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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.


epiregulin, EREG
Epiregulin is a member of the epidermal growth factor family. Epiregulin can function as a ligand of EGFR (epidermal growth factor receptor), as well as a ligand of most members of the ERBB (v-erb-b2 oncogene homolog) family of tyrosine-kinase receptors. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: amphiregulin, Epidermal Growth Factor, EGFR, betacellulin, CAN
Papers on epiregulin
Development of an ErbB4 monoclonal antibody that blocks neuregulin-1-induced ErbB4 activation in cancer cells.
Nagano et al., Tokyo, Japan. In Biochem Biophys Res Commun, Feb 2016
ErbB4/HER4, which contains a ligand-binding extracellular region, is activated by several ligands, including neuregulins (NRGs), heparin-binding EGF-like growth factor, betacellulin and epiregulin.
Ephrin-A5 is required for optimal fertility and a complete ovulatory response to gonadotropins in the female mouse.
Deroo et al., Saint-Hyacinthe, Canada. In Endocrinology, Jan 2016
These results corresponded with a reduction in ovarian mRNA levels of several LH-responsive genes, including Pgr, Ptgs2, Tnfaip6, Ereg, Btc, and Adamts4, suggesting that Efna5(-/-) ovaries exhibit a partially attenuated response to luteinizing hormone.
Mapping the osteocytic cell response to fluid flow using RNA-Seq.
Donahue et al., State College, United States. In J Biomech, Jan 2016
Analyses were complimentary in patterns of regulation, though only 6 transcripts were significant in both RNA-Seq and microarray analyses: Cxcl5, Cxcl1, Zc3h12a, Ereg, Slc2a1, and Egln1.
Yap-dependent reprogramming of Lgr5(+) stem cells drives intestinal regeneration and cancer.
Wrana et al., Toronto, Canada. In Nature, Nov 2015
Accordingly, growth of Yap-deficient organoids is rescued by the Egfr ligand epiregulin, and we find that non-cell-autonomous production of stromal epiregulin may compensate for Yap loss in vivo.
Estrogen promotes the brain metastatic colonization of triple negative breast cancer cells via an astrocyte-mediated paracrine mechanism.
Cittelly et al., Aurora, United States. In Oncogene, Oct 2015
BM occur more frequently in patients with estrogen receptor-negative (ER-) breast cancer subtypes; HER2 overexpressing (HER2+) tumors and triple-negative (TN) (ER-, progesterone receptor-negative (PR-) and normal HER2) tumors.
New findings on primary and acquired resistance to anti-EGFR therapy in metastatic colorectal cancer: do all roads lead to RAS?
Russo et al., Palermo, Italy. In Oncotarget, Oct 2015
Many biomarkers, including KRAS and NRAS mutations, BRAF mutations, PIK3CA mutations, PTEN loss, AREG and EREG expression, and HER-2 amplification have already been identified to select responders to anti-EGFR agents.
Gene expression analysis of pig cumulus-oocyte complexes stimulated in vitro with follicle stimulating hormone or epidermal growth factor-like peptides.
Prochazka et al., Czech Republic. In Reprod Biol Endocrinol, 2014
BACKGROUND: The gonadotropin-induced resumption of oocyte meiosis in preovulatory follicles is preceded by expression of epidermal growth factor (EGF)-like peptides, amphiregulin (AREG) and epiregulin (EREG), in mural granulosa and cumulus cells.
Epiregulin: roles in normal physiology and cancer.
Cullum et al., Auburn, United States. In Semin Cell Dev Biol, 2014
Epiregulin is a 46-amino acid protein that belongs to the epidermal growth factor (EGF) family of peptide hormones.
The reverse-direction method links mass experimental data to human diseases.
Murakami et al., Ōsaka, Japan. In Arch Immunol Ther Exp (warsz), 2014
As an example, the epiregulin-epidermal growth factor receptor pathway was identified as a regulator of the inflammation amplifier, and associated with human diseases by GWAS.
Gene silencing of EREG mediated by DNA methylation and histone modification in human gastric cancers.
Kim et al., Seoul, South Korea. In Lab Invest, 2012
EREG gene expression was low in 7 out of 11 gastric cancer cells and this downregulation was mediated by aberrant CpG methylation of the EREG promoter.
Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4.
Schwabe et al., New York City, United States. In Cancer Cell, 2012
TLR4 and the intestinal microbiota were not required for HCC initiation but for HCC promotion, mediating increased proliferation, expression of the hepatomitogen epiregulin, and prevention of apoptosis.
Evolution of the predictive markers amphiregulin and epiregulin mRNAs during long-term cetuximab treatment of KRAS wild-type tumor cells.
Menendez et al., Girona, Spain. In Invest New Drugs, 2012
Data suggest that expression status of AR and EPI mRNAs might be evaluated as dynamic predictors of response in KRAS WT patients receiving any cetuximab-based therapy.
Epiregulin (EREG) variation is associated with susceptibility to tuberculosis.
Dunstan et al., Thành phố Hồ Chí Minh, Vietnam. In Genes Immun, 2012
Epiregulin (EREG) variation is associated with susceptibility to tuberculosis.
Relationships between progesterone receptor isoforms and the HER/ErbB receptors and ligands network in 299 primary breast cancers.
Bonneterre et al., Lille, France. In Int J Biol Markers, 2012
RESULTS: mRNA levels of the PR isoforms positively correlated with protein levels of estradiol receptors (ER) and PR.
EGFR ligands exhibit functional differences in models of paracrine and autocrine signaling.
Riese et al., West Lafayette, United States. In Growth Factors, 2012
In 32D/EGFR myeloid and MCF10A breast cells, soluble amphiregulin (AR), transforming growth factor alpha (TGFα), neuregulin 2 beta, and epigen stimulate greater EGFR coupling to cell proliferation and DNA synthesis than do EGF, betacellulin, heparin-binding EGF-like growth factor, and epiregulin.
Epiregulin as a marker for the initial steps of ovarian cancer development.
Schreiber et al., Israel. In Int J Oncol, 2011
It is suggested that follow-up of the expression of Ep can serve as a reliable early indication of the development of ovarian cancer.
Epiregulin-dependent amphiregulin expression and ERBB2 signaling are involved in luteinizing hormone-induced paracrine signaling pathways in mouse ovary.
Lee et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2011
This study implicates that EREG mediates signals downstream of Areg mRNA expression and that EGFR-ERBB2 signals contributes to regulation of ovulation process.
Amphiregulin and epiregulin mRNA expression in primary tumors predicts outcome in metastatic colorectal cancer treated with cetuximab.
Tejpar et al., Leuven, Belgium. In J Clin Oncol, 2009
PURPOSE: To study the power of the epidermal growth factor receptor (EGFR) epiregulin (EREG) and amphiregulin (AREG) ligands' expression in primary tumors to predict the outcome in patients with chemorefractory metastatic colorectal cancer (cmCRC) treated with the combination of cetuximab and irinotecan.
Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab.
Mauro et al., Princeton, United States. In J Clin Oncol, 2007
RESULTS: Gene expression profiles showed that patients with tumors that express high levels of the EGFR ligands epiregulin and amphiregulin are more likely to have disease control with cetuximab (EREG, P = .000015;
Mediators of vascular remodelling co-opted for sequential steps in lung metastasis.
Massagué et al., New York City, United States. In Nature, 2007
epiregulin, COX2, and MMP1 and 2 collectively facilitate the assembly of new tumour blood vessels, the release of tumour cells into the circulation, and the breaching of lung capillaries by circulating tumour cells to seed pulmonary metastasis
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