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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Epoxide hydrolase 1, microsomal

epoxide hydrolase, EPHX1, mEH, Microsomal epoxide hydrolase
Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Epoxide hydrolase functions in both the activation and detoxification of epoxides. Mutations in this gene cause preeclampsia, epoxide hydrolase deficiency or increased epoxide hydrolase activity. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2008] (from NCBI)
Top mentioned proteins: soluble epoxide hydrolase, ACID, CAN, HAD, Cyp
Papers on epoxide hydrolase
The Membrane Topology of Vitamin K Epoxide Reductase is conserved between Human Isoforms and the Bacterial Enzyme.
New
Bulleid et al., Glasgow, United Kingdom. In Biochem J, Feb 2016
UNASSIGNED: The membrane topology of vitamin K epoxide hydrolase (VKOR) is controversial with data supporting both a three transmembrane and a four transmembrane model.
Visualizing the mechanism of epoxide hydrolysis by the bacterial virulence enzyme Cif.
New
Madden et al., In Biochemistry, Feb 2016
UNASSIGNED: The CFTR inhibitory factor (Cif) is an epoxide hydrolase (EH) virulence factor secreted by the bacterium Pseudomonas aeruginosa.
Cyclooxygenase- and cytochrome P450-derived eicosanoids in stroke.
Review
New
Wang et al., Guangzhou, China. In Prostaglandins Other Lipid Mediat, Jan 2016
Several elegant studies have contributed to defining the importance of stabilizing the levels of epoxyeicosatrienoic acids (EETs), by inhibiting or deleting soluble epoxide hydrolase (sEH), in stroke research.
Soluble Epoxide Hydrolase: A Potential Target for Metabolic Diseases.
Review
New
Ai et al., Tianjin, China. In J Diabetes, Jan 2016
EETs can be further hydrolyzed to less active diols by the enzyme soluble epoxide hydrolase (sEH).
Renal Ischemia/Reperfusion Injury in Soluble Epoxide Hydrolase-Deficient Mice.
New
Schunck et al., Berlin, Germany. In Plos One, Dec 2015
EETs are rapidly metabolized to dihydroxyeicosatrienoic acids (DHETs) by the soluble epoxide hydrolase (sEH).
A multimodal disease modifying approach to treat neuropathic pain - inhibition of soluble epoxide hydrolase (sEH).
Review
New
Khanna et al., United States. In Drug Discov Today, Nov 2015
Here we review evidence that inhibition of soluble epoxide hydrolase (sEH), the enzyme that degrades epoxyeicosatrienoic acids (EETs), has potential to be a multimodal, disease modifying approach to treat NP: (1) EET actions involve both endogenous opioid system and the GABAergic systems thus provide superior pain relief compared to morphine or gabapentin, (2) EETs are directly anti-inflammatory and inhibit expression of inflammatory cytokines and adhesion molecules thus can prevent continued nerve damage; and (3) EETs promote nerve regeneration in cultured neurons.
Microsomal epoxide hydrolase 1 (EPHX1): Gene, structure, function, and role in human disease.
Review
New
Souček et al., Praha, Czech Republic. In Gene, Nov 2015
Microsomal epoxide hydrolase (EPHX1) is an evolutionarily highly conserved biotransformation enzyme for converting epoxides to diols.
Analysis of DNA Methylation and Hydroxymethylation in the Genome of Crustacean Daphnia pulex.
Lazutka et al., Vilnius, Lithuania. In Genes (basel), 2014
Then, analysis of 5-mC and 5-hmC using pairs of restriction enzymes with different sensitivity to methylation and hydroxymethylation confirmed the presence of both modifications in selected regions of three genes (Cox4, Cand2 and Ephx1).
Reprogramming: A Preventive Strategy in Hypertension Focusing on the Kidney.
Review
Joles et al., Kao-hsiung, Taiwan. In Int J Mol Sci, 2014
Furthermore, a significantly increased expression of gene Ephx2 (soluble epoxide hydrolase) was noted in both genetic and acquired animal models of hypertension.
Association between EPHX1 rs1051740 and lung cancer susceptibility: a meta-analysis.
Long et al., Shanghai, China. In Int J Clin Exp Med, 2014
BACKGROUND: Microsomal epoxide hydrolase 1 (EPHX1) may play an important role in epigenetic change and DNA repair concerned with lung cancer.
The pharmacology of the cytochrome P450 epoxygenase/soluble epoxide hydrolase axis in the vasculature and cardiovascular disease.
Review
Impact
Fleming, Frankfurt am Main, Germany. In Pharmacol Rev, 2014
Moreover, inhibitors of the soluble epoxide hydrolase that increase epoxide but decrease diol levels have potential for the treatment of the metabolic syndrome.
Impact of soluble epoxide hydrolase and epoxyeicosanoids on human health.
Review
Impact
Hammock et al., Davis, United States. In Annu Rev Pharmacol Toxicol, 2012
The presence of epoxyeicosatrienoic acids (EETs) in tissues and their metabolism by soluble epoxide hydrolase (sEH) to 1,2-diols were first reported 30 years ago.
EPHX1 polymorphisms do not modify esophageal carcinoma susceptibility in Dutch Caucasians.
GeneRIF
Peters et al., Nijmegen, Netherlands. In Oncol Rep, 2012
the polymorphisms in exon 3 and exon 4 of the EPHX1 gene do not seem to be modifiers of esophageal squamous cell carcinoma or esophageal adenocarcinoma risk in Dutch Caucasians.
Investigation of a possible relationship between EPHX1 gene polymorphisms and colorectal cancer in Turkish society.
GeneRIF
Yaylim et al., İstanbul, Turkey. In Genet Test Mol Biomarkers, 2012
Exon 3 Tyr113His and exon 4 His139Arg polymorphisms of EPHX1 are risk factors for colorectal cancer in Turkey.
Enzymatic catalysis of anti-Baldwin ring closure in polyether biosynthesis.
Impact
Kim et al., Singapore, Singapore. In Nature, 2012
Recently, we identified Lsd19 from the Streptomyces lasaliensis gene cluster as the epoxide hydrolase responsible for the epoxide-opening cyclization of bisepoxyprelasalocid A to form lasalocid A.
Dicarbonyl reduction by single enzyme for the preparation of chiral diols.
Review
Impact
Wu et al., Nanjing, China. In Chem Soc Rev, 2012
While the preparation of optically pure diols is generally not an easy task in synthetic organic chemistry, three classes of enzymes, namely dicarbonyl reductase, dioxygenase and epoxide hydrolase, display remarkable ability to stereoselectively introduce two hydroxyl groups in a single-step enzymatic conversion.
Association of polymorphisms in EPHX1, UGT2B7, ABCB1, ABCC2, SCN1A and SCN2A genes with carbamazepine therapy optimization.
GeneRIF
Liou et al., Taiwan. In Pharmacogenomics, 2012
the present study revealed that EPHX1, UGT2B7 and SCN1A genetic polymorphisms simultaneously modulated the CBZ maintenance doses and CDRs(concentration-dose ratios)
Epoxides and soluble epoxide hydrolase in cardiovascular physiology.
Review
Impact
Imig, Milwaukee, United States. In Physiol Rev, 2012
The contribution of EETs to vascular and cardiac function is further influenced by soluble epoxide hydrolase (sEH) that degrades EETs to diols.
Low microsomal epoxide hydrolase expression is associated with bladder carcinogenesis and recurrence.
GeneRIF
Kong et al., Shenyang, China. In Asian Pac J Cancer Prev, 2011
Low microsomal epoxide hydrolase expression is associated with bladder carcinogenesis and recurrence.
DNA damage and susceptibility assessment in industrial workers exposed to styrene.
GeneRIF
Teixeira et al., Porto, Portugal. In J Toxicol Environ Health A, 2011
genetic association studies in population of plastics workers in Portugal: investigation of association of genetic polymorphism in EPHX1 and susceptibility to DNA damage/sister chromatid exchange from occupational exposure to styrene
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