Cyclooxygenase- and cytochrome P450-derived eicosanoids in stroke.
Guangzhou, China. In Prostaglandins Other Lipid Mediat, Jan 2016
Several elegant studies have contributed to defining the importance of stabilizing the levels of epoxyeicosatrienoic acids (EETs), by inhibiting or deleting soluble epoxide hydrolase (sEH), in stroke research.
A multimodal disease modifying approach to treat neuropathic pain - inhibition of soluble epoxide hydrolase (sEH).
United States. In Drug Discov Today, Nov 2015
Here we review evidence that inhibition of soluble epoxide hydrolase (sEH), the enzyme that degrades epoxyeicosatrienoic acids (EETs), has potential to be a multimodal, disease modifying approach to treat NP: (1) EET actions involve both endogenous opioid system and the GABAergic systems thus provide superior pain relief compared to morphine or gabapentin, (2) EETs are directly anti-inflammatory and inhibit expression of inflammatory cytokines and adhesion molecules thus can prevent continued nerve damage; and (3) EETs promote nerve regeneration in cultured neurons.
Dicarbonyl reduction by single enzyme for the preparation of chiral diols.
Nanjing, China. In Chem Soc Rev, 2012
While the preparation of optically pure diols is generally not an easy task in synthetic organic chemistry, three classes of enzymes, namely dicarbonyl reductase, dioxygenase and epoxide hydrolase, display remarkable ability to stereoselectively introduce two hydroxyl groups in a single-step enzymatic conversion.