proteins were also identified, including SGIP (Src homology 3 domain growth factor receptor-bound 2 (Grb2)-like (endophilin)-interacting protein 1), AAK1, eps15R, MAP6, alpha/beta-adducin, and HCN1.
EPS15R, TASP1, and PRPF3 are novel disease candidate genes targeted by HNF4alpha splice variants in hepatocellular carcinomas.
GeneRIF
Borlak et al., Hannover, Germany. In Gastroenterology, 2008
EPS15 and EPS15R mediated internalization of activated EGF receptor to result in receptor recycling as to reinforce the proliferative response to EGF.
Different routes of bone morphogenic protein (BMP) receptor endocytosis influence BMP signaling.
Knaus et al., Würzburg, Germany. In Mol Cell Biol, 2006
Furthermore, we show that BRII interacts with Eps15R, a constitutive component of CCPs, and with caveolin-1, the marker protein of caveolae.
RNA interference screen reveals an essential role of Nedd4-2 in dopamine transporter ubiquitination and endocytosis.
Sorkin et al., Aurora, United States. In J Neurosci, 2006
Large-scale RNA interference analysis of PKC-dependent endocytosis of HA-DAT revealed the essential and specific role of an E3 ubiquitin ligase, Nedd4-2 (neural precursor cell expressed, developmentally downregulated 4-2), as well as the involvement of adaptor proteins present in clathrin-coated pits, such as epsin, Eps15 (epidermal growth factor pathway substrate clone 15), and Eps15R (Eps15-related protein).
Bending a membrane: how clathrin affects budding.
Ungewickell et al., Hannover, Germany. In Proc Natl Acad Sci U S A, 2006
We have found that domains containing the adapter complex 2 (AP2)-coated vesicle adapter and the endocytic accessory proteins CALM (clathrin assembly lymphoid myeloid leukemia protein), epsin, and eps15/eps15R (EGF receptor pathway substrate 15-related) nevertheless persist at the plasma membrane.
Gene expression analysis of ELF-MF exposed human monocytes indicating the involvement of the alternative activation pathway.
Simkó et al., Rostock, Germany. In Biochim Biophys Acta, 2006
Significant regulations could be analyzed for 5 genes (expression >2- or <0.5-fold): IL15RA (Interleukin 15 receptor, alpha chain), EPS15R (Epidermal growth factor receptor pathway substrate 15 - like 1), DNMT3A (Hypothetical protein MGC16121), DNMT3A (DNA (cytosine-5) methyltransferase 3 alpha), and one gene with no match to known genes, DKFZP586J1624.
Ubiquilin recruits Eps15 into ubiquitin-rich cytoplasmic aggregates via a UIM-UBL interaction.
van Bergen en Henegouwen et al., Utrecht, Netherlands. In J Cell Sci, 2005
Eps15 and its related protein Eps15R are key components of the clathrin-mediated endocytic pathway.
Clathrin-independent endocytosis of ubiquitinated cargos.
Polo et al., Milano, Italy. In Proc Natl Acad Sci U S A, 2005
Non-clathrin internalization of ubiquitinated EGFR depends on its interaction with proteins harboring the Ub-interacting motif, as shown through the ablation of three Ub-interacting motif-containing proteins, eps15, eps15R, and epsin.
Gene expression profiling of ErbB receptor and ligand-dependent transcription.
Stern et al., New Haven, United States. In Oncogene, 2004
These include ErbB4 targets EPS15R, GATA4, and RAB2 and ErbB2-activated HRY/HES1 and PPAP2A.
A ubiquitin-interacting motif (UIM) is essential for Eps15 and Eps15R ubiquitination.
van Bergen en Henegouwen et al., Utrecht, Netherlands. In J Biol Chem, 2002
Eps15 and its related partner Eps15R play a key role in clathrin-mediated endocytosis of transmembrane receptors.
A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins.
Impact
GeneRIF
Di Fiore et al., Milano, Italy. In Nature, 2002
a short amino-acid stretch at the carboxy-termini of the monoubiquitinated endocytic proteins Eps15 and eps15R is indispensable for their monoubiquitination
The Eps15 homology (EH) domain.
Review
Di Fiore et al., Milano, Italy. In Febs Lett, 2002
The Eps15 homology (EH) domain was originally identified as a motif present in three copies at the NH2-termini of Eps15 and of the related molecule Eps15R.
share on facebooktweetadd +1mail to friends